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21. 发明申请

WO1990011769A1 THERAPEUTIC COMPOUNDS, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：治疗化合物，组合物及其用途
公开(公告)号：WO1990011769A1
公开(公告)日：1990-10-18
申请号：PCT/GB1990000540
申请日：1990-04-10
申请人： CELLTECH LIMITED , NEY, Ursula, Mary , BENNETT, Terence , GARDINER, Sheila, Margaret
发明人： CELLTECH LIMITED
IPC分类号： A61K37/02
CPC分类号： A61K38/23 , A61K31/44 , A61K2300/00
摘要： The invention relates to the therapeutic use of vasodilators and calcium antagonists in combination in the treatment of deficiencies in cerebral blood supply. The vasodilator and calcium antagonist show a selectivity of site of action and are effective in increasing cerebral blood supply without adversely affecting other physiological parameters such as blood pressure and heart rate.
摘要翻译：本发明涉及血管扩张剂和钙拮抗剂联合用于治疗脑血供不足的治疗用途。血管扩张剂和钙拮抗剂显示出作用位点的选择性，并且有效地增加脑血供，而不会不利地影响其他生理参数，例如血压和心率。

22. 发明申请

WO1990007005A1 A PROCESS FOR THE PRODUCTION OF CALCITONIN GENE RELATED PEPTIDES 审中-公开
标题翻译：一种生产钙激素基因相关肽的方法
公开(公告)号：WO1990007005A1
公开(公告)日：1990-06-28
申请号：PCT/GB1989001490
申请日：1989-12-13
申请人： CELLTECH LIMITED , CARNE, Alexander, Fraser , OFFORD, Robin, Ewart , ROSE, Keith
发明人： CELLTECH LIMITED
IPC分类号： C12P21/02
CPC分类号： C07K1/02 , C07K14/57527
摘要： Calcitonin gene related peptides are produced by enzyme-assisted reverse proteolysis. Reaction of a C-terminal truncated calcitonin gene related peptide or a protected derivative with a C-terminal amidated peptide or amino acid, or ammonia in the presence of a hydrolase, yields a calcitonin gene related peptide (CGRP) in good yield and high purity. The CGRP product may be a naturally occurring CGRP or an analogue thereof, such as human α- or β-CGRP. Particular hydrolases include serine proteases such as chymotrypsin, trypsin, thrombin, plasmin, elastase, endoproteinase Lys C; endoproteinase Glu C, or endoproteinase Arg C, acid proteases such as pepsin; metalloproteinases such as thermolysin; and sulphydryl proteinases such as papain or clostripain.

23. 发明申请

WO1990001950A1 PHARMACEUTICAL PRODUCTS FOR ANTI-NEOPLASTIC THERAPY 审中-公开
标题翻译：用于抗神经治疗的药物产品
公开(公告)号：WO1990001950A1
公开(公告)日：1990-03-08
申请号：PCT/GB1989000963
申请日：1989-08-18
申请人： CELLTECH LIMITED , OPAL, Steven, Michael , BODMER, Mark, William , RIDDELL, Alastair, James
发明人： CELLTECH LIMITED
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K39/395 , A61K2300/00
摘要： An antibody (anti-TNF) to tumour necrosis factor-α (TNF-α), preferably a monoclonal antibody, is used to prevent or ameliorate the side effects associated with anti-neoplastic therapy. Side effects which may be treated include nausea, vomiting, anorexia, diarrhoea, alopecia, malaise, neutropenia, septicaemia and other conditions arising therefrom. The anti-TNF may be used in pharmaceutical products and compositions together with an anti-neoplastic agent and/or an anti-microbial agent.

24. 发明申请

WO1989010404A1 RECOMBINANT DNA METHODS, VECTORS AND HOST CELLS 审中-公开
标题翻译：重组DNA方法，载体和宿主细胞
公开(公告)号：WO1989010404A1
公开(公告)日：1989-11-02
申请号：PCT/GB1989000401
申请日：1989-04-18
申请人： CELLTECH LIMITED , BEBBINGTON, Christopher, Robert , YARRANTON, Geoffrey, Thomas
发明人： CELLTECH LIMITED
IPC分类号： C12N15/00
CPC分类号： C12N9/93 , C12N9/6459 , C12N15/67 , C12N15/85 , C12N2840/20 , C12Y304/21069
摘要： The present invention relates to a method for transforming a lymphoid cell line to glutamine independence which comprises: transforming the lymphoid cell line with a vector containing an active glutamine synthetase (GS) gene; growing the transformed cell line on a medium containing glutamine; and continuing the growth of the transformed cell line on a medium in which the glutamine is progressively depleted or on a medium lacking glutamine, and to vectors and host cells for use in the method.

