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21. 发明专利

CA2108971A1 QUINOLINE DERIVATIVES 未知
公开(公告)号：CA2108971A1
公开(公告)日：1992-10-23
申请号：CA2108971
申请日：1992-04-21
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , TSUJI KIYOSHI , NAKAMURA KATSUYA , SPEARS GLEN W
IPC分类号： A61K31/47 , A61P29/00 , A61P35/00 , A61P37/00 , C07D215/36 , C07D215/54 , C07D215/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/06 , A61K31/495 , A61K31/535 , A61K31/54 , C07D409/12 , C07D417/02
摘要： 2108971 9218483 PCTABS00016 Quinoline derivatives of formula (I), wherein R1 is lower alkyl or aryl which may have suitable substituent(s), R2 is hydroxy, protected hydroxy, lower alkoxy, etc., R3 is hydrogen, lower alkyl, lower alkoxy(lower)- alkyl or ar(lower)alkyl and R8 is hydrogen, or R3 and R8 are linked together to form lower alkylene, R4 is an organic group, Z is O or S, and n is 0, 1 or 2; and pharmaceutically acceptable salts thereof which are useful as a medicament.

22. 发明专利

HU204780B PROCESS FOR PRODUCING ALKYL SULFONANILIDE DERIVATIVES 未知
公开(公告)号：HU204780B
公开(公告)日：1992-02-28
申请号：HU271288
申请日：1988-05-27
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , TSUJI KIYOSHI , KONISHI NOBUKIYO , OKUMURA HIROYUKI
IPC分类号： C07D317/16 , A61K31/18 , A61K31/19 , A61K31/275 , A61K31/325 , A61K31/33 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/47 , A61K31/496 , A61K31/505 , A61P25/04 , A61P29/00 , C07C67/00 , C07C303/38 , C07C311/08 , C07C313/00 , C07C315/04 , C07C317/14 , C07C317/32 , C07C317/34 , C07C317/36 , C07C317/48 , C07C319/20 , C07C323/18 , C07C323/37 , C07C323/49 , C07C323/62 , C07C323/65 , C07D213/20 , C07D213/28 , C07D213/50 , C07D213/70 , C07D215/36 , C07D235/28 , C07D249/12 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/36 , C07D277/40 , C07D277/46 , C07D277/52 , C07D295/192 , C07D333/34 , C07D487/04 , C07D521/00 , C07D211/00 , C07D275/02 , C07D333/02 , C07D215/00 , C07D235/04 , C07D471/04
摘要： Alkanesulfonanilide derivatives of the formula : wherein Ar is a group of the formula : wherein R , R , R and R are each hydrogen, halogen, halo(lower)alkyl or lower alkoxy, or heterocyclic group which may have halogen or lower alkyl X is @@@n , - @@ , -CO-, -NHCO-, -CONH- or - @@- wherein n is 0, 1 or 2, R is hydrogen or lower alkyl, R is hydrogen or hydroxy, R is lower alkyl or halo(lower)alkyl, R defines certain substituents, R is hydrogen, nitro lower alkyl or halogen, and pharmaceutical acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them.

23. 发明专利

HUT57733A PROCESS FOR PRODUCING PYRAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 未知
公开(公告)号：HUT57733A
公开(公告)日：1991-12-30
申请号：HU597090
申请日：1990-09-19
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , TSUJI KIYOSHI , KONISHI NOBUKIYO , NAKAMURA KATSUYA
IPC分类号： C07D231/10 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P1/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/18 , C07D231/38 , C07D401/04 , C07D403/04 , C07D409/04 , C07D403/06 , C07D231/40
摘要： A compound of the formula : wherein R is aryl which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino and lower alkyl(acyl)amino; or a heterocyclic group; R is hydrogen; methyl substituted with amino, lower alkylamino, halogen or acyloxy; acyl; acylamino; cyano; halogen; lower alkylthio; lower alkylsulfinyl; or a heterocyclic group; and R is aryl substituted with lower alkyl, lower alkylthio, lower alkylsulfinyl, halogen, amino, lower alkylamino, acylamino, lower alkyl(acyl)amino, lower alkoxy, cyano, hydroxy or acyl; or a heterocyclic group which may be substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; with certain provisions, pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient.

