专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US6117167A Endoluminal prosthesis and system for joining 失效
标题翻译：腔内假体和接合系统
公开(公告)号：US6117167A
公开(公告)日：2000-09-12
申请号：US20749
申请日：1998-02-09
申请人： George Goicoechea , John Hudson , Claude Mialhe , Andrew H. Cragg , Michael D. Dake
发明人： George Goicoechea , John Hudson , Claude Mialhe , Andrew H. Cragg , Michael D. Dake
IPC分类号： A61F2/00 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/848 , A61F2/90 , A61F2/954 , A61F2/958 , A61M25/12 , A61M29/00
CPC分类号： A61F2/852 , A61F2/07 , A61F2/82 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/828 , A61F2002/8486 , A61F2210/0019 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2220/0066 , A61F2220/0075 , A61F2230/0067 , A61F2240/001 , A61F2250/0098 , A61M25/0662 , Y10S623/903 , Y10T29/49826
摘要： A stent joining means is provided for joining a first endoluminal stent to a second endoluminal stent to define a continuous lumen through the first and second endoluminal stents. The stent joining means includes two transversely spaced female portions on the first endoluminal stent. The stent joining means also includes a male engaging portion of the second endoluminal stent. The male engaging portion is configured to be entered into one of the female portions in a radially compressed state and thereafter expanded in the female portion such that an outer surface of the male engaging portion and an inner surface of the female portion are interengaged to resist longitudinal movement to prevent separation of the first and second endoluminal stents in service.
摘要翻译：提供了一种支架接合装置，用于将第一腔内支架接合到第二腔内支架以限定穿过第一和第二腔内支架的连续内腔。支架接合装置包括在第一腔内支架上的两个横向隔开的阴部分。支架接合装置还包括第二腔内支架的阳啮合部分。阳接合部构造成以径向压缩状态进入阴部之一，然后在阴部扩展，使得阳接合部的外表面和阴部的内表面相互接合以抵抗纵向运动以防止第一和第二腔内支架在使用中分离。

22. 发明授权

US10172877B2 Compositions and methods for topical diagnostic and therapeutic transport 有权
公开(公告)号：US10172877B2
公开(公告)日：2019-01-08
申请号：US14642580
申请日：2015-03-09
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K47/64 , A61K47/59 , A61K9/00 , A61K31/343 , A61K31/4164 , A61K31/4196 , A61K31/4418 , A61K31/496 , A61K31/513 , A61K31/7076 , A61K49/00 , A61K31/7048 , A61K38/17 , A61K38/48 , C07K16/32
摘要： Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternatively, the composition can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.

23. 发明授权

US09180081B2 Compositions and methods for topical application and transdermal delivery of botulinum toxins 有权
标题翻译：用于局部应用和经皮递送肉毒杆菌毒素的组合物和方法
公开(公告)号：US09180081B2
公开(公告)日：2015-11-10
申请号：US11367642
申请日：2006-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K38/48 , A61K39/08 , A61K8/64 , A61Q19/08 , A61K9/00
CPC分类号： A61K38/4893 , A61K8/64 , A61K9/00 , A61K9/0014 , A61K9/0019 , A61K47/34 , A61K2800/56 , A61Q19/08 , C12Y304/24069
摘要： Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.
摘要翻译：公开了用于肉毒杆菌毒素透皮递送的改进制剂。制剂包括例如与带有支链或效能基团的带正电的骨架非共价结合的肉毒杆菌毒素。制剂还包括分配剂，寡桥或聚阴离子桥，并且可任选地含有粘度调节剂。该制剂被设计用于局部施用于患者的皮肤上，并且可以用于治疗皱纹，多汗症和其他与健康有关的问题。还描述了用于给药的试剂盒。

24. 发明申请

US20130123904A1 BIFURCATED ENDOLUMINAL PROSTHESIS 失效
标题翻译：分叉内分泌疾病
公开(公告)号：US20130123904A1
公开(公告)日：2013-05-16
申请号：US13601902
申请日：2012-08-31
申请人： Andrew H. Cragg , Claude Mialhe , George Goicoechea , John Hudson , Michael D. Dake
发明人： Andrew H. Cragg , Claude Mialhe , George Goicoechea , John Hudson , Michael D. Dake
IPC分类号： A61F2/852 , A61F2/07
CPC分类号： A61F2/852 , A61F2/07 , A61F2/82 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/828 , A61F2002/8486 , A61F2210/0019 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2220/0066 , A61F2220/0075 , A61F2230/0067 , A61F2240/001 , A61F2250/0098 , A61M25/0662 , Y10S623/903 , Y10T29/49826
摘要： The present disclosure provides a bifurcated stent for use in juxtaposition with an angiological bifurcation. The disclosure provides a bifurcated stent that includes a proximal portion adapted to be disposed within a blood vessel in juxtaposition with a bifurcation, a first distal stent portion adapted to extend across the bifurcation into one of the branched blood vessels, and a second distal stent portion adapted to allow blood to flow from the proximal portion into the other branch blood vessel. The disclosure also provides a bifurcated prosthesis including such a bifurcated stent and a tubular graft layer formed from a biocompatible fabric in juxtaposition with the stent. The disclosure also provides a stent joining means for joining two stents one to the other to define a continuous lumen through the two stents.
摘要翻译：本公开提供了用于与血管分叉并置的分叉支架。本公开提供了一种分叉支架，其包括适于布置在血管内的近端部分，其与分叉并置，第一远端支架部分，其适于延伸穿过分叉进入支支血管之一;以及第二远端支架部分适于允许血液从近端部分流入另一分支血管。本公开还提供了包括这种分叉支架的分叉假体和由与支架并置的生物相容性织物形成的管状移植层。本公开还提供了一种支架接合装置，用于将两个支架彼此连接以限定通过两个支架的连续内腔。

