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21. 发明申请

US20130272591A1 PHASE SENSITIVE T1 MAPPING IN MAGNETIC RESONANCE IMAGING 有权
标题翻译：磁共振成像中的相敏敏感T1映射
公开(公告)号：US20130272591A1
公开(公告)日：2013-10-17
申请号：US13864716
申请日：2013-04-17
申请人： Hui Xue , Peter Kellman , Andreas Greiser
发明人： Hui Xue , Peter Kellman , Andreas Greiser
IPC分类号： G06T11/00
CPC分类号： G06T11/003 , G01R33/50 , G01R33/56509
摘要： Phase sensitive T1 mapping is provided in magnetic resonance (MR). The phase from samples of a modified Look-Locker inversion recovery sequence may be used to normalize contrast, allowing for accurate motion registration without extra information acquisition. The sign may be estimated, allowing T1 mapping with a single application of a non-linear fit.
摘要翻译：在磁共振（MR）中提供相敏T1映射。来自改进的Look-Locker反转恢复序列的样本的相位可以用于对比度的归一化，允许精确的运动注册，而不需要额外的信息获取。可以估计符号，允许使用非线性拟合的单个应用的T1映射。

22. 发明授权

US09129424B2 Phase sensitive T1 mapping in magnetic resonance imaging 有权
标题翻译：磁共振成像中的相敏T1映射
公开(公告)号：US09129424B2
公开(公告)日：2015-09-08
申请号：US13864716
申请日：2013-04-17
申请人： Hui Xue , Peter Kellman , Andreas Greiser
发明人： Hui Xue , Peter Kellman , Andreas Greiser
IPC分类号： G06K9/00 , G06T11/00 , G01R33/50 , G01R33/565
CPC分类号： G06T11/003 , G01R33/50 , G01R33/56509
摘要： Phase sensitive T1 mapping is provided in magnetic resonance (MR). The phase from samples of a modified Look-Locker inversion recovery sequence may be used to normalize contrast, allowing for accurate motion registration without extra information acquisition. The sign may be estimated, allowing T1 mapping with a single application of a non-linear fit.
摘要翻译：在磁共振（MR）中提供相敏T1映射。来自改进的Look-Locker反转恢复序列的样本的相位可以用于对比度的归一化，允许精确的运动注册，而不需要额外的信息获取。可以估计符号，允许使用非线性拟合的单个应用的T1映射。

23. 发明授权

US09053386B2 Method and apparatus of identifying similar images 有权
标题翻译：识别相似图像的方法和装置
公开(公告)号：US09053386B2
公开(公告)日：2015-06-09
申请号：US13509059
申请日：2012-01-18
申请人： Hui Xue
发明人： Hui Xue
IPC分类号： G06K9/62 , G06F17/30
CPC分类号： G06K9/6202 , G06F17/30259 , G06K9/4604 , G06K9/4642 , G06K9/6212 , G06K9/6215
摘要： A user may submit an image and request from a server one or more images that are similar to the submitted image. The server may generate an image signature based on the content of the submitted image. The server may conduct a Hash operation to the image signature to generate one or more Hash values. These Hash values may be used to identify one or more candidate images similar to the image in a Hash table. These candidate images may be sorted and outputted to the user based on similarity. The similarity between each of the candidate images and the image may be determined using at least one of Hamming distance or Euclidean distance.
摘要翻译：用户可以从服务器提交与提交的图像相似的一个或多个图像的图像和请求。服务器可以基于提交的图像的内容生成图像签名。服务器可以对图像签名进行哈希操作，以生成一个或多个哈希值。这些哈希值可用于识别与哈希表中的图像类似的一个或多个候选图像。这些候选图像可以基于相似性被分类并输出给用户。可以使用汉明距离或欧氏距离中的至少一个来确定每个候选图像和图像之间的相似度。

