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21. 发明公开

EP2453983A1 VORRICHTUNG UND VERFAHREN ZUR STEUERUNG EINER BESTRAHLUNGSANLAGE 审中-公开
标题翻译：装置和一种用于控制辐射系统
公开(公告)号：EP2453983A1
公开(公告)日：2012-05-23
申请号：EP10724865.0
申请日：2010-06-18
申请人： Siemens AG , GSI Helmholtzzentrum für Schwerionenforschung GmbH
发明人： BERT, Christoph , RIETZEL, Eike
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B6/541 , A61N5/1067 , A61N2005/1061 , A61N2005/1087
摘要： The invention relates to a device for controlling an irradiation system for irradiating a moved target volume. Said device comprises an evaluation device for evaluating a substitute movement signal; an imaging device for recording image data of the moving target volume, which is activated or deactivated by a control device according to the evaluation of the substitute movement signal; an image evaluation device for evaluating the image data recorded by the imaging device; and an irradiation device that is activated or deactivated by means of an irradiation control device according to the evaluation of the image data. The invention also relates to a method for controlling an irradiation system, carried out on such a device.

22. 发明公开

EP2352556A1 BESTRAHLUNG VON ZUMINDEST ZWEI ZIELVOLUMEN 有权转让
标题翻译：辐射至少两个靶区
公开(公告)号：EP2352556A1
公开(公告)日：2011-08-10
申请号：EP09748234.3
申请日：2009-10-17
申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH , Siemens AG
发明人： BERT, Christophe , RIETZEL, Eike
IPC分类号： A61N5/10 , G21K5/04 , G21K5/10
CPC分类号： A61N5/10 , A61N5/103 , A61N5/1038 , A61N5/1043 , A61N2005/1087
摘要： The invention relates to a teaching for planning irradiation of two target volumes (81, 92), comprising a beam approaching target points (72) for depositing a first target dose distribution in a first of the two target volumes (81, 92) and a second target dose distribution in a second of the two target volumes (81, 92). The teaching is characterized by the steps: associating target points (72) with one of the target volumes (81, 92), defining a superpositioning of a first deposition caused by the approach to a target point (72) associated with the first target volume (81, 92) with a second deposition caused by the approach to a target point (72) associated with the second target volume (81, 92) and adjusting the planning for at least one of the target points (72), the approach to which contributes to the superpositioning of the first and second depositions.

23. 发明公开

EP2482926A1 VERFAHREN UND VORRICHTUNG ZUR ÜBERPRÜFUNG EINER BESTRAHLUNGSPLANUNG SOWIE BESTRAHLUNGSANLAGE 有权转让
标题翻译：方法和装置审查辐射暴露和规划体系
公开(公告)号：EP2482926A1
公开(公告)日：2012-08-08
申请号：EP10748049.3
申请日：2010-08-12
申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH , Siemens AG
发明人： BERT, Christoph , RIETZEL, Eike , SAITO, Nami
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61B2017/00707 , A61N2005/1087 , G21K1/10
摘要： The invention relates to a method for checking an irradiation installation in which a dose distribution is deposited in a target object by means of a treatment beam, said method comprising the following steps: an irradiation planning data record optimised for the irradiation of a moving target volume is provided; a movement signal that reproduces a movement of the target volume is provided; a phantom is irradiated, said phantom being formed for detecting a dose distribution deposited in the phantom during or after the irradiation, using the control parameters stored at the irradiation planning data record and the movement signal; a dose distribution deposited in the phantom is determined; a dose distribution to be expected is calculated on the basis of parameters that are related to the control of the irradiation installation during the irradiation; and the determined dose distribution deposited in the phantom is compared to the calculated dose distribution to be expected. The invention also relates to a corresponding device and an irridation installation comprising such a device.

24. 发明公开

EP2352555A1 VORRICHTUNG UND VERFAHREN ZUR BESTIMMUNG VON STEUERPARAMETERN FÜR EINE BESTRAHLUNGSANLAGE, BESTRAHLUNGSANLAGE UND BESTRAHLUNGSVERFAHREN 有权转让
标题翻译：设备和方法控制参数对辐射系统的测定
公开(公告)号：EP2352555A1
公开(公告)日：2011-08-10
申请号：EP09737348.4
申请日：2009-10-08
申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH , Siemens AG
发明人： BERT, Christoph , RIETZEL, Eike , GEMMEL, Alexander , SAITO, Nami
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61N5/1043 , A61N5/1044 , A61N5/1065 , A61N2005/1087
摘要： the invention relates to a device for determining the control parameters for an irradiation unit, by means of which a number of radiation doses are serially administered to differing target points in a target volume. The device comprises an input device, for recording a target region and the movement of the target region and analytical unit for determining control parameters to control a beam such that, by means of the control parameters a beam may follow the movement for the target region and administer a defined dose distribution to the target region, wherein the analytical unit is designed that on determining the control parameters at least one first selectable control parameter is determined such that the beam only follows the movement for the target region orthogonal to the beam direction or on determining the control parameters at least one first selectable control parameter and a further control parameter representing an energy modulation for the beam are determined, wherein the determination for the at last one first control parameter and the further control parameter occurs taking into account the movement following in the beam direction.

