专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明专利

JP2002286696A MASS SPECTROMETER 审中-公开
公开(公告)号：JP2002286696A
公开(公告)日：2002-10-03
申请号：JP2002000978
申请日：2002-01-08
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , NAKAYAMA KANAE , SAKAIRI MINORU , HIRABAYASHI TSUDOI
IPC分类号： G01N27/62 , G01N27/447 , H01J49/04 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To provide a mass spectrometer which can control the potential of a stainless steel pipe even when a large current flows in a capillary and which can perform a stable electrostatic spraying operation and which can observe ion stably. SOLUTION: By a potential drop due to the impedance of a load 16a and due to a current I2 flowing in the load 16a, the stainless steel pipe 10 is maintained at a potential of several kV. A high voltage is applied to one end of the capillary 2 by a power supply 14 for electrophoresis. A sample which is introduced into the capillary 2 is electrophoresed so as to be moved to the other end of the capillary 2. It is mixed with a sheath flow at the other end of the capillary 2 so as to be electrostatically sprayed to the direction of a counter electrode 11 by a spraying capillary 10.

22. 发明专利

JP2002184346A ION SOURCE AND MASS SPECTROSCOPE 审中-公开
公开(公告)号：JP2002184346A
公开(公告)日：2002-06-28
申请号：JP2001310865
申请日：2001-10-09
申请人： HITACHI LTD
发明人： HIRABAYASHI YUKIKO , NABESHIMA TAKAYUKI , TAKADA YASUAKI , SAKAIRI MINORU , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , G01N1/28 , G01N30/72 , H01J49/04 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To make liquid-drop density that is taken into the mass spectroscope a correct value and reduce the noise in the sonic spray ion source and mass spectroscope. SOLUTION: The solution sample in the sample solution introduction part 1 is introduced into a capillary 2. The capillary 2 is installed in the ion source 6. The gas that is supplied from a gas supply part 4 is introduced into the ion source 6 by a gas tube 5 and flown along the outer circumference of the capillary 2 and discharged from the orifice 3 into the air. The gas flow touches the dispersing member 7 and is dispersed. The fine liquid-drops or ion that are generated in the air pass through a hole 8 of the dispersing member 7 and are taken into the mass spectrometer 11 from a thin hole 10 and analyzed for mass spectrometric analysis. Even in the cases where the flow rate of the sample solution is higher than the conventional sonic spray ion source and mass spectroscope, this can be used. By auto-tuning, the adjustment work of the user is reduced.

23. 发明专利

JP2002042722A MASS SPECTROMETER 审中-公开
公开(公告)号：JP2002042722A
公开(公告)日：2002-02-08
申请号：JP2001220809
申请日：2001-07-23
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , SAKAIRI MINORU , HIRABAYASHI TSUDOI
IPC分类号： G01N27/62 , G01N30/72 , H01J49/04 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To provide a liquid chromatograph/mass spectrometer provided with an electrostatic spray ion source capable of stably observing ion, even if high flow quantity is introduced, by directly connecting the liquid chromatograph to the electrostatic spray ion source. SOLUTION: A center shaft of a spray capillary 11 for electrostatically spraying sample solution and a center shaft of an ion introducing pore 15a for taking generated ion into a vacuum part are inclined and arranged, and only liquid droplets of small particle sizes, in particular, of liquid droplets generated by spray are taken into the vacuum part. The sample solution can be introduced by hundreds of μl/min into the electrostatic spray ion source and the liquid chromatograph and the mass spectrometer can be used by being directly connected.

24. 发明专利

JP2000097911A MASS SPECTROMETER AND ITS ION SOURCE 失效
公开(公告)号：JP2000097911A
公开(公告)日：2000-04-07
申请号：JP30324399
申请日：1999-10-26
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , SAKAIRI MINORU , HIRABAYASHI TSUDOI , KOIZUMI HIDEAKI
IPC分类号： H01J49/04 , G01N27/447 , G01N27/62 , H01J49/18
摘要： PROBLEM TO BE SOLVED: To enlarge the application range of a capillary electrophoresis mass spectrometer by making analyzable a neutral sample without electric charges in a solution and making usable various buffer solutions. SOLUTION: A sample solution separated by a capillary electrophoresis part 18 is atomized by an atomizing part 19, then heated and vaporized by a vaporizing part 20. The obtained sample molecules of a gas are ionized by a chemical ionizing part 21 having a corona discharge part through a protonation reaction or the like by a chemical reaction. The thus-produced ions related to the sample molecules are introduced from an ion introduction thin hole 10a to a vacuum chamber and analyzed by a mass spectrometric part 14 and an ion detector 15. Since the sample is ionized by the chemical ionization, even the sample without electric charges in the solution can be analyzed. Since a sensitivity to ionic substances is low, a buffer solution with salt added can be used.

