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21. 发明授权

US07157500B2 Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality 失效
标题翻译：蛋白质SH基团和氨基酸残基的亚硝化作为治疗方式
公开(公告)号：US07157500B2
公开(公告)日：2007-01-02
申请号：US10216865
申请日：2002-08-13
申请人： Jonathan Stamler , Joseph Loscalzo , Daniel Simon , David Singel
发明人： Jonathan Stamler , Joseph Loscalzo , Daniel Simon , David Singel
IPC分类号： A01N33/18
CPC分类号： C12N9/6472 , A61K38/00 , C07K1/1077 , C07K14/3153 , C07K14/4702 , C07K14/76 , C07K14/765 , C07K14/805 , C07K16/00 , C12N9/6459 , C12Y304/21069
摘要： Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body. The invention also relates to the nitrosylation of oxygen, carbon and nitrogen moieties present on proteins and amino acids, and the use thereof to achieve the above physiological effects.
摘要翻译：蛋白质和氨基酸基团的亚硝化可以选择性调节蛋白质功能，并赋予蛋白质和氨基酸更多的平滑肌松弛剂和血小板抑制能力。因此，本发明涉及通过蛋白质硫醇的亚硝基化实现的新化合物。这些化合物包括：S-亚硝基-t-PA，S-亚硝基组织蛋白酶; S-亚硝基脂蛋白; 和S-亚硝基 - 免疫球蛋白。本发明还涉及S-亚硝基蛋白化合物用于调节蛋白质功能，细胞代谢和影响血管舒张，血小板抑制，非血管平滑肌松弛以及通过血红蛋白和肌红蛋白增加血氧转运的治疗用途。这些化合物也用于以最具生物活性的形式递送一氧化氮，以达到上述效果，或用于身体中存在的分子的体外亚硝基化。本发明还涉及存在于蛋白质和氨基酸上的氧，碳和氮部分的亚硝基化，以及其用于实现上述生理作用的用途。

22. 发明申请

US20050217238A1 Pulsed plasma thruster and method of making 有权
标题翻译：脉冲等离子推进器及制作方法
公开(公告)号：US20050217238A1
公开(公告)日：2005-10-06
申请号：US10965166
申请日：2004-10-14
申请人： H. Land , Daniel Simon , Tharen Rice
发明人： H. Land , Daniel Simon , Tharen Rice
IPC分类号： B64G1/40 , F03H1/00
CPC分类号： B64G1/40 , B64G1/405 , F03H1/00 , F03H1/0087
摘要： A pulsed plasma thruster (PPT) and a method of making the pulsed plasma thruster are disclosed. The PPT includes no moving parts and is able to achieve a small size. The PPT is also designed to facilitate easy and rapid manufacture. The process for making the PPT uses known techniques for making printed circuit board devices. Another PPT also has no moving parts and uses a liquid fuel that is progressively advanced by capillary action.
摘要翻译：公开了脉冲等离子体推进器（PPT）和制造脉冲等离子体推进器的方法。 PPT不包括移动部件，能够实现小型化。 PPT也被设计为便于制造和制造。制造PPT的过程使用已知的技术来制造印刷电路板装置。另一个PPT也没有移动部件，并且使用通过毛细管作用逐渐推进的液体燃料。

23. 发明申请

US20050066164A1 Controlled-content recoverable blinded certificates 有权
公开(公告)号：US20050066164A1
公开(公告)日：2005-03-24
申请号：US10963302
申请日：2004-10-12
申请人： Daniel Simon
发明人： Daniel Simon
IPC分类号： H04L9/32 , H04L29/06 , H04L9/30
CPC分类号： H04L9/3268 , H04L9/3257 , H04L63/0823 , H04L63/126 , H04L2209/42 , H04L2209/60
摘要： In a cryptographic system, a certificate is used to provide information regarding a client device. The certificate is blindly signed by a certifying authority to preserve the anonymity of the client device. However, information is encoded into the signature so that a content server can readily verify security attributes of the client device and make decisions regarding the delivery of electronic content to the client device based on those security attributes.

