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21. 发明申请

US20050187198A1 Methods of preparing substituted tetracyclines with transition metal-based chemistries 有权
标题翻译：用过渡金属化学制备取代四环素的方法
公开(公告)号：US20050187198A1
公开(公告)日：2005-08-25
申请号：US11004559
申请日：2004-12-03
申请人： Mark Nelson , Glen Rennie , Darrell Koza
发明人： Mark Nelson , Glen Rennie , Darrell Koza
IPC分类号： C07C231/12 , C07C237/26 , C07D295/185 , C07D295/192 , A61K31/65
CPC分类号： C07D295/185 , C07C231/12 , C07C237/26 , C07C2603/46 , C07D295/192
摘要： The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed. Such compounds may optionally act as intermediates for making other compounds, e.g., hydrogenation of unsaturated groups on the substituent.
摘要翻译：本发明涉及允许迄今为止在四环素反应状态下表现出显着活性的未获得的取代四环素化合物的新化学物质。本文公开的方法在形成被所需有机取代基取代的四环素化合物的条件下使用基于活性四环素的前体化合物，反应性有机取代基前体和过渡金属催化剂。在本发明的一个实施方案中，取代的四环素化合物可以通过将活性四环素类前体化合物如芳族四环素重氮盐和反应性有机取代基前体例如烯烃，取代的烯烃，乙烯基单体，芳族化合物和在过渡金属催化剂如氯化钯存在下，在形成被有机取代基取代的四环素化合物的条件下，进行杂芳族化合物。这样的化合物可以任选地用作制备其它化合物的中间体，例如取代基上不饱和基团的氢化。

22. 发明申请

US20050183978A1 Shipping package system for fragile panels 审中-公开
标题翻译：运输包装系统，用于脆弱的面板
公开(公告)号：US20050183978A1
公开(公告)日：2005-08-25
申请号：US10856407
申请日：2004-05-28
申请人： D. Christensen , Mark Nelson , Arch Carroll
发明人： D. Christensen , Mark Nelson , Arch Carroll
IPC分类号： B65D57/00 , B65D85/00 , B65D85/48
CPC分类号： B65D57/00 , B65D85/48
摘要： A product vulnerable to damage during shipping, such as an automobile windshield glass, for example, is mounted on a support pad and fixed onto the pad by wrapping a stretch wrapping film around the combination of the pad and glass. The borders of the pad extend beyond the borders of the glass so the package containing the glass can be stood on edge, but the edge of the glass is spaced away from the surface on which the package is stood. Thus the glass, secured to the pad, is suspended away from that surface. Multiple packages can be packed into a shipping container and the loaded container can be lifted and transported by a lift truck with lifting forks received in passageways formed in the container by notches in the bottom edges of the support pads. The pads and containers are made of die-cut. corrugated fiberboard material although other material might also be used in the practice of the invention.
摘要翻译：例如汽车挡风玻璃等运输过程中容易受到损坏的产品安装在支撑垫上，并通过围绕垫和玻璃的组合缠绕拉伸包裹膜而固定在垫上。垫的边界延伸超过玻璃的边界，因此包含玻璃的包装可以站在边缘上，但是玻璃的边缘与包装所在的表面间隔开。因此，固定在垫上的玻璃从该表面悬挂下来。多个包装可以包装在运输容器中，并且装载的容器可以通过提升叉车提升和运输，叉车在支撑垫的底部边缘处由槽口容纳在容器中形成的通道中。垫和容器由模切制成。尽管其他材料也可用于本发明的实践中。

