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21. 发明申请

US20060160245A1 METHODS TO VIEW AND ANALYZE THE RESULTS FROM DIFFRACTION-BASED DIAGNOSTICS 有权
标题翻译：从基于误差的诊断中查看和分析结果的方法
公开(公告)号：US20060160245A1
公开(公告)日：2006-07-20
申请号：US10013972
申请日：2001-12-11
申请人： Rosann Kaylor , Difei Yang , Zdravko Atanassov , Michael Knotts
发明人： Rosann Kaylor , Difei Yang , Zdravko Atanassov , Michael Knotts
IPC分类号： G01N33/543 , G06F19/00
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/4788 , G01N33/02 , G01N33/493 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： An analyzer useful in determining the presence of an analyte using a diffraction based sensing device and methods and systems using this device. The present invention may be used with a variety of different diffraction-based diagnostic methods and systems. The analyzer enhances the accuracy and/or usefulness of these devices in detecting analytes, while providing more ease-of-use and convenience to the user. The analyzer may include a light source, a photodiode, a microprocessor and a display system for informing the user of the result. Other features include mirrors, lenses, a sample holder, and a mask for blocking out some light. The analyzer and related method and system may be used in a large number of environments, including commercial, professional, and individual.
摘要翻译：用于使用基于衍射的感测装置和使用该装置的方法和系统来确定分析物的存在的分析器。本发明可以与各种不同的基于衍射的诊断方法和系统一起使用。分析仪提高了这些设备在检测分析物中的准确性和/或有用性，同时为用户提供了更易于使用和便利的功能。分析器可以包括光源，光电二极管，微处理器和用于向用户通知结果的显示系统。其他功能包括镜子，镜头，样品架和遮挡一些光线的面罩。分析仪及相关方法和系统可用于大量环境中，包括商业，专业和个人。

22. 发明申请

US20050136529A1 Laminated assay devices 有权
标题翻译：层压测定装置
公开(公告)号：US20050136529A1
公开(公告)日：2005-06-23
申请号：US10741434
申请日：2003-12-19
申请人： Kaiyuan Yang , Xuedong Song , Rosann Kaylor
发明人： Kaiyuan Yang , Xuedong Song , Rosann Kaylor
IPC分类号： C12M1/34 , C12Q1/54 , G01N33/543 , G01N33/551
CPC分类号： G01N33/5438
摘要： An electrochemical-based assay device capable of detecting the presence or quantity of an analyte of interest that is provided. The device contains two or more substrates, one containing a detection working electrode and another containing an auxiliary electrode, such as a counter/reference electrode(s). The substrates are positioned in a face-to-face relationship so that the electrodes are adjacent to each other during performance of the assay. Besides the electrodes, any of a variety of other components may also be employed in the assay device.
摘要翻译：能够检测所提供的感兴趣分析物的存在或数量的基于电化学的测定装置。该装置包含两个或更多个基板，一个包含检测工作电极，另一个基板包含辅助电极，例如计数器/参考电极。基板以面对面的关系定位，使得在测定过程中电极彼此相邻。除了电极之外，还可以在测定装置中使用各种其它组分中的任何一种。

23. 发明申请

US20050101841A9 Healthcare networks with biosensors 审中-公开
标题翻译：保健网络与生物传感器
公开(公告)号：US20050101841A9
公开(公告)日：2005-05-12
申请号：US10277170
申请日：2002-10-21
申请人： Rosann Kaylor , Dennis Everhart , Jeff Lindsay
发明人： Rosann Kaylor , Dennis Everhart , Jeff Lindsay
IPC分类号： G06F19/00 , G06F17/60 , A61B5/00 , A61N1/30
CPC分类号： G06F19/3418 , G06F19/00 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要： A healthcare network is provided for sharing information concerning the health of a user with at least one outside source, the network including a biosensor associated with the user that generates a biosensor signal containing the information; and a personal data control means including receiving means for receiving the biosensor signal, input means for receiving a privacy input from the user, and output means for generating a response signal based on the biosensor signal and privacy input. The network also includes a data allocation and processing module including means for receiving the response signal, and means for generating and directing an output signal to the at least one outside source, wherein the module is responsive to the response signal, and wherein the availability of the information to the at least one outside source is responsive to the privacy input.
摘要翻译：提供医疗保健网络，用于与至少一个外部来源共享关于用户的健康的信息，所述网络包括与用户相关联的生物传感器，其生成包含所述信息的生物传感器信号; 以及个人数据控制装置，包括用于接收生物传感器信号的接收装置，用于从用户接收隐私输入的输入装置，以及用于基于生物传感器信号和隐私输入产生响应信号的输出装置。网络还包括数据分配和处理模块，包括用于接收响应信号的装置，以及用于产生和指导输出信号到至少一个外部源的装置，其中模块响应响应信号，并且其中可用性至少一个外部源的信息响应于隐私输入。

