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    • 22. 发明授权
    • Viral polyhedra complexes and methods of use
    • 病毒多面体复合物及其使用方法
    • US08554493B2
    • 2013-10-08
    • US12529110
    • 2008-02-28
    • Peter MetcalfFasseli Joseph CoulibalyHajime MoriNorio HamadaKeiko IkedaYui Lam Elaine ChiuHiroshi Ijiri
    • Peter MetcalfFasseli Joseph CoulibalyHajime MoriNorio HamadaKeiko IkedaYui Lam Elaine ChiuHiroshi Ijiri
    • G06F19/00
    • C07K14/005A01N25/34A01N63/00A61K47/6901A61K47/6949B82Y5/00C07K14/475C07K14/485C07K14/50C07K2319/735C12N2710/14043C12N2720/12022A01N61/00A01N63/02A01N2300/00
    • Cypoviruses and baculoviruses are notoriously difficult to eradicate because the virus particles are embedded in micron-sized protein crystals called polyhedra. The remarkable stability of polyhedra means that like bacterial spores these insect viruses remain infectious for years in soil. Although these unique in vivo protein crystals have been extensively characterized since the early 1900s, their atomic organization remains elusive. Here we describe the 2 crystal structure of both recombinant and infectious silkworm cypovirus polyhedra determined using 5-12 micron crystals purified from insect cells. These are the smallest crystals yet used for de novo X-ray protein structure determination. It was found that polyhedra are made of trimers of the viral polyhedrin protein and contain nucleotides. Although the shape of these building blocks is reminiscent of some capsid trimers, polyhedrin has a new fold and has evolved to assemble in vivo into 3-D cubic crystals rather than icosahedral shells. The polyhedrin trimers are extensively cross-linked in polyhedra by non-covalent interactions and pack with an exquisite molecular complementarity similar to that of antigen-antibody complexes. The resulting ultra-stable and sealed crystals shield the virus particles from environmental damage. The structure suggests that polyhedra can serve as the basis for the development of robust and versatile nanoparticles for biotechnological applications such as in cell culture systems, microarrays and biopesticides.
    • 由于病毒颗粒嵌入称为多面体的微米级蛋白质晶体中,Cypoviruses和杆状病毒众所周知难以根除。 多面体的显着稳定意味着像细菌孢子一样,这些昆虫病毒在土壤中仍然具有传染性多年。 虽然这些独特的体内蛋白质晶体自20世纪初以来已被广泛地表征,但它们的原子组织仍然难以捉摸。 这里我们描述使用从昆虫细胞纯化的5-12微米晶体测定的重组和感染性蚕病毒多面体的2晶体结构。 这些是用于从头X射线蛋白质结构测定的最小晶体。 发现多面体由病毒多角体蛋白的三聚体构成并含有核苷酸。 尽管这些结构单元的形状让人联想到一些衣壳三聚体,但多角体蛋白具有新的折叠,并已发展成体内装配成3-D立方晶体而不是二十面体壳。 多面体三聚体通过非共价相互作用在多面体中广泛交联,并具有类似于抗原 - 抗体复合物的精细分子互补性。 所得到的超稳定和密封的晶体屏蔽病毒颗粒免受环境破坏。 该结构表明,多面体可以作为开发用于生物技术应用的强壮和多功能纳米颗粒的基础,例如在细胞培养系统,微阵列和生物杀虫剂中。
    • 24. 发明申请
    • JET PUMP BEAM AND METHOD FOR PRODUCING THE SAME
    • 喷射泵梁及其制造方法
    • US20110255649A1
    • 2011-10-20
    • US13139835
    • 2009-12-01
    • Yoshinori KatayamaMotoji TsubotaYuuji SaitoHajime MoriNorihiko Tanaka
    • Yoshinori KatayamaMotoji TsubotaYuuji SaitoHajime MoriNorihiko Tanaka
    • G21C15/25C22F1/10
    • G21C15/25C22C19/055C22C19/056C22F1/10Y02E30/40
    • A jet pump beam is made of improved heat-treated precipitation-hardened nickel base alloy excellent in anti-stress corrosion cracking properties and high-temperature strength, and having high ductility and a high elastic modulus. A jet pump beam 27 made of improved heat-treated nickel base alloy is produced by preparing a precipitation-strengthened nickel base alloy material having a component composition containing by mass %, Ni: 50.0% to 55.0%, Cr: 17.0% to 21.0%, Nb+Ta: 4.75% to 5.50%, Mo: 2.8% to 3.3%, Ti: 0.65% to 1.15%, Al: 0.2% to 0.8%, C: 0.08% or less, Mn: 0.35% or less, Si: 0.35% or less, S: 0.015% or less, P: 0.03% or less, Cu: 0.30% or less, B: 0.006% or less, and Co: 1.0% or less, and Fe and inevitable impurities constituting a remaining part, subjecting the nickel base alloy material to solution heat treatment at a temperature of 1010° C. to 1090° C., and subjecting the nickel base alloy material to age-hardening heat treatment at a temperature of 694° C. to 714° C. for 5 to 7 hours after the solution heat treatment.
