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21. 发明授权

US09341691B2 Short TE 3D radial sampling sequence for MRI 有权
标题翻译：用于MRI的短TE 3D径向采样序列
公开(公告)号：US09341691B2
公开(公告)日：2016-05-17
申请号：US13128830
申请日：2009-11-11
申请人： Jang-Yeon Park , Steen Moeller , Ryan Chamberlain , Michael G. Garwood
发明人： Jang-Yeon Park , Steen Moeller , Ryan Chamberlain , Michael G. Garwood
IPC分类号： A61B5/05 , G01R33/48 , G01R33/46
CPC分类号： G01R33/4816 , G01R33/4641
摘要： A method for magnetic resonance imaging includes providing a radio frequency excitation pulse to a specimen. The pulse has a duration. The method includes, concurrent with providing the radio frequency excitation pulse, applying a first gradient having a first polarity. The method includes applying a readout gradient at a time after the duration. The readout gradient has inverse polarity relative to the first polarity. The method includes, concurrent with applying the readout gradient, acquiring magnetic resonance data from the specimen. The method includes generating an image based on the magnetic resonance data.
摘要翻译：一种用于磁共振成像的方法包括向样本提供射频激励脉冲。脉冲持续时间。该方法包括与提供射频激励脉冲同时施加具有第一极性的第一梯度。该方法包括在持续时间之后的一个时间应用读出梯度。读出梯度相对于第一极性具有相反的极性。该方法包括与应用读出梯度同时从样本获取磁共振数据。该方法包括基于磁共振数据生成图像。

22. 发明申请

US20110288398A1 SHORT TE 3D RADIAL SAMPLING SEQUENCE FOR MRI 有权
标题翻译：用于MRI的三维径向采样序列
公开(公告)号：US20110288398A1
公开(公告)日：2011-11-24
申请号：US13128830
申请日：2009-11-11
申请人： Jang-Yeon Park , Steen Moeller , Ryan Chamberlain , Michael G. Garwood
发明人： Jang-Yeon Park , Steen Moeller , Ryan Chamberlain , Michael G. Garwood
IPC分类号： A61B5/055
CPC分类号： G01R33/4816 , G01R33/4641
摘要： A method for magnetic resonance imaging includes providing a radio frequency excitation pulse to a specimen. The pulse has a duration. The method includes, concurrent with providing the radio frequency excitation pulse, applying a first gradient having a first polarity. The method includes applying a readout gradient at a time after the duration. The readout gradient has inverse polarity relative to the first polarity. The method includes, concurrent with applying the readout gradient, acquiring magnetic resonance data from the specimen. The method includes generating an image based on the magnetic resonance data.
摘要翻译：一种用于磁共振成像的方法包括向样本提供射频激励脉冲。脉冲持续时间。该方法包括与提供射频激励脉冲同时施加具有第一极性的第一梯度。该方法包括在持续时间之后的一个时间应用读出梯度。读出梯度相对于第一极性具有相反的极性。该方法包括与应用读出梯度同时从样本获取磁共振数据。该方法包括基于磁共振数据生成图像。

23. 发明授权

US07932719B2 Magnetic resonance contrast using fictitious field relaxation 有权
标题翻译：磁共振对比使用虚拟场弛豫
公开(公告)号：US07932719B2
公开(公告)日：2011-04-26
申请号：US12731936
申请日：2010-03-25
申请人： Timo Liimatainen , Michael G. Garwood , Dennis J. Sorce , Shalom Michaeli
发明人： Timo Liimatainen , Michael G. Garwood , Dennis J. Sorce , Shalom Michaeli
IPC分类号： G01V3/00
CPC分类号： A61B5/055 , G01R33/50
摘要： A system includes a signal generator and a processor. The signal generator is configured to couple with a magnetic resonance transmitter coil. The processor is configured to execute instructions to control the signal generator. The instructions include forming a sequence of waveforms. The sequence is configured to generate spin relaxation in a fictitious field in a third rotating frame of reference based on at least one magnetic field component that arises based on an effective field in a second rotating frame of reference. The third rotating frame of reference is of a higher order than the second rotating frame of reference and the second rotating frame of reference is of a higher order than the first rotating frame of reference.
摘要翻译：系统包括信号发生器和处理器。信号发生器被配置为与磁共振发射器线圈耦合。处理器被配置为执行指令来控制信号发生器。指令包括形成一系列波形。该序列被配置为基于基于第二旋转参考系中的有效场而产生的至少一个磁场分量在第三旋转参考系中的虚拟场中产生自旋弛豫。第三旋转参考系具有比第二旋转参考系更高的顺序，并且第二旋转参考系的参考点比第一旋转参考系高。

