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21. 发明授权

US4605730A Surgical articles of copolymers of glycolide and .epsilon.-caprolactone and methods of producing the same 失效
标题翻译：乙交酯和ε-己内酯共聚物的手术制品及其制备方法
公开(公告)号：US4605730A
公开(公告)日：1986-08-12
申请号：US743117
申请日：1985-06-10
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61F2/00 , A61L17/12 , C08G63/08 , C08G63/10
CPC分类号： C08G63/08 , A61L17/12
摘要： Novel copolymers of .epsilon.-caprolactone and glycolide useful in making surgical articles and particularly surgical sutures having Young's modulus of less than 250,000 psi. New and improved polymerization methods for producing the novel .epsilon.-caprolactone and glycolide copolymers.
摘要翻译： ε-己内酯和乙交酯的新型共聚物可用于制造外科用品，特别是具有小于250,000psi的杨氏模量的手术缝合线。用于生产新型ε-己内酯和乙交酯共聚物的新型改进的聚合方法。

22. 发明授权

US4205399A Synthetic absorbable surgical devices of poly(alkylene oxalates) 失效
标题翻译：聚（亚烷基草酸盐）的合成可吸收外科手术装置
公开(公告)号：US4205399A
公开(公告)日：1980-06-03
申请号：US910042
申请日：1978-05-26
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61L17/10 , A61L27/18 , C08G63/16 , D01F6/62 , D01F6/84 , A61L17/00 , A61F1/00
CPC分类号： D01F6/84 , A61L17/105 , A61L27/18 , C08G63/16 , D01F6/625
摘要： Synthetic filaments composed of homopolymers and copolymers of poly(alkylene oxalates) are absorbable in animal tissue with minimal adverse tissue reaction. Polymers prepared by reacting a dialkyl oxalate with an alkylene diol are melt spun and drawn to obtain oriented fibers having good tensile properties and a high level of flexibility and softness. The filaments are particularly useful in the preparation of surgical prosthesis comprising woven or knitted fabrics and meshes. Other absorbable surgical devices including films and molded items may also be prepared from the disclosed polymer.
摘要翻译：由聚（亚烷基草酸酯）的均聚物和共聚物组成的合成长丝在动物组织中是可吸收的，具有最小的不利组织反应。通过使草酸二烷基酯与亚烷基二醇反应制备的聚合物被熔融纺丝并拉伸，得到具有良好拉伸性能和高柔性和柔软度的取向纤维。长丝在制备包含织造或针织织物和网眼的手术假体中特别有用。其它可吸收外科装置，包括膜和模制品也可以由所公开的聚合物制备。

23. 发明授权

US4130639A Absorbable pharmaceutical compositions based on isomorphic copolyoxalates 失效
标题翻译：基于同型共聚合物的可吸收药物组合物
公开(公告)号：US4130639A
公开(公告)日：1978-12-19
申请号：US837060
申请日：1977-09-28
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61K47/34 , A61K9/14 , A61K9/20 , C08G63/18 , A61K31/74 , A61K31/56
CPC分类号： A61K9/146 , A61K9/204 , C08G63/18
摘要： Absorbable copolyoxalate polymers having isomorphic sequences are formulated with drugs and introduced into the body to provide a slow, sustained release of the drug over an extended period of time in accordance with the rate of absorption of the polymer. The copolyoxalate polymers are derived from mixtures of cyclic and linear diols, each having the same number of carbon atoms. The polymers are biodegradable in animal tissue and absorb with minimal adverse tissue reaction.
摘要翻译：具有同构序列的可吸收的共聚草酸酯聚合物与药物配制并引入体内以根据聚合物的吸收速率在延长的时间段内提供缓慢的持续释放药物。共聚草酸酯聚合物衍生自环状和线性二醇的混合物，每个二醇具有相同数目的碳原子。聚合物在动物组织中是可生物降解的并以最小的不利组织反应进行吸收。

24. 发明授权

US4700704A Surgical articles of copolymers of glycolide and .epsilon.-caprolactone and methods of producing the same 失效
标题翻译：乙交酯和ε-己内酯共聚物的手术制品及其制备方法
公开(公告)号：US4700704A
公开(公告)日：1987-10-20
申请号：US764818
申请日：1985-08-12
申请人： Dennis D. Jamiolkowski , Shalaby W. Shalaby
发明人： Dennis D. Jamiolkowski , Shalaby W. Shalaby
IPC分类号： A61F2/00 , A61L17/12 , C08G63/08 , A61L17/00
CPC分类号： A61L17/12 , C08G63/08
摘要： Novel copolymers of .epsilon.-caprolactone and glycolide useful in making surgical articles and particularly surgical sutures having Young's modulus of less than 350,000 psi. New and improved polymerization methods for producing the novel .epsilon.-caprolactone and glycolide copolymers.
摘要翻译： ε-己内酯和乙交酯的新型共聚物可用于制造外科用品，特别是具有小于350,000psi的杨氏模量的手术缝合线。用于生产新型ε-己内酯和乙交酯共聚物的新型改进的聚合方法。

