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21. 发明申请

US20110200598A1 COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH A PROTEASOME INHIBITOR 审中-公开
标题翻译：抗抑郁剂类型II抗CD20抗体的联合治疗
公开(公告)号：US20110200598A1
公开(公告)日：2011-08-18
申请号：US13075946
申请日：2011-03-30
申请人： Georg Fertig , Thomas Friess , Christian Klein , Pablo Umana
发明人： Georg Fertig , Thomas Friess , Christian Klein , Pablo Umana
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/39558 , A61K31/69 , A61K47/00 , A61K2039/505 , C07K16/2887 , C07K2317/24 , C07K2317/41 , A61K2300/00
摘要： The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a proteasome inhibitor for the treatment of a patient suffering from cancer, particularly a CD20-expressing cancer. An aspect of the invention is a composition comprising a type II anti-CD20 antibody and a proteasome inhibitor. Another aspect of the invention is a kit comprising a type II anti-CD20 antibody and a proteasome inhibitor. Yet another aspect of the invention is a method for the treatment of a patient suffering from cancer comprising co-administering, to a patient in need of such treatment, a type II anti-CD20 antibody and a proteasome inhibitor.
摘要翻译：本发明涉及涉及用于治疗患有癌症的患者，特别是表达CD20的癌症的II型抗-CD20抗体和蛋白酶体抑制剂的组合疗法。本发明的一个方面是包含II型抗CD20抗体和蛋白酶体抑制剂的组合物。本发明的另一方面是包含II型抗CD20抗体和蛋白酶体抑制剂的试剂盒。本发明的另一方面是治疗患有癌症的患者的方法，包括向需要这种治疗的患者共同施用II型抗CD20抗体和蛋白酶体抑制剂。

22. 发明申请

US20110183952A1 NEW CHEMICAL COMPOUNDS 有权
标题翻译：新化学化合物
公开(公告)号：US20110183952A1
公开(公告)日：2011-07-28
申请号：US12665769
申请日：2008-07-01
申请人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Steffen Steurer , Irene Waizenegger
发明人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Steffen Steurer , Irene Waizenegger
IPC分类号： A61K31/397 , C07D401/14 , C07D413/14 , C07D249/04 , C07D403/14 , C07D243/08 , A61K31/4439 , A61K31/5377 , A61K31/4192 , A61K31/497 , A61K31/55 , A61K31/551 , A61P35/00 , A61P37/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D487/08
摘要： The present invention encompasses compounds of general formula (1), wherein the groups R1 to R3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中R 1至R 3和L基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备药物具有上述性质。

23. 发明申请

US20110083108A1 PROVIDING USER INTERFACE FEEDBACK REGARDING CURSOR POSITION ON A DISPLAY SCREEN 审中-公开
标题翻译：在显示屏幕上提供有关游标位置的用户界面反馈
公开(公告)号：US20110083108A1
公开(公告)日：2011-04-07
申请号：US12573282
申请日：2009-10-05
申请人： Christian Klein , Ali Vassigh
发明人： Christian Klein , Ali Vassigh
IPC分类号： G06F3/048
CPC分类号： G06F3/0481 , G06F2203/04801
摘要： Disclosed herein are systems and methods for providing user interface feedback regarding a cursor position on a display screen. A user may use a suitable input device for controlling a cursor in a computing environment. The displayed objects may provide feedback regarding the cursor's position. Particularly, a position of the cursor may be compared to an object's position for determining whether the cursor is positioned on the display screen at the same position as a portion of the object or within a predetermined distance of the portion of the object. In response to determining the cursor is positioned on the display screen at the same position as the portion of the object or within the predetermined distance of the portion of the object, an appearance of the portion of the object may be altered, such as, for example, brightness or color of the object portion.
摘要翻译：本文公开了用于提供关于显示屏上的光标位置的用户界面反馈的系统和方法。用户可以使用合适的输入设备来控制计算环境中的光标。所显示的对象可以提供关于光标位置的反馈。特别地，可以将光标的位置与对象的位置进行比较，以确定光标是否位于与对象的一部分相同的位置处的显示屏幕上，或者在对象的该部分的预定距离内。响应于确定光标位于与物体的部分相同的位置处或者在物体的该部分的预定距离内的显示屏幕上，可以改变对象的该部分的外观，例如，对于例如，对象部分的亮度或颜色。