24. 发明授权

US5648393A Treatment of male impotence with s-nitrosylated compounds 失效
标题翻译：用s-亚硝基化化合物治疗男性阳。
公开(公告)号：US5648393A
公开(公告)日：1997-07-15
申请号：US297698
申请日：1994-08-29
申请人： Jonathan Stamler , Joseph Loscalzo , Adam Slivka , Daniel Simon , Robert Brown , Jeffrey Drazen
发明人： Jonathan Stamler , Joseph Loscalzo , Adam Slivka , Daniel Simon , Robert Brown , Jeffrey Drazen
IPC分类号： A61K38/00 , C07C381/00 , C07K5/02 , A61K31/195 , A61K31/13
CPC分类号： C07C381/00 , C07K5/0215 , A61K38/00
摘要： Methods of relaxing corpus cavernosum smooth muscle, treating disease states responsive to prevention or relaxation of undesirable contractions of corpus cavernosum smooth muscle and of treating male impotence by administering an S-nitrosothiol such as a low molecular weight S-nitrosothiol, S-nitroso-ACE-inhibitor or S-nitroso-protein.
摘要翻译：放松海绵体平滑肌的方法，通过施用S-亚硝基硫醇如低分子量S-亚硝基硫醇，S-亚硝基ACE，治疗响应于预防或放松海绵体平滑肌不期望的收缩和治疗男性阳states的疾病状态抑制剂或S-亚硝基蛋白。

25. 发明授权

US5593876A Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality 失效
标题翻译：蛋白质SH基团和氨基酸残基的亚硝化作为治疗方式
公开(公告)号：US5593876A
公开(公告)日：1997-01-14
申请号：US287830
申请日：1994-08-09
申请人： Jonathan Stamler , Joseph Loscalzo , Daniel Simon , David Singel
发明人： Jonathan Stamler , Joseph Loscalzo , Daniel Simon , David Singel
IPC分类号： A61K35/14 , A61K38/00 , A61K38/02 , A61K38/16 , A61K38/38 , A61K38/42 , A61K38/46 , A61K38/49 , A61K39/395 , A61P9/00 , C07K1/06 , C07K1/107 , C07K14/00 , C07K14/315 , C07K14/47 , C07K14/76 , C07K14/765 , C07K14/805 , C07K16/00 , C07K16/18 , C12N9/00 , C12N9/48 , C12N9/64 , C12N9/70 , C12N9/72 , C12N9/96
CPC分类号： C12N9/6472 , C07K1/1077 , C07K14/3153 , C07K14/4702 , C07K14/76 , C07K14/765 , C07K14/805 , C07K16/00 , C12N9/6459 , C12Y304/21069 , A61K38/00
摘要： Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body. The invention also relates to the nitrosylation of oxygen, carbon and nitrogen moieties present on proteins and amino acids, and the use thereof to achieve the above physiological effects.
摘要翻译：蛋白质和氨基酸基团的亚硝化可以选择性调节蛋白质功能，并赋予蛋白质和氨基酸更多的平滑肌松弛剂和血小板抑制能力。因此，本发明涉及通过蛋白质硫醇的亚硝基化实现的新化合物。这些化合物包括：S-亚硝基-t-PA，S-亚硝基组织蛋白酶; S-亚硝基脂蛋白; 和S-亚硝基 - 免疫球蛋白。本发明还涉及S-亚硝基蛋白化合物用于调节蛋白质功能，细胞代谢和影响血管舒张，血小板抑制，非血管平滑肌松弛以及通过血红蛋白和肌红蛋白增加血氧转运的治疗用途。这些化合物也用于以最具生物活性的形式递送一氧化氮，以达到上述效果，或用于身体中存在的分子的体外亚硝基化。本发明还涉及存在于蛋白质和氨基酸上的氧，碳和氮部分的亚硝基化，以及其用于实现上述生理作用的用途。