25. 发明授权

US08404249B2 Compositions and methods for topical application and transdermal delivery of botulinum toxins 有权
公开(公告)号：US08404249B2
公开(公告)日：2013-03-26
申请号：US11072026
申请日：2005-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K39/08 , A61K45/00 , A61K39/02
CPC分类号： A61Q19/08 , A61K8/64 , A61K9/0014 , A61K47/34 , A61K47/42 , A61K47/645 , Y02A50/469
摘要： A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain polypeptide or nonpeptidyl polymer having attached positively charged branching or “efficiency” groups. The invention also relates to methods for reducing muscle paralysis and other conditions that may be treated with a botulinum toxin, particularly paralysis of subcutaneous, and most particularly, facial, muscles, by topically applying an effective amount of the botulinum toxin and carrier, in conjunction, to the subject's skin or epithelium. Kits for administration are also described.

26. 发明申请

US20080107690A1 Compositions and Methods for Topical Application and Transdermal Delivery of Botulinum Toxins 有权
标题翻译：肉毒毒素的局部应用和透皮输送的组合物和方法
公开(公告)号：US20080107690A1
公开(公告)日：2008-05-08
申请号：US10591732
申请日：2005-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K51/00 , A61K39/40 , A61K39/42
CPC分类号： A61Q19/08 , A61K8/64 , A61K9/0014 , A61K47/34 , A61K47/42 , A61K47/645 , Y02A50/469
摘要： A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain polypeptide or nonpeptidyl polymer having attached positively charged branching or “efficiency” groups. The invention also relates to methods for reducing muscle paralysis and other conditions that may be treated with a botulinum toxin, particularly paralysis of subcutaneous, and most particularly, facial, muscles, by topically applying an effective amount of the botulinum toxin and carrier, in conjunction, to the subject's skin or epithelium. Kits for administration are also described.
摘要翻译：用于局部施用肉毒杆菌毒素（包括肉毒杆菌毒素衍生物）的组合物包含肉毒杆菌毒素和包含聚合物主链的载体，所述载体包含长链多肽或具有带正电支化或“效率”基团的非肽基聚合物。本发明还涉及通过局部施用有效量的肉毒杆菌毒素和载体，减少肌肉麻痹和其它可用肉毒杆菌毒素治疗的病症，特别是皮下，尤其是面部肌肉麻痹的方法。，对受试者的皮肤或上皮。还描述了用于给药的试剂盒。

27. 发明授权

US07048939B2 Methods for the inhibition of neointima formation 失效
公开(公告)号：US07048939B2
公开(公告)日：2006-05-23
申请号：US10101453
申请日：2002-03-11
申请人： Christopher J. Elkins , Michael D. Dake , Jacob M. Waugh
发明人： Christopher J. Elkins , Michael D. Dake , Jacob M. Waugh
IPC分类号： A61F2/00 , A61F2/06 , A61K31/44
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2250/0068 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2300/606
摘要： Restenosis is inhibited through local delivery of anti-restenotic agents including angiotensin converting enzyme inhibitors; nicotine receptor agonists, agents that increase concentrations of nitric oxide, anti-angiogenic agents, agonists of the TGF-beta receptor; death domain receptor ligands; and thrombin inhibitors. In one embodiment of the invention, the localized delivery is effected through the use of a stent modified for delivery of the agent at the site of injury from balloon angioplasty.

