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21. 发明申请

WO9957280A9 NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS 审中-公开
标题翻译： NEISSERIA MENINGITIDIS抗生素和组合物
公开(公告)号：WO9957280A9
公开(公告)日：2002-08-29
申请号：PCT/US9909346
申请日：1999-04-30
申请人： CHIRON CORP , INST GENOMIC RESEARCH , FRASER CLAIRE , GALEOTTI CESIRA , GRANDI GUIDO , HICKEY ERIN , MASIGNANI VEGA , MORA MARIROSA , PETERSEN JEREMY , PIZZA MARIAGRATIA , RAPPUOLI RINO , RATTI GIULIO , SCALATO ENZO , SCARSELLI MARIA , TETTELIN HERVE , VENTER J CRAIG
发明人： FRASER CLAIRE , GALEOTTI CESIRA , GRANDI GUIDO , HICKEY ERIN , MASIGNANI VEGA , MORA MARIROSA , PETERSEN JEREMY , PIZZA MARIAGRATIA , RAPPUOLI RINO , RATTI GIULIO , SCALATO ENZO , SCARSELLI MARIA , TETTELIN HERVE , VENTER J CRAIG
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/095 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/31 , C12P21/08 , C12Q1/68 , C12R1/36
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译：本发明提供脑膜炎奈瑟氏球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。蛋白质被预测为用于疫苗和/或诊断的有用的抗原。

22. 发明申请

WO0071574A3 ANTIGENIC NEISSERIAL PEPTIDES 审中-公开
标题翻译：抗原性神经肽
公开(公告)号：WO0071574A3
公开(公告)日：2002-01-24
申请号：PCT/IB0000831
申请日：2000-05-19
申请人： CHIRON SPA , MASIGNANI VEGA , SCARLATO VINCENZO , SCARSELLI MARIA , GALEOTTI CESIRA , MORA MARIA ROSA
发明人： MASIGNANI VEGA , SCARLATO VINCENZO , SCARSELLI MARIA , GALEOTTI CESIRA , MORA MARIA ROSA
IPC分类号： G01N33/53 , A61K38/00 , A61K39/095 , A61K39/395 , A61K48/00 , A61P25/00 , A61P29/00 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , G01N33/569 , C12N15/31
CPC分类号： C07K14/22 , A61K38/00
摘要： WO99/24578 discloses a large number of proteins from Neisseria meningitidis and Neisseria gonorrhoeae. The present invention relates to fragments of those proteins which comprise at least one antigenic determinant. Homologous sequences and proteins comprising these fragments are also disclosed.
摘要翻译： WO99 / 24578公开了大量来自脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的蛋白质。本发明涉及包含至少一种抗原决定簇的那些蛋白质的片段。还公开了包含这些片段的同源序列和蛋白质。

23. 发明申请

WO0104316A3 ANTIGENIC MENINGOCOCCAL PEPTIDES 审中-公开
标题翻译：抗原性MENINGOCOCCAL肽
公开(公告)号：WO0104316A3
公开(公告)日：2001-08-09
申请号：PCT/IB0001026
申请日：2000-07-13
申请人： CHIRON SPA , MASIGNANI VEGA , SCARLATO VINCENZO , SCARSELLI MARIA , GALEOTTI CESIRA , MORA MARIAROSA
发明人： MASIGNANI VEGA , SCARLATO VINCENZO , SCARSELLI MARIA , GALEOTTI CESIRA , MORA MARIAROSA
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/02 , A61K38/40 , A61K39/00 , A61K39/095 , A61K39/395 , A61K48/00 , A61P31/04 , C07K2/00 , C07K14/195 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/31 , C12Q1/68 , G01N33/569
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , A61K2039/53 , Y10S530/825
摘要： WO99/36544 discloses a large number of proteins from Neisseria Meningitidis . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant. Homologous sequences and proteins comprising these fragments are also disclosed.
摘要翻译： WO99 / 36544公开了来自奈瑟氏脑膜炎奈瑟球菌的大量蛋白质。本发明涉及包含至少一种抗原决定簇的那些蛋白质的片段。还公开了包含这些片段的同源序列和蛋白质。