24. 发明授权

US07279899B2 Contrast from rotating frame relaxation by adiabatic pulses 有权
标题翻译：对比由绝热脉冲旋转框架松弛
公开(公告)号：US07279899B2
公开(公告)日：2007-10-09
申请号：US11244815
申请日：2005-10-06
申请人： Shalom Michaeli , Michael G. Garwood , Kamil Ugurbil , Dennis J. Sorce
发明人： Shalom Michaeli , Michael G. Garwood , Kamil Ugurbil , Dennis J. Sorce
IPC分类号： G01V3/00
CPC分类号： G01R33/446 , G01R33/50
摘要： This document discusses, among other things, a system and method for modulating transverse and longitudinal relaxation time contrast in a rotating frame based on a train of radio frequency pulses.
摘要翻译：本文件尤其涉及一种用于基于一串射频脉冲调制旋转帧中的横向和纵向弛豫时间对比度的系统和方法。

25. 发明申请

US20180085184A1 IMAGING FIDUCIAL MARKERS AND METHODS 审中-公开
公开(公告)号：US20180085184A1
公开(公告)日：2018-03-29
申请号：US15828021
申请日：2017-11-30
申请人： Patrick Bolan , Michael G. Garwood , Michael T. Nelson , Daniel A. Halpern
发明人： Patrick Bolan , Michael G. Garwood , Michael T. Nelson , Daniel A. Halpern
IPC分类号： A61B17/34 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61B8/08 , A61M31/00 , G01R33/48 , G01R33/56 , H01F41/02
CPC分类号： A61B90/39 , A61B8/481 , A61B17/3468 , A61B2090/3908 , A61B2090/3925 , A61B2090/3933 , A61B2090/3954 , A61B2090/3958 , A61B2090/3966 , A61B2090/397 , A61B2090/3995 , A61K49/0002 , A61K49/0447 , A61K49/18 , A61K49/223 , A61M31/002 , A61M31/005 , A61M37/00 , G01R33/4812 , G01R33/4814 , G01R33/5601 , G01R33/58 , H01F41/02 , H01F41/0253 , Y10T29/49075 , Y10T29/49888 , Y10T29/4998 , Y10T29/49982
摘要： An implantable tissue marker incorporates a contrast agent sealed within a chamber in a container formed from a solid material. The contrast agent is selected to produce a change, such as an increase, in signal intensity under magnetic resonance imaging (MRI). An additional contrast agent may also be sealed within the chamber to provide visibility under another imaging modality, such as computed tomographic (CT) imaging or ultrasound imaging.

