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21. 发明申请

WO0073445A3 INTERLEUKIN-1-RECEPTOR ASSOCIATED KINASE-3 (IRAK3) 审中-公开
标题翻译：白细胞介素-1受体相关激酶-3（IRAK3）
公开(公告)号：WO0073445A3
公开(公告)日：2001-03-01
申请号：PCT/US0013705
申请日：2000-05-17
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KUO SOPHIA S , MARK MELANIE R , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , FERRARA NAPOLEONE , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KUO SOPHIA S , MARK MELANIE R , MARSTERS SCOT A , PAONI NICHOLAS F , PITTI ROBERT M , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61P9/00 , A61P9/10 , A61P17/02 , A61P27/02 , A61P35/00 , C07K14/47 , C07K14/52 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N9/99 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/86 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/577
CPC分类号： G01N33/5011 , A61K38/00 , C07K14/475 , C07K14/52 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或心血管化的组合物和方法。药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。此外，本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

22. 发明申请

WO0032776A3 SECRETED AMD TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：分解的AMD转化子多核苷酸和编码其的核酸
公开(公告)号：WO0032776A3
公开(公告)日：2000-12-28
申请号：PCT/US9928301
申请日：1999-12-01
申请人： GENENTECH INC , BAKER KEVIN P , BOTSTEIN DAVID , EATON DAN L , FERRARA NAPOLEONE , FILVAROFF ELLEN , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI CHRISTOPHER J , GURNEY AUSTIN L , HILLAN KENNETH J , KLJAVIN IVAR J , NAPIER MARY A , ROY MARGARET ANN , TUMAS DANIEL , WOOD WILLIAM I
发明人： BAKER KEVIN P , BOTSTEIN DAVID , EATON DAN L , FERRARA NAPOLEONE , FILVAROFF ELLEN , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI CHRISTOPHER J , GURNEY AUSTIN L , HILLAN KENNETH J , KLJAVIN IVAR J , NAPIER MARY A , ROY MARGARET ANN , TUMAS DANIEL , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P19/02 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/78 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/577 , C12N15/62
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

23. 发明申请

WO0216602A3 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO0216602A3
公开(公告)日：2003-02-06
申请号：PCT/US0126626
申请日：2001-08-23
申请人： GENENTECH INC , ASHKENAZI AVI J , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , POLAKIS PAUL , WILLIAMS P MICKEY , WOOD WILLIAM I , WU THOMAS D , ZHANG ZEMIN
发明人： ASHKENAZI AVI J , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , POLAKIS PAUL , WILLIAMS P MICKEY , WOOD WILLIAM I , WU THOMAS D , ZHANG ZEMIN
IPC分类号： C12N15/09 , A61K31/537 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P35/00 , C07K16/30 , C07K16/32 , C12N15/00
CPC分类号： C07K16/30 , A61K47/6455
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

24. 发明申请

WO0216429A3 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO0216429A3
公开(公告)日：2003-01-03
申请号：PCT/US0120118
申请日：2001-06-22
申请人： GENENTECH INC , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , HILLAN KENNETH J , POLAKIS PAUL , SMITH VICTORIA , WOOD WILLIAM I , WU THOMAS D , ZHANG ZEMIN
发明人： GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , HILLAN KENNETH J , POLAKIS PAUL , SMITH VICTORIA , WOOD WILLIAM I , WU THOMAS D , ZHANG ZEMIN
IPC分类号： G01N33/53 , A61K38/17 , A61K39/395 , A61K41/00 , A61K45/00 , A61K47/48 , A61K51/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K14/82 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/32 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N9/64 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/645 , C12R1/91 , G01N33/566 , G01N33/574 , G01N33/577 , G01N33/68 , G01N37/00
CPC分类号： C07K14/705 , A61K47/6455 , C07K16/30 , C07K16/40 , C12N9/0091
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

25. 发明申请

WO9963088A3 MEMBRANE-BOUND PROTEINS AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：膜结合蛋白和核酸编码它们
公开(公告)号：WO9963088A3
公开(公告)日：2001-03-29
申请号：PCT/US9912252
申请日：1999-06-02
申请人： GENENTECH INC , BAKER KEVIN , CHEN JIAN , GODDARD AUDREY , GURNEY AUSTIN L , SMITH VICTORIA , WATANABE COLIN K , WOOD WILLIAM I , YUAN JEAN
发明人： BAKER KEVIN , CHEN JIAN , GODDARD AUDREY , GURNEY AUSTIN L , SMITH VICTORIA , WATANABE COLIN K , WOOD WILLIAM I , YUAN JEAN
IPC分类号： C07K14/705 , C12N15/12 , C07K16/28 , C12N15/62
CPC分类号： C07K14/705 , C07K2319/00
摘要： The present invention is directed to membrane-bound polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及膜结合多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

