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21. 发明专利

NO833529L 未知
公开(公告)号：NO833529L
公开(公告)日：1984-04-02
申请号：NO833529
申请日：1983-09-29
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： UEDA IKUO , NAGANO MASANOBU , AKAHANE ATSUSHI
IPC分类号： A61K31/44 , C07D401/12 , A61K31/4402 , A61K31/4418 , A61P1/04 , C07D213/56 , C07D213/57 , C07D
摘要： New a-aryl-a-pyridylalkanoic acid derivatives of the formula:whereinR 1 is cyano or carbamoyl,R 2 is hydrogen or halogen,R 3 is hydrogen or lower alkyl,one of R 4 and R 5 is hydrogen and another is lower alkyl,R 6 is hydrogen or lower alkyl, andR 7 is lower alkyl, orR 6 and R 7 are taken together to form an N-containing saturated heterocyclic group with the adjacent nitrogen atom, in which the heterocyclic group may be substituted with lower alkyl or optionally protected hydroxy(lower)alkyl, provided that R 2 is halogen or R 3 is lower alkyl, when R 1 is cyano and R 6 and R 7 are each lower alkyl, and salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents and spasmolytic agents.

22. 发明专利

DK421183A 未知
公开(公告)号：DK421183A
公开(公告)日：1984-03-31
申请号：DK421183
申请日：1983-09-15
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： UEDA IKUO , NAGANO MASANOBU , AKAHANE ATSUSHI
IPC分类号： C07D401/12 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P1/04 , C07D213/56 , C07D213/57 , C07D
摘要： New a-aryl-a-pyridylalkanoic acid derivatives of the formula:whereinR 1 is cyano or carbamoyl,R 2 is hydrogen or halogen,R 3 is hydrogen or lower alkyl,one of R 4 and R 5 is hydrogen and another is lower alkyl,R 6 is hydrogen or lower alkyl, andR 7 is lower alkyl, orR 6 and R 7 are taken together to form an N-containing saturated heterocyclic group with the adjacent nitrogen atom, in which the heterocyclic group may be substituted with lower alkyl or optionally protected hydroxy(lower)alkyl, provided that R 2 is halogen or R 3 is lower alkyl, when R 1 is cyano and R 6 and R 7 are each lower alkyl, and salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents and spasmolytic agents.

23. 发明专利

DK421183D0 未知
公开(公告)号：DK421183D0
公开(公告)日：1983-09-15
申请号：DK421183
申请日：1983-09-15
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： UEDA IKUO , NAGANO MASANOBU , AKAHANE ATSUSHI
IPC分类号： C07D401/12 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P1/04 , C07D213/56 , C07D213/57 , C07D213
摘要： New a-aryl-a-pyridylalkanoic acid derivatives of the formula:whereinR 1 is cyano or carbamoyl,R 2 is hydrogen or halogen,R 3 is hydrogen or lower alkyl,one of R 4 and R 5 is hydrogen and another is lower alkyl,R 6 is hydrogen or lower alkyl, andR 7 is lower alkyl, orR 6 and R 7 are taken together to form an N-containing saturated heterocyclic group with the adjacent nitrogen atom, in which the heterocyclic group may be substituted with lower alkyl or optionally protected hydroxy(lower)alkyl, provided that R 2 is halogen or R 3 is lower alkyl, when R 1 is cyano and R 6 and R 7 are each lower alkyl, and salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents and spasmolytic agents.

