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21. 发明申请

US20120190672A1 FUSED AMINODIHYDROTHIAZINE DERIVATIVES 有权
标题翻译：熔融氨基二氢卟吩衍生物
公开(公告)号：US20120190672A1
公开(公告)日：2012-07-26
申请号：US13354716
申请日：2012-01-20
申请人： Adrian Hall , Christopher Neil Farthing , Jose Luis Castro Pineiro
发明人： Adrian Hall , Christopher Neil Farthing , Jose Luis Castro Pineiro
IPC分类号： A61K31/542 , A61P25/28 , A61P3/10 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; A is CH or N; Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or —C≡N; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
摘要翻译：本发明涉及式（I）的稠合氨基二氢噻嗪衍生物：其中X是氢或氟; A是CH或N; Y是甲基，乙基，一氟甲基，二氟甲基，三氟甲基，二氟乙基，甲氧基，乙氧基，甲氧基甲基或-C≡N; 及其药学上可接受的盐; 该化合物具有A＆bgr; 产生抑制作用或BACE1抑制作用，可用作由A＆Bgr引起的神经变性疾病的预防或治疗剂; 并以阿尔茨海默氏型痴呆为代表。

22. 发明申请

US20090298866A1 Indole Compounds 审中-公开
标题翻译：吲哚化合物
公开(公告)号：US20090298866A1
公开(公告)日：2009-12-03
申请号：US12373315
申请日：2007-07-09
申请人： Adrian Hall , David Nigel Hurst , Tiziana Scoccitti , Pamela Joan Theobald
发明人： Adrian Hall , David Nigel Hurst , Tiziana Scoccitti , Pamela Joan Theobald
IPC分类号： A61K31/437 , C07D277/28 , C07D277/24 , C07D417/14 , C07D471/04 , A61K31/427 , A61K31/44 , A61P37/04
CPC分类号： C07D417/04 , C07D413/04
摘要： The present application relates to compounds of formula (I) or a pharmaceutically acceptable derivative thereof: formula (I) wherein X, R1, R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：本申请涉及式（I）化合物或其药学上可接受的衍生物：其中X，R 1，R 2和R 3如说明书中所定义的式（I），制备这些化合物的方法，药物组合物，包含这些化合物和这些化合物在医药中的应用。

23. 发明申请

US20090099169A1 Benzofuran Compounds As EP1 Receptor Antagonists 审中-公开
标题翻译：苯并呋喃化合物作为EP1受体拮抗剂
公开(公告)号：US20090099169A1
公开(公告)日：2009-04-16
申请号：US12295379
申请日：2007-04-03
申请人： Mairi Gibson , Adrian Hall , David Nigel Hurst , Derek Anthony Rawlings
发明人： Mairi Gibson , Adrian Hall , David Nigel Hurst , Derek Anthony Rawlings
IPC分类号： A61K31/5377 , C07D407/06 , A61K31/341 , C07D405/12 , A61K31/4155 , C07D405/14 , A61K31/4523 , C07D413/12
CPC分类号： C07D407/06 , C07D405/06 , C07D405/14
摘要： Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein R1, R2a, R2b, R2c, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物：其中R1，R2a，R2b，R2c和R3如说明书中所定义，制备这些化合物的方法，包含这些化合物的药物组合物及其用途药物中的化合物。

24. 发明申请

US20070294573A1 METHOD AND SYSTEM FOR IMPROVING THE AVAILABILITY OF SOFTWARE PROCESSES UTILIZING CONFIGURABLE FINITE STATE TABLES 有权
标题翻译：利用可配置的有限状态表提高软件流程可用性的方法和系统
公开(公告)号：US20070294573A1
公开(公告)日：2007-12-20
申请号：US11845545
申请日：2007-08-27
申请人： Adrian Hall , Craig Fellenstein , Jean-Marc Berthaud
发明人： Adrian Hall , Craig Fellenstein , Jean-Marc Berthaud
IPC分类号： G06F9/00
CPC分类号： G06F8/61 , G06F9/453
摘要： The invention provides a system and method for providing a high availability application at low cost for a wide range of solution architectures. A user runs a simplistic web-based wizard to install the high availability application. Then, a user designs the high availability application's logic for an individual process or process-group using a finite state table. Next, a standard UNIX init process spawner subsystem is extended to implement the high availability application as a property of a process. Finally, the logic from the finite state table is used to make each process or process-group highly available.
摘要翻译：本发明提供了一种用于为各种解决方案架构以低成本提供高可用性应用的系统和方法。用户运行一个简单的基于Web的向导来安装高可用性应用程序。然后，用户使用有限状态表为单个进程或进程组设计高可用性应用程序的逻辑。接下来，扩展了标准的UNIX init进程spawner子系统，以实现高可用性应用程序作为进程的属性。最后，来自有限状态表的逻辑用于使每个进程或进程组高度可用。