28. 发明授权

US06346118B1 Thoracic graft and delivery catheter 失效
标题翻译：胸腔移植和输送导管
公开(公告)号：US06346118B1
公开(公告)日：2002-02-12
申请号：US08931323
申请日：1997-09-16
申请人： Steve G. Baker , Michael D. Dake , David C. Dillow , Arnold Escano
发明人： Steve G. Baker , Michael D. Dake , David C. Dillow , Arnold Escano
IPC分类号： A61F200
CPC分类号： A61F2/07 , A61B17/11 , A61F2/04 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/95 , A61F2/958 , A61F2/966 , A61F2002/075 , A61F2002/3008 , A61F2002/30451 , A61F2002/8486 , A61F2002/9511 , A61F2002/9517 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2250/0098 , A61M25/10 , A61M2025/1068
摘要： A delivery catheter having an inner catheter assembly, an inferior capsule catheter, and a capsule jacket assembly for use in deploying a graft having a compressible and expandable attachment systems in the thoracic region of an aorta. The graft is comprised of a tubular member having superior and inferior ends, each having an attachment system with wall engaging members secured thereto and is crimped along its midsection to resist kinking and elongation. The delivery catheter includes an inferior capsule assembly for releasably retaining the inferior attachment system of the graft and a superior capsule assembly for releasably retaining the superior attachment system of the graft as well as a releasing system for maintaining the attachment systems in a compressed configuration and for facilitating expansion of the attachment systems. The delivery catheter also includes an anti-elongation wire attached to the inner catheter assembly to prevent stretching of the delivery catheter during deployment of the graft within the aorta. Upon removing the attachment systems from the capsule, the releasing system functions to allow the attachment systems to assume their expanded configuration and engage the walls of the aorta. The graft and attachment systems remain in the vessel after the delivery catheter is withdrawn.
摘要翻译：具有内导管组件，下胶囊导管和胶囊护套组件的输送导管，其用于部署具有在主动脉的胸部区域中的可压缩和可扩张的附接系统的移植物。移植物由具有上端和下端的管状构件组成，每个管状构件具有固定到其上的壁接合构件的附接系统，并沿其中部卷曲以抵抗扭结和伸长。递送导管包括用于可释放地保持移植物的下部附接系统的下部胶囊组件和用于可释放地保持移植物的上部附接系统的上部胶囊组件以及用于将附着系统保持在压缩构型中的释放系统，并且促进附件系统的扩展。递送导管还包括附接到内导管组件的抗延伸丝，以防止在将主动脉内的移植物展开期间伸出导管。在从胶囊中取出附接系统时，释放系统的作用是允许附接系统呈现它们的扩张构型并且接合主动脉的壁。输送导管拔出后，移植物和附着系统保留在血管内。

29. 发明授权

US5716365A Bifurcated endoluminal prosthesis 失效
公开(公告)号：US5716365A
公开(公告)日：1998-02-10
申请号：US461513
申请日：1995-06-05
申请人： George Goicoechea , John Hudson , Claude Mialhe , Andrew H. Cragg , Michael D. Dake
发明人： George Goicoechea , John Hudson , Claude Mialhe , Andrew H. Cragg , Michael D. Dake
IPC分类号： A61F2/00 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/848 , A61F2/90 , A61F2/954 , A61F2/958 , A61M25/12 , A61M29/00 , A61F11/00
CPC分类号： A61F2/852 , A61F2/07 , A61F2/82 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/828 , A61F2002/8486 , A61F2210/0019 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2220/0066 , A61F2220/0075 , A61F2230/0067 , A61F2240/001 , A61F2250/0098 , A61M25/0662 , Y10S623/903 , Y10T29/49826
摘要： An introducer for delivering into the vasculature a straight or bifurcated stent or prosthesis; a method for delivering into the vasculature a straight or bifurcated stent or prosthesis; a method of treating and angeological disease using a bifurcated stent; an endoluminal stent having perpendicular hoop members, each hoop member formed of wire in a sinuous configuration, at least some of juxtaposed apices in neighboring hoops being secured to one another, such stents also forming axially aligned segments in straight stents, and segments of bifurcated stents in particular embodiments. Certain embodiments of such stents also include barbs, fabric covering and radiopaque markers.

30. 发明授权

US4968307A Catheter for uniform distribution of therapeutic fluids 失效
标题翻译：导管可均匀分布治疗液
公开(公告)号：US4968307A
公开(公告)日：1990-11-06
申请号：US335235
申请日：1989-04-10
申请人： Michael D. Dake , Mark A. Maguire
发明人： Michael D. Dake , Mark A. Maguire
IPC分类号： A61M25/00
CPC分类号： A61M25/007
摘要： A vascular catheter for delivering a uniform flow of therapeutic fluid over a length of the catheter. The catheter is particularly suitable for delivering thrombolytic agents to a thrombus or clot in a patient's arterial system. In a preferred embodiment, the catheter has a relatively thick-walled tubular body with a central lumen for advancement over a guidewire and a plurality of fluid delivering lumens disposed within the relatively thick wall. Each of the smaller lumens has a single flow passageway to discharge therapeutic fluid to the exterior of the catheter.
摘要翻译：一种血管导管，用于在导管的长度上输送均匀的治疗流体流。导管特别适用于将血栓溶解剂递送至患者动脉系统中的血栓或凝块。在优选实施例中，导管具有相对厚壁的管状体，其具有用于在导丝上前进的中心腔和设置在相对较厚壁内的多个输送流体的流体。每个较小的腔具有单个流动通道以将治疗流体排放到导管的外部。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式