26. 发明申请

US20140218028A1 BEAM STEERING WITH RESONANCE ALONG A TRAJECTORY 有权
标题翻译：光束转向与谐波在轨道
公开(公告)号：US20140218028A1
公开(公告)日：2014-08-07
申请号：US14174368
申请日：2014-02-06
申请人： Angela Lynn Styczynski Snyder , Carl J. Snyder , Michael G. Garwood , J. Thomas Vaughan, JR.
发明人： Angela Lynn Styczynski Snyder , Carl J. Snyder , Michael G. Garwood , J. Thomas Vaughan, JR.
IPC分类号： G01R33/44 , G01R33/32
CPC分类号： G01R33/4816 , G01R33/4833 , G01R33/56536 , G01R33/56563 , G01R33/5659
摘要： A method for generating a magnetic resonance image includes configuring a magnetic field to correspond to a trajectory within a region of interest. The method includes applying RF excitation to spatially control a region of magnetic resonance corresponding to the trajectory. The method includes modulating the magnetic field coincident with the spatially controlled region of magnetic resonance. The method includes acquiring data corresponding to the region of magnetic resonance and generating an image based on the data.
摘要翻译：用于产生磁共振图像的方法包括配置磁场以对应于感兴趣区域内的轨迹。该方法包括应用RF激励以空间控制对应于轨迹的磁共振区域。该方法包括调制与磁共振的空间受控区域一致的磁场。该方法包括获取对应于磁共振区域的数据并基于该数据生成图像。

27. 发明授权

US08072214B2 Method for magnetic resonance imaging using sequential excitation and refocusing 有权
标题翻译：使用顺序激发和重聚焦的磁共振成像方法
公开(公告)号：US08072214B2
公开(公告)日：2011-12-06
申请号：US12857370
申请日：2010-08-16
申请人： Ryan Chamberlain , Jang-Yeon Park , Michael G. Garwood
发明人： Ryan Chamberlain , Jang-Yeon Park , Michael G. Garwood
IPC分类号： G01V3/00
CPC分类号： G01R33/5615 , G01R33/4835 , G01R33/5616 , G01R33/56527 , G01R33/56536 , G01R33/56554
摘要： A method of magnetic resonance imaging based on rapid acquisition by sequential excitation and refocusing is provided. The method comprises turning on a first time-encoding gradient and applying an excitation pulse in the presence of the first time-encoding gradient. The excitation pulse excites magnetization sequentially along one spatial axis. Thereafter, a first refocusing pulse is applied. A second time-encoding gradient is turned on followed by a second refocusing pulse. A third time-encoding gradient is turned on and a signal is acquired in the presence of the third time-encoding gradient. The third time-encoding gradient sums to zero with the first time-encoding gradient and the second time-encoding gradient for sequential points in space.
摘要翻译：提供了一种通过顺序激发和重新聚焦快速获取的磁共振成像方法。该方法包括打开第一时间编码梯度并在第一时间编码梯度的存在下施加激励脉冲。激励脉冲沿着一个空间轴顺序地激发磁化。此后，施加第一重聚焦脉冲。第二次编码梯度被打开，接着是第二重新聚焦脉冲。第三时间编码梯度被打开，并且在存在第三时间编码梯度的情况下获取信号。第三时间编码梯度与空间中的连续点的第一时间编码梯度和第二时间编码梯度相加。

28. 发明授权

US06650116B2 Method and system for NMR using adiabatic RF pulses producing spatially quadratic phase 有权
标题翻译： NMR的方法和系统使用绝热RF脉冲产生空间二次相
公开(公告)号：US06650116B2
公开(公告)日：2003-11-18
申请号：US09961502
申请日：2001-09-24
申请人： Michael G. Garwood , Kamil Ugurbil , Lance DelaBarre , Patrick Bolan
发明人： Michael G. Garwood , Kamil Ugurbil , Lance DelaBarre , Patrick Bolan
IPC分类号： G01V300
CPC分类号： G01R33/4616 , G01R33/483
摘要： A method and system for performing MRI and NMR spectroscopy that improves the dynamic range of the received signal by using adiabatic RF pulses for spin excitation rather than for spin inversion. The preferred adiabatic RF excitation produces a spatially varying phase across the slab, and a sharp slab profile. The phase variation is divided up by a phase-encoding gradient into voxels having a phase variation that is negligible over the width of the voxel. The phase variation in the slab-select direction is, on the whole, large enough that the peak amplitude of the received signal is reduced and the signal width broadened. This reduces the dynamic range required of the analog to digital converter used in a NMR system. A NMR system suitable for carrying out the methods of the invention is also disclosed.
摘要翻译：用于执行MRI和NMR光谱的方法和系统，其通过使用绝热RF脉冲进行自旋激励而不是自旋反转来改善接收信号的动态范围。优选的绝热RF激发产生横跨板坯的空间变化的相位，并且产生锋利的板坯轮廓。相位变化通过相位编码梯度被划分成具有在体素的宽度上可忽略的相位变化的体素。平板选择方向的相位变化总体上足够大，使得接收信号的峰值幅度减小并且信号宽度变宽。这降低了在NMR系统中使用的模数转换器所需的动态范围。还公开了适用于实施本发明方法的NMR系统。