26. 发明申请

WO0037638A3 METHODS AND COMPOSITIONS FOR INHIBITING NEOPLASTIC CELL GROWTH 审中-公开
标题翻译：抑制细胞生长的方法和组合物
公开(公告)号：WO0037638A3
公开(公告)日：2000-11-09
申请号：PCT/US9928565
申请日：1999-12-02
申请人： GENENTECH INC , ASHKENAZI AVI J , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , MARSTERS SCOT A , NAPIER MARY A , PITTI ROBERT M , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , MARSTERS SCOT A , NAPIER MARY A , PITTI ROBERT M , WOOD WILLIAM I
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P35/02 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , A61K38/17 , C12N15/62
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02 , C12N2799/026 , C12N2799/027
摘要： The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及用于抑制肿瘤细胞生长的方法和组合物。特别地，本发明涉及用于治疗肿瘤的抗肿瘤组合物和方法。本发明还涉及用于鉴定生长抑制性例如抗肿瘤化合物的筛选方法。此外，本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

27. 发明申请

WO9963088A8 SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：分泌和转运蛋白多核苷酸和编码其的核酸
公开(公告)号：WO9963088A8
公开(公告)日：2000-10-19
申请号：PCT/US9912252
申请日：1999-06-02
申请人： GENENTECH INC , BAKER KEVIN , CHEN JIAN , GODDARD AUDREY , GURNEY AUSTIN L , SMITH VICTORIA , WATANABE COLIN K , WOOD WILLIAM I , YUAN JEAN
发明人： BAKER KEVIN , CHEN JIAN , GODDARD AUDREY , GURNEY AUSTIN L , SMITH VICTORIA , WATANABE COLIN K , WOOD WILLIAM I , YUAN JEAN
IPC分类号： C07K14/705 , C12N15/12 , C07K16/28 , C12N15/62
CPC分类号： C07K14/705 , C07K2319/00
摘要： The present invention is directed to polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

28. 发明申请

WO0012708A3 FURTHER PRO POLYPEPTIDES AND SEQUENCES THEREOF 审中-公开
标题翻译：其他多肽及其序列
公开(公告)号：WO0012708A3
公开(公告)日：2001-10-04
申请号：PCT/US9920111
申请日：1999-09-01
申请人： GENENTECH INC , BAKER KEVIN , GODDARD AUDREY , GURNEY AUSTIN L , SMITH VICTORIA , WATANABE COLIN K , WOOD WILLIAM I
发明人： BAKER KEVIN , GODDARD AUDREY , GURNEY AUSTIN L , SMITH VICTORIA , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： C07K14/705 , C12N15/12 , C07K16/28 , C12N5/10 , C12N15/62 , C12Q1/68
CPC分类号： C07K14/705 , C07K2319/00
摘要： Membrane-bound proteins and receptor molecules have various industrial applications, including as pharmaceutical and diagnostic agents. Receptor immunoadhesins, for instance, can be employed as therapeutic agents to block receptor-ligand interactions. The membrane-bound proteins can also be employed for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. Efforts are being undertaken by both industry and academia to identify new, native receptor or membrane-bound proteins. Many efforts are focused on the screening of mammalian recombinant DNA libraries to identifiy the coding sequences for novel receptor or membrane-bound proteins. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：膜结合蛋白和受体分子具有各种工业应用，包括作为药物和诊断剂。例如，受体免疫粘附素可以用作阻断受体 - 配体相互作用的治疗剂。膜结合蛋白也可用于筛选相关受体/配体相互作用的潜在肽或小分子抑制剂。工业界和学术界正在努力确定新的天然受体或膜结合蛋白。许多努力集中在筛选哺乳动物重组DNA文库以鉴定新受体或膜结合蛋白的编码序列。本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

29. 发明申请

WO0073348A3 METHODS AND COMPOSITIONS FOR INHIBITING NEOPLASTIC CELL GROWTH 审中-公开
标题翻译：抑制细胞生长的方法和组合物
公开(公告)号：WO0073348A3
公开(公告)日：2001-07-05
申请号：PCT/US0014941
申请日：2000-05-30
申请人： GENENTECH INC , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , SHELTON DAVID L , SMITH VICTORIA , WATANABE COLIN K , WOOD WILLIAM I
发明人： BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , SHELTON DAVID L , SMITH VICTORIA , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P35/02 , C07K14/435 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/07 , C12N5/077 , C12N5/09 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , A61K38/17 , C12N15/62 , G01N33/53 , G01N33/574
CPC分类号： C07K14/47
摘要： The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g. , antitumor compounds. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及用于抑制肿瘤细胞生长的方法和组合物。特别地，本发明涉及用于治疗肿瘤的抗肿瘤组合物和方法。本发明还涉及用于鉴定生长抑制性例如抗肿瘤化合物的筛选方法。本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

30. 发明申请

WO0053755A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO0053755A3
公开(公告)日：2001-02-08
申请号：PCT/US0000376
申请日：2000-01-06
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , ROY MARGARET ANN , WATANABE COLIN K , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , ROY MARGARET ANN , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , A61K39/395 , C12N15/11 , C12N15/62 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2319/00 , C12N2799/026
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

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