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21. 外观设计

USD659819S1 Food inhaler 有权
标题翻译：食物吸入器
公开(公告)号：USD659819S1
公开(公告)日：2012-05-15
申请号：US29352274
申请日：2009-12-18
申请人： David A. Edwards , Jóse Sanchez , Jonathan Man , Jonathan Jacques Kamler
设计人： David A. Edwards , Jóse Sanchez , Jonathan Man , Jonathan Jacques Kamler

22. 发明申请

US20120114809A1 DELIVERING AEROSOLIZABLE FOOD PRODUCTS 审中-公开
标题翻译：提供可溶性食品
公开(公告)号：US20120114809A1
公开(公告)日：2012-05-10
申请号：US13132469
申请日：2009-12-03
申请人： David A. Edwards , Jonathan Man , Jonathan Jacques Kamler , Jose Sanchez , Marc Bretillot
发明人： David A. Edwards , Jonathan Man , Jonathan Jacques Kamler , Jose Sanchez , Marc Bretillot
IPC分类号： B65D83/14 , A23P1/16
CPC分类号： A61M11/005 , A61M11/002 , A61M15/0025 , A61M15/06
摘要： Aerosolized food products in a determined particle size range are suspended in the air and deposited in the mouth without easily entering into the respiratory tract. An apparatus incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a manner suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus represents a novel means for delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized food particles in a determined size range, suspended in air, to be deposited in the mouth without substantial exposure or entry into the respiratory tract.
摘要翻译：确定粒度范围的气溶胶食品悬浮在空气中并沉积在口中，而不会容易地进入呼吸道。包含烟雾发生装置和食品的装置可以允许以适合于吸入或沉积并随后摄取的方式使食品雾化和输送。食物输送装置代表将食物输送到人类和动物口腔的新颖手段。实际上，本发明的装置被设计成生产，运输和引导悬浮在空气中的确定尺寸范围的雾化食物颗粒，以便沉积在口中而不会大量暴露或进入呼吸道。

23. 再颁专利

USRE42072E1 Compositions and methods for enhancing receptor-mediated cellular internalization 失效
标题翻译：用于增强受体介导的细胞内化的组合物和方法
公开(公告)号：USRE42072E1
公开(公告)日：2011-01-25
申请号：US11821514
申请日：2007-06-21
申请人： Daniel R. Deaver , David A. Edwards , Robert S. Langer
发明人： Daniel R. Deaver , David A. Edwards , Robert S. Langer
IPC分类号： A61F2/02 , A61F13/02 , A61K9/48 , A61K9/20 , A61K9/14
CPC分类号： A61K9/0046 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/006 , A61K9/0073 , A61K9/06 , A61K31/56 , A61K31/573 , A61K31/715 , A61K47/38 , A61K48/00 , A61K48/0008 , A61K48/0083 , Y10S977/906
摘要： Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
摘要翻译：公开了用于改善一种或多种化合物的细胞内化的组合物和方法。组合物包括待递送的化合物和生物相容的粘性材料，例如水凝胶，脂凝胶或高粘度溶胶。该组合物还包括或与其结合使用，其量可以有效地最大化受体的表达或结合，并增强化合物进入细胞的RME。这导致要跨细胞膜递送的化合物的高传输速率，有助于更有效地递送药物和诊断剂。组合物经口，鼻，阴道，直肠和眼部局部应用。增强剂与组合物一起施用或分开施用，全部或优选局部施用。待递送的化合物也可以是增强剂。