26. 发明申请

US20090316361A1 Method and apparatus for controlling the output of solar arrays 审中-公开
标题翻译：用于控制太阳能电池阵列输出的方法和装置
公开(公告)号：US20090316361A1
公开(公告)日：2009-12-24
申请号：US12214831
申请日：2008-06-23
申请人： Daniel Simon
发明人： Daniel Simon
IPC分类号： H05K7/20
CPC分类号： F24D11/003 , F24S90/00 , H02S40/44 , Y02B10/20 , Y02E10/40 , Y02E10/60
摘要： A method to control the temperature of a circulating fluid and thereby control the electrical output of a PV array is provided along with an apparatus for doing so which adds simple mechanical, data measurement and control elements to prior art systems. Given a set amount of sunlight, electrical output from a solar PV array will change if the temperature of the array changes. One can change the temperature of a PV array by circulating a fluid through a loop in thermal contact with the array. Controlling the temperature of this circulating fluid, allows one to control the electrical output from the array.
摘要翻译：提供了一种用于控制循环流体的温度并由此控制PV阵列的电输出的方法以及用于这样做的装置，其将简单的机械，数据测量和控制元件添加到现有技术的系统中。给定一定数量的阳光，如果阵列的温度改变，太阳能光伏阵列的电气输出将会改变。可以通过使流体循环通过与阵列热接触的环路来改变PV阵列的温度。控制该循环液的温度可以控制阵列的电气输出。

27. 发明申请

US20090194096A1 Method and apparatus for concentrating optical radiation using light trapping elements 审中-公开
标题翻译：使用光捕获元件聚集光辐射的方法和装置
公开(公告)号：US20090194096A1
公开(公告)日：2009-08-06
申请号：US12012688
申请日：2008-02-05
申请人： Daniel Simon
发明人： Daniel Simon
IPC分类号： F24J2/16
CPC分类号： H01L31/0547 , F24S23/00 , F24S23/77 , H01L31/0543 , Y02B10/20 , Y02E10/44 , Y02E10/52
摘要： A holographic planar concentrator for collecting and concentrating solar radiation with light trapping elements. A holographic planar concentrator (HPC) comprises a transparent planar plate with at least one holographic film mounted on the face of the planar plate and a solar energy collecting device attached to at least one edge of the planar plate with a reflective surface or coating mounted along the remaining edges of the planar plate. A holographic planar concentrator with light trapping elements reduces potential light losses, and the amount solar energy collecting material required while enabling a more uniform visual appearance and lower manufacturing and installation costs.
摘要翻译：一种全息平面聚光器，用于收集和集中太阳辐射与光捕获元件。全息平面聚光器（HPC）包括透明平板，其具有安装在平面板的表面上的至少一个全息膜，以及太阳能收集装置，其附接到平板的至少一个边缘，其上安装有反射表面或涂层平板的剩余边缘。具有光俘获元件的全息平面聚光器降低了潜在的光损耗，并且所需的太阳能收集材料的量可以实现更均匀的视觉外观和更低的制造和安装成本。

28. 发明申请

US20080029149A1 Method and apparatus for arranging a solar cell and reflector 审中-公开
标题翻译：用于布置太阳能电池和反射器的方法和装置
公开(公告)号：US20080029149A1
公开(公告)日：2008-02-07
申请号：US11497755
申请日：2006-08-02
申请人： Daniel Simon
发明人： Daniel Simon
IPC分类号： H02N6/00
CPC分类号： H01L31/0547 , Y02E10/52
摘要： A system and method of arranging a solar cell and reflector to replace a typical solar cell oriented normal to the incoming sunlight inside a module (i.e. parallel to a module's transparent cover plate or opening). The present invention in a preferred embodiment uses a solar cell oriented at a 45 degree angle to the incoming sunlight, and a reflective surface oriented perpendicular to the cell and at a 45 degree angle to the incoming sunlight. The solar cell and the mirror are the same length/size and form a V shape where the angle between the sloped sides is 90 degrees. Any light falling normally on the arrangement will hit the solar cell either directly or after reflection. In another embodiment, two adjacent reflectors can be used making angles of around 60 degrees and around 30 degrees with respect to the cover or opening. An alternate embodiment can include a second reflector added to the base of the cell and reflector pairings also at an approximate 45 degree angle with the cover or opening. The second reflector can run along an entire row of cell and first reflector pairs such that the first reflectors form 90 degree angles with both the cells and with the second reflector.
摘要翻译：一种布置太阳能电池和反射器的系统和方法，以代替与模块内的入射太阳光垂直的典型太阳能电池（即平行于模块的透明盖板或开口）。在优选实施例中的本发明使用与入射的太阳光成45度角定向的太阳能电池以及垂直于电池定向并与入射的阳光成45度角的反射面。太阳能电池和反射镜具有相同的长度/尺寸，并形成倾斜侧面之间的角度为90度的V形。任何正常落在该装置上的光将直接或反射后将击中太阳能电池。在另一个实施例中，可以使用两个相邻反射器相对于盖或开口形成大约60度和大约30度的角度。一个替代实施例可以包括第二反射器，该第二反射器还与盖或开口成大约45度的角度加入到电池的底座和反射器配对。第二反射器可以沿着整行的单元和第一反射器对运行，使得第一反射器与单元和第二反射器形成90度角。

