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21. 发明申请

US20110077598A1 VASCULAR ACCESS TO CLOSURE SHEATH AND METHODS 审中-公开
标题翻译：血管接近闭合和方法
公开(公告)号：US20110077598A1
公开(公告)日：2011-03-31
申请号：US12889733
申请日：2010-09-24
申请人： Catherine A. Pipenhagen , Vasanth R. Shenai
发明人： Catherine A. Pipenhagen , Vasanth R. Shenai
IPC分类号： A61M25/00 , A61B17/03
CPC分类号： A61B17/3468 , A61B17/0057 , A61B17/3439 , A61B2017/00623 , A61B2017/00659 , A61B2017/00663 , A61B2017/00778 , A61B2017/00867 , A61B2017/0409 , A61B2017/0417 , A61B2017/3484 , A61M25/0023 , A61M25/0662 , A61M2025/0024
摘要： An insertion sheath and related methods include a tube member and a shape memory feature. The tube member defines an insertion lumen. The shape memory feature is positioned at a distal end portion of the tube member. The shape memory feature provides a monofold shape in the tube member when in a first state, and a radially expanded shape in the tube member in a second state upon application of an expansion force. The shape memory feature returns the monofold shape after removal of the expansion force. The insertion sheath may function as an access to closure sheath that is suitable for use as a procedural insertion sheath when treating the patient and a closure insertion sheath when sealing closed the vascular puncture.
摘要翻译：插入鞘和相关方法包括管构件和形状记忆特征。管构件限定插入腔。形状记忆特征位于管构件的远端部分。当处于第一状态时，形状记忆特征在管构件中提供单倍形状，并且在施加膨胀力时在第二状态下在管构件中形成径向扩张形状。形状记忆特征在去除膨胀力之后返回单峰形状。插入护套可用作接近闭合护套，当封闭血管穿刺时，当治疗患者时，适合用作手术插入鞘，以及封闭插入鞘。

22. 发明申请

US20090171282A1 VASCUAR CLOSURE DEVICE HAVING A FLOWABLE SEALING MATERIAL 有权
标题翻译：具有流动密封材料的容器闭合装置
公开(公告)号：US20090171282A1
公开(公告)日：2009-07-02
申请号：US11968020
申请日：2007-12-31
申请人： Catherine A. Pipenhagen , Melissa K. Gardner , Jyue Boon Lim , William R. Fiehler , Gary J. Schorr , Janet L. Jacobsen
发明人： Catherine A. Pipenhagen , Melissa K. Gardner , Jyue Boon Lim , William R. Fiehler , Gary J. Schorr , Janet L. Jacobsen
IPC分类号： A61M25/10 , A61M25/00
CPC分类号： A61B17/0057 , A61B2017/0065 , A61B2017/00884 , A61B2017/00951 , A61F2/00 , A61L24/00 , A61L24/0042 , A61L2400/04 , A61L2400/06 , A61M25/04 , A61M2025/0233
摘要： Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids.
摘要翻译：显示并公开了用于在经皮诊断或治疗介入程序之后闭合血管通路穿刺部位的装置的各种实施例。血管闭合装置构造成安全且准确地展开在展开在组织道内时经历相变的密封材料。密封材料在室温下可以是固体，在体温下可以是液体或凝胶。此外，密封材料在与体液接触时可能会从液体或凝胶变为立方相。

23. 发明授权

US09795476B2 Collapsible heart valve with angled frame 有权
公开(公告)号：US09795476B2
公开(公告)日：2017-10-24
申请号：US13703978
申请日：2011-06-14
申请人： Catherine A. Pipenhagen
发明人： Catherine A. Pipenhagen
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2403 , A61F2/2418 , A61F2220/0066 , A61F2230/0054 , A61F2230/008 , A61F2250/0037
摘要： A prosthetic heart valve includes a stent and a valve assembly attached to the stent. The stent has a longitudinal axis, a distal end and a proximal end adapted to reside adjacent the aortic annulus of a patient. The proximal end of the stent is oriented at an oblique angle to the longitudinal axis.

24. 发明授权

US09282953B2 Systems and methods for locating and closing a tissue puncture 有权
标题翻译：用于定位和关闭组织穿刺的系统和方法
公开(公告)号：US09282953B2
公开(公告)日：2016-03-15
申请号：US11967979
申请日：2007-12-31
申请人： Catherine A. Pipenhagen , Jyue Boon Lim , Neil J. Modeland
发明人： Catherine A. Pipenhagen , Jyue Boon Lim , Neil J. Modeland
IPC分类号： A61B17/03 , A61B17/00
CPC分类号： A61B17/0057
摘要： A vascular closure device includes a main body and an expandable portion that can be selectively expanded and contracted. The vascular closure device may be used to close the hole in a wall of a vessel after a medical procedure. For example, the vascular closure device may be used to close the hole in an artery after a medical procedure that required access to the artery. In one embodiment, the expandable portion may be oriented at an oblique angle relative to the main body. This may be desirable in situations where the vessel puncture is oriented at an angle relative to the vessel. Orienting the expandable portion at an oblique angle relative to the main body may help the expandable portion to cover the hole in the wall of the vessel.
摘要翻译：血管闭合装置包括主体和可选择性地膨胀和收缩的可扩张部分。血管闭合装置可用于在医疗程序之后关闭血管壁中的孔。例如，血管闭合装置可以用于在需要进入动脉的医疗程序之后关闭动脉中的孔。在一个实施例中，可膨胀部分可以相对于主体以倾斜的角度定向。在容器穿刺相对于血管以一定角度取向的情况下，这是可取的。相对于主体以倾斜角度定向可扩张部分可以帮助可膨胀部分覆盖容器壁中的孔。