24. 发明申请

US20110011394A1 DELIVERING AEROSOLIZABLE FOOD PRODUCTS 有权
标题翻译：提供可溶性食品
公开(公告)号：US20110011394A1
公开(公告)日：2011-01-20
申请号：US12747703
申请日：2008-10-08
申请人： David A. Edwards , Jonathan Ma , Jonathan Jacques Kamler , José Sanchez
发明人： David A. Edwards , Jonathan Ma , Jonathan Jacques Kamler , José Sanchez
IPC分类号： A61M11/00
CPC分类号： A23G1/505 , A23G1/305 , A23G1/50 , A24F7/00 , A61M11/001 , A61M11/005
摘要： Aerosolized food products can be of sufficient size to deposit in the mouth without easily entering into the respiratory tract and of small enough size so as to allow for suspension in air. An apparatus (110) incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a matter suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus (110) represents a novel means of delivering food to the mouths of humans and animals. Indeed, the apparatus (110) of the invention is designed to produce, transport, and direct aerosolized food particles of sufficient size to deposit in the mouth without substantial exposure or entry into the respiratory tract and of small enough size so as to allow for suspension in air.
摘要翻译：气溶胶食品可以具有足够的尺寸以沉积在口中，而不会容易地进入呼吸道和足够小的尺寸，以便允许在空气中悬浮。结合烟雾发生装置和食品的装置（110）可以允许食物产品的雾化及其在适于吸入或沉积和随后摄取的物质中的输送。食物输送装置（110）代表将食物输送到人和动物口中的新颖手段。实际上，本发明的装置（110）被设计成产生，运输和引导足够尺寸的雾化食物颗粒以沉积在口中而不会大量暴露或进入呼吸道并且具有足够小的尺寸以允许悬浮在空气中

25. 发明授权

US07260745B1 Detection of information on an interconnect 有权
标题翻译：检测互连上的信息
公开(公告)号：US07260745B1
公开(公告)日：2007-08-21
申请号：US09410642
申请日：1999-10-01
申请人： David A. Edwards , Andrew M. Jones , Anthony W. Rich
发明人： David A. Edwards , Andrew M. Jones , Anthony W. Rich
IPC分类号： G06F11/00
CPC分类号： G06F11/3636 , G06F11/364 , G06F11/3648
摘要： In a system comprising an interconnect and a plurality of modules connected to said interconnect for putting information onto the interconnect, a circuit comprising circuitry for receiving at least part of said of said information; circuitry for determining if said at least part of said information satisfies one or more conditions; and circuitry for performing one or more actions in response to the determination that at least part of the information satisfies one or more conditions.
摘要翻译：在包括互连和连接到所述互连以将信息放置到互连上的多个模块的系统中，包括用于接收所述信息的至少一部分的电路的电路; 用于确定所述信息的至少一部分是否满足一个或多个条件的电路; 以及用于响应于至少部分信息满足一个或多个条件的确定而执行一个或多个动作的电路。

26. 发明授权

US06779145B1 System and method for communicating with an integrated circuit 有权
标题翻译：与集成电路进行通信的系统和方法
公开(公告)号：US06779145B1
公开(公告)日：2004-08-17
申请号：US09410860
申请日：1999-10-01
申请人： David A. Edwards , Stephen James Wright , Bernard Ramanadin
发明人： David A. Edwards , Stephen James Wright , Bernard Ramanadin
IPC分类号： G01R3128
CPC分类号： G06F11/3636 , G06F11/3656
摘要： A system and method for communicating with an integrated circuit is provided that allows an integrated circuit to communicate debugging information and system bus transaction information with an external system. The system may include an interface protocol that provides flow control between the integrated circuit and the external system. The system may include a high-speed link and/or a JTAG link for communicating information. A link may be automatically selected by a debug circuit, or selected by an on-chip device or external system. The high-speed link enables real-time collection of trace information. Links may be memory-mapped, such that on-chip devices and other devices attached to the system bus may access the external system. The high-speed link may also operate at a rate which is integrally coupled with a rate of the processor or system bus. Further, the high-speed link may be adapted to change speeds in response to a change in operating speed of the system bus or processor. The JTAG interface may utilize standard JTAG components and instructions such that external devices such as debug adaptors adopting these components and instructions may be re-used for different integrated circuit types. Information transmitted over the JTAG-or high-speed link may be compressed to optimize available bandwidth of the links. Also, processor control signals can be transferred through links that allow an external system to manipulate and monitor operation of the processor and its associated modules.
摘要翻译：提供了一种用于与集成电路通信的系统和方法，其允许集成电路与外部系统通信调试信息和系统总线事务信息。该系统可以包括在集成电路和外部系统之间提供流量控制的接口协议。该系统可以包括用于传送信息的高速链路和/或JTAG链路。链路可以由调试电路自动选择，或由片上设备或外部系统选择。高速链路可实时追踪跟踪信息。链路可以是存储器映射的，使得连接到系统总线的片上设备和其他设备可以访问外部系统。高速链路也可以以与处理器或系统总线的速率整体耦合的速率工作。此外，高速链路可以适应于响应于系统总线或处理器的操作速度的变化来改变速度。 JTAG接口可以使用标准的JTAG组件和指令，使得诸如使用这些组件和指令的调试适配器的外部设备可以被重新用于不同的集成电路类型。通过JTAG或高速链路发送的信息可以被压缩以优化链路的可用带宽。此外，处理器控制信号可以通过允许外部系统操纵和监视处理器及其相关模块的操作的链路传送。