25. 发明申请

WO1989003686A1 CGRP FOR CEREBRAL BLOOD SUPPLY IMPROVEMENT 审中-公开
标题翻译： CGRP用于小儿血液供应改善
公开(公告)号：WO1989003686A1
公开(公告)日：1989-05-05
申请号：PCT/GB1988000877
申请日：1988-10-20
申请人： CELLTECH LIMITED , RIDDELL, Alistair, James , EDWARDS, Christopher, Richard, Watkin
发明人： CELLTECH LIMITED
IPC分类号： A61K37/02
CPC分类号： C07K14/57527
摘要： A new medical use for calcitonin gene-related peptide (CGRP) is disclosed. The use of CGRP for the treatment of deficiencies in cerebral blood supply is described. The cerebral blood supply may become deficient for a number of reasons such as in the body's natural response to cerebral bleeding. CGRP is described as being particulary useful in the treatment of subarachnoid haemorrhage.
摘要翻译：公开了降钙素基因相关肽（CGRP）的新型医疗用途。描述了使用CGRP来治疗脑血供不足。由于诸如身体对脑出血的自然反应等诸多原因，脑血供可能会变得不足。 CGRP被描述为特别适用于治疗蛛网膜下腔出血。

26. 发明申请

WO1986007605A1 FERMENTER 审中-公开
标题翻译：发酵罐
公开(公告)号：WO1986007605A1
公开(公告)日：1986-12-31
申请号：PCT/GB1986000359
申请日：1986-06-20
申请人： CELLTECH LIMITED , THOMPSON, Philip, William , WOOD, Lesley, Anne
发明人： CELLTECH LIMITED
IPC分类号： C12M01/12
CPC分类号： C12M29/08 , C12M29/04
摘要： A continuous fermenter vessel (1) such as an air-lift fermenter for receiving a suspension culture of cells, the vessel comprising; means (19), in use, for agitating a suspension culture received in the vessel and causing a gross flow movement of the suspension culture, an inlet for continuously supplying culture medium to the vessel, an outlet for removing culture supernatant (21), and a filter material (5, 7) between the outlet and the vessel (23) to prevent removal of cells from the suspension culture (21) wherein the filter material (5, 7) is located such that, in use, the gross flow movement of the suspension culture substantially prevents clogging of the filter material by cells and/or cell debris.
摘要翻译：一种连续发酵罐（1），例如用于接收细胞的悬浮培养的空气提升发酵罐，所述容器包括：（19），用于搅拌容器中收集的悬浮培养物，并引起悬浮培养物的大量流动，向容器连续供应培养基的入口，用于除去培养上清液的出口（21），以及在出口和容器（23）之间的过滤材料（5,7），以防止从悬浮培养物（21）中移除细胞，其中过滤材料（5,7）被定位成使得在使用中总流动的悬浮培养物基本上防止了细胞和/或细胞碎片堵塞过滤材料。

27. 发明申请

WO1986005807A1 TRANSFORMED MYELOMA CELL-LINE AND A PROCESS FOR THE EXPRESSION OF A GENE CODING FOR A EUKARYOTIC POLYPEPTIDE EMPLOYING SAME 审中-公开
标题翻译：转化的MYELOMA细胞系和用于表达使用其的多核苷酸的基因编码的方法
公开(公告)号：WO1986005807A1
公开(公告)日：1986-10-09
申请号：PCT/GB1986000187
申请日：1986-04-01
申请人： CELLTECH LIMITED , KENTEN, John, Henry , BOSS, Michael, Alan
发明人： CELLTECH LIMITED
IPC分类号： C12N15/00
CPC分类号： C12N9/6459 , C12N15/85 , C12Y304/21069
摘要： A myeloma cell-line transformed with a vector including a gene coding for a eukariotic polypeptide and a non-immunoglobulin promoter such that expression occurs of the gene coding for the eukariotic polypeptide, directed by the non-immunoglobulin promoter. The promoter may be a viral promoter, such as an SV40 promoter, a Rous sarcoma virus long terminal repeat or a Moloney murine leukemia long terminal repeat, or a non-viral promoter such as the mouse metallothionein promoter. Rat and mouse host myeloma cell-lines such as the rat YB2/3.0 Ag20 hybridoma, the mouse SP-20 Ag hybridoma and the mouse NSO hybridoma are employed. The production of tissue plasminogen activator (tPA) is exemplified.

