专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US07361680B2 Indole compounds useful for the treatment of cancer 失效
标题翻译：吲哚化合物可用于治疗癌症
公开(公告)号：US07361680B2
公开(公告)日：2008-04-22
申请号：US11467472
申请日：2006-08-25
申请人： Dennis A. Carson , Howard B. Cottam , Lorenzo M. Leoni
发明人： Dennis A. Carson , Howard B. Cottam , Lorenzo M. Leoni
IPC分类号： A61K31/407 , C07D471/04
CPC分类号： A61K31/407 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K31/7056 , G01N33/57434 , G01N2800/52
摘要： The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.
摘要翻译：本发明提供了可用于抑制癌症或使癌细胞对化学治疗剂，辐射或其它抗癌治疗敏感的新型吲哚衍生物。

22. 发明授权

US07098216B2 Thiazolopyrimidines useful as TNFα inhibitors 失效
标题翻译：噻唑并嘧啶可用作TNFα抑制剂
公开(公告)号：US07098216B2
公开(公告)日：2006-08-29
申请号：US10952077
申请日：2004-09-28
申请人： Dennis A. Carson , Howard B. Cottam , Lynn Deng
发明人： Dennis A. Carson , Howard B. Cottam , Lynn Deng
IPC分类号： C07D513/04 , A61K31/519 , A61P11/06 , A61P19/02 , A61P37/06
CPC分类号： C07D513/04
摘要： The invention provides derivatives of thiazolo[4,5-d1]pyrimidine and their use as inhibitors of proinflammatory cytokines.
摘要翻译：本发明提供噻唑并[4,5-d]嘧啶的衍生物及其作为促炎细胞因子抑制剂的用途。

23. 发明授权

US06930101B1 Thiazolopyrimidines useful as TNFα inhibitors 失效
标题翻译：噻唑并嘧啶可用作TNFα抑制剂
公开(公告)号：US06930101B1
公开(公告)日：2005-08-16
申请号：US09313048
申请日：1999-05-17
申请人： Dennis A. Carson , Howard B. Cottam , Lynn Deng
发明人： Dennis A. Carson , Howard B. Cottam , Lynn Deng
IPC分类号： C07D239/54 , A61K9/08 , A61K9/14 , A61K9/48 , A61K31/513 , A61K31/519 , A61P1/00 , A61P3/10 , A61P9/10 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/06 , C07D513/04 , A61P11/06
CPC分类号： C07D513/04
摘要： The invention provides derivatives of thiazolo[4,5-dl]pyrimidine and their use as inhibitors of proinflammatory cytokines.
摘要翻译：本发明提供噻唑并[4,5-d]嘧啶的衍生物及其作为促炎细胞因子抑制剂的用途。

24. 发明授权

US06911309B2 Nucleic acids encoding MTAse 失效
标题翻译：编码MTAse的核酸
公开(公告)号：US06911309B2
公开(公告)日：2005-06-28
申请号：US09780114
申请日：2001-02-09
申请人： Tsutomu Nobori , Dennis A. Carson , Kenji Takabayashi
发明人： Tsutomu Nobori , Dennis A. Carson , Kenji Takabayashi
IPC分类号： G01N33/566 , C07H21/04 , C07K7/06 , C07K7/08 , C07K16/40 , C12N1/21 , C12N5/06 , C12N9/10 , C12N9/12 , C12N15/00 , C12N15/02 , C12N15/09 , C12P19/34 , C12P21/08 , C12Q1/00 , C12Q1/25 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/573
CPC分类号： C12Q1/25 , C07K16/40 , C12N9/1077 , C12Q1/6886 , G01N33/5005 , G01N33/573
摘要： A method for detecting whether methyladenosine phosphatase (MTAse) is present in a cell sample. In one respect, the method comprises adding oligonucleotide probes to the sample, which probes are capable of specifically hybridizing to any MTAse encoding nucleic acid in the sample under conditions favoring that hybridization. Absence of MTAse in a sample is considered to be indicative of malignancy. Polynucleotides encoding MTAse, MTAse peptides and antibodies to MTAse, as well as kits for performing the methods of the invention, are provided.
摘要翻译：检测细胞样品中是否存在甲基腺苷磷酸酶（MTAse）的方法。在一个方面，该方法包括向样品中加入寡核苷酸探针，该探针能够在有利于杂交的条件下与样品中任何MTAs编码核酸特异性杂交。样本中缺少MTAs被认为是恶性肿瘤的指征。提供编码MTAse，MTAse肽和MTAse抗体的多核苷酸，以及用于实施本发明方法的试剂盒。

