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21. 发明专利

AU2008202946B2 Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue 未知
公开(公告)号：AU2008202946B2
公开(公告)日：2011-03-24
申请号：AU2008202946
申请日：2008-07-03
申请人： GENELUX CORP
发明人： SZALAY ALADAR A , SHABAHANG SHAHROKH , YU YONG A
IPC分类号： C12Q1/02 , G01R33/28 , A61B5/055 , A61K35/545 , A61K35/74 , A61K35/76 , A61K38/00 , A61K38/22 , A61K38/43 , A61K48/00 , A61K49/00 , A61K49/18 , A61P1/04 , A61P9/02 , A61P9/10 , A61P17/02 , A61P19/02 , A61P29/00 , C12Q1/18 , C12Q1/66 , G01N24/08 , G01N33/15 , G01N33/483 , G01N33/68
摘要： Described is the use of a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g., a luminescent or fluorescent protein for the preparation of a diagnostic composition for diagnosis and/or visualization of wounded or inflamed tissue or a disease associated therewith. Moreover, therapeutic uses are described, wherein said microorganism or cell additionally contain an expressible DNA sequence encoding a protein suitable for therapy, e.g. an enzyme causing cell death or digestion of debris.

22. 发明专利

SG165992A1 LIGHT EMITTING MICROORGANISMS AND CELLS FOR DIAGNOSIS AND THERAPY OF DISEASES ASSOCIATED WITH WOUNDED OR INFLAMED TISSUE 未知
公开(公告)号：SG165992A1
公开(公告)日：2010-11-29
申请号：SG2007016132
申请日：2003-06-05
申请人： GENELUX CORP
发明人： SZALAY ALADAR A , SHABAHANG SHAHROKH , YU YONG A
IPC分类号： G01R33/28 , A61B5/055 , A61K35/545 , A61K35/74 , A61K35/76 , A61K38/00 , A61K38/22 , A61K38/43 , A61K48/00 , A61K49/00 , A61K49/18 , A61P1/04 , A61P9/02 , A61P9/10 , A61P17/02 , A61P19/02 , A61P29/00 , C12Q1/02 , C12Q1/18 , C12Q1/66 , G01N24/08 , G01N33/15 , G01N33/483 , G01N33/68
摘要： Described is the use of a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g., a luminescent or fluorescent protein for the preparation of a diagnostic composition for diagnosis and/or visualization of wounded or inflamed tissue or a disease associated therewith. Moreover, therapeutic uses are described, wherein said microorganism or cell additionally contain an expressible DNA sequence encoding a protein suitable for therapy, e.g. an enzyme causing cell death or digestion of debris.

23. 发明专利

NZ569767A Microorganisms and cells for diagnosis and therapy of tumors 未知
公开(公告)号：NZ569767A
公开(公告)日：2009-03-31
申请号：NZ56976702
申请日：2002-07-31
申请人： GENELUX CORP
发明人： SZALAY ALADAR A
IPC分类号： A61K35/66 , A61K35/74 , C12N1/20
摘要： Disclosed is the use of a bacterium in the preparation of a composition for detection of a tumor, tumor tissue, cancer or metastasis in a subject, wherein: (a) the bacterium is selected from among Vibrio, a metal-accumulating bacterium, Lactobacillus, Bacillus, Mycobacterium, Actinomyces, Eubacterium, Peptostreptococcus, Peptococcus, Acidaminococcus, Clavibacter, Agrobacterium, Erwinia, Azorhizobium, Xanthomonas, Bifidobacterium, Streptococcus thermophilus, Enterococcus, Pseudomonas, Staphylococcus, Clostridium, a milk-associated bacterium or a cheese-associated bacterium; and (b) the bacterium: (i) accumulates at a tumor, tumor tissue, cancer or metastasis due only to protection of the bacterium in the tumorous environment from clearance from the subject by the immune system; (ii) cannot differentiate between a cancerous cell or tissue and a non-cancerous counterpart cell or tissue; (iii) is not tumor-targeted; (iv) is an attenuated form of a pathogenic organism or is a non-pathogenic organism; and (v) comprises DNA encoding a detectable protein or protein that induces a detectable signal.

24. 发明专利

AU2004289953B2 Modified recombinant vaccina viruses and other microorganisms, uses thereof 未知
公开(公告)号：AU2004289953B2
公开(公告)日：2008-09-25
申请号：AU2004289953
申请日：2004-06-18
申请人： GENELUX CORP
发明人： TIMIRYASOVA TATYANA , YU YONG A , SZALAY ALADAR A , ZHANG QIAN
IPC分类号： A61K35/74 , A61K35/744 , A61K35/76 , A61K35/768 , A61K39/00 , A61K48/00 , A61P35/00 , C07K16/30 , C07K16/40 , C12N7/04 , C12N15/863
摘要： Recombinant vaccinia viruses useful as tumor-specific delivery vehicle for cancer gene therapy and vaccination Therapeutic methods and microorganisms therefore are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Methods for making tumor specific antibodies and also methods of making gene products encoded by the microorganism as well as antibodies reactive therewith are provided.

