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    • 24. 发明授权
    • Connecting rod made of fiber reinforced synthetic material
    • 由纤维增强合成材料制成的连杆
    • US4555961A
    • 1985-12-03
    • US508031
    • 1983-06-27
    • Thomas Fischer
    • Thomas Fischer
    • F16C7/00F16C9/04G05G1/00
    • F16C7/026F16C9/04Y10T29/49288Y10T74/2162
    • A connecting rod has a closed bearing at one end for connecting, for exam, a piston bolt to the rod. At the other end the rod has a divided bearing for connecting, for example, a crankpin to the rod. The rod is made of fiber reinforced synthetic materials. The divided bearing is enclosed by an inner and an outer bearing bail and by a compression member. The free ends of a fiber reinforced loop which surrounds the closed bearing and the ends of the inner and outer bearing bails are formed into flanges which are interlocked by bolts. In another embodiment an endless loop is folded to form an open loop and the free ends of the open loop legs are interconnected by a bolt extending through the loop ends and through an outer bail made of fiber compound material or metal.
    • 连杆在一端具有封闭的轴承,用于将例如活塞螺栓连接到杆上。 在另一端,杆具有用于将例如曲柄销连接到杆的分开的轴承。 该杆由纤维增强合成材料制成。 分离的轴承由内外轴承圈和压缩构件包围。 围绕封闭轴承的纤维增强环的自由端和内外轴承座的端部形成为由螺栓联锁的凸缘。 在另一个实施例中,环形环被折叠以形成开环,并且开环腿的自由端通过延伸穿过环端并穿过由纤维复合材料或金属制成的外圈的螺栓来互连。
    • 28. 发明授权
    • Use of 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives in leukemia management
    • 在白血病管理中使用3-(吲哚基) - 或3-(azaindolyl)-4-芳基马来酰亚胺衍生物
    • US08841319B2
    • 2014-09-23
    • US12746630
    • 2008-12-04
    • Gerd DannhardtThomas FischerFlorian Heidel
    • Gerd DannhardtThomas FischerFlorian Heidel
    • A61K31/40A61K31/44
    • A61K31/404A61K31/437
    • The present invention relates to the use of a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy groups and R3 is indolyl or azaindolyl which may carry one or two substituents independently selected from C1-C6-alkyl, C1-C6-alkoxy, phenyl, OH, halogen, NH2, C1-C6-alkylamino, di-C1-C6-alkylamino, heteroaryl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S, or heterocyclyl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S, a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) or of the salt thereof, for the prevention or treatment of leukemia.
    • 本发明涉及其中R 1为H,C 1 -C 6 - 烷基,苯基-C 1 -C 4烷基或苯基的式(I)化合物的用途,R 2为被2或3个C1- C6烷氧基,R3是可带有一个或两个独立地选自C 1 -C 6 - 烷基,C 1 -C 6 - 烷氧基,苯基,OH,卤素,NH 2,C 1 -C 6 - 烷基氨基, 含有1或2个独立地选自O,N和S的杂原子的5或6个环原子的杂芳基,或具有5或6个含1或2个独立地选自O,N, 和S,其生理上可接受的盐,或式(I)化合物或其盐的溶剂化物,用于预防或治疗白血病。
    • 30. 发明授权
    • Test element having combined control and calibration zone
    • 具有组合控制和校准区域的测试元件
    • US08569073B2
    • 2013-10-29
    • US13132624
    • 2009-12-02
    • Thomas Fischer
    • Thomas Fischer
    • G01N33/558G01N33/544G01N33/545
    • G01N33/558
    • A test element, for example in the form of an immunological test strip functioning according to the sandwich principle, for the fluorophoric detection of one or more analytes in a sample comprising an analyte detection zone and a combined control and calibration zone. The combined control and calibration zone include a fluorophore and binding partners for the specific binding of reagents labelled with a fluorophore. Furthermore, the invention concerns a method for calibrating an analyte-specific measurement signal, a method for determining the concentration of an analyte in a sample and the use of the test element for calibrating a signal generated in the analyte detection zone of a test element.
    • 测试元件,例如以根据夹心原理起作用的免疫测试条形式,用于在包含分析物检测区域和组合的控制和校准区域的样品中的一种或多种分析物的荧光检测。 组合的对照和校准区包括用荧光团标记的试剂的特异性结合的荧光团和结合配偶体。 此外,本发明涉及校准分析物特异性测量信号的方法,用于确定样品中分析物的浓度的方法以及用于校准在测试元件的分析物检测区域中产生的信号的测试元件的使用。