24. 发明专利

ES2179352T3 未知
公开(公告)号：ES2179352T3
公开(公告)日：2003-01-16
申请号：ES97930832
申请日：1997-07-17
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： AKAHANE ATSUSHI , KURODA SATORU , ITANI HIROMICHI , SHIMIZU YASUYO
IPC分类号： A61K31/501 , A61P1/04 , A61P3/10 , A61P9/00 , A61P11/06 , A61P13/12 , A61P25/00 , A61P37/06 , A61P43/00 , C07D471/04 , C07D453/02 , A61K31/50
摘要： PCT No. PCT/JP97/02493 Sec. 371 Date Jan. 19, 1999 Sec. 102(e) Date Jan. 19, 1999 PCT Filed Jul. 17, 1997 PCT Pub. No. WO98/03507 PCT Pub. Date Jan. 29, 1998A pyrazolopyridine compound of formula (I) wherein R1 is aryl, and R2 is lower alkyl substituted with unsaturated 3 to 8-membered heteromonocyclic group containing 1 or 2 sulfur atom(s) and 1 to 3 nitrogen atom(s) which may have one or more substituent(s); a group of formula (1) wherein R3 is hydrogen, lower alkyl, ar(lower)alkyl or acyl, R4 is hydrogen or hydroxy, A is lower alkylene, m is an integer of 0 or 1, and n is an integer of 1 or 2; a group of formula (2) wherein R5 and R6 are each lower alkyl; or quinuclidinyl, or a salt the The pyrazolopyridine compound (I) and a salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, etc.), anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure, and the like.

25. 发明专利

DE69715891D1 未知
公开(公告)号：DE69715891D1
公开(公告)日：2002-10-31
申请号：DE69715891
申请日：1997-07-17
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： AKAHANE ATSUSHI , KURODA SATORU , ITANI HIROMICHI , SHIMIZU YASUYO
IPC分类号： A61K31/501 , A61P1/04 , A61P3/10 , A61P9/00 , A61P11/06 , A61P13/12 , A61P25/00 , A61P37/06 , A61P43/00 , C07D471/04 , C07D453/02 , A61K31/50
摘要： PCT No. PCT/JP97/02493 Sec. 371 Date Jan. 19, 1999 Sec. 102(e) Date Jan. 19, 1999 PCT Filed Jul. 17, 1997 PCT Pub. No. WO98/03507 PCT Pub. Date Jan. 29, 1998A pyrazolopyridine compound of formula (I) wherein R1 is aryl, and R2 is lower alkyl substituted with unsaturated 3 to 8-membered heteromonocyclic group containing 1 or 2 sulfur atom(s) and 1 to 3 nitrogen atom(s) which may have one or more substituent(s); a group of formula (1) wherein R3 is hydrogen, lower alkyl, ar(lower)alkyl or acyl, R4 is hydrogen or hydroxy, A is lower alkylene, m is an integer of 0 or 1, and n is an integer of 1 or 2; a group of formula (2) wherein R5 and R6 are each lower alkyl; or quinuclidinyl, or a salt the The pyrazolopyridine compound (I) and a salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, etc.), anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure, and the like.

26. 发明专利

DE69232323T2 未知
公开(公告)号：DE69232323T2
公开(公告)日：2002-08-08
申请号：DE69232323
申请日：1992-01-28
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： SHIOKAWA YOUICHI , AKAHANE ATSUSHI , KATAYAMA HIROHITO , MITSUNAGA TAKAFUMI
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/52 , A61K31/522 , A61K31/535 , A61K31/55 , A61K45/00 , A61P1/00 , A61P1/04 , A61P43/00 , C07D471/04 , C07D473/02 , C07D473/06 , C07D473/20 , C07D473/22

27. 发明专利

AT211384T 未知
公开(公告)号：AT211384T
公开(公告)日：2002-01-15
申请号：AT92101308
申请日：1992-01-28
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： SHIOKAWA YOUICHI , AKAHANE ATSUSHI , KATAYAMA HIROHITO , MITSUNAGA TAKAFUMI
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/52 , A61K31/522 , A61K31/535 , A61K31/55 , A61K45/00 , A61P1/00 , A61P1/04 , A61P43/00 , C07D471/04 , C07D473/02 , C07D473/06 , C07D473/20 , C07D473/22

