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21. 发明申请

US20070004961A1 Methods for modifying vascular vessel walls 有权
标题翻译：改变血管壁的方法
公开(公告)号：US20070004961A1
公开(公告)日：2007-01-04
申请号：US11295866
申请日：2005-12-07
申请人： Brian Case , Michael Hiles , Jacob Flagle , F. Obermiller , Umesh Patel
发明人： Brian Case , Michael Hiles , Jacob Flagle , F. Obermiller , Umesh Patel
IPC分类号： A61F2/00
CPC分类号： A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

22. 发明申请

US20060212107A1 Delivery systems, kits and methods for implanting an intraluminal medical device in a body vessel 审中-公开
标题翻译：用于将管腔内医疗装置植入体内的输送系统，套件和方法
公开(公告)号：US20060212107A1
公开(公告)日：2006-09-21
申请号：US11376864
申请日：2006-03-16
申请人： Brian Case , Jacob Flagle
发明人： Brian Case , Jacob Flagle
IPC分类号： A61F2/06
CPC分类号： A61B5/1076 , A61B5/02007 , A61B2090/061 , A61F2/2436 , A61F2/2475 , A61F2/95 , A61F2250/0097
摘要： Delivery systems, kits and methods for implanting an intraluminal medical device in a body vessel are provided. Indicia are used on one or more devices to facilitate placement of the intraluminal medical device at a desired point within the body vessel, such as a point at which a size determination has been made.
摘要翻译：提供了将体内血管植入管腔内医疗装置的输送系统，套件和方法。标记用于一个或多个装置上以便于将管腔内医疗装置放置在身体容器内的所需位置，例如进行尺寸确定的点。

23. 发明申请

US20070260327A1 Artificial Valve Prosthesis with Improved Flow Dynamics 有权
标题翻译：人工瓣膜假体具有改善的流动动力学
公开(公告)号：US20070260327A1
公开(公告)日：2007-11-08
申请号：US10554494
申请日：2004-04-21
申请人： Brian Case , Michael Garrison , Andrew Hoffa , Darin Schaeffer , Jacob Flagle
发明人： Brian Case , Michael Garrison , Andrew Hoffa , Darin Schaeffer , Jacob Flagle
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，该支撑结构被配置为扩大邻近阀结构的区域，使逆行流的流动模式以便于冲洗瓣膜区域底部的口袋的方式进行改变，以防止滞留在静脉系统中的体液可导致血栓形成。扩大的口袋区域可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。在另一组实施例中，相对的小叶与支撑框架和/或血管壁之间的附接通路包括将小叶彼此延伸接触的近端部分，并且远侧部分相对于相邻壁形成大角度，在传单的底部创造了一个大口袋。在一个实施例中，附接通道沿着一对基本上平行的纵向连接支柱向远侧延伸，以产生延伸的小叶接触区域，然后沿着远侧连接支柱沿着周向和远端远离成形器，以限定传单的底部边缘。

24. 发明申请

US20060058865A1 Delivery system with controlled frictional properties 审中-公开
标题翻译：具有受控摩擦性能的输送系统
公开(公告)号：US20060058865A1
公开(公告)日：2006-03-16
申请号：US11210998
申请日：2005-08-24
申请人： Brian Case , Jacob Flagle
发明人： Brian Case , Jacob Flagle
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/966 , A61F2002/9583 , A61F2002/9665
摘要： Delivery systems and methods of making delivery systems are provided. A delivery system according to the invention facilitates delivery of an intraluminal medical device to a point of treatment in a body vessel. A dilator includes a means for resisting relative movement between an associated intraluminal medical device and the dilator during relative movement between the dilator and an associated tubular member disposed about the dilator.
摘要翻译：提供了交付系统和交付系统的方法。根据本发明的递送系统便于将管腔内医疗装置递送到体内血管的治疗点。扩张器包括用于在扩张器和围绕扩张器设置的相关联的管状构件之间的相对运动期间抵抗相关联的管腔内医疗装置和扩张器之间的相对运动的装置。

25. 发明申请

US20050228486A1 Implantable frame with variable compliance 有权
标题翻译：植入式框架具有可变顺应性
公开(公告)号：US20050228486A1
公开(公告)日：2005-10-13
申请号：US11103137
申请日：2005-04-11
申请人： Brian Case , Jacob Flagle , Charles Agnew
发明人： Brian Case , Jacob Flagle , Charles Agnew
IPC分类号： A61F2/00 , A61F2/02 , A61F2/24 , A61F2/86 , A61F2/90 , A61F2/06
CPC分类号： A61F2/86 , A61F2/07 , A61F2/2418 , A61F2/2475 , A61F2/848 , A61F2/89 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. Embodiments of the invention relate to medical devices comprising a frame having a compliance that can change upon implantation of the medical device within the lumen of a body vessel. Controlled fracture or bioabsorption of frame material can, in some embodiments, increase the compliance of a frame after implantation. Medical devices comprising a frame and one or more valve members adapted to regulate fluid flow in a body vessel, such as a vein, are also provided.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。本发明的实施例涉及医疗装置，其包括具有在体内血管内腔内植入医疗装置时能够改变的顺应性的框架。在一些实施例中，框架材料的受控断裂或生物吸收可以在植入后增加框架的顺应性。还提供了包括框架和适于调节诸如静脉的体容器中的流体流动的一个或多个阀构件的医疗装置。