29. 发明申请

US20070248318A1 System and method for flexible mapping of AV vs record channels in a programmable transport demultiplexer/PVR engine 审中-公开
标题翻译：用于在可编程传输解复用器/ PVR引擎中AV与记录通道的灵活映射的系统和方法
公开(公告)号：US20070248318A1
公开(公告)日：2007-10-25
申请号：US11394877
申请日：2006-03-31
申请人： Stephane Rodgers , Daniel Simon
发明人： Stephane Rodgers , Daniel Simon
IPC分类号： H04N5/95
CPC分类号： H04N5/781 , H04N5/85 , H04N9/8042 , H04N21/2389 , H04N21/4147 , H04N21/4341 , H04N21/4385
摘要： A method and system are provided for flexible mapping of AV vs. Record channels in a programmable transport demultiplexer/PVR engine. The method may involve processing a portion of an incoming packet, which may result in a partially processed packet. The preprocessing may comprise extracting information from the packet to configure parameters associated with the packet and storing the configured parameters in memory. The configured parameters may be based on the type of the packet, AV v. Record, and used to configure the channels used to transport the packets to decoders and Record engines, respectively. The number of channels used for AV data and the number of channels used for Record data may vary depending on the needs of the system.
摘要翻译：提供了一种方法和系统，用于在可编程传输解复用器/ PVR引擎中对AV与记录信道的灵活映射。该方法可以涉及处理输入分组的一部分，其可能导致部分处理的分组。预处理可以包括从分组提取信息以配置与分组相关联的参数并将配置的参数存储在存储器中。配置的参数可以基于分组的类型AV v。Record，并分别用于配置用于将数据包传输到解码器和Record引擎的通道。用于AV数据的通道数量和用于记录数据的通道数量可能会因系统的需要而有所不同。

30. 发明申请

US20050235150A1 Bi-directionally verifying measurable aspects associated with modules, pre-computing solutions to configuration challenges, and using configuration challenges along with other authentication mechanisms 审中-公开
标题翻译：双向验证与模块相关的可测量方面，预配置挑战的计算解决方案，以及使用配置挑战以及其他身份验证机制
公开(公告)号：US20050235150A1
公开(公告)日：2005-10-20
申请号：US10827082
申请日：2004-04-19
申请人： Christopher Kaler , John Shewchuk , Bradford Lovering , Daniel Simon
发明人： Christopher Kaler , John Shewchuk , Bradford Lovering , Daniel Simon
IPC分类号： G06F21/00 , H04L9/00 , H04L29/06
CPC分类号： H04L63/0869 , G06F21/31 , G06F2221/2103
摘要： The present invention extends to validating measurable aspects of computing system. A provider causes a challenge to be issued to the requester, the challenge requesting proof that the requester is appropriately configured to access the resource. The requester accesses information that indicates how the requester is to prove an appropriate configuration for accessing the resource. The requester formulates and sends proof that one or more measurable aspects of the requester's configuration are appropriate. The provider receives proof that one or more measurable aspects of the requester's configuration are appropriate and authorizes the requester to access the resource. Proof of one more measurable aspects of a requester can be used along with other types of authentication to authorize a requester to access a resource of a provider. Solutions to challenges can be pre-computed and stored in a location accessible to a provider.
摘要翻译：本发明扩展到验证计算系统的可测量方面。提供者会向请求者发出一个挑战，质询请求证明请求者被正确地配置为访问资源。请求者访问指示请求者如何证明访问资源的适当配置的信息。请求者制定并发送证据，证明请求者配置的一个或多个可衡量的方面是适当的。提供者收到证据，证明请求者配置的一个或多个可衡量的方面是适当的，并授权请求者访问该资源。请求者的一个可衡量方面的证明可以与其他类型的认证一起使用，以授权请求者访问提供商的资源。挑战的解决方案可以预先计算并存储在供应商可访问的位置。

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