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21. 发明公开

US20240091320A1 ANTI-INFLAMMATORY PEPTIDES AND COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：US20240091320A1
公开(公告)日：2024-03-21
申请号：US18446712
申请日：2023-08-09
申请人： Sang Jae Kim , Gemvax & Kael Co., Ltd.
发明人： Sang Jae KIM , Kyung Hee KIM , Kyu-Yong LEE , Seong-Ho KOH , Hyun-Hee PARK , Sung Jin HUH , Woo Jin LEE , Bum Joon KIM
IPC分类号： A61K38/45 , A23L33/18 , A61K8/64 , A61Q19/00 , C07K7/08 , C07K14/47 , C12N9/02
CPC分类号： A61K38/45 , A23L33/18 , A61K8/64 , A61Q19/00 , C07K7/08 , C07K14/4703 , C12N9/0069 , C12N9/0083 , C12Y113/11 , C12Y114/99001 , C12Y207/07049 , A23V2002/00 , A61K38/00 , Y02A50/30
摘要： The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid sequence with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has an outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating and preventing a variety of different types of inflammatory diseases.

22. 发明公开

US20240084273A1 CELL PENETRATING PEPTIDE, CONJUGATE COMPRISING SAME, AND COMPOSITION COMPRISING CONJUGATE 审中-公开
公开(公告)号：US20240084273A1
公开(公告)日：2024-03-14
申请号：US18451280
申请日：2023-08-17
申请人： Sang Jae Kim , GemVax & KAEL CO., LTD.
发明人： Sang Jae KIM
IPC分类号： C12N9/12 , A23L33/18 , A61K8/64 , A61K8/66 , A61K47/64 , A61K49/00 , A61Q19/00 , C07K7/08 , C07K14/00 , G01N33/58
CPC分类号： C12N9/1276 , A23L33/18 , A61K8/64 , A61K8/66 , A61K47/64 , A61K49/0002 , A61K49/0043 , A61K49/0056 , A61Q19/00 , C07K7/08 , C07K14/00 , G01N33/582 , A61K38/00 , C07K2319/10
摘要： The present invention relates to a conjugate of cell penetrating peptide and an active ingredient; and its use. Specifically, a conjugate including a cell penetrating peptide which is a peptide comprising any one amino acid sequence of SEQ ID NO: 1 to SEQ ID NO: 156, a fragment of any one sequence of SEQ ID NO: 1 to SEQ ID NO: 156, or a peptide having above 80% homology with the above-mentioned sequence; and a composition comprising the same are disclosed.

23. 发明申请

US20200208127A1 ANTI-INFLAMMATORY PEPTIDES AND COMPOSITION COMPRISING SAME 审中-公开
公开(公告)号：US20200208127A1
公开(公告)日：2020-07-02
申请号：US16818001
申请日：2020-03-13
申请人： Sang Jae Kim , GemVax & KAEL Co., Ltd.
发明人： Sang Jae KIM , Kyung Hee Kim , Kyu-Yong Lee , Seong-Ho KOH , Bum Joon Kim , Hyun-Hee PARK , Sung Jin HUH , Woo Jin LEE , Hwain JANG , Jung Soon HA
IPC分类号： C12N9/12 , A61K38/45 , A23L33/18
摘要： The present invention relates to methods of treating or preventing inflammation with a peptide having anti-inflammatory activity, wherein the peptide consists of the amino acid sequence of SEQ ID NO: 101. According to the present invention, the peptide of SEQ ID NO: 101 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the method comprising administration of the peptide of this invention can be used in anti-inflammatory pharmaceutical or cosmetic applications, in turn, treating and preventing a variety of different types of inflammatory diseases.

24. 发明申请

US20190269803A1 CELL PENETRATING PEPTIDE, CONJUGATE COMPRISING SAME, AND COMPOSITION COMPRISING CONJUGATE 审中-公开
公开(公告)号：US20190269803A1
公开(公告)日：2019-09-05
申请号：US16273689
申请日：2019-02-12
申请人： GEMVAX & KAEL CO., LTD.
发明人： Sang Jae KIM
IPC分类号： A61K49/00 , A61K9/00 , A61K47/64 , A23L33/18 , A23L33/175 , C07K7/08 , C07K14/00
摘要： The present invention relates to a conjugate of cell penetrating peptide and an active ingredient; and its use. Specifically, a conjugate including a cell penetrating peptide which is a peptide comprising any one amino acid sequence of SEQ ID NO: 2 to SEQ ID NO: 178, a fragment of any one sequence of SEQ ID NO: 2 to SEQ ID NO: 178, or a peptide having above 80% homology with the above-mentioned sequence; and a composition comprising the same are disclosed.