25. 发明申请

US20070060596A1 Heterocyclyl compounds 审中-公开
标题翻译：杂环化合物
公开(公告)号：US20070060596A1
公开(公告)日：2007-03-15
申请号：US10576460
申请日：2004-10-21
申请人： Gerard Giblin , Adrian Hall , David Hurst , Xiao Lewell , Olivier Lorthioir , Stephen Mickeown , Tiziana Scoccitti , Stephen Watson
发明人： Gerard Giblin , Adrian Hall , David Hurst , Xiao Lewell , Olivier Lorthioir , Stephen Mickeown , Tiziana Scoccitti , Stephen Watson
IPC分类号： A61K31/519
CPC分类号： C04B35/632 , C07D207/34 , C07D231/14 , C07D401/12 , C07D409/04
摘要： Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein W, X, Y, Z, R1, R2a, R2b, and Rx, R8 and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物：其中W，X，Y，Z，R 1，R 2a，R 2b， >，且R x，R 8和R 9如说明书中所定义，制备这些化合物的方法，药物组合物包括这些化合物和这些化合物在医药中的用途。

26. 发明授权

US09139594B2 Fused aminodihydropyrimidone derivatives 有权
标题翻译：熔融氨基二氢嘧啶酮衍生物
公开(公告)号：US09139594B2
公开(公告)日：2015-09-22
申请号：US13386199
申请日：2010-07-21
申请人： Jose Luis Castro Pineiro , Adrian Hall , Andrew Madin , Ngoc-Tri Vo
发明人： Jose Luis Castro Pineiro , Adrian Hall , Andrew Madin , Ngoc-Tri Vo
IPC分类号： A61K31/519 , A61P25/28 , C07D491/048
CPC分类号： C07D491/048
摘要： A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1, R2 and Rx are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
摘要翻译：由通式（I）表示的化合物或其药学上可接受的盐或其溶剂合物，其中环A为C 6-14芳基等，L为-NReCO-等（其中Re为氢原子等），环B为C 6-14芳基等，X为C 1-3亚烷基等，Y为单键等，Z为C1-3亚烷基等 R 1，R 2和R 3各自独立地为氢原子等，R 3，R 4，R 5和R 6独立地为氢原子，卤素原子等，具有A＆bgr; 产生抑制作用或BACE1抑制作用，可用作由A＆Bgr引起的神经变性疾病的预防或治疗剂; 并以阿尔茨海默氏型痴呆为代表。

27. 发明授权

US08822455B2 Fused aminodihydrothiazine derivatives 有权
标题翻译：融合氨基二氢噻嗪衍生物
公开(公告)号：US08822455B2
公开(公告)日：2014-09-02
申请号：US13978062
申请日：2012-01-05
申请人： Paschalis Dimopoulos , Adrian Hall , Yoichi Kita , Andrew Madin , Nicola Louise Shuker
发明人： Paschalis Dimopoulos , Adrian Hall , Yoichi Kita , Andrew Madin , Nicola Louise Shuker
IPC分类号： C07D513/14 , A61K31/542
CPC分类号： C07D513/14 , A61K31/542 , A61K45/06 , C07D279/08 , C07D513/04
摘要： The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein R is hydrogen or C1-6alkyl, optionally substituted by one to five halogen atoms; n is 0, 1, 2 or 3; Ar is phenyl or a 5- or 6-membered heteroaromatic group containing 1, 2 or 3 N atoms, which Ar is optionally substituted by one to three substituents selected from hal, hydroxyl, —CN, C1-6alkyl, C2-3alkenyl, C2-3alkynyl, C1-6alkoxy, C3-6cycloalkoxy and pyrazine, where C1-6alkyl and C1-6alkoxy are optionally substituted by one to three halogen atoms; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
摘要翻译：本发明涉及式（I）的稠合氨基二氢噻嗪衍生物：其中R是氢或被1-6个卤素原子取代的C1-6烷基; n为0,1,2或3; Ar是苯基或含有1,2或3个N原子的5或6元杂芳族基团，Ar任选被一至三个选自卤素，羟基，-CN，C 1-6烷基，C 2-3烯基，C 2 -3-炔基，C 1-6烷氧基，C 3-6环烷氧基和吡嗪，其中C 1-6烷基和C 1-6烷氧基任选被一至三个卤素原子取代; 及其药学上可接受的盐; 该化合物具有A＆bgr; 产生抑制作用或BACE1抑制作用，可用作由A＆Bgr引起的神经变性疾病的预防或治疗剂; 并以阿尔茨海默氏型痴呆为代表。

