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21. 发明授权

US08092824B2 Antibiotic coating of implants 有权
标题翻译：植入物的抗生素涂层
公开(公告)号：US08092824B2
公开(公告)日：2012-01-10
申请号：US11335323
申请日：2006-01-19
申请人： Klaus-Dieter Kühn , Sebastian Vogt , Matthias Schnabelrauch
发明人： Klaus-Dieter Kühn , Sebastian Vogt , Matthias Schnabelrauch
IPC分类号： A61F2/02
CPC分类号： A61L27/54 , A61L27/28 , A61L2300/404 , A61L2300/606
摘要： An antibiotic coating of implants is described, which is characterized in that the coating comprises at least one saturated, organic, hydrophobic, low molecular matrix former whose melting point is in the temperature range of 45° C. to 100° C., in which a low molecular, hydrophobic additive is dissolved and that an antibiotic/antibiotics is/are suspended in the mixture of matrix former and additive and/or in which an antibiotic/antibiotics miscible with a mixture of matrix former and additive is/are dissolved.
摘要翻译：描述了植入物的抗生素涂层，其特征在于该涂层包含至少一种饱和的，有机的，疏水的，低分子量的基质，其熔点在45℃至100℃的温度范围内，其中溶解低分子疏水性添加剂，并且将抗生素/抗生素悬浮在基质前体和添加剂的混合物中，和/或其中溶解有与基质前体和添加剂的混合物混溶的抗生素/抗生素。

22. 发明授权

US08075907B2 Polymethylmethacrylate revision bone cement 有权
标题翻译：聚甲基丙烯酸甲酯修复骨水泥
公开(公告)号：US08075907B2
公开(公告)日：2011-12-13
申请号：US12017499
申请日：2008-01-22
申请人： Klaus-Dieter Kühn , Sebastian Vogt , Hubert Büchner
发明人： Klaus-Dieter Kühn , Sebastian Vogt , Hubert Büchner
IPC分类号： A61F2/28
CPC分类号： A61L24/0015 , A61L24/06 , A61L27/16 , A61L27/54 , A61L2300/406 , A61L2300/45 , A61L2300/622 , A61L2430/02 , C08L33/12
摘要： The invention relates to a PMMA revision bone cement having powder and liquid component, in which the powder component contains two or more granular antibiotics whose grain size distribution is equal in that the main screening fraction each of the individual antibiotics is in the same grain size range, in particular in the range of 100-250 μm or 150-250 μm.
摘要翻译：本发明涉及具有粉末和液体组分的PMMA修复骨水泥，其中粉末组分含有两种或更多种粒度分布相等的粒状抗生素，因为各个抗生素的主要筛选部分具有相同的粒度范围，特别是在100-250μm或150-250μm的范围内。

23. 发明授权

US08075905B2 Dental materials equipped with active anti-plaque substance(s) 有权
标题翻译：装有活性抗菌斑物质的牙科材料
公开(公告)号：US08075905B2
公开(公告)日：2011-12-13
申请号：US12429353
申请日：2009-04-24
申请人： Klaus Ruppert , Karl-Heinz Renz , Sebastian Vogt
发明人： Klaus Ruppert , Karl-Heinz Renz , Sebastian Vogt
IPC分类号： A61F13/00 , A61K7/16
CPC分类号： A61K6/083 , A61K6/0017 , A61K6/0023 , A61K6/0067 , A61K6/09 , C08L33/04 , C08L75/16
摘要： A process by means of which the colonization by plaque on dental materials can be permanently prevented or delayed without the product properties of the dental material being negatively influenced. The process involves equipping the dental material with anti-plaque substance, namely at least one molecularly dispersely distributed octenidine salt or dequalinium salt. Also disclosed is a dental material so equipped.
摘要翻译：通过这种方法，可以永久地防止或延迟牙科材料上的斑块定居，而不影响牙科材料的产品性质。该方法包括为牙科材料配备抗斑块物质，即至少一种分子分散分布的辛烯尼酮盐或脱喹啉盐。还公开了如此装备的牙科材料。