24. 发明申请

WO0234771A2 NUCLEIC ACIDS AND PROTEINS FROM STREPTOCOCCUS GROUPS A & B 审中-公开
标题翻译：来自STREPTOCOCCUS组A＆B的核酸和蛋白质
公开(公告)号：WO0234771A2
公开(公告)日：2002-05-02
申请号：PCT/GB0104789
申请日：2001-10-29
申请人： CHIRON SPA , INST GENOMIC RESEARCH , TELFORD JOHN , MASIGNANI VEGA , MARGARIT Y ROS IMMACULADA , GRANDI GUIDO , FRASER CLAIRE , TETTELIN HERVE
发明人： TELFORD JOHN , MASIGNANI VEGA , MARGARIT Y ROS IMMACULADA , GRANDI GUIDO , FRASER CLAIRE , TETTELIN HERVE
IPC分类号： A61K39/00 , C07K14/315 , C07K14/195
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018
摘要： The invention provides proteins from group B streptococcus ( Streptococcus agalactiae ) and group A streptococcus ( Streptococcus pyogenes ), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译：本发明提供了来自B族链球菌（无乳链球菌）和A型链球菌（脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。蛋白质也是抗生素的靶标。

25. 发明申请

WO2006069200A2 GROUP B STREPTOCOCCUS 审中-公开
标题翻译： B组STREPTOCOCCUS
公开(公告)号：WO2006069200A2
公开(公告)日：2006-06-29
申请号：PCT/US2005046491
申请日：2005-12-21
申请人： CHIRON CORP , TETTELIN HERVE , MASIGNANI VEGA
发明人： TETTELIN HERVE , MASIGNANI VEGA
CPC分类号： C07K14/315 , A61K39/00
摘要： Polypeptides and nucleic acids from Streptococcus agalactiae which can be used in the development of vaccines, for diagnostic purposes, and as targets for antibiotics.
摘要翻译：来自无乳链球菌的多肽和核酸，其可用于疫苗的开发，用于诊断目的和作为抗生素的靶标。

26. 发明申请

WO02094868A3 STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS 审中-公开
标题翻译：。US。。。。。。。。。。。。。。。。
公开(公告)号：WO02094868A3
公开(公告)日：2003-09-18
申请号：PCT/IB0202637
申请日：2002-03-27
申请人： CHIRON SRL , MASIGNANI VEGA , MORA MARIROSA , SCARSELLI MARIA
发明人： MASIGNANI VEGA , MORA MARIROSA , SCARSELLI MARIA
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/10 , A61K39/102 , A61K39/118 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/205 , A61K39/395 , A61K48/00 , A61P31/04 , C07K14/31 , C07K16/12 , C07K19/00
CPC分类号： A61K39/085 , A61K2039/70 , C07K14/31
摘要： The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
摘要翻译：本发明提供了来自金黄色葡萄球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。该蛋白质可用于疫苗，免疫原性组合物，诊断，酶学研究以及抗生素靶标。

27. 发明申请

WO2005111066A8 POLYPEPTIDES FROM NON-TYPEABLE HAEMOPHILUS INFLUENZAE 审中-公开
标题翻译：来自非类型HAEMOPHILUS INFLUENZAE的多肽
公开(公告)号：WO2005111066A8
公开(公告)日：2007-05-18
申请号：PCT/IB2005001775
申请日：2005-05-16
申请人： CHIRON SRL , MASIGNANI VEGA , ARICO MARIA
发明人： MASIGNANI VEGA , ARICO MARIA
IPC分类号： C07K14/285 , A61K39/00 , C07K16/12
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K2039/505 , A61K2039/53
摘要： Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be usedin medicine for treating or preventing disease and/or infection caused by H.influenzae, such as otitis media.
摘要翻译：包含不可分型流感嗜血杆菌（NTHi）氨基酸序列的多肽。公开了超过2500种特异性NTHi蛋白。本发明还提供了相关的多肽，核酸，抗体和方法。这些都可用于治疗或预防由H.influenzae引起的疾病和/或感染的药物，例如中耳炎。

28. 发明申请

WO2005111066A3 POLYPEPTIDES FROM NON-TYPEABLE HAEMOPHILUS INFLUENZAE 审中-公开
标题翻译：来自非类型HAEMOPHILUS INFLUENZAE的多肽
公开(公告)号：WO2005111066A3
公开(公告)日：2006-05-26
申请号：PCT/IB2005001775
申请日：2005-05-16
申请人： CHIRON SRL , MASIGNANI VEGA , ARICO MARIA
发明人： MASIGNANI VEGA , ARICO MARIA
IPC分类号： C07K14/285 , A61K39/00 , C07K16/12
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K2039/505 , A61K2039/53
摘要： Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be usedin medicine for treating or preventing disease and/or infection caused by H.influenzae, such as otitis media.
摘要翻译：包含不可分型流感嗜血杆菌（NTHi）氨基酸序列的多肽。公开了超过2500种特异性NTHi蛋白。本发明还提供了相关的多肽，核酸，抗体和方法。这些都可用于治疗或预防由H.influenzae引起的疾病和/或感染的药物，例如中耳炎。