25. 发明授权

US09039738B2 Vascular sealing device with high surface area sealing plug 有权
公开(公告)号：US09039738B2
公开(公告)日：2015-05-26
申请号：US13305586
申请日：2011-11-28
申请人： Catherine A. Pipenhagen , Kedar R. Belhe , John Avi Roop
发明人： Catherine A. Pipenhagen , Kedar R. Belhe , John Avi Roop
IPC分类号： A61B17/04 , A61B17/00
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B2017/00592 , A61B2017/00615 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00663 , A61B2017/00668
摘要： An internal tissue puncture closure method and apparatus. The method and apparatus provide a folded sealing plug that provides more surface area than conventional plugs to more fully cover and seal an external situs of an internal tissue puncture. The folded sealing plug may have a weave pattern that tends to cause the sealing plug to corkscrew into the internal tissue puncture as it is compressed toward an anchor placed inside of the tissue puncture.

26. 发明授权

US08840640B2 Vascular closure device having an improved plug 有权
标题翻译：具有改进插头的血管闭合装置
公开(公告)号：US08840640B2
公开(公告)日：2014-09-23
申请号：US11967896
申请日：2007-12-31
申请人： Catherine A. Pipenhagen , William R. Fiehler , Melissa K. Gardner , Janet L. Jacobsen
发明人： Catherine A. Pipenhagen , William R. Fiehler , Melissa K. Gardner , Janet L. Jacobsen
IPC分类号： A61B17/03 , A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00654
摘要： Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device includes an improved plug that is configured to be positioned adjacent to the hole in the vasculature. The plug may be shaped to prevent the plug from moving away from the hole in the blood vessel due to pulsatile pressure from the blood. In one embodiment, the plug may include a plurality of projections that extend outward from the plug and contact surrounding tissue in the tissue puncture tract to prevent the plug from moving away from the hole in the blood vessel.
摘要翻译：显示并公开了用于在经皮诊断或治疗介入程序之后闭合血管通路穿刺部位的装置的各种实施例。血管闭合装置包括改进的塞子，其构造成邻近脉管系统中的孔定位。塞子可以成形为防止由于来自血液的脉动压力而使塞子远离血管中的孔移动。在一个实施例中，插塞可以包括从插头向外延伸并接触组织穿刺道中的周围组织的多个突起，以防止插头从血管中的孔移开。

27. 发明授权

US08834493B2 Device and method for vascular closure 有权
标题翻译：用于血管闭合的装置和方法
公开(公告)号：US08834493B2
公开(公告)日：2014-09-16
申请号：US11551523
申请日：2006-10-20
申请人： Raimar Boehlke , Kedar R. Belhe , Catherine A. Pipenhagen
发明人： Raimar Boehlke , Kedar R. Belhe , Catherine A. Pipenhagen
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B2017/0454 , A61B2017/0458 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0477 , A61B2017/0496
摘要： A vascular closure delivery system is provided comprising a needle and suture delivery unit and a suture knot system. The delivery unit may comprise a tube, a leg, a tensioning device, a pusher, a needle, and an actuator, the tube being configured to house the needle. In an open position, the tensioning device exerts tension on the leg, and the pusher and suturing apparatus are in a delivery configuration for delivering the needle to the internal tissue wall. Further, actuation of the actuator moves the pusher towards an expulsion end of the tube such that the pusher engages the needle and expels the needle from the tube. The suture knot system comprises a shaft, an inner tubular member, and an inner rod. The inner tubular member is radially translatable with respect to the shaft. The inner rod is slidably coupled to and is axially translatable within the inner tubular member.
摘要翻译：提供了一种血管闭合递送系统，其包括针和缝合线递送单元和缝线结系统。输送单元可以包括管，腿，张紧装置，推动器，针和致动器，所述管被配置为容纳针。在打开位置，张紧装置在腿部施加张力，并且推动器和缝合装置处于用于将针输送到内部组织壁的输送构造。此外，致动器致动器将推动器朝向管的排出端移动，使得推动器接合针并将针从管排出。缝合结系统包括轴，内管状构件和内杆。内部管状构件可相对于轴径向平移。内杆可滑动地联接到内部管状构件中并在其内可轴向平移。