24. 发明申请

US20130301935A1 Method and Apparatus of Identifying Similar Images 有权
标题翻译：识别类似图像的方法和装置
公开(公告)号：US20130301935A1
公开(公告)日：2013-11-14
申请号：US13509059
申请日：2012-01-18
申请人： Hui Xue
发明人： Hui Xue
IPC分类号： G06K9/62
CPC分类号： G06K9/6202 , G06F17/30259 , G06K9/4604 , G06K9/4642 , G06K9/6212 , G06K9/6215
摘要： A user may submit an image and request from a server one or more images that are similar to the submitted image. The server may generate an image signature based on the content of the submitted image. The server may conduct a Hash operation to the image signature to generate one or more Hash values. These Hash values may be used to identify one or more candidate images similar to the image in a Hash table. These candidate images may be sorted and outputted to the user based on similarity. The similarity between each of the candidate images and the image may be determined using at least one of Hamming distance or Euclidean distance.
摘要翻译：用户可以从服务器提交与提交的图像相似的一个或多个图像的图像和请求。服务器可以基于提交的图像的内容生成图像签名。服务器可以对图像签名进行哈希操作，以生成一个或多个哈希值。这些哈希值可用于识别与哈希表中的图像类似的一个或多个候选图像。这些候选图像可以基于相似性被分类并输出给用户。可以使用汉明距离或欧氏距离中的至少一个来确定每个候选图像和图像之间的相似度。

25. 发明申请

US20130289912A1 EIGEN-VECTOR APPROACH FOR COIL SENSITIVITY MAPS ESTIMATION 审中-公开
标题翻译：用于线圈灵敏度估计的EIGEN-VECTOR方法
公开(公告)号：US20130289912A1
公开(公告)日：2013-10-31
申请号：US13779999
申请日：2013-02-28
申请人： Jun Liu , Hui Xue , Marcel Dominik Nickel , Ti-chiun Chang , Mariappan S. Nadar , Alban Lefebvre , Edgar Mueller , Qiu Wang , Zhili Yang , Nirmal Janardhanan , Michael Zenge
发明人： Jun Liu , Hui Xue , Marcel Dominik Nickel , Ti-chiun Chang , Mariappan S. Nadar , Alban Lefebvre , Edgar Mueller , Qiu Wang , Zhili Yang , Nirmal Janardhanan , Michael Zenge
IPC分类号： G01R33/24
CPC分类号： G01R33/243 , G01R33/246 , G01R33/5611
摘要： A method for estimating a coil sensitivity map for a magnetic resonance (MR) image includes providing (61) a matrix A of sliding blocks of a 2D image of coil calibration data, calculating (62) a left singular matrix V∥ from a singular value decomposition of A corresponding to τ leading singular values, calculating (63) P=V∥V∥H, calculating (64) a matrix S that is an inverse Fourier transform of a zero-padded matrix P, and solving (65) MHcr=(Sr)Hcr for cr, where cr is a vector of coil sensitivity maps for all coils at spatial location r, and M  ( ( 1 1 … 1 0 0 … 0 … … … 0 0 … 0 )  ( 0 0 … 0 1 1 … 1 … … … 0 0 … 0 )   …   ( 0 0 … 0 0 0 … 0 … … … 1 1 … 1 ) ) .
摘要翻译：用于估计磁共振（MR）图像的线圈灵敏度映射的方法包括提供（61）线圈校准数据的2D图像的滑块的矩阵A，从奇异值计算（62）左奇异矩阵V∥ 计算（63）P = V || V | H，计算（64）作为零填充矩阵P的逆傅里叶变换的矩阵S，求解（65）MHcr = （Sr）Hcr，其中cr是空间位置r处所有线圈的线圈灵敏度图的向量，M（（1 1 ... 1 0 0 ... 0 ... ... ... 0 0 ... 0）0（0 0 ... 0 1 1 ... 1 ... ... ... 0 0 ... 0） 0 0 0 ... 0 ... ... ... 1 1 ... 1））。