23. 发明申请

US20050177025A1 PROPHYLACTIC POLYMER PROBE COVER 审中-公开
标题翻译：丙烯聚合物探针罩
公开(公告)号：US20050177025A1
公开(公告)日：2005-08-11
申请号：US10905996
申请日：2005-01-28
申请人： Marc Jaker , Mark Nelson
发明人： Marc Jaker , Mark Nelson
IPC分类号： A61B1/00 , A61B1/04
CPC分类号： A61B1/00135 , A61B1/00142
摘要： A closed end polymerric cover for medical probes such as pressure sensing urodynamic catheters, gastroesophogeal manometer probes, televideo probes, such as endoscopes, of which there are several types, and the like. The polymeric covers will minimize the cleaning of the proboscopic devices between procedures/patients. Thus, the closed end polymeric probe is more aseptic and cost effective to the current required FDA protocols and also reduce the number of probes a clinic/hospital may need to possess. The distal end may be a flexible, perhaps clarified, clear window to permit the endoscope to survey the body cavity. The sheathing material in one embodiment is preferably a chemically bio-inert Fluoropolymer such as polytetrafluoroethylene (PTFE), fluorinate ethylene propylene (FEP), perfluoroalkoxy (PFA), or polyethylene terephthalate (PET), Urethane, Silicone, polyethylene, or another similar singular high slip substrate film that facilitates covering and uncovering the probe.
摘要翻译：用于医疗探针的封闭端聚合物盖，例如压力感测尿动力导管，胃肠壁压力计探针，诸如内窥镜的视频内窥镜探针，其中有几种类型。聚合物覆盖物将使程序/患者之间的观察装置的清洁最小化。因此，封闭端聚合物探针对目前所需的FDA方案更无菌且成本有效，并且还减少了诊所/医院可能需要拥有的探针数量。远端可以是柔性的，可能是澄清的清洁窗口，以允许内窥镜调查体腔。在一个实施方案中，护套材料优选为化学生物惰性的含氟聚合物，例如聚四氟乙烯（PTFE），氟化乙烯丙烯（FEP），全氟烷氧基（PFA）或聚对苯二甲酸乙二醇酯（PET），聚氨酯，硅氧烷，聚乙烯或另一类似的单数有利于覆盖和揭开探头的高滑移基底膜。

24. 发明申请

US20050143353A1 13-Substituted methacycline compounds 审中-公开
标题翻译： 13-取代的甲基环霉素化合物
公开(公告)号：US20050143353A1
公开(公告)日：2005-06-30
申请号：US11015966
申请日：2004-12-17
申请人： Mark Nelson , Beena Bhatia , Laura McIntyre , Glen Rennie
发明人： Mark Nelson , Beena Bhatia , Laura McIntyre , Glen Rennie
IPC分类号： C07C237/26 , A61K31/65
CPC分类号： C07C231/12 , C07C237/26
摘要： 13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
摘要翻译：描述了13-取代的甲基环霉素化合物，治疗四环素应答状态的方法和含有13-取代的甲基环霉素化合物的药物组合物。

25. 发明授权

US5508681A Interactive safe for disposal of medical needles 失效
标题翻译：交互式安全处理医用针头
公开(公告)号：US5508681A
公开(公告)日：1996-04-16
申请号：US235286
申请日：1994-04-29
申请人： Mark Nelson , David Vangeison , Phillip K. Evans , Robert Wells
发明人： Mark Nelson , David Vangeison , Phillip K. Evans , Robert Wells
IPC分类号： A61M5/32 , G08B21/00
CPC分类号： A61M5/3205
摘要： A closed automatic system for removing (for facilitating the removal) and safely storing potentially contaminated medical (or other) needles in which the operator only uses one hand to operate the system. The system has a counter which counts the number of actuations of the needle sensor. When a predetermined limit is reached the device signals the operator that the safe is nearly full. A further fixed number of needles can then be removed, when that limit is reached, a fuse on the safe is blown causing the system to be inoperative until a new box is installed. Removal of the box also causes the fuse to be blown and the circuit is disabled until a new box is inserted. The safe storage box contains a tab which when fixed in the locked position can not be opened except upon the application of substantial force with a tool. The system uses a Motorola 705 EPROM or similar microcontroller. (Motorola product literature is incorporated by reference herein.)
摘要翻译：一种封闭的自动系统，用于移除（用于促进移除）并安全地存储潜在污染的医疗（或其他）针，操作人员仅使用其中一只手来操作系统。该系统具有计数针传感器的致动次数的计数器。当达到预定的限制时，设备向操作者发信号通知保险箱已经接近满。然后可以移除另外固定数量的针，当达到该限制时，保险丝上的保险丝被吹动，导致系统不工作，直到安装新的盒子。取出盒子也会导致保险丝熔断，电路被禁用，直到插入一个新的盒子。安全存储箱包含一个卡扣，当固定在锁定位置时，不能打开，除非在使用工具施加相当大的力量的情况下。该系统使用摩托罗拉705 EPROM或类似的微控制器。（摩托罗拉产品文献通过引用并入本文。

