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21. 发明公开

EP2477668A2 NOVEL HEPARIN ENTITIES AND METHODS OF USE 有权
标题翻译：使用HEPARINEINHEITEN UND ANWENDUNGSVERFAHREN
公开(公告)号：EP2477668A2
公开(公告)日：2012-07-25
申请号：EP10755304.2
申请日：2010-09-16
申请人： Gore Enterprise Holdings, Inc.
发明人： BIRAN, Roy , CLAUDE, Charles, D. , CLEEK, Robert, L. , DRUMHELLER, Paul, D. , LI, Mei , MARDIROSIAN, Nora
IPC分类号： A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L33/0011 , A61L27/54 , A61L29/16 , A61L31/022 , A61L31/048 , A61L31/10 , A61L31/16 , A61L33/08 , A61L33/128 , A61L2300/236 , A61L2300/42 , C08L27/12
摘要： The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive.
摘要翻译：本发明涉及在操作后保留显着的生物活性的固定的生物活性物质。本发明还包括包含通过至少一个肝素分子结合到底物上的肝素实体的医用底物，其中所述结合的肝素实体是肝素酶-1敏感的。

22. 发明公开

EP2205294A2 IMMOBILIZED BIOLOGICALLY ACTIVE ENTITIES HAVING A HIGH DEGREE OF BIOLOGICAL ACTIVITY 有权
标题翻译：益生菌生物学
公开(公告)号：EP2205294A2
公开(公告)日：2010-07-14
申请号：EP08850202.6
申请日：2008-11-06
申请人： Gore Enterprise Holdings, Inc.
发明人： CLEEK, Robert, L. , DALY, Michael, D. , PIETRZAK, Krzysztof, R.
IPC分类号： A61L33/00 , A61L33/08 , A61L33/06
CPC分类号： A61L31/16 , A61K31/727 , A61K38/1709 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/042 , A61L33/0011 , A61L33/0029 , A61L2300/222 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/45 , C08L5/02 , C08L5/10
摘要： The present invention relates to immobilized biologically active entities having heparin cofactor Il binding activity.
摘要翻译：本发明涉及具有肝素辅因子II结合活性的固定生物活性物质。

23. 发明授权

EP1545642B1 THERMOPLASTIC FLUOROPOLYMER-COATED MEDICAL DEVICES 有权转让
标题翻译：热塑性氟聚合物涂覆的医疗器具
公开(公告)号：EP1545642B1
公开(公告)日：2009-02-25
申请号：EP03767251.6
申请日：2003-08-05
申请人： Gore Enterprise Holdings, Inc.
发明人： CHANG, James, W. , CLEEK, Robert, L. , CULLY, Edward, H. , VONESH, Michael, J.
IPC分类号： A61L29/04 , A61L31/10 , C08L35/08
CPC分类号： A61L31/10 , A61L27/34 , C08L101/04
摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered 'functionally transparent ' because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used. The desirable mechanical characteristics are surprising given the absence of cross-linking monomers and curing agents that would otherwise render such materials inadequately biocompatible. The perfluoroalkylvinylether may be perfluoromethylvinylether, perfluoroethylvinylether or perfluoropropylvinylether.

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