24. 发明申请

US20100254988A1 Bispecific Anti ErbB2 / Anti cMet Antibodies 审中-公开
标题翻译：双特异性抗ErbB2 /抗cMet抗体
公开(公告)号：US20100254988A1
公开(公告)日：2010-10-07
申请号：US12753141
申请日：2010-04-02
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-2 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译：本发明涉及针对人ErbB-2和针对人c-Met的双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。

25. 发明申请

US20090175851A1 BIVALENT, BISPECIFIC ANTIBODIES 失效
公开(公告)号：US20090175851A1
公开(公告)日：2009-07-09
申请号：US12332531
申请日：2008-12-11
申请人： Christian Klein , Wolfgang Schaefer
发明人： Christian Klein , Wolfgang Schaefer
IPC分类号： A61K39/395 , C07K16/00 , C12P21/00 , C12N5/10
CPC分类号： C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2319/00
摘要： The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.

26. 发明申请

US20090060913A1 COMBINATION THERAPY WITH TYPE I AND TYPE II ANTI-CD20 ANTIBODIES 审中-公开
标题翻译：与I型和II型抗CD20抗体的联合治疗
公开(公告)号：US20090060913A1
公开(公告)日：2009-03-05
申请号：US12203321
申请日：2008-09-03
申请人： Thomas Friess , Christian Klein , Pablo Umana
发明人： Thomas Friess , Christian Klein , Pablo Umana
IPC分类号： A61K39/395 , A61P31/00
CPC分类号： A61K39/39558 , A61K2039/507 , C07K16/2887 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56
摘要： The present invention is directed to a combination therapy involving a type I anti-CD20 antibody and a type II anti-CD20 antibody for the treatment of a patient suffering from cancer, particularly a CD20-expressing cancer.An aspect of the invention is a composition comprising a type I anti-CD20 antibody and a type II anti-CD20 antibody.Another aspect of the invention is a kit comprising a type I anti-CD20 antibody and a type II anti-CD20 antibody.Yet another aspect of the invention is a method for the treatment of a patient suffering from cancer comprising co-administering, to a patient in need of such treatment, a type I anti-CD20 antibody and a type II anti-CD20 antibody.
摘要翻译：本发明涉及涉及用于治疗患有癌症的患者，特别是CD20表达癌症的患者的I型抗CD20抗体和II型抗-CD20抗体的组合疗法。本发明的一个方面是包含I型抗CD20抗体和II型抗-CD20抗体的组合物。本发明的另一方面是包含I型抗CD20抗体和II型抗CD20抗体的试剂盒。本发明的另一方面是用于治疗患有癌症的患者的方法，包括向需要这种治疗的患者共同给予I型抗CD20抗体和II型抗-CD20抗体。

27. 发明申请

US20070283077A1 Memory and Memory Communication System 有权
标题翻译：内存和内存通信系统
公开(公告)号：US20070283077A1
公开(公告)日：2007-12-06
申请号：US11754854
申请日：2007-05-29
申请人： Christian Klein , Stefan Linz , Helmut Reinig
发明人： Christian Klein , Stefan Linz , Helmut Reinig
IPC分类号： G06F12/00
CPC分类号： G11C7/22 , G11C7/1045 , G11C7/1072
摘要： A memory system includes a selection element for selecting a selectable access rate from a plurality of access rates and a memory element for providing or for accepting data at the selectable access rate.
摘要翻译：存储器系统包括用于从多个访问速率中选择可选访问速率的选择元件和用于以可选择访问速率提供或接收数据的存储器元件。