27. 发明授权

US06622200B1 Method of performing reliable updates in a symmetrically blocked nonvolatile memory having a bifurcated storage architecture 失效
标题翻译：在具有分叉存储架构的对称阻挡的非易失性存储器中执行可靠更新的方法
公开(公告)号：US06622200B1
公开(公告)日：2003-09-16
申请号：US09659025
申请日：2000-09-06
申请人： Robert N. Hasbun , David A. Edwards , Andrew H. Gafken , Christopher J. Spiegel
发明人： Robert N. Hasbun , David A. Edwards , Andrew H. Gafken , Christopher J. Spiegel
IPC分类号： G06F1200
CPC分类号： G06F9/5016 , G06F8/654 , G06F12/0246
摘要： Methods of allocating, writing, reading, de-allocating, re-allocating, and reclaiming space within a nonvolatile memory having a bifurcated storage architecture are described. A method of reliably re-allocating a first object includes the step of storing a location of a first object in a first data structure. A location of the first data structure is stored in a second data structure. A duplicate of the first object is formed by initiating a copy of the first object. An erase of the first object is initiated. A write of a second object to the location of the first object is then initiated. The duplicate object is invalidated. The status of copying, erasing, and writing is tracked. The copy status, erase status, write status, and a restoration status are used to determine a recovery state upon initialization of the nonvolatile memory. The duplicate object is invalidated, if the writing status indicates that the writing of the second object has been completed. The first object is erased, if a restoration status indicates copying of the duplicate object was initiated but not completed. The erasing of the first object is completed, if the erase status indicates that erasure of the first object is not completed. A restoration of the duplicate object to the location of the first object is initiated, if the copying status indicates that copying of the first object was completed. The copying of the duplicate object is tracked as a restoration status.
摘要翻译：描述在具有分叉存储架构的非易失性存储器内分配，写入，读取，分配，重新分配和回收空间的方法。可靠地重新分配第一对象的方法包括将第一对象的位置存储在第一数据结构中的步骤。第一数据结构的位置被存储在第二数据结构中。通过启动第一个对象的副本来形成第一个对象的副本。启动第一个对象的擦除。然后启动对第一对象的位置的第二对象的写入。重复的对象无效。跟踪复制，删除和写入的状态。复制状态，擦除状态，写入状态和恢复状态用于在初始化非易失性存储器时确定恢复状态。如果写入状态指示第二个对象的写入已经完成，则重复的对象无效。第一个对象被删除，如果恢复状态指示复制对象的复制被启动但未完成。如果擦除状态指示第一个对象的擦除未完成，则完成第一个对象的擦除。如果复制状态指示第一个对象的复制已经完成，那么将重新启动对象到第一个对象的位置的恢复。复制对象的复制被跟踪为恢复状态。