29. 发明授权

US09320452B2 Magnetic resonance imaging of amyloid plaque in the brain 有权
标题翻译：脑中淀粉样斑块的磁共振成像
公开(公告)号：US09320452B2
公开(公告)日：2016-04-26
申请号：US11631581
申请日：2005-06-28
申请人： Michael G. Garwood , Clifford R. Jack, Jr. , Joseph F Poduslo , Thomas M. Wengenack
发明人： Michael G. Garwood , Clifford R. Jack, Jr. , Joseph F Poduslo , Thomas M. Wengenack
IPC分类号： A61B5/055 , A61B5/00 , G01R33/567
CPC分类号： A61B5/055 , A61B5/4088 , A61B5/7285 , G01R33/5673
摘要： Amyloid plaque in the brain of a subject is imaged in an MRI system with or without the use of a contrast agent. Contrast is achieved using a spin-echo pulse sequence that is both respiratory gated and cardiac gated to reduce motion artifacts at the very high image resolution required to see plaque. A preparatory pulse sequence is used to insure longitudinal magnetization remains constant for all the acquired views even if the effective TR changes during the scan due to irregular breathing.
摘要翻译：受试者脑中的淀粉样斑块在使用或不使用造影剂的MRI系统中成像。使用呼吸门控和心脏门控的自旋回波脉冲序列来实现对比，以在看到斑块所需的非常高的图像分辨率下减少运动伪影。准备脉冲序列用于确保纵向磁化对于所有获取的视图保持恒定，即使由于不规则呼吸而在扫描期间有效TR发生变化。

30. 发明申请

US20100287887A1 TISSUE MARKER FOR MULTIMODALITY RADIOGRAPHIC IMAGING 有权
标题翻译：组织标记的多尺度放射成像
公开(公告)号：US20100287887A1
公开(公告)日：2010-11-18
申请号：US12762837
申请日：2010-04-19
申请人： Patrick Bolan , Michael G. Garwood , Michael T. Nelson , Daniel A. Halpern
发明人： Patrick Bolan , Michael G. Garwood , Michael T. Nelson , Daniel A. Halpern
IPC分类号： B65B3/02
CPC分类号： A61B90/39 , A61B8/481 , A61B17/3468 , A61B2090/3908 , A61B2090/3925 , A61B2090/3954 , A61B2090/3958 , A61B2090/3966 , A61B2090/397 , A61B2090/3995 , A61K49/0002 , A61K49/0447 , A61K49/18 , A61K49/223 , A61M31/002 , A61M31/005 , G01R33/4812 , G01R33/4814 , G01R33/5601 , H01F41/02 , H01F41/0253 , Y10T29/49075 , Y10T29/49888 , Y10T29/4998 , Y10T29/49982
摘要： An implantable tissue marker incorporates a contrast agent sealed within a chamber in a container formed from a solid material. The contrast agent is selected to produce a change, such as an increase, in signal intensity under magnetic resonance imaging (MRI). An additional contrast agent may also be sealed within the chamber to provide visibility under another imaging modality, such as computed tomographic (CT) imaging or ultrasound imaging.
摘要翻译：可植入组织标记包括密封在由固体材料形成的容器中的腔室内的造影剂。选择造影剂以在磁共振成像（MRI）下产生信号强度的变化，例如增加。还可以在腔室内密封另外的造影剂以提供另一成像模态（例如计算机断层摄影（CT）成像或超声成像）下的可视性。

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