28. 发明申请

US20050282250A1 Method for the recombinant production and purification of protein kinases 失效
标题翻译：蛋白激酶重组生产和纯化方法
公开(公告)号：US20050282250A1
公开(公告)日：2005-12-22
申请号：US11000867
申请日：2004-12-01
申请人： Hubert Hertenberger , Konrad Honold , Christian Klein , Petra Rueger
发明人： Hubert Hertenberger , Konrad Honold , Christian Klein , Petra Rueger
IPC分类号： C12N9/12 , C12N15/11 , C12P21/06
CPC分类号： C12N9/1205
摘要： A method for the recombinant production and purification of a protein kinase selected from the group consisting of tyrosine protein kinases and serine/threonine kinases by expressing a nucleic acid encoding said kinase in a microbial host cell, forming inclusion bodies containing said kinase, isolating, solubilizing, naturing, and purifying said kinase wherein said purification is performed by hydrophobic interaction with an hydrophobic adsorbent under conditions whereby at least 70% of said protein kinase are not bound to said adsorbent and the protein kinase not bound to said adsorbent is recovered.
摘要翻译：一种通过在微生物宿主细胞中表达编码所述激酶的核酸，重组产生和纯化选自酪氨酸蛋白激酶和丝氨酸/苏氨酸激酶的方法，形成含有所述激酶的包涵体，分离，增溶，变性和纯化所述激酶，其中所述纯化通过与疏水性吸附剂的疏水相互作用进行，其中至少70％的所述蛋白激酶不与所述吸附剂结合，并且不结合所述吸附剂的蛋白激酶被回收。

29. 发明授权

US5248620A Non-ionic block copolymers of propylene oxide and ethylene oxide 失效
标题翻译：丙烯氧化物和乙烯氧化物的非离子嵌段共聚物
公开(公告)号：US5248620A
公开(公告)日：1993-09-28
申请号：US720305
申请日：1991-06-25
申请人： Peter Sluka , Christian Klein , Hans-Werner Griesser , Uwe Kobold
发明人： Peter Sluka , Christian Klein , Hans-Werner Griesser , Uwe Kobold
IPC分类号： G01N33/531 , B01F17/42 , C08G65/30 , G01N33/543
CPC分类号： G01N33/54393 , C08G65/30 , Y10S435/962 , Y10S436/817 , Y10S436/826
摘要： The invention concerns a method for the determination of a partner in an immunological reaction based on an immunoassay in which one of the reaction partners is present in a solid phase, wherein a polyethylene oxidepolypropylene oxide block copolymer having the formula I ##STR1## is used as the surface-active agent in which a can have a value between 40 and 150 and b a value between 10 and 50, which is characterized in that a hydrophilic block copolymer composition having the formula I is used which in a 1 % aqueous solution (weight/volume) has a surface tension of at least 45 mN/m and in which the average molar ratio of ethylene oxide groups to propylene oxide groups (2a/b) in the composition is at least 5.8. In addition the invention comprises a reagent for carrying out the above method.
摘要翻译：本发明涉及一种基于其中一个反应配偶体存在于固相中的免疫测定法来确定免疫反应中的配偶体的方法，其中将具有式I的聚乙烯氧化聚环氧丙烷嵌段共聚物用作其中罐的值可以在40到150之间，ba值在10和50之间的表面活性剂，其特征在于使用具有式I的亲水性嵌段共聚物组合物，其在1％水溶液（重量/ 体积）具有至少45mN / m的表面张力，其中组合物中环氧乙烷基团与环氧丙烷基团的平均摩尔比（2a / b）为至少5.8。此外，本发明包括用于实施上述方法的试剂。

30. 发明授权

US09982036B2 Dual FC antigen binding proteins 有权
公开(公告)号：US09982036B2
公开(公告)日：2018-05-29
申请号：US13406411
申请日：2012-02-27
申请人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
发明人： Birgit Bossenmaier , Hubert Kettenberger , Christian Klein , Klaus-Peter Kuenkele , Joerg-Thomas Regula , Wolfgang Schaefer , Manfred Schwaiger , Claudio Sustmann
IPC分类号： C07K16/30 , C07K16/28 , C07K16/00 , C07K16/32
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/41 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.

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