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21. 发明申请

US20070178108A1 Colon Specific Gene and Protein and Cancer 审中-公开
标题翻译：结肠特异性基因和蛋白质和癌症
公开(公告)号：US20070178108A1
公开(公告)日：2007-08-02
申请号：US11696199
申请日：2007-04-04
申请人： Patrick Dillon , Yi Li , Daniel Soppet , Adam Bell , D. Duan , Ralph Alderson , Wendy Halpern
发明人： Patrick Dillon , Yi Li , Daniel Soppet , Adam Bell , D. Duan , Ralph Alderson , Wendy Halpern
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , A61K39/395
CPC分类号： C07K16/18 , A61K38/00 , A61K48/00 , C07K14/47 , C12Q1/6886 , C12Q2600/136 , G01N33/57419
摘要： Human Colon Specific Polynucleotides (DNA and RNA), Polypeptides, and Antibodies, as well as methods for using and producing such polynucleotides, polypeptides, and antibodies are disclosed. More particularly, methods are disclosed for utilizing such polynucleotides, polypeptides, and antibodies to detect, diagnose, prevent, treat, and/or ameliorate cancer (particularly gastrointestinal tract cancers such as colon and pancreatic cancer). Also disclosed are compositions and methods for targeting and destroying cancer cells (particularly gastrointestinal tract cancers such as colon and pancreatic cancer) via the Colon Specific Protein and/or via the Colon Specific Protein Receptor. Moreover, methods of screening for antagonists and binding partners of the Colon Specific Protein and therapeutic uses of such antagonists and binding partners are also disclosed.
摘要翻译：公开了人结肠特异性多核苷酸（DNA和RNA），多肽和抗体，以及使用和产生这种多核苷酸，多肽和抗体的方法。更具体地，公开了利用这些多核苷酸，多肽和抗体检测，诊断，预防，治疗和/或改善癌症（特别是胃肠道癌症如结肠癌和胰腺癌）的方法。还公开了通过结肠特异性蛋白质和/或通过结肠特异性蛋白质受体靶向和破坏癌细胞（特别是胃肠道癌症例如结肠和胰腺癌）的组合物和方法。此外，还公开了筛选结肠特异性蛋白质的拮抗剂和结合配偶体的方法以及这些拮抗剂和结合配偶体的治疗用途。

22. 发明授权

US06338951B1 G-protein parathyroid hormone receptor HLTDG74 失效
公开(公告)号：US06338951B1
公开(公告)日：2002-01-15
申请号：US09236468
申请日：1999-01-25
申请人： Daniel Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K1472
CPC分类号： C07K14/723 , A61K48/00 , C12N2799/026
摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

23. 发明申请

US20050214281A1 G-protein coupled receptor 审中-公开
标题翻译： G蛋白偶联受体
公开(公告)号：US20050214281A1
公开(公告)日：2005-09-29
申请号：US10986025
申请日：2004-11-12
申请人： Yi Li , Craig Rosen , Jeannine Gocayne
发明人： Yi Li , Craig Rosen , Jeannine Gocayne
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/24 , A61P25/26 , A61P37/08 , A61P43/00 , C07H21/04 , C07K14/705 , C07K16/28 , C12N5/00 , C12N5/06 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026
摘要： A human G-protein coupled receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequence.
摘要翻译：公开了人G-蛋白偶联受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽鉴定这种多肽的拮抗剂和激动剂的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变的诊断方法。

24. 发明申请

US20050123998A1 C5a receptor 审中-公开
标题翻译： C5a受体
公开(公告)号：US20050123998A1
公开(公告)日：2005-06-09
申请号：US10984898
申请日：2004-11-10
申请人： Yi Li , Craig Rosen
发明人： Yi Li , Craig Rosen
IPC分类号： A61K48/00 , C07K14/705 , G01N33/53 , C07H21/04 , C07K16/28
CPC分类号： C07K14/70596 , A61K48/00
摘要： A human C5a receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or stimulate the C5a receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
摘要翻译：公开了人类C5a受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽鉴定这种多肽的拮抗剂和激动剂的方法。拮抗剂和激动剂可用于治疗性地抑制或刺激C5a受体。还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。

25. 发明申请

US20060014249A1 Human G-protein coupled receptor 审中-公开
公开(公告)号：US20060014249A1
公开(公告)日：2006-01-19
申请号：US11169976
申请日：2005-06-30
申请人： Yi Li , Craig Rosen
发明人： Yi Li , Craig Rosen
IPC分类号： C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/723 , A61K38/00 , C07K14/705
摘要： A human G-protein coupled receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or stimulate the G-protein coupled receptor. Also disclosed are assays for detecting mutations in the nucleic acid sequence encoding the G-protein coupled receptor.