28. 发明授权

US06436443B2 Porous particles comprising excipients for deep lung delivery 有权
标题翻译：包含用于深肺输送的赋形剂的多孔颗粒
公开(公告)号：US06436443B2
公开(公告)日：2002-08-20
申请号：US09888688
申请日：2001-06-25
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137 , Y10S514/826 , Y10S514/851
摘要： Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The porous particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.
摘要翻译：提供用于向肺系统递送药物的改进的多孔颗粒，以及用于其合成和给药的方法。在优选的实施方案中，多孔颗粒由可生物降解的材料制成，其质量密度小于0.4g / cm 3 /。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述聚酯接枝共聚物由具有至少一个氨基酸基团的直链α-羟基酸聚酯主链和至少一个从氨基酸延伸的聚（氨基酸）侧链组成集团在聚酯骨干。在一个实施方案中，具有相对大的平均直径，例如大于5um的多孔颗粒可用于增强治疗剂递送至肺的肺泡区域。掺入治疗剂的多孔颗粒可以有效地雾化，用于给予呼吸道以允许全身或局部递送多种治疗剂。

29. 发明授权

US5937434A Method of managing a symmetrically blocked nonvolatile memory having a bifurcated storage architecture 失效
标题翻译：管理具有分叉存储架构的对称封锁非易失性存储器的方法
公开(公告)号：US5937434A
公开(公告)日：1999-08-10
申请号：US801781
申请日：1997-02-14
申请人： Robert N. Hasbun , David A. Edwards , Andrew H. Gafken
发明人： Robert N. Hasbun , David A. Edwards , Andrew H. Gafken
IPC分类号： G06F11/14 , G06F12/02
CPC分类号： G06F12/023 , G06F11/1433 , G06F12/0246
摘要： Methods of allocating, writing, reading, de-allocating, re-allocating, and reclaiming space within a nonvolatile memory having a bifurcated storage architecture are described. A method of storing an object within a managed object space of the nonvolatile memory includes the step of determining an object class for the object. Objects of a first class are stored contiguously proceeding from a first end towards a second end of the managed object space to form a first class of space. Objects of a second class are stored contiguously proceeding from the second end towards the first end of managed object space to form a second class of space. A header identifying the object is stored at a bottom of the first class of space. The object is stored at a selected one of the bottom of the first class of space and a bottom of the second class of space in accordance with the object class.
摘要翻译：描述在具有分叉存储架构的非易失性存储器内分配，写入，读取，分配，重新分配和回收空间的方法。将对象存储在非易失性存储器的管理对象空间内的方法包括确定对象的对象类的步骤。第一类的对象从被管理对象空间的第一端到第二端连续存储以形成第一类空间。第二类的对象从被管理对象空间的第二端向第一端连续存储以形成第二类空间。识别对象的标题存储在第一类空间的底部。根据对象类，对象存储在第一类空间的底部的选定的一个和第二类空间的底部。

30. 发明授权

US5550982A Video application server 失效
标题翻译：视频应用服务器
公开(公告)号：US5550982A
公开(公告)日：1996-08-27
申请号：US82227
申请日：1993-06-24
申请人： James E. Long , Joseph M. Gang, Jr. , Charles J. Bedard , Randall B. Baird , David A. Edwards
发明人： James E. Long , Joseph M. Gang, Jr. , Charles J. Bedard , Randall B. Baird , David A. Edwards
IPC分类号： H04L29/06 , G06F13/42
CPC分类号： H04L29/06 , H04L65/4076 , H04N21/2747 , H04L29/06027 , H04L67/42
摘要： A local area network for supporting video applications comprises a transmission medium, one or more data file servers connected to the transmission medium for supporting data applications in the local area network, a dedicated video server for supporting video applications in the local area network and one or more clients connected to the local area network. The server includes software for managing multiple simultaneous video streams transmitted across the LAN. The client includes software for accessing the dedicated video server across the LAN to transmit video to the server or receive video from the server.
摘要翻译：用于支持视频应用的局域网包括传输介质，连接到传输介质的用于在局域网中支持数据应用的一个或多个数据文件服务器，用于在局域网中支持视频应用的专用视频服务器，以及一个或多个更多的客户端连接到局域网。该服务器包括用于管理跨LAN传输的多个同时视频流的软件。客户端包括用于访问跨LAN的专用视频服务器的软件，以将视频传输到服务器或从服务器接收视频。

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