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21. 发明专利

JP2008086324A Human g protein chemokine receptor hdgnr10 审中-公开
标题翻译：人类G蛋白激素受体HDGNR10
公开(公告)号：JP2008086324A
公开(公告)日：2008-04-17
申请号：JP2007278211
申请日：2007-10-25
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： LI YI , RUBEN STEVEN M
IPC分类号： C12N15/09 , C07K14/715
摘要： PROBLEM TO BE SOLVED: To provide a compositions and a method for treating and/or diagnosing a number of physiological and pathological states containing immunological diseases. SOLUTION: There provided are new mature receptor polypeptides as well as physiologically active and diagnostically or therapeutically useful fragments, analogs and derivatives thereof, wherein the receptor polypeptides of the present invention are of human origin. Or in accordance with another aspect of the present invention, there are provided isolated nucleic acid molecules encoding the receptor polypeptides of the present invention, including an mRNA, a DNA, a cDNA, a genomic DNA as well as antisense analogs thereof and biologically active and diagnostically or therapeutically useful fragments thereof. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种治疗和/或诊断含有免疫疾病的生理和病理状态的组合物和方法。提供了新的成熟受体多肽以及生理活性和诊断或治疗上有用的片段，类似物和衍生物，其中本发明的受体多肽是人源的。或者根据本发明的另一方面，提供了编码本发明的受体多肽的分离的核酸分子，其包括mRNA，DNA，cDNA，基因组DNA及其反义类似物，并且具有生物活性和其诊断或治疗有用的片段。版权所有（C）2008，JPO＆INPIT

22. 发明专利

JP2007130021A Human g protein chemokine receptor hdgnr10 审中-公开
标题翻译：人类G蛋白激素受体HDGNR10
公开(公告)号：JP2007130021A
公开(公告)日：2007-05-31
申请号：JP2006331207
申请日：2006-12-07
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッドHuman Genome Sciences, Inc.
发明人： LI YI , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P7/00 , A61P11/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07K14/715
摘要： PROBLEM TO BE SOLVED: To provide a composition and a method for treating and/or diagnosing many physiological and disease conditions including immunological disease. SOLUTION: The new matured receptor polypeptide and the fragment, the analogue and the derivative thereof, biologically active and useful for diagnosis and treatment (wherein, the receptor peptide is derived from human beings) are provided. In another aspect, the isolated nucleic acid molecule encoding the receptor polypeptide (the nucleic acid molecule includes a mRNA, a DNA, a cDNA, a genome DNA, and an antisense analogue and a biologically active fragment useful for diagnosis and treatment) is also provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供治疗和/或诊断包括免疫疾病在内的许多生理和疾病状况的组合物和方法。解决方案：提供了新的成熟受体多肽和其生物活性并且可用于诊断和治疗（其中受体肽源自人类）的片段，其类似物和衍生物。在另一方面，还提供编码受体多肽（核酸分子包括mRNA，DNA，cDNA，基因组DNA，以及用于诊断和治疗的反义类似物和生物活性片段）的分离的核酸分子。版权所有（C）2007，JPO＆INPIT

23. 发明专利

JP2001025391A HUMAN G PROTEIN CHEMOKINE RECEPTOR HDGNR10 失效
公开(公告)号：JP2001025391A
公开(公告)日：2001-01-30
申请号：JP2000171338
申请日：2000-06-07
申请人： HUMAN GENOME SCIENCES INC
发明人： LI YI , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61P11/06 , A61P17/02 , A61P19/02 , A61P37/08 , C07K14/715 , C12P21/02 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain a new polynucleotide which codes for a human G protein chemokine receptor polypeptide having a specific amino acid sequence, and is useful for treating and diagnosing many physiological and disease conditions including immunological diseases and so on. SOLUTION: This is a new polynucleotide which is selected from the group consisting of a polynucleotide coding for the (mature) polypeptide represented by formula I, a polynucleotide containing the base sequence represented by formula II coding for a (mature) human G protein chemokine receptor peptide, a polynucleotide having a homology at 90% or more, 95% or more, or 97% or more, respectively, to these polynucleotides, polynucleotides complimentary to these and so on, and is useful for producing a composition for treating and diagnosing many physiological and disease conditions including immunological diseases such as injury healing, blood formation regulation, allergy, asthma, arthritis and so on. This polynucleotide is obtained by screening a cDNA library derived from a human monocyte.

