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21. 发明授权

US07279107B2 Blood component processing system, apparatus, and method 有权
公开(公告)号：US07279107B2
公开(公告)日：2007-10-09
申请号：US10414475
申请日：2003-04-16
申请人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
发明人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
IPC分类号： B01D21/26 , B04B11/00
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.

22. 发明授权

US06726671B2 Cell storage maintenance and monitoring system 失效
标题翻译：电池存储维护和监控系统
公开(公告)号：US06726671B2
公开(公告)日：2004-04-27
申请号：US09971744
申请日：2001-10-04
申请人： Larry Joe Dumont , Frank Corbin, III
发明人： Larry Joe Dumont , Frank Corbin, III
IPC分类号： A61B1900
CPC分类号： A61J1/10 , A61J1/1468 , G01N33/84 , Y10S128/24
摘要： A cell storage maintenance and monitoring system includes a blood product storage container, such as a flexible bag, and a microporous membrane which may be attached to an inner wall of the blood storage container to form a contained space between the inner wall and the membrane. The membrane includes a plurality of pores, preferably filled with an erodible substance responsive to a selected characteristic of the blood product.
摘要翻译：细胞储存维护和监测系统包括诸如柔性袋的血液制品存储容器和可以附着到血液存储容器的内壁上的微孔膜，以在内壁和膜之间形成容纳空间。膜包括多个孔，优选地填充有对所选择的血液制品特征的可侵蚀物质。

23. 发明授权

US06258577B1 Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers 失效
标题翻译：使用内源性环氮嗪或异环嗪类光敏剂灭活生物污染物的方法和装置
公开(公告)号：US06258577B1
公开(公告)日：2001-07-10
申请号：US09119666
申请日：1998-07-21
申请人： Raymond Paul Goodrich, Jr. , Frank Corbin, III , Edward C. Wood, Jr.
发明人： Raymond Paul Goodrich, Jr. , Frank Corbin, III , Edward C. Wood, Jr.
IPC分类号： C12N1300
CPC分类号： A61L2/0082 , A61L2/0011 , A61L2/0047 , A61L2/0052 , A61L2/08 , A61L2/10 , A61L2/23 , A61L2202/22 , A61M1/3683 , C12N7/04
摘要： Methods and apparatuses are provided for inactivation of microorganisms in a fluid containing blood or blood products and comprising biologically active proteins. The method includes the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid; exposing the fluid to photoradiation sufficient to activate the endogenous photosensitizer; and allowing the activated endogenous photosensitizer to interfere with nucleic acid present in microorganisms in the fluid so that the microorganisms are inactivated. Isoalloxazines and K- and L-vitamins are among the preferred photosensitizers. Systems and apparatuses are also provided for decontamination of such fluids using photosensitizers which include means for adding photosensitizer to the fluid; a photopermeable container for exposing the fluid to an amount of photoradiation sufficient to activate the photosensitizer; and a photoradiation source, preferably comprising a light guide, for providing sufficient photoradiation of a type and amount selected to activate the photosensitizer. Means for controlling photosensitizer concentration in the fluid and rate of fluid flow through the container, including computer processors may be included in such systems.
摘要翻译：提供了用于灭活含有血液或血液制品并含有生物活性蛋白质的流体中的微生物的方法和装置。该方法包括将有效的无毒量的内源性光敏剂添加到流体中的步骤; 使流体暴露于足以激活内源性光敏剂的光照射; 并允许活化的内源性光敏剂干扰流体中存在于微生物中的核酸，使得微生物失活。优选的光敏剂是异环氧嗪和K-和L-维生素。还提供了系统和装置，用于使用光敏剂对这种流体进行净化，其包括将光敏剂添加到流体中的装置; 用于将流体暴露于足以激活光敏剂的光辐射量的光透过容器; 以及优选地包括光导的光引发源，用于提供所选择的激活光敏剂的类型和量的足够的光照射。用于控制流体中光敏剂浓度和通过容器（包括计算机处理器）的流体流速的方法可以包括在这样的系统中。

24. 发明授权

US5738644A Extracorporeal blood processing methods and apparatus 失效
公开(公告)号：US5738644A
公开(公告)日：1998-04-14
申请号：US483574
申请日：1995-06-07
申请人： Brian M. Holmes , Jeffrey J. Blakeslee , Marlene Adele Bainbridge , Frank Corbin, III
发明人： Brian M. Holmes , Jeffrey J. Blakeslee , Marlene Adele Bainbridge , Frank Corbin, III
IPC分类号： A61M1/36 , B04B5/04 , B04B9/08 , A61M35/00
CPC分类号： B04B5/0442 , A61M1/3624 , A61M1/3639 , A61M1/3652 , A61M1/3693 , A61M1/3696 , B04B9/08 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/505 , B04B2005/045
摘要： An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

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