26. 发明授权

US5482207A System for facilitating the removal and safe disposition of medical needles 失效
标题翻译：用于促进医疗针头拆卸和安全处理的系统
公开(公告)号：US5482207A
公开(公告)日：1996-01-09
申请号：US235388
申请日：1994-04-29
申请人： Mark Nelson , David Vangeison , Phillip K. Evans , Robert Wells
发明人： Mark Nelson , David Vangeison , Phillip K. Evans , Robert Wells
IPC分类号： A61M5/32 , B65D91/00
CPC分类号： A61M5/3205 , A61M2005/3208
摘要： A closed automatic system for removing (for facilitating the removal) and safely storing potentially contaminated medical (or other) needles in which the operator only uses one hand to operate the system. The user simply inserts a syringe with needle attached in the opening provided in the top of the device and resists the rotation of the needle hub after the hub is engaged by the motor driven cams. Sensors detect the presence of the needle and cause the motor to start driving a chuck mechanism (through a shaft to which gears are attached) which engages the needle and rotates it a predetermined, but changeable, number of times sufficient to disengage the needle from the syringe. The operator then removes the syringe and the needle drops or has dropped into the safe. The system has a counter which counts the number of actuations of the needle sensor. When a predetermined limit is reached the device signals the operator that the safe is nearly full. A further fixed number of needles can then be removed, when that limit is reached, a fuse on the safe is blown causing the system to be inoperative until a new box is installed. Removal of the box also causes the fuse to be blown and the circuit is disabled until a new box is inserted. The safe storage box contains a tab which when fixed in the locked position can not be opened except upon the application of substantial force with a tool. The system uses a Motorola 705 EPROM or similar microcontroller.
摘要翻译：一种封闭的自动系统，用于移除（用于促进移除）并安全地存储潜在污染的医疗（或其他）针，操作人员仅使用其中一只手来操作系统。用户只需将装有针的注射器插入设置在设备顶部的开口中，并在轮毂与马达驱动的凸轮接合之后抵抗针座的转动。传感器检测针的存在并使电动机开始驱动卡盘机构（通过连接有齿轮的轴），该机构与针接合并将其旋转预定的但可更换的次数以使针脱离注射器。然后，操作人员移除注射器，针头掉落或掉入保险箱。该系统具有计数针传感器的致动次数的计数器。当达到预定的限制时，设备向操作者发信号通知保险箱已经接近满。然后可以移除另外固定数量的针，当达到该限制时，保险丝上的保险丝被吹动，导致系统不工作，直到安装新的盒子。取出盒子也会导致保险丝熔断，电路被禁用，直到插入一个新的盒子。安全存储箱包含一个卡扣，当固定在锁定位置时，不能打开，除非在使用工具施加相当大的力量的情况下。该系统使用摩托罗拉705 EPROM或类似的微控制器。

27. 发明申请

US20140025003A1 Introducer Handle Notch Design/Concept 有权
标题翻译：介绍者处理凹槽设计/概念
公开(公告)号：US20140025003A1
公开(公告)日：2014-01-23
申请号：US13555470
申请日：2012-07-23
申请人： Scott Kimmel , Nicholas Kampa , Mark Nelson , Blane Larson
发明人： Scott Kimmel , Nicholas Kampa , Mark Nelson , Blane Larson
IPC分类号： A61M25/01 , A61M29/00
CPC分类号： A61M25/0043 , A61B17/34 , A61M25/0097 , A61M25/0668 , A61M29/00
摘要： An improved splittable medical device introducer designed to introduce a medical device such as a lead or catheter, into a patient's vasculature without loss of blood or introduction of air is described. The introducer assembly is designed with a notch provided at the proximal end of the introducer housing. The notch, which may comprise a multitude of cross-sectional geometries, is designed to reduce the force required to separate the housing and the introducer sheath, thereby minimizing the possibility of unintentional dislodgement during separation. The notch also increases the repeatability and consistency of the amount of force required to separate the introducer housing and sheath.
摘要翻译：描述了一种改进的可分裂医疗装置导引器，其被设计成将诸如引线或导管的医疗装置引入病人的脉管系统中而不会损失血液或引入空气。导引器组件设计成具有设置在导引器壳体的近端处的凹口。可以包括多个横截面几何形状的凹口被设计成减小分离壳体和导引器鞘所需的力，从而最小化在分离期间意外移动的可能性。切口还增加了分离导引器壳体和护套所需的力的重复性和一致性。