24. 发明专利

JP2003102486A HUMAN CHEMOKINE beta-8, CHEMOKINE beta-1 AND MACROPHAGE INFLAMMATORY PROTEIN-4 审中-公开
公开(公告)号：JP2003102486A
公开(公告)日：2003-04-08
申请号：JP2002181851
申请日：2002-06-21
申请人： HUMAN GENOME SCIENCES INC
发明人： ROSEN CRAIG A , RUBEN STEVEN M , LI HAODONG , ADAMS MARK D
IPC分类号： F28F9/02 , A61K31/70 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/10 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K14/52 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12R1/91 , F25B1/00 , F25B39/00 , F28D1/053 , F28F9/18 , F28F9/22 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide human Ckβ-8, MIP-4 and Ckβ-1, a DNA (RNA) encoding such chemokine polypeptide, a method for producing the polypeptide by a recombination technology and a method for using the polypeptide for the treatment of leukemia, tumor, chronic infection, autoimmune disease, fibrosis, disorder healing and psoriasis. SOLUTION: The invention discloses an antagonist against the chemokine polypeptide, the use of the antagonist as an agent for the treatment of rheumatoid arthritis, autoimmune disease, acute inflammation and infection, allergic reaction, prostaglandin-dependent fever and bone marrow insufficiency, a diagnostic assay for the detection of diseases relating to the mutation in the nucleic acid sequence and a diagnostic assay for the detection of the varied concentration of the polypeptide.

25. 发明专利

JP2003088364A SERUM PARAOXONASE 审中-公开
公开(公告)号：JP2003088364A
公开(公告)日：2003-03-25
申请号：JP2002187866
申请日：2002-06-27
申请人： HUMAN GENOME SCIENCES INC
发明人： HUDSON PETER L , HE WEI WU , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K48/00 , A61P39/00 , A61P43/00 , C07K14/47 , C07K16/18 , C07K16/40 , C12N1/21 , C12N5/06 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/12 , C12N15/55 , C12P21/02 , C12P21/04 , G01N33/53 , G01N33/567
摘要： PROBLEM TO BE SOLVED: To provide a human serum paraoxonase enzyme, a DNA (RNA) encoding such serum paraoxonase, and a procedure for producing such peptide by using a recombinant technology. SOLUTION: The use of this polypeptide comprises the use as an antidote for an organic phosphoric acid salt poisoning and the use for avoiding apoptosis. The diagnostic assays for identifying a mutation in the nucleic acid sequence encoding the polypeptide and for detecting the changed level of the polypeptide are also provided.

26. 发明专利

JP2002325588A HUMAN DNA MISMATCH REPAIR PROTEIN 审中-公开
公开(公告)号：JP2002325588A
公开(公告)日：2002-11-12
申请号：JP2002016830
申请日：2002-01-25
申请人： HUMAN GENOME SCIENCES INC
发明人： HASELTINE WILLIAM A , RUBEN STEVEN M , IN FEI UEI , ADAMS MARK D , FLEISCHMANN ROBERT D , FRASER CLAIRE M , FULDNER REBECCA A , KIRKNESS EWEN F , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19
摘要： PROBLEM TO BE SOLVED: To provide a human DNA repair protein and a DNA (RNA) encoding the protein and further a process for producing the protein by a recombinant technique and a method for diagnosing an alteration in hMLH1, hMLH2 and hMLH3 genes. SOLUTION: The sequences of the hMLH1, hMLH2 and hMLH3 genes are provided and the method for diagnosing an alteration in the hMLH1, hMLH2 and hMLH3 genes is provided.

27. 发明专利

JP2003033192A G-protein parathyroid hormone receptor hltdg74 审中-公开
标题翻译： G-PROTEIN PARATHYROID HORMONE RECEPTOR HLTDG74
公开(公告)号：JP2003033192A
公开(公告)日：2003-02-04
申请号：JP2002137833
申请日：2002-05-13
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッド
发明人： DANIEL R SOPETTO , RI I , ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P3/14 , A61P5/00 , A61P13/12 , A61P19/10 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To identify an antagonist to or an agonist for a therapeutically usable polypeptide for inhibiting or stimulating a human G-protein parathyroid hormone(PTH) receptor. SOLUTION: The human G-protein parathyroid hormone(PTH) receptor is expressed on the surface of a cell, the cell is contacted with a receptor ligand and a compound to be screened, and whether the secondary signal is generated from the interaction between the ligand and the receptor is determined; further, whether the compound to be screened is an agonist or antagonist is identified.
摘要翻译：要解决的问题：鉴定用于抑制或刺激人G蛋白甲状旁腺激素（PTH）受体的治疗用多肽的拮抗剂或激动剂。解决方案：人G蛋白甲状旁腺激素（PTH）受体在细胞表面表达，细胞与待筛选的受体配体和化合物接触，以及辅助信号是否由配体之间的相互作用产生并确定受体; 进一步确定待筛选的化合物是否是激动剂或拮抗剂。