25. 发明申请

US20180207241A1 PEPTIDE HAVING FIBROSIS INHIBITORY ACTIVITY AND COMPOSITION CONTAINING SAME 审中-公开
公开(公告)号：US20180207241A1
公开(公告)日：2018-07-26
申请号：US15922468
申请日：2018-03-15
申请人： GEMVAX & KAEL CO., LTD.
发明人： Sang Jae KIM
IPC分类号： A61K38/45 , C12N9/12 , A61K31/7068 , A61K45/06
CPC分类号： A61K38/45 , A61K31/7068 , A61K45/06 , C12N9/1276 , C12Y207/07049
摘要： The present invention relates to a composition for inhibiting fibrosis and more specifically, to a composition for inhibiting fibrosis, wherein the composition is effective in inhibiting fibrosis of tissue cells by containing a peptide derived from telomerase. The peptide according to the present invention exhibits an effect of inhibiting the progression of various kinds of fibrosis, including fibrosis due to occurrence of cancer, fibrosis due to the administration of chemotherapy anticancer drugs, fibrosis due to the exposure to radiation, or progressive fibrosis of tissues, including a TGF-β signaling procedure, and thus can provide a composition for anti-fibrosis or inhibiting fibrosis and a method for treating diseases due to fibrosis.

26. 发明申请

US20170028035A1 Peptide Having Fibrosis Inhibitory Activity and Composition Containing Same 有权
标题翻译：具有纤维化抑制活性的肽和含有其的组合物
公开(公告)号：US20170028035A1
公开(公告)日：2017-02-02
申请号：US15303370
申请日：2015-04-10
申请人： GemVax & KAEL Co., Ltd.
发明人： Sang Jae KIM
IPC分类号： A61K38/45 , C12N9/12 , A61K31/7068 , A61K45/06
CPC分类号： A61K38/45 , A61K31/7068 , A61K45/06 , C12N9/1276 , C12Y207/07049
摘要： The present invention relates to a composition for inhibiting fibrosis and more specifically, to a composition for inhibiting fibrosis, wherein the composition is effective in inhibiting fibrosis of tissue cells by containing a peptide derived from telomerase. The peptide according to the present invention exhibits an effect of inhibiting the progression of various kinds of fibrosis, including fibrosis due to occurrence of cancer, fibrosis due to the administration of chemotherapy anticancer drugs, fibrosis due to the exposure to radiation, or progressive fibrosis of tissues, including a TGF-β signaling procedure, and thus can provide a composition for anti-fibrosis or inhibiting fibrosis and a method for treating diseases due to fibrosis.
摘要翻译：本发明涉及一种抑制纤维化的组合物，更具体地说，涉及一种抑制纤维化的组合物，其中组合物通过含有源自端粒酶的肽有效抑制组织细胞的纤维化。根据本发明的肽显示抑制各种纤维化的进展的效果，包括由于癌症的发生引起的纤维化，由于施用化疗抗癌药物引起的纤维化，由于暴露于放射线引起的纤维化或进行性纤维化组织，包括TGF-β信号传导过程，因此可以提供用于抗纤维化或抑制纤维化的组合物和用于治疗由于纤维化引起的疾病的方法。