25. 发明专利

JP2000057991A ION SOURCE 失效
公开(公告)号：JP2000057991A
公开(公告)日：2000-02-25
申请号：JP22343099
申请日：1999-08-06
申请人： HITACHI LTD
发明人： HIRABAYASHI TSUDOI , HIRABAYASHI YUKIKO , SAKAIRI MINORU , TAKADA YASUAKI , NABESHIMA TAKAYUKI , KOIZUMI HIDEAKI
IPC分类号： H01J49/10 , G01N27/447 , G01N27/62 , G01N30/72 , H01J49/04
摘要： PROBLEM TO BE SOLVED: To produce positive or negative ions with high efficiency, by installing an electrode near a spray capillary and by applying an electric field on liquid and by spraying the liquid, in a sonic spray ionization method. SOLUTION: This ion source is equipped with a capillary 2 for spraying liquid into the atmospheric air, and an orifice 3 installed by inserting a part near the head of the capillary 2 and formed so that gas will flow up to the head of the capillary 2 along the circumferential wall surface of the capillary 2. A gas flow velocity near the head of the capillary 2 is about a sound velocity, and a voltage is applied between the liquid in the capillary 2 and the orifice 3 or an electrode installed near the capillary 2. Hereby, the electric potential of the liquid can be set equally to the earth potential, and combination of a solution separation means with a liquid introduction part is easily realized. Also, the polarity of produced ions can be controlled according to the polarity of the voltage applied on the electrode. Besides, multi-charged ions of material having a large mass, such as a protein or the like, or the like can be produced with high efficiency and excellent repeatability.

26. 发明专利

JPH11304761A MONITORING DEVICE 失效
公开(公告)号：JPH11304761A
公开(公告)日：1999-11-05
申请号：JP10902198
申请日：1998-04-20
申请人： HITACHI LTD
发明人： SAKAIRI MINORU
IPC分类号： G01N27/68 , H01T19/00
摘要： PROBLEM TO BE SOLVED: To detect dioxin or the like without using a high-resolution magnetic field type mass spectrograph by ionizing dioxin or the like that is an organic chlorine compound using negative corona discharge and observing the change in the amount of current due to the generated negative ion. SOLUTION: A gas sample through a sample heating furnace 3 is introduced to a corona discharge part 7 for ionization. The tip of a gas sample introduction path 8 is located near a wire electrode 11 for corona discharge and the diameter of the tip is small with a constriction, thus securing introducing the gas sample to a discharge region. Temperature is maintained at 50-300 deg.C by a corona discharge part heating heater power supply 10 and a corona discharge part heating heater 9. A negative high voltage is applied to the wire electrode 11 by a power supply 12 for corona discharge. The high voltage depends on the distance between the wire electrode 11 and a counter electrode 16 but is approximately -1--6 kV. The distance should be approximately several mm. A metal wire heater 5 for heating a gas sample is controlled to 50-400 deg.C by a metal wire heater heating power supply 6, thus preventing particles from being introduced into a corona discharge region.

27. 发明专利

JPH1055777A MASS ANALYSER AND ELECTRODE HEATING METHOD 失效
公开(公告)号：JPH1055777A
公开(公告)日：1998-02-24
申请号：JP21081896
申请日：1996-08-09
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , HIRABAYASHI YUKIKO , NABESHIMA TAKAYUKI , SAKAIRI MINORU , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , G01N30/72 , H01J49/06 , H01J49/34
摘要： PROBLEM TO BE SOLVED: To improve analysis precision of an ion trap mass analyzer by providing an inductance coil in the vicinity of a ring electrode and high-frequency heating the ring electrode by Joule's heat after generating eddy current on the ring electrode. SOLUTION: When a magnetic field is induced by an inductance coil 11, a ring electrode 5 generates an eddy current having an action for eliminating variation of that magnetic field. When an eddy current flows this electrode 5, Joule's heat is generated because of electric resistance of an electrode, and the ring electrode 5 is heated. The ring electrode can be heated efficiently by feeding an a.c. current to this coil 11 using an AC power source 12. In analysis of samples, after the samples are separated by a GC1, it is fed to an ion trap mass analyzer 3 by a pipe 2 together with carrier gas. The samples are ionized by an electron beam 9 to be discharged from an electron gun 8, stored in the mass analyzer for a constant time, and then mass-analyzed. The mass- analyzed ion is detected 10, and its output is processed by a data processor.