29. 发明申请

WO02077021A3 STREPTOCOCCUS PNEUMONIAE PROTEINS AND NUCLEIC ACIDS 审中-公开
标题翻译： STREPTOCOCCUS PNEUMONIAE蛋白质和核酸
公开(公告)号：WO02077021A3
公开(公告)日：2003-08-28
申请号：PCT/IB0202163
申请日：2002-03-27
申请人： CHIRON SRL , INST GENOMIC RESEARCH , MASIGNANI VEGA , TETTELIN HERVE , FRASER CLAIRE
发明人： MASIGNANI VEGA , TETTELIN HERVE , FRASER CLAIRE
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/095 , A61K39/102 , A61K39/118 , A61K39/20 , A61K39/205 , A61K39/29 , A61K39/395 , A61P11/00 , A61P25/00 , A61P27/16 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N15/31 , C12R1/46 , A61K39/09 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/3156 , A61K39/00
摘要： The invention provides proteins and nucleic acid sequences from Streptocccus pneumoniae, together with a genome sequence. These are useful for the development of vaccines, diagnostics, and antibiotics.
摘要翻译：本发明提供了来自肺炎链球菌的蛋白质和核酸序列，以及基因组序列。这些可用于开发疫苗，诊断和抗生素。

30. 发明申请

WO2008146164A2 STREPTOCOCCUS PNEUMONIAE PILUS ANTIGENS 审中-公开
标题翻译： STREPTOCOCCUS PNEUMONIAE PILUS抗原
公开(公告)号：WO2008146164A2
公开(公告)日：2008-12-04
申请号：PCT/IB2008002108
申请日：2008-05-23
申请人： NOVARTIS AG , DONATI CLAUDIO , MASIGNANI VEGA , MORA MARIROSA , MOSCHIONI MONICA
发明人： DONATI CLAUDIO , MASIGNANI VEGA , MORA MARIROSA , MOSCHIONI MONICA
IPC分类号： C07K14/315 , A61K39/09 , C07K16/12 , C12N9/10 , C12N9/52
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12N9/52 , G01N33/56944 , G01N2333/315 , G01N2469/10
摘要： Polypeptides from Streptococcus pneumoniae are described. In some aspects the polypeptides include pili polypeptides from a second pili island (pilus II island (INVl 04B)) identified in Streptococcus pneumoniae isolate INVl 04. In other aspects the polypeptides include pili polypeptides and non-pilus polypeptides from Streptococcus pneumoniae strains 23F, INV200, and OXC141 that are absent from Streptococcus pneumoniae isolate INV104. The polypeptides, including fragments and variants thereof, may be used in immunogenic compositions for prophylactic or therapeutic immunization against Streptococcus pneumoniae. The polypeptides are also disclosed to be used in compositions useful for the production of antibodies and immunostimulants. Also presented are methods of inhibiting Streptococcus pneumoniae, methods of treating Streptococcus pneumoniae infection, methods of identifying inhibitors of Streptococcus pneumoniae and methods for diagnosing/detecting Streptococcus pneumoniae infection.
摘要翻译：描述了来自肺炎链球菌的多肽。在一些方面，多肽包括来自肺炎链球菌分离株INV04中鉴定的第二个皮岛（pilus II岛（INVl 04B））的多肽。在其它方面，多肽包括来自肺炎链球菌菌株23F，INV200的多肽和非菌毛多肽，和OXC141，其不存在于肺炎链球菌分离株INV104中。多肽，包括其片段和变体，可用于免疫原性组合物，用于针对肺炎链球菌的预防性或治疗性免疫。还公开了将多肽用于可用于产生抗体和免疫兴奋剂的组合物中。还提出了抑制肺炎链球菌的方法，肺炎链球菌感染的治疗方法，肺炎链球菌抑制剂的鉴定方法和肺炎链球菌感染诊断方法。

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