24. 发明专利

PT95389A 未知
公开(公告)号：PT95389A
公开(公告)日：1991-05-22
申请号：PT9538990
申请日：1990-09-21
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , TSUJI KIYOSHI , KONISHI NOBUKIYO , NAKAMURA KATSUYA
IPC分类号： C07D231/10 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P1/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/18 , C07D231/38 , C07D401/04 , C07D403/04 , C07D409/04
摘要： A compound of the formula : wherein R is aryl which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino and lower alkyl(acyl)amino; or a heterocyclic group; R is hydrogen; methyl substituted with amino, lower alkylamino, halogen or acyloxy; acyl; acylamino; cyano; halogen; lower alkylthio; lower alkylsulfinyl; or a heterocyclic group; and R is aryl substituted with lower alkyl, lower alkylthio, lower alkylsulfinyl, halogen, amino, lower alkylamino, acylamino, lower alkyl(acyl)amino, lower alkoxy, cyano, hydroxy or acyl; or a heterocyclic group which may be substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; with certain provisions, pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient.

25. 发明专利

NO904134A 未知
公开(公告)号：NO904134A
公开(公告)日：1991-03-25
申请号：NO904134
申请日：1990-09-21
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , TSUJI KIYOSHI , KONISHI NOBUKIYO , NAKAMURA KATSUYA
IPC分类号： C07D231/10 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P1/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/18 , C07D231/38 , C07D401/04 , C07D403/04 , C07D409/04
CPC分类号： C07D231/12 , C07D231/14 , C07D401/04 , C07D403/04 , C07D409/04

26. 发明专利

CA2025599A1 PYRAZOLE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 未知
公开(公告)号：CA2025599A1
公开(公告)日：1991-03-23
申请号：CA2025599
申请日：1990-09-18
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , TSUJI KIYOSHI , KONISHI NOBUKIYO , NAKAMURA KATSUYA
IPC分类号： C07D231/10 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P1/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/18 , C07D231/38 , C07D401/04 , C07D403/04 , C07D409/04
摘要： There are described compounds of the formula: (see formula I) wherein R1 is aryl which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino and lower alkyl(acyl)- amino; or a heterocyclic group; R2 is hydrogen; methyl substituted with amino, lower aklylamino, halogen or acyloxy; acyl; acylamino; cyano; halogen; lower alkylthio; lower alkylsufinyl; or a hetero- cyclic group; and R3 is aryl substituted with lower alkyl, lower alkylthio, lower alkylsulfinyl, halogen, amino, lower alkylamino, acylamino, lower alkyl(acyl)amino, lower alkoxy, cyano, hydroxy or acyl; or a heterocyclic group which may be substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl provided that when R2 is carboxy, esterified carboxy or tri(halo)methyl, then R3 is aryl substituted with lower alkylthio, lower alkylsulfinyl, amino, lower alkylamino, acylamino, lower alkyl(acyl)amino, hydroxy or acyl; or a heterocyclic group substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; or R1 is aryl substituted with substituent(s) selected from the group consisting of lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino and lower alkyl(acyl)amino; or a heterocyclic group; and a pharmaceutically acceptable salts thereof. These compounds are useful for the treatment and/or prevention of inflammation and pain in joint and muscle [e.g. rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis, etc.], inflammatory skin condition [e.g. sunburn, eczema, etc.] inflammatory eye condition [e.g. conjunctivitis, etc.], lung disorder in which inflammation is involved [e.g. asthma, bronchitis, pigeon fancier's disease, farmer's lung, etc.], condition of the gastro- intestinal tract associated with inflammation [e.g. aphthous ulcer, Chrohn's disease, atropic gastritis, gastritis varialoforme, ulcerative colitis, coeliac disease, regional ileitis, irritable bowel syndrome, etc.], gingivitis, inflammation, pain and tumescence after operation or injury, pyresis, pain and other conditions associated with inflammation, particularly those in which lipoxygenase and cyclooxygenase products are a factor, systemic lupus erythematosus, scleroderma, polymyositis, periarteritis nodosa, rheumatic fever, Sjögren's syndrome, Behcet disease, thyroiditis, type I diabetes, nephrotic syndrome, aplastic anemia, myasthenia gravis, uveitis contact dermatitis, psoriasis, Kawasaki disease, sarcoidosis, Hodgkin's disease, and the like. Additionally, the compounds are expected to be useful as thera- peutical and/or preventive agents for cardiovascular or cerebrovascular diseases, the diseases caused by hyperglycemia and hyperlipemia. Also disclosed are the preparation of these compounds, pharmaceutical preparations containing them and therapeutic treat- ments involving the use of these compounds.