24. 发明授权

US07989519B2 Initiator system for self-curing plastic materials, its use, and bone cement compositions containing it 有权
标题翻译：用于自固化塑料材料的引发剂体系，其用途和含有它的骨水泥组合物
公开(公告)号：US07989519B2
公开(公告)日：2011-08-02
申请号：US12254541
申请日：2008-10-20
申请人： Sebastian Vogt , Hubert Buchner
发明人： Sebastian Vogt , Hubert Buchner
IPC分类号： A61K6/083 , C09K3/00
CPC分类号： A61L24/043 , A61L24/001 , A61L27/26 , A61L27/50 , A61L2430/02 , C08L33/12
摘要： An initiator system for self-curing plastic material comprises a) at least one salt of a dialklylbarbituric acid and/or an alkylcycloalkylbarbituric acid and/or alkylarylbarbituric acid and/or a cycloalkylarylbarbituric acid that is insoluble in methacrylate monomers; b) at least one heavy metal salt that is insoluble in methacrylate monomers; c) at least one halogenide ion donor that is insoluble in methacrylate monomers; and d) at least one acid that is soluble in methacrylate monomers. The initiator system can be used for the preparation of paste/paste, paste/powder, paste/liquid, powder/liquid, and liquid/liquid combinations for the production of medical plastic material and dental materials. Additionally, a bone cement composition containing the initiator system is described.
摘要翻译：用于自固化塑料材料的引发剂体系包括：a）不溶于甲基丙烯酸酯单体的至少一种二烷基巴比妥酸和/或烷基环烷基巴比妥酸和/或烷基芳基巴比妥酸和/或环烷基芳基巴比妥酸的盐; b）至少一种不溶于甲基丙烯酸酯单体的重金属盐; c）至少一种不溶于甲基丙烯酸酯单体的卤化物离子供体; 和d）至少一种可溶于甲基丙烯酸酯单体的酸。引发剂系统可用于制备糊剂/糊剂，糊剂/粉末，糊剂/液体，粉末/液体和液体/液体组合，用于生产医用塑料材料和牙科材料。此外，描述了含有引发剂体系的骨水泥组合物。

25. 发明授权

US07829133B2 Surgical suture material with an antimicrobial surface and process for providing an antimicrobial coating on surgical suture material 有权
标题翻译：具有抗微生物表面的手术缝合材料和用于在外科缝合材料上提供抗微生物涂层的方法
公开(公告)号：US07829133B2
公开(公告)日：2010-11-09
申请号：US11877846
申请日：2007-10-24
申请人： Sebastian Vogt , Klaus-Dieter Kuhn , Hubert Buchner
发明人： Sebastian Vogt , Klaus-Dieter Kuhn , Hubert Buchner
IPC分类号： B05D3/00
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/005 , A61L17/145 , A61L2300/208 , A61L2300/404 , A61L2300/606 , A61L2300/802 , B05D1/18 , B05D2256/00
摘要： A surgical suture material with an antimicrobial surface is described, the surface exhibiting a coating containing a) at least one fatty acid, b) octenidine dichloride and/or dequalinium chloride and c) optionally oligomeric lactic acid esters. In addition, a process for coating surgical suture material is described which is characterized by the fact that the thread material is wetted with a homogeneous methanolic solution of octenidine dichloride and/or dequalinium chloride and subsequently the methanol is evaporated, a coating forming on the thread surface.
摘要翻译：描述了具有抗微生物表面的外科缝合材料，所述表面显示包含a）至少一种脂肪酸，b）二氯化奥立芬和/或氯化脱氯化物的涂层，以及c）任选的低聚乳酸酯。另外，描述了用于涂覆外科缝合材料的方法，其特征在于螺纹材料被二氯化二苯胺和/或氯化金合金的均匀甲醇溶液润湿，随后甲醇蒸发，在螺纹上形成涂层表面。

26. 发明授权

US07635056B2 Pressure plate assembly, clutch disk arrangement, and friction clutch, especially a multi-disk clutch 失效
标题翻译：压板组件，离合器盘装置和摩擦离合器，特别是多盘式离合器
公开(公告)号：US07635056B2
公开(公告)日：2009-12-22
申请号：US12187835
申请日：2008-08-07
申请人： Andreas Orlamünder , Thorsten Müller , Michael Kühner , Winfried Bokisch , Sebastian Vogt , Waldemar Mensch
发明人： Andreas Orlamünder , Thorsten Müller , Michael Kühner , Winfried Bokisch , Sebastian Vogt , Waldemar Mensch
IPC分类号： F16D13/70
CPC分类号： F16D13/385
摘要： A pressure plate arrangement for a friction clutch includes a housing rotatably fixed to an abutment arrangement for joint rotation about an axis of rotation and a plate arrangement with at least one intermediate plate and a pressure plate. At least one of the intermediate and pressure plates is mounted in the housing and axially movable relative thereto and rotateable about the axis of rotation. An energy storage device coupled to the housing generates an elastic restoring force on the plate arrangement. A releasing spring arrangement located between the housing and plate arrangement is tensioned to generate an elastic restoring force on the pressure plate in a second direction opposite to the first direction. A clutch disk arrangement is clamped between the abutment arrangement and the at least one intermediate plate, or between any two plates of the plate arrangement.
摘要翻译：用于摩擦离合器的压力板装置包括可旋转地固定到邻接装置的壳体，用于围绕旋转轴线的联合旋转和具有至少一个中间板和压力板的板装置。中间板和压板中的至少一个安装在壳体中并且可相对于其轴向移动并围绕旋转轴线旋转。耦合到壳体的能量存储装置在板装置上产生弹性恢复力。位于壳体和板装置之间的释放弹簧装置被张紧以在与第一方向相反的第二方向上在压板上产生弹性恢复力。离合器盘布置被夹持在邻接装置和至少一个中间板之间，或者在板装置的任何两个板之间。