27. 发明申请

US20160120966A1 BIOLOGICAL MARKERS USEFUL IN CANCER IMMUNOTHERAPY 审中-公开
标题翻译：生物标志物可用于癌症免疫治疗
公开(公告)号：US20160120966A1
公开(公告)日：2016-05-05
申请号：US14896358
申请日：2014-06-05
申请人： Sang Jae KIM , GEMVAX & KAEL CO., LTD.
发明人： Sang Jae KIM
IPC分类号： A61K39/00 , G01N33/574 , A61K31/7068
CPC分类号： A61K39/0011 , A61K31/7068 , A61K38/08 , A61K38/10 , G01N33/57438 , G01N33/57488 , G01N33/6893 , G01N2333/4737 , G01N2333/521 , G01N2333/523 , G01N2800/24 , G01N2800/52 , G01N2800/7095
摘要： Methods are disclosed that are based on the finding that serum and plasma levels of eotaxin, MIP1α, and CRP act as important biomarkers that are useful for determining the feasibility in instigating immunotherapeutic treatment of cancer when immunizing with the GV1001 peptide (EARPALLTSRLRFIPK; derived from human telomerase protein), optionally when combined with state of the art combination treatment with Gemcitabine and Capecitabine. In particular, the present invention provides methods for determining whether patients should be treated GV1001 and for determining whether instigated treatment should be continued.
摘要翻译：公开了基于以下发现的方法：eotaxin，MIP1α和CRP的血清和血浆水平作为重要的生物标志物，其用于确定在用GV1001肽（EARPALLTSRLRFIPK;衍生自人类）免疫时引发免疫治疗性治疗的可行性端粒酶蛋白），任选地当与吉西他滨和卡培他滨的最新组合治疗组合时。特别地，本发明提供了确定患者是否应该被治疗GV1001并确定是否应继续进行治疗的方法。

28. 发明公开

US20240158768A1 ANTI-INFLAMMATORY PEPTIDES AND COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：US20240158768A1
公开(公告)日：2024-05-16
申请号：US18411838
申请日：2024-01-12
申请人： Sang Jae KIM , GemVax & KAEL Co., Ltd.
发明人： Sang Jae KIM , Kyung Hee KIM , Kyu-Yong LEE , Seong-Ho KOH , Bum Joon KIM , Hyun-Hee PARK , Sung Jin HUH , Woo Jin LEE , Hwain JANG , Jung Soon HA
IPC分类号： C12N9/12 , A23L33/18 , A61K38/45
CPC分类号： C12N9/1276 , A23L33/18 , A61K38/45 , A23V2002/00 , C12Y207/07049 , Y02A50/30
摘要： The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises any one amino acid sequence of SEQ ID NO: 1 to SEQ ID NO: 161, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, a peptide that has at least one amino acid sequence of SEQ ID NO: 1 to SEQ ID NO: 161 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptides of this invention can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.

29. 发明申请

US20210085757A1 Anti-Inflammatory Peptides and Composition Comprising the Same 有权
公开(公告)号：US20210085757A1
公开(公告)日：2021-03-25
申请号：US17112935
申请日：2020-12-04
申请人： Sang Jae KIM , GemVax & KAEL Co., Ltd.
发明人： Sang Jae KIM , Kyung Hee KIM , Kyu-Yong LEE , Seong-Ho KOH , Hyun-Hee PARK , Sung Jin HUH , Woo Jin LEE , Bum Joon KIM
IPC分类号： A61K38/45 , C12N9/02 , A61K8/64 , A61Q19/00 , C07K7/08 , C07K14/47 , A23L33/18
摘要： The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises at least one amino acid sequence among SEQ ID NO: 2 to SEQ ID NO: 179, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, the peptides that have at least one amino acid sequence of SEQ ID NO: 2 to SEQ ID NO: 179 shows outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptides of this invention can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.

30. 发明申请

US20200016230A1 PEPTIDE FOR TREATING OCULAR DISEASES AND COMPOSITION FOR TREATING OCULAR DISEASES COMPRISING SAME 审中-公开
公开(公告)号：US20200016230A1
公开(公告)日：2020-01-16
申请号：US16582014
申请日：2019-09-25
申请人： GemVax & KAEL CO., LTD.
发明人： Sang Jae KIM
IPC分类号： A61K38/02 , A61K38/17
摘要： The present specification discloses a pharmaceutical composition for preventing or treating ophthalmopathy. More particularly, disclosed is a composition comprising a peptide derived from telomerase and being effective in treating and preventing ophthalmopathy. The disclosed peptide, a peptide having a sequence 80% identical to the sequence thereof, or a peptide as a fragment thereof is superiorly effective in treating ophthalmopathy.

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