25. 发明授权

US4608428A Copolymers of a 4,4'-(ethylenedioxy)bis benzoate, an alkylene diol and a (2-alkenyl or alkyl) succinic anhydride; and surgical devices formed therefrom 失效
标题翻译： 4,4' - （亚乙二氧基）双苯甲酸酯，亚烷基二醇和（2-烯基或烷基）琥珀酸酐的共聚物; 和从其形成的手术装置
公开(公告)号：US4608428A
公开(公告)日：1986-08-26
申请号：US648446
申请日：1984-09-10
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： C08G63/66
CPC分类号： C08G63/66
摘要： Copolymers of an (ethylenedioxy)bis benzoate, an alkylene diol and a (2-alkenyl or alkyl) succinic anhydride, as well as surgical devices formed therefrom; especially, flexible monofilament surgical sutures having unique handling and knot-tying characteristics.
摘要翻译：（亚乙二氧基）双苯甲酸酯，亚烷基二醇和（2-烯基或烷基）琥珀酸酐的共聚物，以及由其形成的手术装置; 特别是柔性单丝手术缝合线具有独特的处理和打结特征。

26. 发明授权

US4226243A Surgical devices of polyesteramides derived from bis-oxamidodiols and dicarboxylic acids 失效
标题翻译：衍生自双 - 氧杂酰亚氨基二醇和二羧酸的聚酯酰胺的手术装置
公开(公告)号：US4226243A
公开(公告)日：1980-10-07
申请号：US61339
申请日：1979-07-27
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61L17/10 , A61L27/18 , C08G69/44 , A61L17/00 , A61F1/00
CPC分类号： C08G69/44 , A61L17/10 , A61L27/18 , Y10S623/924
摘要： Alternating esteramide polymers are obtained from the reaction of bis-oxamidodiols such as N,N'-bis(.omega.-hydroxyalkylene)oxamide with a dicarboxylic acid or diesters such as diethyl oxalate, diethyl succinate, diethyl suberate, or dimethyl terephthalate. The polymers are obtained in good yield and have film- and fiber-forming properties. Some polymers are absorbable in biological systems and are useful as absorbable surgical devices. Other of these polymers are nonabsorbable and are useful as textile fibers.
摘要翻译：交替的酯酰胺聚合物是由二氧杂二恶醇如N，N'-双（ω-羟基亚烷基）草酰胺与二羧酸或二酯如草酸二乙酯，琥珀酸二乙酯，辛二酸二乙酯或对苯二甲酸二甲酯的反应得到的。以高产率获得聚合物并具有成膜和成膜性能。一些聚合物在生物系统中是可吸收的并且可用作可吸收外科装置。其他这些聚合物是不可吸收的并且可用作纺织纤维。

27. 发明授权

US4435590A Radiation sterilizable absorbable polymeric materials and methods for manufacturing the same 失效
标题翻译：辐射灭菌吸收性聚合材料及其制造方法
公开(公告)号：US4435590A
公开(公告)日：1984-03-06
申请号：US290641
申请日：1981-08-06
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61B17/06 , A61B17/00 , A61L2/08 , A61L17/00 , A61L17/10 , C08G63/00 , C08G63/12 , C08G63/60 , C08G63/66 , C08G63/672 , C08G63/78 , C07C69/76
CPC分类号： A61L2/08 , A61L17/105 , C08G63/672
摘要： Radiation sterilizable polymeric materials, particularly radiation sterilizable absorbable, surgical products made from such polymeric materials.
摘要翻译：辐射灭菌聚合物材料，特别是由这种聚合材料制成的可辐射消毒的可吸收的外科手术产品。