27. 发明授权

US07358232B2 Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage 有权
标题翻译：具有互连微腔以及涂层体的物体的抗生素涂层方法及其用途
公开(公告)号：US07358232B2
公开(公告)日：2008-04-15
申请号：US10174682
申请日：2002-06-19
申请人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
IPC分类号： A61K31/70 , C07H15/02
CPC分类号： A61K9/0024
摘要： The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in that in the microcavities of non-metallic bodies an aqueous solution 1, which contains at least one easily water-soluble antibiotic component from the groups of the aminoglycoside antibiotics, the tetracycline antibiotics, the lincosamide antibiotics and the 4-quinolone antibiotics, and an aqueous solution 2, which contains at least one easily water-soluble amphiphilic component from the groups of the alkyl sulfates, alkyl sulfonates, alkylaryl sulfates, dialkylaryl sulfates, alkylaryl sulfonates, dialkylaryl sulfonates, cycloalkyl sulfates, cycloalkyl sulfonates, alkylcycloalkyl sulfates, are introduced, wherein between the introduction of solutions 1 and 2 the water is basically removed through vaporization and/or evaporation, and whereby from the components of solutions 1 and 2 in the microcavities a deposit is formed, which is sparingly soluble in water.
摘要翻译：本发明涉及一种用于具有互连微腔的物体的抗生素包被的方法以及这种方式涂覆的物体及其用途。本发明的方法的特征在于，在非金属体的微腔中，含有来自氨基糖苷类抗生素组的至少一种容易水溶性抗生素成分的水溶液1，四环素抗生素，林可素类抗生素和4- 喹诺酮抗生素和水溶液2，其含有至少一种容易水溶性的两亲成分，分别为烷基硫酸盐，烷基磺酸盐，烷基芳基硫酸盐，二烷基芳基硫酸盐，烷基芳基磺酸盐，二烷基芳基磺酸盐，环烷基硫酸盐，环烷基磺酸盐，烷基环烷基硫酸盐，其中在引入溶液1和2之间基本上通过蒸发和/或蒸发除去水，并且由此在微腔中的溶液1和2的组分中形成沉积物，其沉积物微溶于水。

28. 发明申请

US20060293407A1 Polymethylmethacrylate bone cement 有权
标题翻译：聚甲基丙烯酸甲酯骨水泥
公开(公告)号：US20060293407A1
公开(公告)日：2006-12-28
申请号：US11447807
申请日：2006-06-06
申请人： Klaus-Dieter Kuhn , Sebastian Vogt
发明人： Klaus-Dieter Kuhn , Sebastian Vogt
IPC分类号： A61K6/08
CPC分类号： A61L27/50 , A61L24/001 , A61L24/06 , A61L27/16 , A61L2430/02 , C08L33/12
摘要： A polymethylmethacrylate bone cement with a liquid monomer component and a solid component contains in the monomer liquid, for example, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, for example, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer for the dye or dye mixture. The solubilizer preferably is liquid or pasty at room temperature. The monomer liquid is translucent at room temperature. Preferably, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, preferably, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer that is liquid or pasty at room temperature are homogeneously dissolved in the polymethacrylate or polymethylacrylate of the powder component.
摘要翻译：具有液体单体组分和固体组分的聚甲基丙烯酸甲酯骨粘固剂在单体液体中含有例如0.001-1.00质量％的不溶于或难溶于甲基丙烯酸甲酯的染料或染料混合物，例如，用于染料或染料混合物的合成产生的无蛋白质，疏水性，低分子或低聚增溶剂的2.00质量％。增溶剂在室温下优选为液体或糊状。单体液体在室温下是半透明的。优选0.001〜1.00质量％的不溶于或难溶于甲基丙烯酸甲酯的染料或染料混合物，优选0.001-2.00质量％的合成产生的无蛋白质，疏水性，低分子或低聚物的增溶剂，其为液体或糊状物均匀地溶解在粉末组分的聚甲基丙烯酸酯或聚甲基丙烯酸甲酯中。