26. 发明申请

US20050228472A1 Implantable medical device with optimized shape 有权
标题翻译：具有优化形状的植入式医疗器械
公开(公告)号：US20050228472A1
公开(公告)日：2005-10-13
申请号：US11099713
申请日：2005-04-06
申请人： Brian Case , Jacob Flagle
发明人： Brian Case , Jacob Flagle
IPC分类号： A61F2/00 , A61F2/24 , A61F2/90 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2/90 , A61F2002/30014 , A61F2002/3011 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0002 , A61F2230/0017 , A61F2230/0054 , A61F2250/0018 , A61F2250/0036
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. Embodiments of the invention relate to medical devices comprising a frame having cross-section that can substantially conform to body vessel shapes that have elliptical or circular cross-sections, and dynamically respond to changes in the cross-section of a body vessel. Frames with directionally-dependent radial compressibility or expandability characteristics are also provided. Medical devices comprising a frame and one or more valve members adapted to regulate fluid flow in a body vessel, such as a vein, are also provided.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。本发明的实施例涉及包括框架的医疗装置，该框架具有基本上符合具有椭圆形或圆形横截面的身体血管形状的横截面，并且动态地响应身体血管横截面的变化。还提供了具有方向依赖的径向压缩性或可扩展性特征的框架。还提供了包括框架和适于调节诸如静脉的体容器中的流体流动的一个或多个阀构件的医疗装置。

27. 发明申请

US20070067022A1 Implantable support frame with electrolytically removable material 审中-公开
标题翻译：具有电解可移除材料的可植入支架
公开(公告)号：US20070067022A1
公开(公告)日：2007-03-22
申请号：US11511008
申请日：2006-08-28
申请人： Brian Case , Jacob Flagle
发明人： Brian Case , Jacob Flagle
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2250/0031
摘要： Endoluminally implantable medical devices having an electrolytically removable portion are provided, as well as methods pertaining to the same. The electrolytically removable portion can be dissolved within a body vessel after implantation of the medical device, by application of an electrical current from an electrode on a catheter inside the body vessel or by induction of an electrical current within the removable region. Electrolytic dissolution of the removable portion can alter the mechanical strength of the implanted frame within the body vessel. Medical devices can be an endovascular valve comprising a frame and one or more valve members adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了具有电解可移除部分的可植入植入式医疗装置以及与之相关的方法。电解移除部分可以在植入医疗装置之后溶解在体内容器中，通过将电流从电极施加到体内容器内的导管上或通过在可移除区域内感应电流来溶解。可移除部分的电解溶解可以改变植入框架在体内容器内的机械强度。医疗装置可以是血管内瓣膜，其包括框架和一个或多个阀构件，其适于调节诸如静脉的体容器中的流体流动。

28. 发明申请

US20060173532A1 Intraluminal support frame and medical devices including the support frame 有权
公开(公告)号：US20060173532A1
公开(公告)日：2006-08-03
申请号：US11314661
申请日：2005-12-20
申请人： Jacob Flagle , Brian Case
发明人： Jacob Flagle , Brian Case
IPC分类号： A61F2/24 , A61F2/06 , A61F2/90
CPC分类号： A61F2/91 , A61F2/2418 , A61F2/2475 , A61F2/915 , A61F2002/075 , A61F2002/825 , A61F2002/91533 , A61F2002/91575 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054
摘要： Intraluminal support frames for placement within a body vessel are provided. The support frames include a plurality of ring structures and first and second sets of connector segments. Connector segments of the first set join adjacent pairs of ring structures while connector segments of the second set join at least three ring structures. Medical devices are also provided that include a support frame and an additional component, such as a graft member or valve member.

29. 发明申请

US20050283178A1 Delivery system that facilitates visual inspection of an intraluminal medical device 有权
标题翻译：输送系统，便于目视检查管腔内医疗器械
公开(公告)号：US20050283178A1
公开(公告)日：2005-12-22
申请号：US11123312
申请日：2005-05-06
申请人： Jacob Flagle , Brian Case , Andrew Hoffa , Michael Garrison
发明人： Jacob Flagle , Brian Case , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/01 , A61M25/10 , A61M29/00
CPC分类号： A61M25/0043 , A61F2/95 , A61F2250/0091 , A61M25/10 , A61M2025/1079
摘要： Delivery systems, methods of making delivery systems, and methods of treatment are provided. A delivery system according to the invention facilitates a visual inspection of an intraluminal medical device included in the delivery system.
摘要翻译：提供交付系统，交付系统的方法和处理方法。根据本发明的递送系统便于对包括在递送系统中的管腔内医疗装置的目视检查。

30. 发明申请

US20070100435A1 Artificial prostheses with preferred geometries 有权
标题翻译：具有优选几何形状的人造假体
公开(公告)号：US20070100435A1
公开(公告)日：2007-05-03
申请号：US11586285
申请日：2006-10-25
申请人： Brian Case , Ram Paul , Grant Hoffman
发明人： Brian Case , Ram Paul , Grant Hoffman
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/0039
摘要： Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.
摘要翻译：提供可植入的医疗装置，例如可植入后的支架和瓣膜，其具有某些优选的形状。优选地，可植入医疗装置的一部分可以限定具有优选几何形状的窦区。窦区可以具有本文所述的一种或多种优选的几何构型，例如减轻或预防体内血栓形成。医疗装置可以包括阀装置，例如位于窦区内的一个或多个瓣叶。可植入的医疗装置可以从身体容器内的导管输送，并且优选地可以从压缩构型扩展到径向扩张的构型。可植入的框架可以是自膨胀的或球囊的可膨胀的。医疗装置的一部分，例如可植入框架或瓣膜小叶，任选地涂覆有一种或多种生物活性材料。

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