26. 发明申请

US20170015997A1 DUAL TARGETING ANTISENSE OLIGONUCLEOTIDES AS APOPTOTIC INHIBTOR THERAPEUTIC COMPOSTIONS AND METHODS FOR THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：作为抗肿瘤药物治疗组合物的双重抗凝反应寡核苷酸及其在治疗癌症中的应用
公开(公告)号：US20170015997A1
公开(公告)日：2017-01-19
申请号：US15211857
申请日：2016-07-15
申请人： Yuzhuo Wang , Hui Xue , Sze Ue Luk , Peter Wilhelm Gout , Martin E. Gleave , Colin C. Collins
发明人： Yuzhuo Wang , Hui Xue , Sze Ue Luk , Peter Wilhelm Gout , Martin E. Gleave , Colin C. Collins
IPC分类号： C12N15/113 , A61K9/00 , A61K9/127 , A61K31/7125
CPC分类号： C12N15/113 , A61K31/7125 , C12N2310/11 , C12N2310/3125 , C12N2310/3145 , C12N2310/315 , C12N2310/3181 , C12N2310/3233 , C12N2310/3341 , C12N2310/3519 , C12N2310/51 , C12N2310/321 , C12N2310/3525 , C12N2310/3527
摘要： Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).
摘要翻译：本文提供了调节IAP活性或治疗癌症的组合物，方法和用途。所述组合物包含用于给予癌细胞的双靶向反义寡核苷酸（dASO），其中所述癌细胞的特征可能在于BIRC6，cIAP1或存活蛋白中的一种之一升高。癌症可以选自以下中的一种或多种：前列腺癌; 儿童从头急性骨髓性白血病; 结肠直肠癌; 神经母细胞瘤黑色素瘤和非小细胞肺癌。前列腺癌可能是去势抗性前列腺癌（CRPC）。

27. 发明申请

US20140088899A1 EIGEN-VECTOR APPROACH FOR COIL SENSITIVITY MAPS ESTIMATION 审中-公开
标题翻译：用于线圈灵敏度估计的EIGEN-VECTOR方法
公开(公告)号：US20140088899A1
公开(公告)日：2014-03-27
申请号：US14038958
申请日：2013-09-27
申请人： Jun Liu , Hui Xue , Marcel Dominik Nickel , Ti-chiun Chang , Mariappan S. Nadar , Alban Lefebvre , Edgar Mueller , Qiu Wang , Zhili Yang , Nirmal Janardhanan , Michael Zenge
发明人： Jun Liu , Hui Xue , Marcel Dominik Nickel , Ti-chiun Chang , Mariappan S. Nadar , Alban Lefebvre , Edgar Mueller , Qiu Wang , Zhili Yang , Nirmal Janardhanan , Michael Zenge
IPC分类号： G01R33/24
CPC分类号： G01R33/243 , G01R33/246 , G01R33/5611
摘要： A method for estimating a coil sensitivity map for a magnetic resonance (MR) image includes providing a matrix A of sliding blocks of a 3D image of coil calibration data, calculating a left singular matrix V∥ from a singular value decomposition of A corresponding to τ leading singular values, calculating P=V∥V∥H, calculating a matrix S that is an inverse Fourier transform of a zero-padded matrix P, and solving MHcr=(Sr)Hcr for cr, where cr is a vector of coil sensitivity maps for all coils at spatial location r, and M = ( ( 1 1 … 1 0 0 … 0 … … … 0 0 … 0 )  ( 0 0 … 0 1 1 … 1 … … … 0 0 … 0 )   …   ( 0 0 … 0 0 0 … 0 … … … 1 1 … 1 ) ) .
摘要翻译：用于估计磁共振（MR）图像的线圈灵敏度图的方法包括提供线圈校准数据的3D图像的滑动块的矩阵A，从对应于τ的A的奇异值分解计算左奇异矩阵V∥ 计算P = V || V | H，计算作为零填充矩阵P的傅立叶逆变换的矩阵S，求解cr的MHcr =（Sr）Hcr，其中cr是线圈灵敏度的向量对于空间位置r处的所有线圈的映射，M =（（1 1 ... 1 0 0 ... 0 ... ... 0 0 ... 0）（0 0 ... 0 1 1 ... 1 ... ... 0 0 ... 0） ...（0 0 ... 0 0 0 ... 0 ...... ... 1 1 ... 1））。

