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21. 发明授权

US07232435B2 Delivery of a sympatholytic cardiovascular agent to the central nervous system to counter heart failure and pathologies associated with heart failure 有权
标题翻译：向中枢神经系统递送交感神经心血管药物以对抗心力衰竭和与心力衰竭相关的病理
公开(公告)号：US07232435B2
公开(公告)日：2007-06-19
申请号：US10773965
申请日：2004-02-06
申请人： Keith R. Hildebrand , Michael R. Ujhelyi , Xiaohong Zhou , Daniel C. Sigg , Linda M. Page
发明人： Keith R. Hildebrand , Michael R. Ujhelyi , Xiaohong Zhou , Daniel C. Sigg , Linda M. Page
IPC分类号： A61K9/22
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms and otherwise treat heart failure (HF) and pathologies associated with HF. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with HF (or pathologies associated with HF) and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist, e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine.
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解症状，另外治疗与HF有关的心力衰竭（HF）和病理学。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与HF相关的生理学参数（或与HF相关的病理学）和触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药物是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂组成的组之一，例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫西康定，甲基多巴，甲苯噻嗪，胍法辛，右美托咪定。

22. 发明授权

US08672917B2 Pressure monitoring to control delivery of therapeutic agent 有权
公开(公告)号：US08672917B2
公开(公告)日：2014-03-18
申请号：US12767224
申请日：2010-04-26
申请人： Daniel C. Sigg , Prasanga D. Hiniduma-Lokuge , Mary M. Morris
发明人： Daniel C. Sigg , Prasanga D. Hiniduma-Lokuge , Mary M. Morris
IPC分类号： A61M31/00
CPC分类号： A61B5/036 , A61B5/0031 , A61B5/0215 , A61B5/4839 , A61M5/14276 , A61M5/16854 , A61M5/1723 , A61M2005/1726 , A61M2205/3331 , A61M2205/3334
摘要： A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.

23. 发明授权

US08332051B2 High impedance active fixation electrode of an electrical medical lead 有权
标题翻译：电气医用引线的高阻抗主动固定电极
公开(公告)号：US08332051B2
公开(公告)日：2012-12-11
申请号：US12782465
申请日：2010-05-18
申请人： John L. Sommer , Daniel C. Sigg , James A. Coles, Jr.
发明人： John L. Sommer , Daniel C. Sigg , James A. Coles, Jr.
IPC分类号： A61N1/00
CPC分类号： A61N1/0573
摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.
摘要翻译：公开了具有主动固定电极的电医疗引线，特别是旨在拧入身体组织（例如心脏）的螺旋电极，其具有选择性地施加的绝缘体以优化暴露的电极表面积，并将暴露的电极表面区域设置成较少受到创伤的组织螺钉固定螺旋引起的损伤。在优选的制造方法中，外部螺旋表面通过与掩蔽管的接触而被掩蔽，同时将电介质涂层施加到螺旋线圈匝的内螺旋形表面，并且当电介质涂层固化时，掩蔽管被去除。在一个变型中，通过掩蔽管侧壁形成至少一个孔，暴露外螺旋表面的一个区域，从而中断未绝缘的外螺旋电极。

24. 发明授权

US08126549B2 Cardiac protection system and method 有权
标题翻译：心脏保护系统及方法
公开(公告)号：US08126549B2
公开(公告)日：2012-02-28
申请号：US12173780
申请日：2008-07-15
申请人： Daniel C. Sigg , James A. Coles, Jr. , Dwight H. Warkentin , Deborah Ann Jaye
发明人： Daniel C. Sigg , James A. Coles, Jr. , Dwight H. Warkentin , Deborah Ann Jaye
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61B5/0031 , A61N1/368 , A61N1/3702 , A61N1/37258 , A61N1/37282 , A61N1/37288
摘要： A cardiac ischemic protection system and method for conditioning a patient's heart is provided. The method can include detecting acute myocardial infarction, angina pectoris, silent ischemia, or stunning and providing closed-loop dyssynchronous pacing to the patient's heart to precondition and/or postcondition the patient's heart in order to reduce ischemic damage.
摘要翻译：提供了用于调节患者心脏的心脏缺血保护系统和方法。该方法可以包括检测急性心肌梗塞，心绞痛，静息缺血或惊恐，并向患者的心脏提供闭环异步起搏以预先和/或后置病人的心脏以减少缺血性损伤。