28. 发明专利

EA001899B1 ПРОИЗВОДНЫЕ ПИРАЗОЛОПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ФАРМАЦЕВТИЧЕСКОГО ПРЕПАРАТА 未知
公开(公告)号：EA001899B1
公开(公告)日：2001-10-22
申请号：EA199900135
申请日：1997-07-17
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： AKAHANE ATSUSHI , KURODA SATORU , ITANI HIROMOCHI , SHIMIZU YASUYO
IPC分类号： A61K31/501 , A61P1/04 , A61P3/10 , A61P9/00 , A61P11/06 , A61P13/12 , A61P25/00 , A61P37/06 , A61P43/00 , C07D471/04 , C07D45 , C07D
摘要： Изобретениеотноситсяк соединениюпиразолопиридинаформулы (I), вкоторой Rявляетсяариломи Rявляется (C-C) алкилом, замещеннымненасыщенной 3-8 членнойгетеромоноциклическойгруппой, содержащей 1 или 2 атомасерыи 1-3 атомаазота, котораяможетиметьодинилинесколько (C-C) алкильныхзаместителей; группойформулы (I), вкоторой Rобозначаетводород, (C-C) алкил, ар(C-C) алкилилиацил, Rобозначаетводородилигидрокси, Аобозначает (C-C) алкилен, m являетсяцелымчислом, равным 0 или 1, и n являетсяцелымчислом, равным 1 или 2; группойформулы (II), вкоторой Rи Rобозначают (C-C) алкил; илихинуклидинилом, либок егосоли, способамегополучения, фармацевтическойкомпозициинаегоосновеи способуееполучения. Соединениепиразолопиридинаформулы (I) илиегосольпонастоящемуизобретениюявляютсяантагонистамиаденозина; они, атакжефармацевтическиекомпозициинаихосновемогутэффективноиспользоватьсядлялеченияи/илипрофилактикиболезней, вотношениикоторыхэффективнодействуетантагонистаденозина, такихкакдепрессия, слабоумие (например, болезньАльцгеймера, цереброваскулярноеслабоумие, болезньПаркинсонаи т.п.), состояниестраха, болевойсиндром, цереброваскулярноезаболевание (например, инсульти т.д.), сердечнаянедостаточностьи т.п.

29. 发明专利

AU733034B2 Pyrazolopyridine compound and pharmaceutical use thereof 未知
公开(公告)号：AU733034B2
公开(公告)日：2001-05-03
申请号：AU3462197
申请日：1997-07-17
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： AKAHANE ATSUSHI , KURODA SATORU , ITANI HIROMICHI , SHIMIZU YASUYO
IPC分类号： A61K31/50 , C07D453/02 , C07D471/04

30. 发明专利

DE69130412D1 未知
公开(公告)号：DE69130412D1
公开(公告)日：1998-12-03
申请号：DE69130412
申请日：1991-07-13
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： SHIOKAWA YOUICHI , AKAHANE ATSUSHI , KATAYAMA HIROHITO , MITSUNAGA TAKAFUMI
IPC分类号： A61K31/435 , A61K31/501 , A61P1/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P7/02 , A61P7/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P19/06 , A61P25/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P37/04 , A61P43/00 , C07D471/04 , A61K31/50
摘要： A pyrazolopyridine compound of the following formula: wherein R is aryl, and R is amino(lower)alkyl; lower alkylamino(lower)alkyl; carboxy(lower)alkylamino(lower)alkyl; protected carboxy(lower)alkylamino(lower)alkyl; lower alkylamino(lower)alkyl having hydroxy and aryloxy; protected amino(lower)alkyl; cyano(lower)alkyl; cyano(higher)alkyl; lower alkyl having heterocyclic group, in which heterocyclic group may have one or more suitable substituent(s); higher alkyl having heterocyclic group, in which heterocyclic group may have one or more suitable substituent(s); ar(lower)alkyl; lower alkenyl; or heterocyclic group which may have one or more suitable substituent(s), and a pharmaceutically acceptable salt thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in admixture with a pharmaceutically acceptable carrier or excipient.

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