28. 发明授权

US08338407B2 Fused aminodihydrothiazine derivatives 有权
标题翻译：融合氨基二氢噻嗪衍生物
公开(公告)号：US08338407B2
公开(公告)日：2012-12-25
申请号：US13354716
申请日：2012-01-20
申请人： Adrian Hall , Christopher Neil Farthing
发明人： Adrian Hall , Christopher Neil Farthing
IPC分类号： C07D513/04 , A61K31/542
CPC分类号： C07D513/04
摘要： The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; A is CH or N; Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or —C≡N; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
摘要翻译：本发明涉及式（I）的稠合氨基二氢噻嗪衍生物：其中X是氢或氟; A是CH或N; Y是甲基，乙基，一氟甲基，二氟甲基，三氟甲基，二氟乙基，甲氧基，乙氧基，甲氧基甲基或-C≡N; 及其药学上可接受的盐; 该化合物具有A＆bgr; 产生抑制作用或BACE1抑制作用，可用作由A＆Bgr引起的神经变性疾病的预防或治疗剂; 并以阿尔茨海默氏型痴呆为代表。

29. 发明申请

US20080207708A1 Oxazole and Thiazole Compounds and Their Use in the Treatment of Pge2 Mediated Disorders 审中-公开
标题翻译：恶唑和噻唑化合物及其在治疗Pge2介导性疾病中的应用
公开(公告)号：US20080207708A1
公开(公告)日：2008-08-28
申请号：US11912336
申请日：2006-04-24
申请人： Rino Antonio Bit , Adrian Hall , David Nigel Hurst , Tiziana Scoccitti
发明人： Rino Antonio Bit , Adrian Hall , David Nigel Hurst , Tiziana Scoccitti
IPC分类号： A61K31/426 , C07D277/22 , C07D263/30 , A61K31/421 , C07D413/02 , C07D417/02
CPC分类号： C07D263/34 , C07D263/32 , C07D263/48 , C07D277/30 , C07D277/46 , C07D277/56 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein X, Z, Y′, Y″, R1, R2a, R2b, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物：其中X，Z，Y'，Y“，R 1，R 2a，R 2b ＆lt;＆gt;和＆lt; x＆gt;如本说明书中所定义的，制备这些化合物的方法，包含这些化合物的药物组合物和这些化合物在医药中的用途。

30. 发明授权

US09079914B2 Fused aminodihydro-oxazine derivatives 有权
标题翻译：熔融氨基二氢恶嗪衍生物
公开(公告)号：US09079914B2
公开(公告)日：2015-07-14
申请号：US13386092
申请日：2010-07-21
申请人： John Mark Ellard , Christopher Neil Farthing , Adrian Hall
发明人： John Mark Ellard , Christopher Neil Farthing , Adrian Hall
IPC分类号： C07D498/04 , A61K31/5365
CPC分类号： C07D498/04
摘要： A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
摘要翻译：由通式表示的化合物或其药学上可接受的盐或其溶剂化物，其中环A是C 6-14芳基等，L是-NReCO-等（其中Re是氢原子或环）B是C 6-14芳基等，X是C 1-3亚烷基等，Y是单键等，Z是C 1-3亚烷基等，R 1 和R 2各自独立地为氢原子等，R 3，R 4，R 5和R 6独立地为氢原子，卤素原子等，具有A＆bgr; 产生抑制作用或BACE1抑制作用，可用作由A＆Bgr引起的神经变性疾病的预防或治疗剂; 并以阿尔茨海默氏型痴呆为代表。

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