24. 发明授权

US08367013B2 Reading device, method, and system for conducting lateral flow assays 有权
公开(公告)号：US08367013B2
公开(公告)日：2013-02-05
申请号：US10035013
申请日：2001-12-24
申请人： Rosann Kaylor , Difei Yang , Michael Knotts
发明人： Rosann Kaylor , Difei Yang , Michael Knotts
IPC分类号： G01N33/48
CPC分类号： G01N21/8483 , G01N33/558
摘要： An optical reflectance kit including a reading device and membrane test strip is disclosed for conducting a lateral flow assay. The reading device is portable. Assays may be conducted on bodily fluids to detect with high sensitivity the presence of certain hormones, glucose, or other bodily fluids of interest. Membrane test strips may receive a test fluid or test sample containing an analyte to be detected. The membrane test strips may be inserted directly into a receiving port of a reading device. Shielding stray light from the receiving port improves sensitivity and reduces the entry of stray or ambient light into the reading device. The reading device also includes one or more sensors capable of detecting the intensity of reflected electromagnetic radiation.

25. 发明授权

US08034397B2 Methods of making assay devices utilizing hollow particles 有权
标题翻译：使用中空颗粒制备测定装置的方法
公开(公告)号：US08034397B2
公开(公告)日：2011-10-11
申请号：US12891967
申请日：2010-09-28
申请人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
发明人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
IPC分类号： G01N1/31
CPC分类号： G01N33/587 , G01N33/558
摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
摘要翻译：提供了用于各种类型的测定装置的中空颗粒。由于其中空或空隙结构，颗粒可能表现出各种有益的性质。例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

26. 发明授权

US07943089B2 Laminated assay devices 有权
标题翻译：层压测定装置
公开(公告)号：US07943089B2
公开(公告)日：2011-05-17
申请号：US10741434
申请日：2003-12-19
申请人： Kaiyuan Yang , Xuedong Song , Rosann Kaylor
发明人： Kaiyuan Yang , Xuedong Song , Rosann Kaylor
IPC分类号： G01N27/00
CPC分类号： G01N33/5438
摘要： An electrochemical-based assay device capable of detecting the presence or quantity of an analyte of interest that is provided. The device contains two or more substrates, one containing a detection working electrode and another containing an auxiliary electrode, such as a counter/reference electrode(s). The substrates are positioned in a face-to-face relationship so that the electrodes are adjacent to each other during performance of the assay. Besides the electrodes, any of a variety of other components may also be employed in the assay device.
摘要翻译：能够检测所提供的感兴趣分析物的存在或数量的基于电化学的测定装置。该装置包含两个或更多个基板，一个包含检测工作电极，另一个基板包含辅助电极，例如计数器/参考电极。基板以面对面的关系定位，使得在测定过程中电极彼此相邻。除了电极之外，还可以在测定装置中使用各种其它组分中的任何一种。

27. 发明授权

US07829328B2 Assay devices that utilize hollow particles 有权
标题翻译：使用中空颗粒的测定装置
公开(公告)号：US07829328B2
公开(公告)日：2010-11-09
申请号：US11440956
申请日：2006-05-25
申请人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
发明人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
IPC分类号： C12M1/34
CPC分类号： G01N33/587 , G01N33/558
摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
摘要翻译：提供了用于各种类型的测定装置的中空颗粒。由于其中空或空隙结构，颗粒可能表现出各种有益的性质。例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