25. 发明公开

EP2344250A1 BESTRAHLUNG EINES ZIELVOLUMENS UNTER BERÜCKSICHTIGUNG EINES ZU SCHÜTZENDEN VOLUMENS 有权转让
标题翻译：被保护在一个卷的光具有目标容积辐照
公开(公告)号：EP2344250A1
公开(公告)日：2011-07-20
申请号：EP09744065.5
申请日：2009-10-17
申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH , Siemens AG
发明人： BERT, Christoph , RIETZEL, Eike
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1043 , A61N2005/1087
摘要： The teaching relates to irradiation of a target volume (53), wherein intensities are determined for target points (70), which are approached successively with a beam, comprising the following steps: detecting a volume (63) to be protected, in which a dose created by irradiating the target volume (53) is not to exceed a predetermined maximum value; determining intensities for target points (70) such that the dose created does not exceed the predetermined maximum value within the volume (63) to be protected, wherein a dose contribution data record is used for determining the intensities, said record comprising the dose created with a predetermined intensity at other locations (73) for target points (70) by directing the beam (20) at one of the target points (70).
摘要翻译：为目标点的目标体积的想法关注照射（53）worin强度（70）是确定性的开采被顺序通过光束走近，包括以下步骤：检测体积（63）被保护，worin所产生的剂量辐照目标体积（53）的大小限制在预定的最大值; 在寻求一种方式，目标点（70）确定的开采强度做了体积（63），以免受所产生的剂量不超过预定最大值内，worin剂量份额数据记录被用于确定开采强度，哪种剂量贡献数据包括：通过在具有预定强度的目标点（70）中的一个引导所述光束（10）在记录其他部位（73）所产生的剂量。

26. 发明公开

EP2285448A1 DEPOSITION EINER SOLLDOSISVERTEILUNG IN EINEM ZYKLISCH BEWEGTEN ZIELGEBIET 有权转让
标题翻译：沉积在一个周期MOVING目标区域的目标剂量分布
公开(公告)号：EP2285448A1
公开(公告)日：2011-02-23
申请号：EP09761445.7
申请日：2009-06-08
申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH , Siemens AG
发明人： BERT, Christoph , RIETZEL, Eike
IPC分类号： A61N5/10
摘要： The invention relates to a method for depositing an intended dose distribution in a cyclically moved target area (102) by multiple irradiation with a beam (105) which approaches grid points of a target grid in at least two passes, in which grid points are approached in succession in each of the passes. It is characterized by the following steps: setting the maximum tolerated local deviation from the intended dose distribution, de-synchronizing the procedure of the irradiation and the cyclical movement of the target area (102), and dividing the irradiation of the target area into a sufficient number of passes such that local deviations from the intended dose distribution correspond to at most the maximum tolerated deviation from the intended target distribution. Furthermore, the invention also relates to an irradiation device for carrying out such a method and a method for determining the control parameters for this irradiation device.

27. 发明公开

EP2326389A1 SCHNELLES SCANNING EINES ZIELGEBIETS 有权转让
标题翻译：目标区域的快速扫描
公开(公告)号：EP2326389A1
公开(公告)日：2011-06-01
申请号：EP09778501.8
申请日：2009-09-12
申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH , Siemens AG , Heidelberger Ionenstrahltherapie (Hit) Betriebs-Gesellschaft Am Universitätsklinikum Heidelberg MbH
发明人： BERT, Christoph , HABERER, Thomas , RIETZEL, Eike
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N5/1043 , A61N2005/1085
摘要： The invention relates to a method for irradiating a target with a beam moving to a target point, comprising the following steps: measuring at least one of the variables relating to the position of the beam and intensity of the beam, changing the beam as a function of the at least one measured variable, particularly as a function of a variance relating to the at least one measured variable. The method is characterized in that per target point, the at least one measured variable is measured no more than once. The invention further relates to a device for irradiating a target according to the claimed method and to a control system for controlling a device of said kind.