    • 喷射泵梁由改进的经热处理的沉淀硬化镍基合金制成,具有优异的抗应力腐蚀开裂性能和高温强度,并且具有高延展性和高弹性模量。 通过制备具有以质量%计含量的组分组成的沉淀强化镍基合金材料制备由改进的热处理镍基合金制成的喷射泵梁27,Ni:50.0%至55.0%,Cr:17.0%至21.0% ,Nb + Ta:4.75〜5.50%,Mo:2.8〜3.3%,Ti:0.65%〜1.15%,Al:0.2〜0.8%,C:0.08%以下,Mn:0.35% :0.35%以下,S:0.015%以下,P:0.03%以下,Cu:0.30%以下,B:0.006%以下,Co:1.0%以下,Fe和不可避免的杂质构成残留 将镍基合金材料在1010℃至1090℃的温度下进行固溶热处理,并将镍基合金材料在694℃至714℃的温度下进行老化硬化热处理 C.溶解热处理后5〜7小时。
    • 25. 发明申请
    • STORAGE SYSTEM, CONTROL METHOD OF STORAGE DEVICE
    • 存储系统,存储设备的控制方法
    • US20110016336A1
    • 2011-01-20
    • US12602691
    • 2009-07-15
    • Hajime MoriKatsumi OuchiYuichi Taguchi
    • Hajime MoriKatsumi OuchiYuichi Taguchi
    • G06F1/32G06F1/26G06F12/00
    • G06F3/0634G06F3/0625G06F3/067G06F3/0674Y02D10/154
    • The present invention provides a technique that enables, in an environment in which an upper limit of electric energy consumption is prescribed for a specific period, operations of a storage device while keeping the electric energy consumption within the prescribed upper limit and, at the same time, maintaining operations of a disk device of a storage device necessary for providing services to a user. A storage system according to the present invention includes a storage device having one or more energized parts and a management device that manages operations of the storage device. The management device acquires electric energy consumption of the energized part and controls the operational state of the energized part so that the electric energy consumption of the storage device over a predetermined period does not exceed a prescribed upper limit.
    • 本发明提供一种技术,其能够在将电能消耗保持在规定上限的同时,在一定时间内规定电能消耗的上限的环境中进行存储装置的动作,同时, 维护为用户提供服务所必需的存储设备的磁盘设备的操作。 根据本发明的存储系统包括具有一个或多个通电部件的存储装置和管理该存储装置的操作的管理装置。 管理装置取得通电部的电能消耗,控制通电部的动作状态,使得在规定期间内的存储装置的电能消耗不超过规定的上限。
    • 26. 发明授权
    • Storage control device, and control method for storage control device
    • 存储控制装置及存储控制装置的控制方法
    • US07865664B2
    • 2011-01-04
    • US12324277
    • 2008-11-26
    • Hajime MoriAkira Nishimoto
    • Hajime MoriAkira Nishimoto
    • G06F13/10
    • G06F3/0661G06F3/0608G06F3/064G06F3/0689G06F11/1076G06F12/0866G06F12/0886G06F2211/1007G06F2212/262G06F2212/401
    • The storage control device of the present invention is able to perform input and output of data between blocks whose size is different with good efficiency. The size of extended logical blocks, which are units of data input and output within a storage control device, and the size of physical blocks, which are provided within the storage device, are different from one another. A write object range generation unit reads out both of the extended logical blocks which are adjacent to the write data, and creates a write object range by linking them to the write data. An assurance code checking unit checks a corresponding assurance code for each of these extended logical blocks. And a block size adjustment unit deletes superfluous data from the adjacent blocks, and adjusts the size of the write object range, so that it becomes an integral multiple of the size of the physical blocks.
    • 本发明的存储控制装置能够以高效率在大小不同的块之间进行数据的输入输出。 作为存储控制装置内的数据输入和输出的单位的扩展逻辑块的大小和存储装置内的物理块的大小彼此不同。 写对象范围生成单元读出与写入数据相邻的两个扩展逻辑块,并通过将写入对象范围与写入数据相连接来创建写入对象范围。 保证代码检查单元检查每个这些扩展逻辑块的相应保证代码。 并且块大小调整单元从相邻块中删除多余的数据,并调整写入对象范围的大小,使其成为物理块大小的整数倍。