28. 发明授权

US09790500B2 Dual targeting antisense oligonucleotides as apoptotic inhibtor therapeutic compostions and methods for their use in the treatment of cancer 有权
公开(公告)号：US09790500B2
公开(公告)日：2017-10-17
申请号：US15211857
申请日：2016-07-15
申请人： Yuzhuo Wang , Hui Xue , Sze Ue Luk , Peter Wilhelm Gout , Martin E. Gleave , Colin C. Collins
发明人： Yuzhuo Wang , Hui Xue , Sze Ue Luk , Peter Wilhelm Gout , Martin E. Gleave , Colin C. Collins
IPC分类号： C12N15/11 , C12N15/113 , A61K31/7125
CPC分类号： C12N15/113 , A61K31/7125 , C12N2310/11 , C12N2310/3125 , C12N2310/3145 , C12N2310/315 , C12N2310/3181 , C12N2310/3233 , C12N2310/3341 , C12N2310/3519 , C12N2310/51 , C12N2310/321 , C12N2310/3525 , C12N2310/3527
摘要： Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).

29. 发明授权

US09279873B2 Self consistent parallel imaging with temporal sensitivity estimation in real-time magnetic resonance imaging 有权
标题翻译：自适应并行成像与实时磁共振成像中的时间灵敏度估计
公开(公告)号：US09279873B2
公开(公告)日：2016-03-08
申请号：US13534112
申请日：2012-06-27
申请人： Hui Xue , Yu Ding
发明人： Hui Xue , Yu Ding
IPC分类号： G01V3/00 , G01R33/561 , G01R33/565
CPC分类号： G01R33/5611 , G01R33/56509
摘要： Parallel imaging magnetic resonance reconstruction is performed with temporal sensitivity. Rather than estimate the coil sensitivity once for each coil of an array, the coil sensitivity at different times is estimated. The movement of the patient may result in different sensitivities at different times. By using the time varying sensitivity in iterative, self-consistent, non-linear parallel imaging, real-time imaging may be provided with stable artifacts in view of increasing SNR even with higher reduction factors (e.g., 4-6).
摘要翻译：平行成像磁共振重建以时间灵敏度进行。不是对阵列的每个线圈估计线圈灵敏度，而是估计不同时间的线圈灵敏度。患者的运动可能导致不同时间的不同灵敏度。通过在迭代，自相一致的非线性并行成像中使用时变灵敏度，考虑到即使具有较高的减少因子（例如，4-6）也增加了SNR，可以提供稳定的伪像。

30. 发明申请

US20130278259A1 METHOD FOR A RAPID DETERMINATION OF SPATIALLY RESOLVED MAGNETIC RESONANCE RELAXATION PARAMETERS IN AN AREA OF EXAMINATION 有权
标题翻译：用于快速确定空间分辨率的磁共振松弛参数在检查领域的方法
公开(公告)号：US20130278259A1
公开(公告)日：2013-10-24
申请号：US13866328
申请日：2013-04-19
申请人： Andreas Greiser , Peter Schmitt , Hui Xue
发明人： Andreas Greiser , Peter Schmitt , Hui Xue
IPC分类号： G01R33/50
CPC分类号： G01R33/50 , G01R33/56 , G01R33/56509
摘要： In a method for a rapid determination of spatially resolved magnetic resonance relaxation parameters in an area of examination, a preparation pulse is radiated into the area of examination. During the relaxation of the longitudinal magnetization, spatially encoded magnetic resonance signals are acquired at a minimum of two different points in time using a fast magnetic resonance sequence. At each inversion time, an image data record is reconstructed from the magnetic resonance signals, which are elastically registered to each other. From the recorded image data records, values of magnetic resonance relaxation parameters are spatially accurately determined.
摘要翻译：在用于在检查区域中快速确定空间分辨的磁共振松弛参数的方法中，准备脉冲被辐射到检查区域中。在松弛纵向磁化期间，使用快速磁共振序列在至少两个不同的时间点获取空间编码的磁共振信号。在每个反转时间，从彼此弹性对准的磁共振信号重建图像数据记录。从记录的图像数据记录中，磁共振松弛参数的值在空间上被精确地确定。

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