28. 发明授权

US07731726B2 Suture based vascular closure apparatus and method incorporating a pre-tied knot 有权
标题翻译：基于缝合的血管闭合装置和包含预先束缚结的方法
公开(公告)号：US07731726B2
公开(公告)日：2010-06-08
申请号：US10726994
申请日：2003-12-03
申请人： Kedar R. Belhe , John Avi Roop , Catherine A. Pipenhagen
发明人： Kedar R. Belhe , John Avi Roop , Catherine A. Pipenhagen
IPC分类号： A61B17/04
CPC分类号： A61B17/0057 , A61B17/0469 , A61B2017/00637 , A61B2017/00663 , A61B2017/00672 , A61B2017/0472 , A61B2017/0474 , A61B2017/0477 , A61B2017/0496 , A61B2017/061
摘要： A pre-tied knot is used in conjunction with a vascular closure device to approximate tissue surrounding an opening in a corporeal vessel. The pre-tied knot is positioned on a proximal end of the suture such that a distal end of the suture can be inserted through the pre-tied knot to complete the knot. A typical medical procedure as contemplated by the present invention is performed through a sheath inserted through an opening in the vessel wall to access the inside of the vessel. The device used to perform the medical procedure is then removed from the sheath and a vascular closure device is inserted through the sheath to position a suture across the vessel opening. The pre-tied knot assists in approximating tissue surrounding the vessel opening.
摘要翻译：预先束缚的结与血管闭合装置结合使用以近似体表血管中的开口周围的组织。预先束缚的结被定位在缝合线的近端，使得缝合线的远端可以穿过预先束缚的结插入以完成结。本发明考虑的典型的医疗过程是通过插入血管壁中的开口的护套进行的，以便进入血管内部。用于执行医疗过程的装置然后从鞘中移除，并且血管闭合装置插入穿过护套以将缝合线定位在血管开口处。预先束缚的结有助于近似围绕血管开口的组织。

29. 发明授权

US07621937B2 Vascular sealing device with high surface area sealing plug 有权
标题翻译：具有高表面积密封塞的血管密封装置
公开(公告)号：US07621937B2
公开(公告)日：2009-11-24
申请号：US10726966
申请日：2003-12-03
申请人： Catherine A. Pipenhagen , Kedar R. Belhe , John Avi Roop
发明人： Catherine A. Pipenhagen , Kedar R. Belhe , John Avi Roop
IPC分类号： A61B17/04 , A61B17/08
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B2017/00592 , A61B2017/00615 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00663 , A61B2017/00668
摘要： An internal tissue puncture closure method and apparatus. The method and apparatus provide a folded sealing plug that provides more surface area than conventional plugs to more fully cover and seal an external situs of an internal tissue puncture. The folded sealing plug may have a weave pattern that tends to cause the sealing plug to corkscrew into the internal tissue puncture as it is compressed toward an anchor placed inside of the tissue puncture.
摘要翻译：内部组织穿刺闭合方法和装置。该方法和装置提供折叠的密封塞，其提供比常规塞子更多的表面积，以更完全地覆盖和密封内部组织穿刺的外部部位。折叠的密封塞可以具有编织图案，其趋向于使得当密封塞被压缩到放置在组织穿刺内部的锚定处时，密封塞开始开启到内部组织穿刺中。

30. 发明申请

US20090054926A1 EXTRA-VASCULAR SEALING DEVICE AND METHOD 有权
标题翻译：超声波密封装置及方法
公开(公告)号：US20090054926A1
公开(公告)日：2009-02-26
申请号：US11842509
申请日：2007-08-21
申请人： Catherine A. Pipenhagen , Melissa K. Gardner , William Fiehler , Janet L. Jacobsen , Gary J. Schorr , Jyue Boon Lim
发明人： Catherine A. Pipenhagen , Melissa K. Gardner , William Fiehler , Janet L. Jacobsen , Gary J. Schorr , Jyue Boon Lim
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/0467 , A61B2017/00637 , A61B2017/00654 , A61B2017/00898 , A61B2017/00986 , A61B2017/0475 , A61B2017/0496 , A61B2090/0811
摘要： Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. In one embodiment, the closure device includes a vessel locating member, an anchor and a sealing material. The closure device may be configured to deploy the anchor and the sealing material outside of a hole in a blood vessel to close the hole. The vessel locating member may be used to locate the blood vessel to ensure that the anchor and/or the sealing material are properly placed adjacent to the hole. The closure device may also include a tamper member configured to push or tamp the sealing material against the anchor. The closure device may also include a suture that is used to hold the sealing material and the anchor together adjacent to the hole in the blood vessel.
摘要翻译：显示并公开了用于在经皮诊断或治疗介入程序之后闭合血管通路穿刺部位的装置的各种实施例。在一个实施例中，封闭装置包括容器定位构件，锚固件和密封材料。闭合装置可以构造成将锚和密封材料在血管中的孔的外部展开以关闭孔。血管定位构件可以用于定位血管，以确保锚和/或密封材料适当地放置在孔附近。封闭装置还可以包括构造成将密封材料推压或夯在锚上的捣固构件。闭合装置还可以包括用于将密封材料和锚固体保持在邻近血管孔的缝合线。

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