25. 发明授权

US06562819B2 Compounds for inhibition of ceramide-mediated signal transduction 失效
公开(公告)号：US06562819B2
公开(公告)日：2003-05-13
申请号：US09951198
申请日：2001-09-13
申请人： Dennis A. Carson , Howard Cottam
发明人： Dennis A. Carson , Howard Cottam
IPC分类号： C07D21724
CPC分类号： C07D239/545 , C07D213/76 , C07D217/24 , C07D239/96 , C07D473/06 , C07D473/10 , C07D475/02 , C07D513/04
摘要： Novel, heterocyclic compounds having at least one ring nitrogen, disclosed side chains and, in some embodiments, an oxygen ortho to the ring nitrogen inhibit inflammatory responses associated with TNF-&agr; and fibroblast proliferation in vivo and in vitro. The compounds of the invention neither appreciably inhibit the activity of cAMP phosphodiesterase nor the hydrolysis of phosphatidic acid, and are neither cytotoxic nor cytostatic. Preferred compounds of the invention are esters. Methods for the use of the novel compounds to inhibit ceramide-mediated intracellular responses in stimuli in vivo (particularly TN-&agr;) are also described. The methods are expected to be of use in reducing inflammatory responses (for example, after angioplasty), in limiting fibrosis (for example, of the liver in cirrhosis), in inhibiting cell senescence, cell apoptosis and UV induced cutaneous immune suppression. Compounds having enhanced water solubility are also described.

26. 发明授权

US06323201B1 Compounds for inhibition of ceramide-mediated signal transduction 失效
标题翻译：用于抑制神经酰胺介导的信号转导的化合物
公开(公告)号：US06323201B1
公开(公告)日：2001-11-27
申请号：US08858778
申请日：1997-05-19
申请人： Dennis A. Carson , Howard Cottam
发明人： Dennis A. Carson , Howard Cottam
IPC分类号： C07D41306
CPC分类号： C07D239/545 , C07D213/76 , C07D217/24 , C07D239/96 , C07D473/06 , C07D473/10 , C07D475/02 , C07D513/04
摘要： Novel, heterocyclic compounds having at least one ring nitrogen, disclosed side chains and, in some embodiments, an oxygen ortho to the ring nitrogen inhibit inflammatory responses associated with TNF-&agr; and fibroblast proliferation in vivo and in vitro. The compounds of the invention neither appreciably inhibit the activity of cAMP phosphodiesterase nor the hydrolysis of phosphatidic acid, and are neither cytotoxic nor cytostatic. Preferred compounds of the invention are esters. Methods for the use of the novel compounds to inhibit ceramide-mediated intracellular responses in stimuli in vivo (particularly TN-&agr;) are also described. The methods are expected to be of use in reducing inflammatory responses (for example, after angioplasty), in limiting fibrosis (for example, of the liver in cirrhosis), in inhibiting cell senescence, cell apoptosis and UV induced cutaneous immune suppression. Compounds having enhanced water solubility are also described.
摘要翻译：新颖的，具有至少一个环氮的杂环化合物，在一些实施方案中，环氮原子上的氧被抑制与体内和体外TNF-α和成纤维细胞增殖相关的炎性反应。本发明的化合物既不明显地抑制cAMP磷酸二酯酶的活性也不抑制磷脂酸的水解，既不是细胞毒性的也不是细胞抑制的。本发明优选的化合物是酯。还描述了使用新化合物抑制体内刺激中神经酰胺介导的细胞内应答的方法（特别是TN-α）。预期这些方法可用于减少炎症反应（例如血管成形术后），限制纤维化（例如肝硬化），抑制细胞衰老，细胞凋亡和UV诱导的皮肤免疫抑制。还描述了具有增强的水溶性的化合物。

27. 发明授权

US06214571B1 Method for inhibiting adenylosuccinate synthetase activity in malignant methylthioadenosine phosphorylase deficient cells 失效
标题翻译：恶性甲基硫代腺苷磷酸化酶缺陷型细胞中腺苷酸琥珀酸合成酶抑制活性的方法
公开(公告)号：US06214571B1
公开(公告)日：2001-04-10
申请号：US09199137
申请日：1998-11-24
申请人： Carlos J. Carrera , Dennis A. Carson , Howard B. Cottam , Tsutomu Nobori
发明人： Carlos J. Carrera , Dennis A. Carson , Howard B. Cottam , Tsutomu Nobori
IPC分类号： C12Q134
CPC分类号： C12Q1/6886 , A61K31/198 , C12N9/1077
摘要： An in vivo method for depleting mammalian cells of adenosine 5′-monophosphate (AMP) useful in the treatment of certain cancers is provided. According to the method, a population of cells is obtained from a host and assayed for loss of methylthioadenosine phosphorylase (MTAse) activity. MTAse catabolizes methylthioadenosine to adenine for endogenous salvage incorporation into the intracellular AMP pool. The preferred method for assaying loss of MTAse activity is a hybridization technique for detection of a homozygous loss of the gene which encodes MTAse. Hosts having MTAse deficient tumors are treated with a therapeutically effective amount of an agent which inhibits the activity of adenylsuccinate synthetase, which converts inosine 5-monophosphate to AMP, thus depleting the tumor cells of substrates for de novo AMP production. L-alanosine is the preferred ASS inhibitory agent for use in the method of the invention.
摘要翻译：提供了用于消除用于治疗某些癌症的腺苷5'-单磷酸（AMP）的哺乳动物细胞的体内方法。根据该方法，从宿主获得细胞群并测定甲硫基腺苷磷酸化酶（MTAse）活性的损失。 MTAs将甲基硫代腺苷分解为腺嘌呤，用于内源性补救并入细胞内AMP库。用于测定MTAse活性丧失的优选方法是用于检测编码MTAse的基因的纯合丢失的杂交技术。具有MTAse缺陷肿瘤的宿主用治疗有效量的抑制腺苷酸琥珀酸合成酶活性的药物进行治疗，其将5-单磷酸肌苷转化为AMP，从而消耗底物的肿瘤细胞用于从头AMP产生。 L-肌氨酸是用于本发明方法的优选的ASS抑制剂。

