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    • 21. 发明申请
    • Fluorescent Silica-Based Nanoparticles
    • 荧光二氧化硅基纳米颗粒
    • US20100035365A1
    • 2010-02-11
    • US12579302
    • 2009-10-14
    • Ulrich WiesnerHooisweng Ow
    • Ulrich WiesnerHooisweng Ow
    • G01N33/566
    • C09K11/025B82Y30/00C01B33/18C01P2002/80C01P2004/03C01P2004/64C07K16/00C07K2317/52C09K11/06G01N33/5005G01N33/54346G01N33/582G01N33/587Y10T428/2438Y10T428/31663
    • The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.
    • 本发明提供了纳米颗粒组合物,其包含例如包含荧光硅烷化合物的核心; 和核心上的二氧化硅壳。 还提供了制备纳米颗粒组合物的方法,包括荧光纳米颗粒,连接荧光纳米颗粒,具有治疗剂的连接荧光纳米颗粒,以及与分析物偶联或相关联的连接荧光纳米颗粒。 还提供了用于检测连接的荧光纳米颗粒的方法: 用于将所述连接的荧光纳米颗粒与感兴趣的细胞组分结合,并记录或监测细胞组分的运动; 用于通过将治疗剂与连接的荧光纳米颗粒组合并将组合接触或施用于细胞或生物体来改善治疗剂的治疗性质; 用于在例如用于检测各种分析物的诊断剂等的应用中制造和使用荧光纳米颗粒。