28. 发明申请

US20070048182A1 Nitrite detection technique 有权
标题翻译：亚硝酸盐检测技术
公开(公告)号：US20070048182A1
公开(公告)日：2007-03-01
申请号：US11217099
申请日：2005-08-31
申请人： Xuedong Song , Rosann Kaylor
发明人： Xuedong Song , Rosann Kaylor
IPC分类号： B01L3/00
CPC分类号： G01N33/526 , G01N2800/348 , Y10T436/173076
摘要： A diagnostic test kit for detecting the presence or absence of nitrites within a test sample is provided. The test kit comprises an aromatic primary amine that is capable of reacting with a nitrite to form a diazonium ion. The test kit also comprises a lateral flow device that comprises a chromatographic medium and an absorbent material that receives the test sample after flowing through the chromatographic medium. The chromatographic medium defines a detection zone within which is contained a detection reagent (e.g., nucleophilic aromatic amine) that is capable of reacting with the diazonium ion to form an indicator (e.g., azo compound). The indicator exhibits a color that is different than the color of the detection reagent.
摘要翻译：提供了用于检测测试样品中亚硝酸盐存在或不存在的诊断测试试剂盒。测试试剂盒包括能够与亚硝酸盐反应形成重氮离子的芳族伯胺。测试试剂盒还包括侧流装置，其包括色谱介质和在流过色谱介质之后接收测试样品的吸收材料。色谱介质限定了检测区，其中含有能够与重氮离子反应形成指示剂（例如偶氮化合物）的检测试剂（例如亲核芳族胺）。指示剂显示与检测试剂的颜色不同的颜色。

29. 发明申请

US20060127886A1 Sample-efficient lateral flow immunoassay 审中-公开
标题翻译：采样效率的侧流免疫测定
公开(公告)号：US20060127886A1
公开(公告)日：2006-06-15
申请号：US11012759
申请日：2004-12-15
申请人： Rosann Kaylor , Ning Wei , Chibueze Chidebelu-Eze , Shawn Feaster , Paul Christopher
发明人： Rosann Kaylor , Ning Wei , Chibueze Chidebelu-Eze , Shawn Feaster , Paul Christopher
IPC分类号： C12Q1/70 , G01N33/554 , G01N33/53 , G01N33/558 , G01N33/569 , C12Q1/68
CPC分类号： G01N33/558
摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in communication with a conjugate pad and a wicking pad. The porous membrane has a detection zone which has an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. A control zone may be located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. The sample is deposited between the control and detection zones. A buffer release zone is located upstream of the conjugate pad and provides for buffer addition to the device, the buffer serving to move the detection probes to the detection and control zones.
摘要翻译：提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与缀合垫和芯吸垫连通的多孔膜。多孔膜具有检测区，其具有被配置为结合至少一部分分析物和分析物 - 共轭复合物的固定的第一捕获试剂以产生检测信号。控制区可以位于多孔膜上的检测区的下游，并且具有固定在控制区内的第二捕获试剂。缀合垫位于检测区的上游，并具有用于分析物的具有特异性结合构件的检测探针。样品沉积在控制区和检测区之间。缓冲区释放区位于缀合垫的上游，并为缓冲器添加缓冲区，该缓冲器用于将检测探针移动到检测和控制区。

30. 发明申请

US20090314946A1 Membrane-Based Assay Devices that Utilize Time-Resolved Fluorescence 审中-公开
标题翻译：使用时间分辨荧光的基于膜的测定装置
公开(公告)号：US20090314946A1
公开(公告)日：2009-12-24
申请号：US12551048
申请日：2009-08-31
申请人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
发明人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
IPC分类号： G01N21/64 , G01T1/20
CPC分类号： G01N21/274 , G01N21/6408 , G01N21/6428 , G01N33/525 , G01N33/533 , G01N33/542 , G01N33/558 , G01N33/582 , G01N2021/6439 , G01N2201/062 , G01N2201/0696
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes time-resolved fluorescence to detect the signals generated by excited fluorescent labels. Because the labels can have relatively long emission lifetime, short-lived background interference can be practically eliminated through delayed fluorescence detection. In addition, the resulting fluorescent reader can have a simple and inexpensive design. For instance, in one embodiment, the reader can utilize a silicon photodiode and a pulsed light-emitting diode (LED) to accurately excite labels and detect fluorescence on a membrane-based assay device without requiring the use of expensive components, such as monochromators or narrow emission band width optical filters.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置利用时间分辨荧光检测激发的荧光标记产生的信号。因为标签的发光寿命可以较长，所以通过延迟荧光检测实际上可以消除短暂的背景干扰。此外，所得到的荧光读取器可以具有简单且便宜的设计。例如，在一个实施例中，读取器可以利用硅光电二极管和脉冲发光二极管（LED）来精确地激发标签并在基于膜的测定装置上检测荧光，而不需要使用昂贵的组件，例如单色仪或窄发射带宽滤光片。

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