25. 发明申请

US20110077574A1 SYSTEM AND METHOD TO REGULATE ULTRAFILTRATION 有权
标题翻译：用于调节超滤的系统和方法
公开(公告)号：US20110077574A1
公开(公告)日：2011-03-31
申请号：US12571127
申请日：2009-09-30
申请人： Daniel C. Sigg , Sarah Anne Audet , Tommy D. Bennett , Dwight H. Warkentin
发明人： Daniel C. Sigg , Sarah Anne Audet , Tommy D. Bennett , Dwight H. Warkentin
IPC分类号： A61M1/36
CPC分类号： A61M1/3403 , A61M1/16 , A61M1/34 , A61M1/3406 , A61M1/341 , A61M1/36 , A61M1/3669 , A61M2205/18 , A61M2205/33 , A61M2205/3334 , A61M2205/3344 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/005 , A61M2230/04 , A61M2230/20 , A61M2230/201 , A61M2230/30 , A61M2230/65
摘要： A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.
摘要翻译：包括生理传感器和超滤单元的医疗装置系统感测患者的生理信号，并使用生理信号计算患者的流体状况测量。根据响应于流体状态测量而建立的治疗递送控制参数将超滤治疗递送给患者。

26. 发明申请

US20100292768A1 HIGH IMPEDANCE ACTIVE FIXATION ELECTRODE OF AN ELECTRICAL MEDICAL LEAD 有权
标题翻译：电气医疗铅的高阻抗活性固定电极
公开(公告)号：US20100292768A1
公开(公告)日：2010-11-18
申请号：US12782465
申请日：2010-05-18
申请人： John L. Sommer , Daniel C. Sigg , James A. Coles, JR.
发明人： John L. Sommer , Daniel C. Sigg , James A. Coles, JR.
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.
摘要翻译：公开了具有主动固定电极的电医疗引线，特别是旨在拧入身体组织（例如心脏）的螺旋电极，其具有选择性地施加的绝缘体以优化暴露的电极表面积，并将暴露的电极表面区域设置成较少受到创伤的组织螺钉固定螺旋引起的损伤。在优选的制造方法中，外部螺旋表面通过与掩蔽管的接触而被掩蔽，同时将电介质涂层施加到螺旋线圈匝的内螺旋形表面，并且当电介质涂层固化时，掩蔽管被去除。在一个变型中，通过掩蔽管侧壁形成至少一个孔，暴露外螺旋表面的一个区域，从而中断未绝缘的外螺旋电极。

27. 发明授权

US07742809B2 Electroporation catheter with sensing capabilities 有权
标题翻译：具有感应能力的电穿孔导管
公开(公告)号：US07742809B2
公开(公告)日：2010-06-22
申请号：US10647522
申请日：2003-08-25
申请人： Daniel C. Sigg , Daisy P. Cross , Jesus W. Casas-Bejar , Rodolfo A. Padua
发明人： Daniel C. Sigg , Daisy P. Cross , Jesus W. Casas-Bejar , Rodolfo A. Padua
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61N1/0575
摘要： In general, the invention is directed to techniques for delivering macromolecules to a tissue site via electroporation. Particularly, a catheter detects contact between a distal end of the catheter and a target tissue site via a sensing electrode at the distal end of the catheter. The catheter delivers a fluid containing macromolecules to the tissue site upon detecting contact between the tissue site and the catheter. Concurrently or soon after delivery of the fluid, an electrical stimulus is applied to the tissue site. The electrical stimulus can be applied by the catheter or directly from a power supply, such as an implanted pulse generator. The electrical stimulus causes membranes of cells within the tissue site to destabilize, in turn, forming pores through which the macromolecules migrate into the cells of the tissue site.
摘要翻译：通常，本发明涉及通过电穿孔将大分子递送到组织部位的技术。特别地，导管通过导管远端处的感测电极来检测导管的远端与目标组织部位之间的接触。当检测到组织部位和导管之间的接触时，导管将含有大分子的流体输送到组织部位。流体同时或不久之后，电刺激被施加到组织部位。电刺激可以由导管或直接从诸如注入脉冲发生器的电源施加。电刺激导致组织部位内的细胞膜破坏稳定，反过来，形成孔，大分子通过这些孔迁移到组织部位的细胞中。

