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21. 发明申请

WO2006097748A2 PEPTIDE STABILIZER COMPOUNDS AND SCREENING METHOD 审中-公开
标题翻译：肽类稳定剂化合物及筛选方法
公开(公告)号：WO2006097748A2
公开(公告)日：2006-09-21
申请号：PCT/GB2006000967
申请日：2006-03-16
申请人： ISOGENICA LTD , ELDRIDGE WILLIAM , FITZGERALD KEVIN , COOLEY NEIL , MCGREGOR DUNCAN
发明人： ELDRIDGE WILLIAM , FITZGERALD KEVIN , COOLEY NEIL , MCGREGOR DUNCAN
IPC分类号： C12Q1/68 , C07K7/08 , C12N15/10
CPC分类号： C07K7/08 , C12N15/1034 , C12N15/1075
摘要： Peptide stabilizer compounds are provided that in combination with a biologically active peptide, can increase the protease elimination half-time of the biologically active peptide in vivo. The peptide stabilizer compounds are preferably in the form of peptide sequences that confer resistance to proteolysis upon conjugated biologically active peptides. Also provided is a method for the selection of novel proteolysis resistant compounds from in vitro generated libraries, and pharmaceutical compositions comprising the stabilizer compounds identified thereby.
摘要翻译：提供肽稳定剂化合物，其与生物活性肽组合可以增加体内生物活性肽的蛋白酶消除半衰期。肽稳定剂化合物优选为赋予缀合的生物活性肽蛋白水解抗性的肽序列形式。还提供了用于从体外产生的文库中选择新的抗蛋白水解化合物的方法，以及包含由其鉴定的稳定剂化合物的药物组合物。

22. 发明申请

WO2004041551A3 E.X.O. RIMWEAR 审中-公开
标题翻译： E.X.O. RIMWEAR
公开(公告)号：WO2004041551A3
公开(公告)日：2004-09-30
申请号：PCT/US0334969
申请日：2003-11-04
申请人： KMC WHEEL COMPANY , FITZGERALD KEVIN
发明人： FITZGERALD KEVIN
IPC分类号： B60B3/10 , B60B7/00 , B60B7/06
CPC分类号： B60B7/18 , B60B3/10 , B60B7/0053 , B60B7/065 , B60B7/066 , B60B7/14
摘要： A wheel upon which interchangeable components may be mounted to the change the appearance thereof, is provided. The wheel may include a base wheel skeleton including a rim, a hub and spokes. Each spoke may include threaded holes adjacent the rim. Additional threaded holes may be disposed generally around a periphery of the hub. A hub cap may be attachable to the wheel on a first side of the wheel and include mounting extensions for attachment of the hub cap to the threaded holes around hub. Skin elements may be attachable to the wheel and include holes for attachment of one end of the skin element to one of the threaded holes adjacent the connection of the spokes to the rim. The skin elements may further include an extension disposable under a portion of the hub cap for retention of another end of the skin element by the hub cap.
摘要翻译：提供了一种车轮，其上可以安装可互换的部件以改变其外观。该轮子可以包括一个包括轮缘，轮毂和辐条的基轮骨架。每个辐条可以包括与轮缘相邻的螺纹孔。另外的螺纹孔可以大体围绕轮毂的周边布置。轮毂盖可以在轮的第一侧上附接到轮并且包括用于将轮毂盖附接到轮毂周围的螺纹孔的安装延伸部。蒙皮元件可以附接到轮子并且包括用于将蒙皮元件的一端附接到邻近辐条与轮缘的连接处的螺纹孔中的一个的孔。蒙皮元件还可以包括一次性在轮毂盖的一部分下面的延伸部，用于通过轮毂盖保持蒙皮元件的另一端。

23. 发明专利

AU2003259717A1 MODULATORS OF RABGGT AND METHODS OF USE THEREOF 未知
公开(公告)号：AU2003259717A1
公开(公告)日：2004-02-25
申请号：AU2003259717
申请日：2003-08-07
申请人： EXELIXIS
发明人： MANNE VEERASWAMY , LYNCH MARK , ROSS-MACDONALD PETRA B , STOUCH TERRY , LANGE NAOMI , CARROLL PAMELA , FITZGERALD KEVIN , COSTA MICHAEL R , MAXWELL MARK E , KINDT RACHEL M , LACKNER MARK R , HUNG TAK , O'BRIEN CAROL L , ZHANG HAI GUANG , BROWN KATHERINE S , LEE JAE MOON , LOMBARDO LOUIS J
IPC分类号： A61K31/00 , C07K14/47 , C12N9/10 , C12N15/113 , G01N33/50

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