28. 发明专利

JP2003024068A Human g-protein receptor hgber32 审中-公开
标题翻译：人类G蛋白受体HGBER32
公开(公告)号：JP2003024068A
公开(公告)日：2003-01-28
申请号：JP2002162221
申请日：2002-06-03
申请人： Human Genome Sciences Inc , ヒューマンジノームサイエンシーズ, インコーポレイテッド
发明人： DANIEL R SOPETTO , RI I , ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： C12N15/09
摘要： PROBLEM TO BE SOLVED: To obtain human G-protein receptor HGBER32 and techniques regarding the same. SOLUTION: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods for using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：要解决的问题：获得人类G蛋白受体HGBER32及其相关技术。解决方案：公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

29. 发明专利

JPH1099087A INTELEUKIN-1 BETA CONVERTING ENZYMELIKE APOPTOTIC PROTEASE-6 失效
公开(公告)号：JPH1099087A
公开(公告)日：1998-04-21
申请号：JP16783897
申请日：1997-05-20
申请人： SMITHKLINE BEECHAM CORP , HUMAN GENOME SCIENCES INC , UNIV MICHIGAN
发明人： DIXIT VISHVA M , HE WEI-WU , KIKLY KRISTINE K , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/10 , A61P25/00 , A61P25/28 , A61P31/04 , A61P43/00 , C07K14/47 , C07K16/40 , C12N5/00 , C12N5/10 , C12N9/64 , C12N9/99 , C12N15/12 , C12Q1/68 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain a new nucleic acid, capable of encoding an interleukin-1β converting enzymelike apoptotic protease containing a specific amino acid sequence and useful for production, etc., of the enzyme, capable of controlling the apoptosis and useful in treatment, etc., of viral infection and tumor. SOLUTION: This new isolated polynucleotide comprises a member selected from the group consisting of a polynucleotide having at least a 70% identity to a polynucleotide capable of encoding a polypeptide containing an amino acid represented by the formula, a polynucleotide which is complementary to the polynucleotide and a polynucleotide, etc., containing at least 15 bases of the polynucleotides and is useful for production, etc., of interleukin-1 βconverting enzymelike apoptotic protease 6 (ICE LAP-6), capable of controlling the apoptosis from the genetic field and useful for treatment, etc., of susceptibility to viral infection, tumorigenesis and to diseases and defects in the control of embryogenesis and tissue homeostasis by a recombinant technique.

30. 发明专利

JP2002053490A MACROPHAGE INFLAMMATORY PROTEIN-3, -4 AND -1gamma 审中-公开
公开(公告)号：JP2002053490A
公开(公告)日：2002-02-19
申请号：JP2001196723
申请日：2001-06-28
申请人： HUMAN GENOME SCIENCES INC
发明人： LI HAODONG , ROSEN CRAIG A , RUBEN STEVEN M , ADAMS MARK D
IPC分类号： C12N15/09 , A01N37/18 , A61K38/00 , A61K48/00 , A61P7/00 , A61P9/10 , A61P11/10 , A61P17/00 , A61P17/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/08 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/52 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12R1/19 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain human macrophage inflammatory protein-3, human macrophage inflammatory protein-4, human macrophage inflammatory protein-1γ polypeptide and a DNA (RNA) encoding the polypeptide. SOLUTION: A method for producing these polypeptides by a recombination technique and a method for producing antibodies against such polypeptides are provided. An antagonist and/or an inhibitor against the polypeptides for inhibiting the functions of these polypeptides is also provided. In a separate aspect, a combination of the polypeptide and a proper medical carrier is provided so as to supply a therapeutically effective amount of a polypeptide to treat various related diseases.

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