28. 发明申请

US20080228133A1 DELIVERY OF A SYMPATHOLYTIC CARDIOVASCULAR AGENT TO THE CENTRAL NERVOUS SYSTEM 有权
标题翻译：向中央神经系统递送病理性心脏血管代谢
公开(公告)号：US20080228133A1
公开(公告)日：2008-09-18
申请号：US12128046
申请日：2008-05-28
申请人： KEITH R. HILDEBRAND , Michael R. Ujhelyi , Xiaohong Zhou , Daniel C. Sigg , Linda M. Page
发明人： KEITH R. HILDEBRAND , Michael R. Ujhelyi , Xiaohong Zhou , Daniel C. Sigg , Linda M. Page
IPC分类号： A61M31/00
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西林，美托洛尼，美托咪定和右美托咪定）。

29. 发明授权

US07274966B2 Medical fluid delivery system 有权
标题翻译：医疗液体输送系统
公开(公告)号：US07274966B2
公开(公告)日：2007-09-25
申请号：US10754173
申请日：2004-01-08
申请人： John L. Sommer , James A. Coles, Jr. , Daniel C. Sigg
发明人： John L. Sommer , James A. Coles, Jr. , Daniel C. Sigg
IPC分类号： A61N1/00
CPC分类号： A61M25/0082 , A61M25/0026 , A61M25/0084 , A61M2025/0089 , A61M2025/0095 , A61N1/05 , A61N1/0575 , A61N1/0587
摘要： A medical fluid delivery system includes an implantable medical lead including a fixation element adapted to secure the lead to a tissue site and a fluid delivery device including a tissue piercing distal tip; the device is adapted to pass through a proximal port, a lumen and a distal port of the lead. The system further includes means for adjusting a position of the device distal tip with respect to the lead distal port.
摘要翻译：医疗流体递送系统包括可植入医疗引线，其包括适于将引线固定到组织部位的固定元件和包括组织穿刺远端的流体输送装置; 该装置适于穿过导线的近端口，内腔和远端口。所述系统还包括用于调节所述装置远侧尖端相对于所述引线远端端口的位置的装置。

30. 发明授权

US06931286B2 Delivery of active fixation implatable lead systems 失效
标题翻译：交付主动固定牵引系统
公开(公告)号：US06931286B2
公开(公告)日：2005-08-16
申请号：US10423116
申请日：2003-04-25
申请人： Daniel C. Sigg , John L. Sommer
发明人： Daniel C. Sigg , John L. Sommer
IPC分类号： A61M25/00 , A61N1/05 , A61N1/00
CPC分类号： A61M25/0082 , A61M25/0026 , A61M25/0084 , A61M2025/0089 , A61M2025/0095 , A61N1/05 , A61N1/0575 , A61N1/0587
摘要： An implantable lead system includes an elongated device slideably engaged within a lumen of a lead body. A distal portion of the elongated device is slidable through a helix tip coupled to a distal end of the lead body by passing through a pierceable fluid-tight seal disposed in proximity to the distal end of the lead body; the seal prevents ingress of bodily fluid into the lumen of the lead body.
摘要翻译：可植入引线系统包括可滑动地接合在引线主体的内腔内的细长装置。细长装置的远端部分可以通过穿过设置在引线主体的远端附近的可刺穿的流体密封的密封件，该螺旋尖端联接到引线主体的远端; 密封件防止体液进入引线体的内腔。

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