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21. 发明申请

US20110190342A1 GLYCINE B ANTAGONIST 失效
标题翻译：糖蛋白B拮抗剂
公开(公告)号：US20110190342A1
公开(公告)日：2011-08-04
申请号：US12998246
申请日：2009-09-30
申请人： Markus Henrich , Angela Bauer , Jens Nagel , Meik Sladek , Christopher Graham Raphael Parsons , Wojciech Danysz , Valerjans Kauss , Jevgenijs Rozhkovs , Igos Starchenkovs , Dina Trifanova
发明人： Markus Henrich , Angela Bauer , Jens Nagel , Meik Sladek , Christopher Graham Raphael Parsons , Wojciech Danysz , Valerjans Kauss , Jevgenijs Rozhkovs , Igos Starchenkovs , Dina Trifanova
IPC分类号： A61K31/4709 , C07D401/12 , C07D215/54 , C07D409/12 , C07D409/14 , A61K31/47 , A61P29/00 , A61P31/12 , A61P35/00 , A61P9/10 , A61P25/00 , A61P19/02 , A61P19/06 , A61P3/10 , A61P31/18 , A61P7/10 , A61P27/16 , A61P25/14 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/18 , A61P25/24 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P3/04 , A61P3/08 , A61P25/06 , A61P11/00 , A61P11/06 , A61P27/02 , A61P27/06 , A61P31/00 , A61P1/12 , A61P3/00 , A61P17/00 , A61P1/04 , A61P1/08
CPC分类号： C07D215/54
摘要： The invention relates to quinoline derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.
摘要翻译：本发明涉及喹啉衍生物及其药学上可接受的盐。本发明还涉及制备这些化合物的方法。本发明的化合物是甘氨酸B拮抗剂，因此可用于控制和预防各种疾病，包括神经障碍。

22. 发明申请

US20110003820A1 PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE 审中-公开
标题翻译：吡咯并嘧啶，其制备方法及其作为医药使用
公开(公告)号：US20110003820A1
公开(公告)日：2011-01-06
申请号：US12735605
申请日：2009-01-30
申请人： Markus Henrich , Tanja Weil , Sibylle Muller , Jens Nagel , Andreas Gravius , Valerjans Kauss , Ronalds Zemribo , Elina Erdmane
发明人： Markus Henrich , Tanja Weil , Sibylle Muller , Jens Nagel , Andreas Gravius , Valerjans Kauss , Ronalds Zemribo , Elina Erdmane
IPC分类号： A61K31/519 , C07D487/04 , A61K31/5025 , A61K31/53 , A61P25/00 , A61P35/00
CPC分类号： C07D519/00 , C07D487/04
摘要： The invention relates to pyrazolopyrimidine derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
摘要翻译：本发明涉及吡唑并嘧啶衍生物及其药学上可接受的盐。本发明还涉及制备这些化合物的方法。本发明的化合物是mGluR5调节剂，因此可用于控制和预防急性和/或慢性神经障碍。

23. 发明申请

US20080032998A1 Pyrazolopyrimidines, a process for their preparation and their use as medicine 审中-公开
标题翻译：吡唑并嘧啶，其制备方法及其用作药物
公开(公告)号：US20080032998A1
公开(公告)日：2008-02-07
申请号：US11890230
申请日：2007-08-03
申请人： Wojciech Danysz , Andrzej Dekundy , Mirko Hechenberger , Markus Henrich , Claudia Jatzke , Jens Nagel , Christopher Parsons , Tanja Weil , Juris Fotins , Aleksandrs Gutcaits , Ivars Kalvinsh , Ronalds Zemribo , Valerjans Kauss
发明人： Wojciech Danysz , Andrzej Dekundy , Mirko Hechenberger , Markus Henrich , Claudia Jatzke , Jens Nagel , Christopher Parsons , Tanja Weil , Juris Fotins , Aleksandrs Gutcaits , Ivars Kalvinsh , Ronalds Zemribo , Valerjans Kauss
IPC分类号： A61K31/519 , A61P1/00 , A61P25/00 , A61P3/00 , A61P35/00 , A61P9/00 , C07D239/70
CPC分类号： C07D487/04 , C07D519/00
摘要： Substituted pyrazolopyrimidine derivatives of formula (I) wherein R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 independently represent e.g. hydrogen or C1-6-alkyl; R8 represents a radical R9 or a radical R10, whereby one of the two radicals R8 represents R9 and the other radical R8 represents Ret; R9 represents e.g. a phenyl or thiophene group, and R10 represents e.g. hydrogen or methyl; are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.
摘要翻译：式（I）的取代的吡唑并嘧啶衍生物其中R 1表示氯或溴; R 2，R 3，R 4，R 5，R 6和R 6，和 R＆lt; 7＆gt;独立地代表例如氢或C 1-6 - 烷基; R 8表示基团R 9或基团R 10，其中两个基团R 8中的一个表示 R 9和另一个基团R 8表示Ret; R 9表示例如，苯基或噻吩基团，R 10代表例如。氢或甲基; 是有效的mGluR5调节剂，可用于预防急性和慢性神经障碍。