27. 发明专利

NO904134D0 未知
公开(公告)号：NO904134D0
公开(公告)日：1990-09-21
申请号：NO904134
申请日：1990-09-21
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , TSUJI KIYOSHI , KONISHI NOBUKIYO , NAKAMURA KATSUYA
IPC分类号： C07D231/10 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P1/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/18 , C07D231/38 , C07D401/04 , C07D403/04 , C07D409/04 , C07D231/00
摘要： A compound of the formula : wherein R is aryl which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino and lower alkyl(acyl)amino; or a heterocyclic group; R is hydrogen; methyl substituted with amino, lower alkylamino, halogen or acyloxy; acyl; acylamino; cyano; halogen; lower alkylthio; lower alkylsulfinyl; or a heterocyclic group; and R is aryl substituted with lower alkyl, lower alkylthio, lower alkylsulfinyl, halogen, amino, lower alkylamino, acylamino, lower alkyl(acyl)amino, lower alkoxy, cyano, hydroxy or acyl; or a heterocyclic group which may be substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; with certain provisions, pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient.

28. 发明专利

FI904602A0 未知
公开(公告)号：FI904602A0
公开(公告)日：1990-09-19
申请号：FI904602
申请日：1990-09-19
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , TSUJI KIYOSHI , KONISHI NOBUKIYO , NAKAMURA KATSUYA
IPC分类号： C07D231/10 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P1/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/18 , C07D231/38 , C07D401/04 , C07D403/04 , C07D409/04 , C07D
摘要： A compound of the formula : wherein R is aryl which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino and lower alkyl(acyl)amino; or a heterocyclic group; R is hydrogen; methyl substituted with amino, lower alkylamino, halogen or acyloxy; acyl; acylamino; cyano; halogen; lower alkylthio; lower alkylsulfinyl; or a heterocyclic group; and R is aryl substituted with lower alkyl, lower alkylthio, lower alkylsulfinyl, halogen, amino, lower alkylamino, acylamino, lower alkyl(acyl)amino, lower alkoxy, cyano, hydroxy or acyl; or a heterocyclic group which may be substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; with certain provisions, pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient.

29. 发明专利

ZA883534B NEW ALKANESULFONANILIDE DERIVATIVES,PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 未知
公开(公告)号：ZA883534B
公开(公告)日：1989-01-25
申请号：ZA883534
申请日：1988-05-18
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： MATSUO MASAAKI , MASAAKI MATSUO , TSUJI KIYOSHI , KIYOSHI TSUJI , KONISHI NOBUKIYO , NOBUKIYO KONISHI , OKUMURA HIROYUKI , HIROYUKI OKUMURA
IPC分类号： C07C20060101 , C07C

30. 发明专利

NO158345C 未知
公开(公告)号：NO158345C
公开(公告)日：1988-08-24
申请号：NO793077
申请日：1979-09-25
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： TAKAYA TAKAO , TAKASUGI HISASHI , TSUJI KIYOSHI , CHIBA TOSHIYUKI
IPC分类号： C07D20060101 , C07D501/20

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