26. 发明申请

US20060148708A1 C5a receptor 审中-公开
公开(公告)号：US20060148708A1
公开(公告)日：2006-07-06
申请号：US11367538
申请日：2006-03-06
申请人： Yi Li , Craig Rosen
发明人： Yi Li , Craig Rosen
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , A61K38/00 , C07K14/723
摘要： A human C5a receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or stimulate the C5a receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

27. 发明申请

US20050266522A1 Human amine receptor 审中-公开
标题翻译：人类胺受体
公开(公告)号：US20050266522A1
公开(公告)日：2005-12-01
申请号：US10875716
申请日：2004-06-25
申请人： Yi Li , Steven Ruben
发明人： Yi Li , Steven Ruben
IPC分类号： C07H21/04 , C07K14/705 , C12N15/12 , C12P21/06
CPC分类号： C07K14/705
摘要： A Human amine receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting compounds which bind to and activate and bind to and inhibit such polypeptide and the use of compounds for treating diseases related to the under-expression and over-expression of the Human amine receptor of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
摘要翻译：公开了人类胺受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还提供了用于检测结合并活化并结合并抑制这种多肽的化合物的方法以及用于治疗与本发明的人胺受体的低表达和过表达有关的疾病的化合物的用途。还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

28. 发明申请

US20050123961A1 Human G-protein coupled receptors 审中-公开
标题翻译：人类G蛋白偶联受体
公开(公告)号：US20050123961A1
公开(公告)日：2005-06-09
申请号：US10968990
申请日：2004-10-21
申请人： Yi Li , Steven Ruben
发明人： Yi Li , Steven Ruben
IPC分类号： C12N15/09 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C07H21/04 , C07K14/74
CPC分类号： C07K14/705
摘要： Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.
摘要翻译：公开了两种人G-蛋白偶联受体多肽和编码每种这样的多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽鉴定这种多肽的拮抗剂和激动剂的方法。还公开了用于检测每个G蛋白偶联受体的核酸序列中的突变的诊断方法。

29. 发明申请

US20050196831A1 Human G-protein chemokine receptor (CCR5) HDGNR10 审中-公开
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：US20050196831A1
公开(公告)日：2005-09-08
申请号：US10127764
申请日：2002-04-23
申请人： Yi Li , Steven Ruben
发明人： Yi Li , Steven Ruben
IPC分类号： A61K38/00 , C07K14/715 , C12P21/08 , A61K38/17 , C12N5/06 , C12P21/02
CPC分类号： C07K14/7158 , A61K38/00 , C12N2799/026
摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
摘要翻译：公开了人G-蛋白趋化因子受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白趋化因子受体多肽的低表达和过表达有关的病症的方法。还公开了用于检测G蛋白趋化因子受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式的水平的诊断方法。

30. 发明授权

US09851071B2 Light source employing a wavelength conversion device with a light introducing device and a light collecting device 有权
公开(公告)号：US09851071B2
公开(公告)日：2017-12-26
申请号：US13992144
申请日：2011-12-07
申请人： Fei Hu , Yi Li , Yi Yang
发明人： Fei Hu , Yi Li , Yi Yang
IPC分类号： F21V9/08 , F21S10/00 , G03B21/28 , F21V9/10 , G03B21/20 , G03B21/14 , F21V9/16 , F21V13/08 , G02B26/00 , G02B19/00 , F21Y101/00 , F21Y115/10
CPC分类号： G03B21/204 , F21K9/64 , F21S10/007 , F21V9/08 , F21V9/30 , F21V9/40 , F21V13/08 , F21Y2101/00 , F21Y2115/00 , F21Y2115/10 , G02B19/0028 , G02B19/0047 , G02B26/008 , G02F2002/006 , G03B21/14 , G03B21/2066 , G03B21/28 , H04N9/3114 , H04N9/3117 , H04N9/315 , H04N9/3155 , H04N2209/043
摘要： A light source comprising an excitation light source for providing excitation light, and an optical wavelength conversion member disposed at a distance from the excitation light source. The optical wavelength conversion member comprises an optical wavelength conversion material for converting the excitation light into stimulated light. The light source also comprises an optical-guiding member that allows the excitation light to be incident on the optical wavelength conversion material, and an optical-collecting member for collecting converted light originating from the optical wavelength conversion material. To separate the paths of the converted light and the excitation light, the etendue of the optical-guiding member is less than or equal to ¼ of the etendue of the optical-collecting member. This allows the optical-guiding member to draw in the excitation light while preventing the excessive escape of the converted light through the optical-guiding member.

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