28. 发明授权

US6153200A Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis 失效
公开(公告)号：US6153200A
公开(公告)日：2000-11-28
申请号：US107615
申请日：1998-06-30
申请人： Dennis A. Carson , Salvatore Albani
发明人： Dennis A. Carson , Salvatore Albani
IPC分类号： A61K38/00 , A61K31/00 , A61K35/74 , A61K38/22 , A61K39/00 , A61K39/395 , A61K39/40 , A61K45/00 , A61K48/00 , A61P19/00 , A61P19/02 , A61P29/00 , A61P37/00 , C07K14/245 , C07K14/47 , C07K14/74 , C07K16/04 , C07K16/12 , C12N15/09 , C12N15/31 , G01N33/53 , G01N33/564 , A61K39/116 , A61K39/38 , A61K38/16 , A01N37/18
CPC分类号： G01N33/6854 , A61K38/1841 , A61K39/0008 , A61K39/40 , C07K14/245 , C07K14/70539 , C07K16/04 , C07K16/12 , G01N33/6893 , A61K39/00 , A61K48/00 , G01N2800/102 , G01N2800/50
摘要： Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.

29. 发明授权

US5942393A Method for the detection of the presence or absence of methylthioadenosine phosphorylase (MTASE) in a cell sample by detection of the presence or absence of MTASE encoding nucleic acid in the cell sample 失效
标题翻译：通过检测细胞样品中MTASE编码核酸的存在或不存在来检测细胞样品中甲硫基腺苷磷酸化酶（MTASE）的存在或不存在的方法
公开(公告)号：US5942393A
公开(公告)日：1999-08-24
申请号：US772113
申请日：1996-12-18
申请人： Tsutomu Nobori , Dennis A. Carson , Kenji Takabayashi
发明人： Tsutomu Nobori , Dennis A. Carson , Kenji Takabayashi
IPC分类号： G01N33/566 , C07H21/04 , C07K7/06 , C07K7/08 , C07K16/40 , C12N1/21 , C12N5/06 , C12N9/10 , C12N9/12 , C12N15/00 , C12N15/02 , C12N15/09 , C12P19/34 , C12P21/08 , C12Q1/00 , C12Q1/25 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/573 , C12N15/63
CPC分类号： C07K16/40 , C12N9/1077 , C12Q1/25 , C12Q1/6886 , G01N33/5005 , G01N33/573
摘要： A method for the detecting whether methyladenosine phosphatase (MTAse) is present in a cell sample in either a catalytically active or catalytically inactive form. In one respect, the method comprises adding oligonucleotide probes to the sample, which probes are capable of specifically hybridizing to any MTAse encoding nucleic acid in the sample under conditions favoring that hybridization. Absence of MTAse in a sample is considered to be indicative of malignancy. Polynucleotides encoding MTAse, MTAse peptides and antibodies to MTAse, as well as kits for performing the methods of the invention, are provided.
摘要翻译：检测甲基腺苷磷酸酶（MTAse）是否以催化活性或催化无活性形式存在于细胞样品中的方法。在一个方面，该方法包括向样品中加入寡核苷酸探针，该探针能够在有利于杂交的条件下与样品中任何MTAs编码核酸特异性杂交。样本中缺少MTAs被认为是恶性肿瘤的指征。提供编码MTAse，MTAse肽和MTAse抗体的多核苷酸，以及用于实施本发明方法的试剂盒。

30. 发明授权

US5703055A Generation of antibodies through lipid mediated DNA delivery 失效
标题翻译：通过脂质介导的DNA递送产生抗体
公开(公告)号：US5703055A
公开(公告)日：1997-12-30
申请号：US187630
申请日：1994-01-26
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61K9/127 , A61K48/00 , C07K14/16 , C07K14/61 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/78 , C12N15/87 , A61K39/00 , A61K39/395 , C12P21/06
CPC分类号： C07K14/005 , A61K48/00 , A61K9/1272 , C07K14/61 , C12N15/87 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12Y113/12007 , C12N2740/16122
摘要： A method is disclosed for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy. In particular, a method is disclosed for the generation of detectable antibodies by the direct administration to a tissue in a mammal a DNA sequence encoding a immunogen where the DNA is complexed to a cationic lipid.
摘要翻译：公开了一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，其包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并发挥治疗效果在脊椎动物上。该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因治疗。具体地，公开了通过直接向哺乳动物的组织施用编码免疫原的DNA序列产生可检测抗体的方法，其中DNA与阳离子脂质复合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式