28. 发明专利

JPH1031005A METHOD OF OPERATING ION SOURCE AND MASS SPECTROMETRY DEVICE 失效
公开(公告)号：JPH1031005A
公开(公告)日：1998-02-03
申请号：JP18720996
申请日：1996-07-17
申请人： HITACHI LTD
发明人： HIRABAYASHI YUKIKO , NABESHIMA TAKAYUKI , TAKADA YASUAKI , SAKAIRI MINORU , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , G01N30/72 , H01J49/04 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To prevent the periphery of a capillary orifice from being contaminated with drops of a sample solution by starting the feed of the sample solution after gas feed is started, and stopping the gas feed after the sample solution is stopped. SOLUTION: An LC pump 8 with flow detector changes the flow rate of a sample solution by a control 10 and feeds the sample solution to a capillary 2 the tip part of which is inserted to an orifice 3. The gas of a gas feeding part 4 is sent to an ion source body 6 by a gas tube 5, carried along the circumferential part of the capillary 2, and blown out to the atmosphere through the orifice 3. A flowmeter 9 changes the gas flow rate by the control 10 and transmits the flow rate information of gas to a control part 10. The control part 10 starts the feed of the sample solution when the flow rate reaches the atomizable value of the sample solution, stops the feed when it is lower than the atomizable value, and successively stops the gas feed. The sample solution in the capillary 2 is atomized by the blowout gas to generate the gaseous pseudo molecular ions of the sample molecule, and they are subjected to mass spectrometry 7.

29. 发明专利

JPH09318601A ANALYSIS METER 失效
公开(公告)号：JPH09318601A
公开(公告)日：1997-12-12
申请号：JP13618896
申请日：1996-05-30
申请人： HITACHI LTD
发明人： SAKAIRI MINORU , TAKADA YASUAKI , HIRABAYASHI YUKIKO , NABESHIMA TAKAYUKI , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , G01N27/70
摘要： PROBLEM TO BE SOLVED: To provide qualititative information, such as ions present in the solution, by atomizing a sample solution fed from a liquid pump, inducing an electric charge on liquid droplets by a high tension electric source, collecting the droplets in a collector, and detecting a current flowing to the collector. SOLUTION: A sample solution is fed to an atomizing section 3 with the liquid pump 2 from a sample 1. The sample solution is transformed into the small charged liquid droplets in an atomizing section 3. The small charged liquid droplets collide against the collector 4, and are detected as a current with a micro-ammeter. The current is transferred to a data processor 6. A high pressure gas supply source 7 and the high tension electric source 8 are provided near the atomizer 3 and the sample liquid droplets are effectively charged with electricity.

30. 发明专利

JPH09243600A MASS ANALYSER 失效
公开(公告)号：JPH09243600A
公开(公告)日：1997-09-19
申请号：JP5132596
申请日：1996-03-08
申请人： HITACHI LTD
发明人： TAKADA YASUAKI , HIRABAYASHI YUKIKO , HIRABAYASHI TSUDOI , NABESHIMA TAKAYUKI , SAKAIRI MINORU , KOIZUMI HIDEAKI
IPC分类号： G01N27/62 , G01N27/447 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To simplify the constitution of a capillary electrophoresis/mass analyser (CE/MS) and to reduce the danger of the electric shock of an operator by using a spray auxiliary soln. feed means dispensing with a liquid feed pump. SOLUTION: The sample electrophoretically separated in a capillary to reach the end on the cathode side of the capillary 1 is mixed with a spray auxiliary soln. 4 and the resulting mixture is sprayed by the high speed gas stream allowed to flow to the gap between a metal pipe 3 and an orifice 18. The gaseous ions obtained by this spraying are introduced into a vacuum from an ion introducing fine orifice 10a to be subjected to mass analysis by a mass analyzing part. The soln. 4 is introduced into a metal pipe 3 from a spray auxiliary soln. tank 19 through piping 6 and a connector 20. Since the pressure at the end part of the metal pipe 3 becomes lower than the pressure (atmospheric pressure) of the part where the soln. tank 19 is arranged by the gas stream, the soln. 4 is sent by pressure difference. As a result, a liquid feed pump for feeding the soln. 4 becomes unnecessary and the ion source structure of CE/MS can be simplified.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式