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    • 25. 发明授权
    • Methods and compositions for interaction trap assays
    • 相互作用阱测定法的方法和组成
    • US07029847B2
    • 2006-04-18
    • US09990762
    • 2001-11-14
    • J. Keith JoungJeffrey MillerCarl O. Pabo
    • J. Keith JoungJeffrey MillerCarl O. Pabo
    • C12Q1/68G01N33/53G01N33/567
    • C12N15/1055C12Q1/6897G01N33/50G01N33/5008G01N33/502C12Q2565/201
    • The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the invention may also be used to identify agents which may agonize or antagonize a protein-protein, protein-DNA, or protein-RNA interaction. In certain embodiments, the interaction trap system of the invention is useful for screening libraries with greater than 107 members. In other embodiments, the interaction trap system of the invention is used in conjunction with flow cytometry. The invention further provides a means for simultaneously screening a target protein or nucleic acid sequence for the ability to interact with two or more test proteins or nucleic acids.
    • 本发明提供了用于检测蛋白质 - 蛋白质,蛋白质-DNA或蛋白质 - RNA相互作用的相互作用阱测定法的方法和组合物。 本发明的方法和组合物还可用于鉴定可能激动或拮抗蛋白质 - 蛋白质,蛋白质-DNA或蛋白质 - RNA相互作用的试剂。 在某些实施方案中,本发明的相互作用捕获系统可用于筛选具有大于10个成员的文库。 在其它实施方案中,本发明的相互作用阱系统结合流式细胞术使用。 本发明还提供了用于同时筛选靶蛋白或核酸序列以获得与两种或多种测试蛋白或核酸相互作用的能力的方法。
    • 27. 发明申请
    • Ionic polymer membranes
    • 离子聚合物膜
    • US20060049102A1
    • 2006-03-09
    • US10933593
    • 2004-09-03
    • Jeffrey MillerGeorge HuffWilliam KorosCharles Hoppin
    • Jeffrey MillerGeorge HuffWilliam KorosCharles Hoppin
    • B01D71/06
    • B01D53/228B01D71/82
    • Compositions and processes are disclosed for economical separation of fluid mixtures. Broadly, the present invention discloses ionic polymer compositions that are useful for perm-selective membrane separations. More particularly, ionic polymers of the invention comprise a plurality of repeating structural units having as a constituent part thereof organic ionic moieties consisting of nitrogen containing anions and/or cations. In the form of non-porous membranes, ionic polymers of the invention facilitate recovery of purified organic and inorganic products from fluid mixtures by means of perm-selective membrane separations. The present invention also provides methods for forming the ionic polymers, for example by treating selected nitrogen-containing organic polymers with acids, or treating a polymeric material comprising a plurality of carboxylate groups with an amine. Ionic polymer compositions of the invention are particularly useful for simultaneous recovery of a permeate product of an increased concentration, and a desired non-permeate stream, from a fluid mixture containing at least two compounds of different boiling point temperatures.
    • 公开了用于经济分离流体混合物的组合物和方法。 广泛地,本发明公开了可用于烫发选择性膜分离的离子聚合物组合物。 更具体地,本发明的离子聚合物包含多个重复结构单元,其具有由含有阴离子和/或阳离子的氮组成的有机离子部分的组成部分。 以无孔膜的形式,本发明的离子聚合物便于通过选择性膜分离从流体混合物中回收纯化的有机和无机产物。 本发明还提供了形成离子聚合物的方法,例如通过用酸处理选定的含氮有机聚合物,或用胺处理包含多个羧酸酯基团的聚合物材料。 本发明的离子聚合物组合物特别可用于从含有至少两种不同沸点温度的化合物的流体混合物中同时回收浓度增加的渗透产物和期望的非渗透物流。
    • 28. 发明申请
    • Optical switch using rare earth doped glass
    • 使用稀土掺杂玻璃的光开关
    • US20050225839A1
    • 2005-10-13
    • US10820098
    • 2004-04-07
    • Falgun PatelJeffrey Miller
    • Falgun PatelJeffrey Miller
    • G02B6/34H01S3/00H01S3/067
    • H01S3/06754H01S3/10007
    • The present invention provides an optical switch including a loss element having a signal loss, and a rare earth doped gain element optically connected in series with the loss element. The rare earth doped gain element is operable to produce a signal gain. The signal gain and the signal loss are about equal. The present invention also provides a method of optical switching including optically connecting a loss element in series with a rare earth doped gain element and passing an optical signal through the loss element and the gain element. The loss element attenuates the optical signal by a first amount. The method further includes selectively applying an optical pump to the gain element to perform the switching, the gain element amplifying the optical signal by the first amount in response to the optical pump.
    • 本发明提供了一种光开关,其包括具有信号损耗的损耗元件和与损耗元件串联光学连接的稀土掺杂增益元件。 稀土掺杂增益元件可操作以产生信号增益。 信号增益和信号损耗大致相等。 本发明还提供一种光学切换的方法,包括将稀土元素与稀土掺杂的增益元件串联光学连接并使光信号通过损耗元件和增益元件。 损耗元件将光信号衰减第一量。 该方法还包括选择性地将光泵施加到增益元件以执行切换,增益元件响应光泵将光信号放大第一量。