28. 发明公开

EP2279027A1 METHOD AND APPARATUS FOR IRRADIATION OF A TARGET VOLUME 审中-公开
标题翻译：方法和装置照射靶区
公开(公告)号：EP2279027A1
公开(公告)日：2011-02-02
申请号：EP09712035.6
申请日：2009-02-16
申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH , Siemens AG
发明人： BERT, Christoph , RIETZEL, Eike , ROHREGGER, Martin
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N5/1043 , A61N5/1067 , A61N2005/1087
摘要： A method of generating a data set defining a plurality of target points in a target volume in a body at which a particle beam is to be directed in a continuous or discontinuous process includes directing a particle beam to each of the target points so as to provide a spatial dose distribution in an area around the respective target point. The target points include a first target point having z-spacing, measured in a direction of the particle beam in a homogenous body equivalent to the body, from an adjacent second target point at a higher or lower particle energy. The method also includes defining the target points in the data set by at least one of the z-spacing and the spatial dose distribution in dependence upon a particle energy of the respective target point.

29. 发明公开

EP2190531A1 METHOD AND APPARATUS FOR IRRADIATION OF A MOVING TARGET VOLUME 有权转让
标题翻译：装置照射运动的目标体积的
公开(公告)号：EP2190531A1
公开(公告)日：2010-06-02
申请号：EP08802631.5
申请日：2008-09-25
申请人： GSI Helmholtzzentrum für Schwerionenforschung GmbH , Siemens AG
发明人： BERT, Christoph , KRAFT, Gerhard , RIETZEL, Eike , SCHMIDT, Alexander
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1043 , A61N5/1067 , A61N2005/1061 , A61N2005/1072 , A61N2005/1087
摘要： A method of determining an actual, especially an actual effective, radiation dose distribution of a moving target volume includes detecting first and further positions of volume elements of the target volume in a first and at least one further motional state of the moving target volume, determining transformation parameters by transformation of the first positions into the further positions, irradiating the moving target volume in accordance with an irradiation plan which comprises a plurality of raster points to be irradiated, wherein during the irradiation of a raster point it is detected which of the motional states is occupied by the moving target volume, assigning raster points to subirradiation plans and determining the actual effective dose for each of the plurality of volume elements, in each case from contributions from the raster points of the subirradiation plans using the transformation parameters. Calculation and application of correction parameters which compensate for changes, caused by movement, to the position of the Bragg maximum and to the biologically effective dose applied.

30. 发明公开

EP2453984A1 BESTRAHLUNG BZW. BESTRAHLUNGSPLANUNG FÜR EIN RESCANNING-VERFAHREN MIT EINEM PARTIKELSTRAHL 失效转让
标题翻译： BESTRAHLUNG BZW. BESTRAHLUNGSPLANUNGFÜREIN RESCANNING-VERFAHREN MIT EINEM PARTIKELSTRAHL
公开(公告)号：EP2453984A1
公开(公告)日：2012-05-23
申请号：EP10730121.0
申请日：2010-06-18
申请人： Siemens AG , GSI Helmholtzzentrum für Schwerionenforschung GmbH
发明人： BERT, Christoph , RIETZEL, Eike
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/103 , A61N5/1044 , A61N2005/1087
摘要： The invention relates to a method for planning the irradiation of a target volume, according to which a target region with individual approachable target points is established, and a number of rescan stages are determined, in which the target region is scanned several times, in such a way that the target points of the target region are often approached differently during the rescan stages, whereby at least some of the target points are not approached during each rescan stage. The approaching of the target points is distributed between the rescan stages in such a way that, for at least one target point that is not approached in each rescan stage, at least one other rescan stage in which said target point is not approached is carried out before the last rescan stage in which said target point is approached. The invention also relates to a corresponding irradiation method, a corresponding irradiation planning device, a corresponding control device for controlling an irradiation system and a corresponding irradiation system.
摘要翻译：用于照射目标体积的方法包括限定具有多个目标点的目标区域。目标点是单独平易近人的。该方法包括定义多个重新扫描通过，其中目标区域被扫描多次，使得目标区域的多个目标点在重新扫描过程中经常不同地接近。在所有重新扫描通行证中，不接近多个目标点中的至少一些目标点。多个目标点的接近被分配在重新扫描通过之间，使得对于在所有重新扫描通过中未接近的多个目标点的目标点，至少一个进一步的重新扫描通过，其中目标点是没有接近，位于最终重新扫描通过之前，其中接近目标点。

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