24. 发明授权

US07158678B2 Text input method for personal digital assistants and the like 有权
标题翻译：用于个人数字助理的文本输入方法等
公开(公告)号：US07158678B2
公开(公告)日：2007-01-02
申请号：US09909202
申请日：2001-07-19
申请人： Jens Nagel , Giovanni Seni
发明人： Jens Nagel , Giovanni Seni
IPC分类号： G06K9/62
CPC分类号： G06K9/222
摘要： A handheld device 100 with a graphical user interface for entering handwritten text 102. The handheld device includes word and character input areas 104, 106 within a designated input area 108. Icons 110, 112, 114, 116 and 118 are disposed at the right side of the handwriting user interface 102. A scroll bar 120 may be disposed at the right side of the interface display 102. An entry that begins in the word input area 104 is treated as a handwritten word. A handwritten entry that begins in the character input area 106 is treated as a single character and may be one character in character string. Handwritten character entries are each matched against all potential characters.
摘要翻译：具有用于输入手写文本102的图形用户界面的手持设备100。手持设备包括在指定的输入区域108内的字和字符输入区域104,106。图标110,112,114,116和118设置在手写用户界面102的右侧。滚动条120可以设置在界面显示器102的右侧。在字输入区域104中开始的条目被视为手写字。在字符输入区域106中开始的手写条目被视为单个字符，并且可以是字符串中的一个字符。手写字符条目都与所有潜在字符匹配。

25. 发明授权

US4400853A Needle bar drawing device 失效
标题翻译：针杆拉丝装置
公开(公告)号：US4400853A
公开(公告)日：1983-08-30
申请号：US307795
申请日：1981-10-02
申请人： Jens Nagel
发明人： Jens Nagel
IPC分类号： D01H5/02
CPC分类号： D01H5/02
摘要： In an needle bar drawing device or gill box comprising needle bars carried by chains is arranged a bristle mat consisting of one or few layers of bristles extending along the whole needle field up to the proximity of a clamping gap formed between a pair of exit rollers. The bristle mat is penetrated by the needles of the needle field and creates a stripping effect at the disappearing position of the needles in the region of the nip, this stripping effect avoiding the conveying of fibers freely swimming in the sliver, and thus the danger and disadvantage of any lap forming.
摘要翻译：在包括由链条承载的针杆的针杆拉拔装置或鳃盒中布置有由沿着整个针场延伸直到形成在一对出口辊之间的夹紧间隙附近的一层或几层刷毛组成的刷毛垫。毛针垫被针场的针刺穿，并且在辊隙区域的针的消失位置产生剥离效果，这种剥离效果避免了纤维在棉条中自由游动的传送，因此危险和任何搭接成型的缺点。

26. 发明授权

US4351089A Needle bar draw frame 失效
标题翻译：针杆画框
公开(公告)号：US4351089A
公开(公告)日：1982-09-28
申请号：US169923
申请日：1980-07-17
申请人： Joachim Jahnke , Gunther Lehming , Helmut Kunig , Jens Nagel
发明人： Joachim Jahnke , Gunther Lehming , Helmut Kunig , Jens Nagel
IPC分类号： D01H5/08 , D01G19/00
CPC分类号： D01H5/08
摘要： The invention concerns a needle bar draw frame or gill box with a needle field or gilling area of needle bars carried by chains. With the aim of attaining the usual performances in respect of speed and drawing ratio at the same quality also in the case of voluminous short-staple slivers with draw frames operating with an upper and a lower needle field, control means engaging from above into the needle field are used in a draw frame provided merely with a lower needle field. These control means are constructed as bristle-like holding down devices which are arranged particularly immediately upstream of a pair of drawing rollers and possibly shortly downstream of a pair of entry rollers, while the central region is controlled in the usual manner by a bar roller or bar chain.
摘要翻译：本发明涉及一种具有针状针的针杆拉制框架或鳃盒或由链条承载的针杆的开口区域。为了在相同质量下获得关于速度和拉伸比的通常性能，在具有用上下针场操作的拉伸框架的大量短缝条的情况下，控制装置从上方啮合到针场用于仅提供较低针场的拉丝框架中。这些控制装置被构造成刷毛状的压紧装置，其特别紧紧地布置在一对拉伸辊的上游，并且可能在一对进入辊的下游可能不久，同时中央区域以通常的方式由一个滚筒或酒吧链。

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