28. 发明授权

US4208511A Isomorphic copolyoxalates and sutures thereof 失效
标题翻译：同构共聚阴离子及其缝线
公开(公告)号：US4208511A
公开(公告)日：1980-06-17
申请号：US915500
申请日：1978-06-14
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61B17/00 , A61B17/06 , A61L17/10 , C08G63/199 , C08G63/18
CPC分类号： C08G63/199 , A61B17/06133 , A61B17/06166 , A61L17/105 , A61B2017/00004
摘要： Synthetic absorbable sutures are prepared from copolyoxalate polymers having isomorphic sequences. The polymers are derived from mixtures of cyclic and linear diols, each having the same carbon chain length of 6 or 8 atoms. The cyclic diol may be aliphatic or aromatic. The diols are polymerized with dialkyl oxalate, preferably in the presence of an inorganic or organometallic catalyst, to obtain a highly crystalline isomorphic copolyoxalate polymer which is melt extruded and drawn to form oriented filaments. The filaments are characterized by good initial tensile and knot strength and a high order of softness and flexibility. When implanted in living animal tissue, the fibers have good strength retention over a period of at least 21 days and eventually absorb with a minimal degree of adverse tissue reaction.
摘要翻译：合成可吸收缝线由具有同构序列的共聚草酸酯聚合物制备。聚合物衍生自环状和线性二醇的混合物，每一种具有相同的碳链长度为6或8个原子。环状二醇可以是脂肪族或芳香族的。二醇与草酸二烷基酯进行聚合，优选在无机或有机金属催化剂的存在下进行聚合，得到熔融挤出和拉伸形成定向长丝的高度结晶的同晶共聚草酸酯聚合物。长丝的特征在于初始拉伸强度和结强度高，柔软度高的柔顺性。当植入活的动物组织中时，纤维在至少21天的时间内具有良好的强度保留，并且最终以最小程度的不良组织反应吸收。

29. 发明授权

US4186189A Absorbable pharmaceutical compositions based on poly(alkylene oxalates) 失效
标题翻译：基于聚（亚烷基草酸盐）的可吸收药物组合物
公开(公告)号：US4186189A
公开(公告)日：1980-01-29
申请号：US837076
申请日：1977-09-28
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61K47/34 , A61K9/16 , A61K9/20 , A61K9/50 , A61K31/74 , A61K9/22 , A61K9/32 , A61K9/52
CPC分类号： A61K9/5031 , A61K9/1647 , A61K9/204
摘要： Absorbable polymers derived from alkylene oxalates are formulated with drugs and introduced into the body to provide a slow, sustained release of the drug over an extended period of time in accordance with the rate of absorption of the polymer. Polymers of alkylene oxalates, particularly wherein the alkylene moiety is C.sub.3 to C.sub.16, are biodegradable in animal tissue and absorb with minimal adverse tissue reaction.
摘要翻译：衍生自草酸亚烷基酯的可吸收聚合物与药物配制并引入体内，以根据聚合物的吸收速率在延长的时间段内提供缓慢，持续释放的药物。草酸亚烷基酯，特别是其中亚烷基部分为C3至C16的聚合物在动物组织中是可生物降解的并以最小的不利组织反应进行吸收。

30. 发明授权

US4141087A Isomorphic copolyoxalates and sutures thereof 失效
标题翻译：同构共聚阴离子及其缝线
公开(公告)号：US4141087A
公开(公告)日：1979-02-27
申请号：US752374
申请日：1977-01-19
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61B17/00 , A61B17/06 , A61L17/10 , A61L27/18 , A61F1/24 , A61F1/00 , A61L17/00 , C08G63/18
CPC分类号： A61L17/105 , A61B17/06133 , A61B17/06166 , A61L27/18 , A61B2017/00004
摘要： Synthetic absorbable sutures are prepared from copolyoxalate polymers having isomorphic sequences. The polymers are derived from mixtures of cyclic and linear diols, each having the same carbon chain length of 6 or 8 atoms. The cyclic diol may be aliphatic or aromatic. The diols are polymerized with dialkyl oxalate, preferably in the presence of an inorganic or organometallic catalyst, to obtain a highly crystalline isomorphic copolyoxalate polymer which is melt extruded and drawn to form oriented filaments. The filaments are characterized by good initial tensile and knot strength and a high order of softness and flexibility. When implanted in living animal tissue, the fibers have good strength retention over a period of at least 21 days and eventually absorb with a minimal degree of adverse tissue reaction.
摘要翻译：合成可吸收缝线由具有同构序列的共聚草酸酯聚合物制备。聚合物衍生自环状和线性二醇的混合物，每一种具有相同的碳链长度为6或8个原子。环状二醇可以是脂肪族或芳香族的。二醇与草酸二烷基酯进行聚合，优选在无机或有机金属催化剂的存在下进行聚合，得到熔融挤出和拉伸形成定向长丝的高度结晶的同态共聚草酸酯聚合物。长丝的特征在于初始拉伸强度和结强度高，柔软度高的柔顺性。当植入活的动物组织中时，纤维在至少21天的时间内具有良好的强度保留，并且最终以最小程度的不良组织反应吸收。

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