28. 发明授权

US08601573B2 Facial recognition for document and application data access control 有权
标题翻译：文档和应用程序数据访问控制的面部识别
公开(公告)号：US08601573B2
公开(公告)日：2013-12-03
申请号：US12561639
申请日：2009-09-17
申请人： Mark Nelson , Kevin H. Peters , Louis R. Ruggiero
发明人： Mark Nelson , Kevin H. Peters , Louis R. Ruggiero
IPC分类号： G06F7/04 , G06F21/62
CPC分类号： G06F21/6218 , G06F21/32 , G06F21/84 , G06F2221/2101 , G07C9/00158
摘要： A presentation system including a computing device, a display device coupled to the computing device and an image capture device that obtains an image containing facial images of at least two individuals capable of viewing the display device, the at least two individuals including a primary user and at least one secondary user, is provided. The system also includes a recognition apparatus operably coupled to the computing device and including a permission engine, the permission engine applying a policy to a protected information element displayed on the display screen, the policy causing one or more actions to be taken based on the identify of the primary and one or more of the secondary users.
摘要翻译：一种呈现系统，包括计算设备，耦合到所述计算设备的显示设备和获得包含能够观看所述显示设备的至少两个人的面部图像的图像的图像捕获设备，所述至少两个人包括主用户和提供至少一个次要用户。该系统还包括可操作地耦合到计算设备的识别设备，并且包括权限引擎，许可引擎将策略应用于显示在显示屏幕上的受保护信息元素，该策略导致基于识别的一个或多个动作的主要和一个或多个次要用户。

29. 发明授权

US08283524B2 Bacillus thuringiensis gene with lepidopteran activity 有权
公开(公告)号：US08283524B2
公开(公告)日：2012-10-09
申请号：US12436171
申请日：2009-05-06
申请人： Andre R. Abad , Hua Dong , Susan B. Lo , Mark Nelson , Xiaomei Shi , Clement W. K. Waine , Takashi Yamamoto
发明人： Andre R. Abad , Hua Dong , Susan B. Lo , Mark Nelson , Xiaomei Shi , Clement W. K. Waine , Takashi Yamamoto
IPC分类号： A01H5/00 , A01H5/10 , C12N15/82 , C12N15/32 , C12N1/21 , C07K14/325 , A01N37/18
CPC分类号： C12N15/8286 , C07K14/32 , Y02A40/162
摘要： The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.

30. 发明授权

US08078290B2 System and methods for controlling embedded devices using device style sheets 有权
标题翻译：使用设备样式表控制嵌入式设备的系统和方法
公开(公告)号：US08078290B2
公开(公告)日：2011-12-13
申请号：US11301651
申请日：2005-12-13
申请人： Mark Nelson
发明人： Mark Nelson
IPC分类号： G05B11/01 , G05B13/02 , G06F3/00 , G06F7/00 , G06F17/00
CPC分类号： G05B19/042 , G05B2219/25168 , G05B2219/32143
摘要： Systems and methods for controlling ambiance devices, or an embedded device, using a device style sheet are disclosed. Ambiance devices include devices used to control an environment in a room or area, such as a lighting device or a heating/cooling system. A device style sheet declaration is received, in one embodiment, at an ambiance device controller. The declaration comprises a scope selector that identifies a scope of a style to be applied, a property identifier that identifies a style property to be altered, and a property value that identifies a style property value to be applied. At least one ambiance device, within the scope identified by the scope selector, that is in electronic communication with the ambiance device controller is identified. A control signal for the ambiance device is formulated based on the property identifier and property value. The control signal is then transmitted to the ambiance device.
摘要翻译：公开了使用设备样式表来控制环境设备或嵌入式设备的系统和方法。环境设备包括用于控制房间或区域中的环境的设备，例如照明设备或加热/冷却系统。在一个实施例中，在环境设备控制器处接收设备样式表声明。声明包括范围选择器，用于标识要应用的样式的范围，标识要更改的样式属性的属性标识符以及标识要应用的样式属性值的属性值。识别与范围选择器识别的范围内至少一个与环境设备控制器进行电子通信的环境设备。基于属性标识符和属性值来制定环境设备的控制信号。然后将控制信号发送到环境设备。

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