29. 发明申请

US20050238223A1 Flexible generation of digitally reconstructed radiographs 有权
标题翻译：灵活地生成数字重建的X光片
公开(公告)号：US20050238223A1
公开(公告)日：2005-10-27
申请号：US10953342
申请日：2004-09-29
申请人： Jens Guhring , Sebastian Vogt , Ali Khamene
发明人： Jens Guhring , Sebastian Vogt , Ali Khamene
IPC分类号： G06K9/00 , G06K9/36 , G06T15/08
CPC分类号： G06T15/08
摘要： A system and corresponding method for flexible generation of digitally reconstructed radiograph (DRR) images on a graphics processing unit (GPU) are provided, the system including a processor, an imaging adapter in signal communication with the processor for receiving volumetric data, an integration unit in signal communication with the processor for integrating the volumetric data into incremental line integrals, and a modeling unit in signal communication with the processor for modeling composite line integrals from the incremental line integrals; and the corresponding method including receiving three-dimensional (3D) volumetric data into a graphics pipeline, integrating the 3D volumetric data into incremental line integrals along a plurality of viewing rays, modeling composite line integrals from the incremental line integrals, and adding the incremental line integrals for each composite line integral to form pixels of the DRR image.
摘要翻译：提供了一种用于在图形处理单元（GPU）上灵活生成数字重建X射线照片（DRR）图像的系统和相应方法，该系统包括处理器，与处理器进行信号通信的成像适配器，用于接收体积数据，整合单元与处理器的信号通信，用于将体积数据集成到增量线积分中，以及与处理器进行信号通信的建模单元，用于从增量线积分建模复合线积分; 以及相应的方法，包括将三维（3D）体积数据接收到图形管线中，将3D体积数据集成到沿着多个观察射线的增量线积分中，从增量线积分建模复合线积分，以及将增量线每个复合线的积分积分以形成DRR图像的像素。

30. 发明授权

US06913764B2 Antibiotic(s) preparation with retarding active ingredient release 失效
标题翻译：具有延缓活性成分释放的抗生素制剂
公开(公告)号：US06913764B2
公开(公告)日：2005-07-05
申请号：US10100839
申请日：2002-03-19
申请人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kühn
IPC分类号： A61K9/00 , A61K9/10 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/70 , A61K31/00 , A61K31/70 , A61K31/7036 , A61K31/726 , A61K45/06 , A61K45/08 , A61K47/02 , A61K47/14 , A61K47/16 , A61K47/20 , A61K47/24 , A61L27/54 , A61L31/16 , A61K2/02
CPC分类号： A61K31/7036 , A61K9/0024 , A61K9/2013 , A61K31/00 , A61L27/54 , A61L2300/406 , A61L2300/602 , A61L2300/802
摘要： The present invention concerns an antibiotic/antibiotics preparation for resorbable and non-resorbable implants for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue. The invented antibiotic/antibiotics preparation is a mixture consisting of at least one amphiphilic component of a representative of the alkyl sulfates, aryl sulfates, alkylaryl sulfates, cycloalkyl sulfates, alkylcycloalkyl sulfates, alkyl sulfamates, cycloalkyl sulfamates, alkylcycloalkyl sulfamates, aryl sulfamates, alkylaryl sulfamates, alkyl sulfonates, fatty acid-2-sulfonates, aryl sulfonates, alkylaryl sulfonates, cycloalkyl sulfonates, alkylcycloalkyl sulfonates, alkyl disulfates, cycloalkyl disulfates, alkyl disulfonates, cycloalkyl disulfonates, aryl disulfonates, alkylaryl disulfonates, aryl trisulfonates and alkylaryl trisulfonates as well as at least one antibiotic component from the group of aminoglycoside antibiotics, lincosamide antibiotics, 4-quinolone antibiotics and tetracycline antibiotics, and if need be at least one anhydrous organic auxiliary component and if need be at least one inorganic auxiliary component and if need be at least one biologically active component. The antibiotic/antibiotics preparation of the invention has a retarding active ingredient release.
摘要翻译：本发明涉及用于人和兽医药物的可再吸收和不可吸收植入物的抗生素/抗生素制剂，用于治疗硬组织和软组织中的局部微生物感染。本发明的抗生素/抗生素制剂是由至少一种代表烷基硫酸盐，芳基硫酸盐，烷基芳基硫酸盐，环烷基硫酸盐，烷基环烷基硫酸盐，氨基磺酸烷基酯，环烷基磺酸盐，烷基环烷基氨基磺酸盐，芳基亚磺酸盐，烷基芳基亚磺酸盐烷基磺酸盐，脂肪酸-2-磺酸盐，芳基磺酸盐，烷基芳基磺酸盐，环烷基磺酸盐，烷基环烷基磺酸盐，烷基二硫酸盐，环烷基二硫酸盐，烷基二磺酸盐，环烷基二磺酸盐，芳基二磺酸盐，烷基芳基二磺酸盐，芳基三磺酸盐和烷基芳基三磺酸盐以及至少一种来自氨基糖苷类抗生素的抗生素成分，林可素类抗生素，4-喹诺酮类抗生素和四环素抗生素，如果需要至少一种无机有机辅助成分，如果需要至少一种无机辅助成分，如果需要至少一种生物活性成分 ent。本发明的抗生素/抗生素制剂具有缓释活性成分释放。

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