25. 发明专利

AU2008264201B2 Modified recombinant vaccinia viruses and other microorganisms, uses thereof 未知
公开(公告)号：AU2008264201B2
公开(公告)日：2011-07-28
申请号：AU2008264201
申请日：2008-12-24
申请人： GENELUX CORP
发明人： SZALAY ALADAR A , YU YONG A , QIAN ZHANG , TATYANA TIMIRYASOVA
IPC分类号： C07K16/30 , A61K35/74 , A61K35/744 , A61K35/76 , A61K35/768 , A61K39/00 , A61K48/00 , A61P35/00 , C07K16/40 , C12N7/04 , C12N15/863
摘要： MODIFIED RECOMBINANT VACCINIA VIRUSES AND OTHER MICROORGANISMS, USES THEREOF Abstract Recombinant vaccinia viruses useful as tumor-specific delivery vehicle for cancer gene therapy and vaccination Therapeutic methods and microorganisms therefore are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as tumors and other proliferating tissue and in inflamed tissues, compared to other 1o tissues, cells and organs, so that they exhibit relatively low toxicity to host organisme. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Methods for 15 making tumor specific antibodies and also methods of making gene products encoded by the microorganism as well as antibodies reactive therewith are provided.

26. 发明专利

DE60234793D1 未知
公开(公告)号：DE60234793D1
公开(公告)日：2010-01-28
申请号：DE60234793
申请日：2002-07-31
申请人： GENELUX CORP
发明人： SZALAY ALADAR A , YU YONG A , SHABAHANG SHAHROKH , TIMIRYSOVA TATYANA
IPC分类号： A61K39/00 , C12Q1/66 , A61K35/12 , A61K35/74 , A61K35/76 , A61K49/00 , A61K49/18 , C12N1/21 , C12N15/03 , C12Q1/00 , C12Q1/02 , G01N33/50 , G01N33/574
摘要： Described are diagnostic and pharmaceutical compositions comprising a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g. a luminescent or fluorescent protein. Moreover, the use of said microorganism or cell for tumor-targeting or tumor-imaging is described. For therapeutic uses, said microorganism or cell additionally contain an expressible DNA sequence encoding a protein suitable for tumor therapy, e.g. a cytotoxic or cytostatic protein.

27. 发明专利

AU2008264201A1 Modified recombinant vaccinia viruses and other microorganisms, uses thereof 未知
公开(公告)号：AU2008264201A1
公开(公告)日：2009-01-29
申请号：AU2008264201
申请日：2008-12-24
申请人： GENELUX CORP
发明人： SZALAY ALADAR A , YU YONG A , ZHANG QIAN , TIMIRYASOVA TATYANA
IPC分类号： A61K35/74 , A61K35/744 , A61K35/76 , A61K35/768 , A61K39/00 , A61K48/00 , A61P35/00 , C07K16/30 , C07K16/40 , C12N7/04 , C12N15/863

28. 发明专利

NZ530818A Use of a LIVP strain of vaccina virus in the preparation of a composition for detection of a tumor 未知
公开(公告)号：NZ530818A
公开(公告)日：2007-07-27
申请号：NZ53081802
申请日：2002-07-31
申请人： GENELUX CORP
发明人： SZALAY ALADAR A , YU YONG A , SHABAHANG SHAHROKH , TIMIRYASOVA TATYANA
IPC分类号： A61K39/00 , A61K35/12 , A61K35/74 , A61K35/76 , A61K49/00 , A61K49/18 , C12N1/21 , C12N15/03 , C12Q1/00 , C12Q1/02 , C12Q1/66 , G01N33/50 , G01N33/574
摘要： Disclosed is the use of an LIVP strain of vaccinia virus in the preparation of a composition for detection of a tumour, tumour tissue, cancer or metastasis in a subject, wherein: (1) the virus comprises DNA encoding a detectable protein or protein capable of inducing a detectable signal; (2) the virus is capable of replicating in the subject; (3) the virus is recognized by the immune system of the subject; (4) the virus is not pathogenic or is attenuated.

29. 发明专利

BRPI0411526A 未知
公开(公告)号：BRPI0411526A
公开(公告)日：2006-08-01
申请号：BRPI0411526
申请日：2004-06-18
申请人： GENELUX CORP
发明人： SZALAY ALADAR A , TIMIRYASOVA TATYANA , YU YOUNG A , ZHANG QIAN
IPC分类号： A61K35/74 , A61K35/744 , A61K35/76 , A61K35/768 , A61K39/00 , A61K48/00 , C07K16/30 , C07K16/40 , C12N7/04 , C12N15/863 , C12Q1/02

30. 发明专利

AU2004289953A1 Modified recombinant vaccina viruses and other microorganisms, uses thereof 未知
公开(公告)号：AU2004289953A1
公开(公告)日：2005-05-26
申请号：AU2004289953
申请日：2004-06-18
申请人： GENELUX CORP
发明人： TIMIRYASOVA TATYANA , YU YONG A , SZALAY ALADAR A , ZHANG QIAN
IPC分类号： C12N7/04 , A61K35/74 , A61K35/744 , A61K35/76 , A61K35/768 , A61K39/00 , A61K48/00 , C07K16/30 , C07K16/40 , C12N15/863 , C12Q1/02

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