28. 发明申请

WO1986000926A1 EUCARYOTIC EXPRESSION VECTORS 审中-公开
标题翻译：真实表达载体
公开(公告)号：WO1986000926A1
公开(公告)日：1986-02-13
申请号：PCT/GB1985000325
申请日：1985-07-22
申请人： CELLTECH LIMITED , NASMYTH, Kim, Ashley , MILLER, Allan, Malcolm
发明人： CELLTECH LIMITED
IPC分类号： C12N15/00
CPC分类号： C12N15/85 , C12N15/81
摘要： A eucariotic expression vector includes a controllable repressor operator sequence within the expression control sequence of the vector. The controllable repressor operator sequence represses expression of a heterologous structural gene located downstream of the expression control sequence in the presence of a gene product or a combination of gene products of a yeast mating type locus. This allows control of the expression level of the heterologous structural gene. Controllable repressor operator sequences responsive to the a1/ alpha 2 and alpha 2 gene products of the MATa and MAT alpha yeast mating type locus alleles are described, both derived from genetic material and synthesised chemically.
摘要翻译：显性表达载体包含载体表达控制序列内的可控阻遏物操纵子序列。在基因产物或酵母交配型基因座的基因产物的组合存在下，可控阻遏物操纵子序列抑制位于表达调控序列下游的异源结构基因的表达。这允许控制异源结构基因的表达水平。描述了响应于MATa和MATα酵母交配型基因座等位基因的a1 /α2和α2基因产物的可控阻遏物操纵子序列，均来自遗传物质并化学合成。

29. 发明申请

WO1985003948A1 MACROPHAGE ACTIVATING FACTOR 审中-公开
标题翻译：宏观激励因子
公开(公告)号：WO1985003948A1
公开(公告)日：1985-09-12
申请号：PCT/GB1985000088
申请日：1985-03-04
申请人： CELLTECH LIMITED , REES, Ann, Dorothy, Mary
发明人： CELLTECH LIMITED
IPC分类号： C12P21/00
CPC分类号： C07K14/57 , A61K38/00
摘要： A macrophage activating factor which is antigenically distinct from interferon - gamma . Such macrophage activating factors are produced by culturing cloned human T cell lines TB 68.2.1, TB 68.2.2 and TB 68.2.6.
摘要翻译：与干扰素-γ抗原性不同的巨噬细胞激活因子。通过培养克隆的人T细胞系TB 68.2.1，TB 68.2.2和TB 68.2.6来产生这样的巨噬细胞活化因子。

30. 发明申请

WO1984003712A2 MULTICHAIN POLYPEPTIDES OR PROTEINS AND PROCESSES FOR THEIR PRODUCTION 审中-公开
标题翻译：多聚多肽或蛋白质及其生产过程
公开(公告)号：WO1984003712A2
公开(公告)日：1984-09-27
申请号：PCT/GB1984000094
申请日：1984-03-23
申请人： CELLTECH LIMITED , BOSS, Michael, Alan , KENTEN, John, Henry , EMTAGE, John, Spencer , WOOD, Clive, Ross
发明人： CELLTECH LIMITED
IPC分类号： C12N15/00
CPC分类号： C07K16/462 , A61K38/00 , B01D15/3809 , C07K2317/24 , C12N15/63 , G01N33/531
摘要： Multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multichain polypeptide or protein in a single host cell, which comprises transforming the host cell with DNA sequences coding for each of the polypeptide chains and expressing said polypeptide chains in said transformed host cell. According to another aspect of the present invention there is provided as a product of recombinant DNA technology an Ig heavy or light chain or fragment thereof having an intact variable domain. The invention also provides a process for increasing the level of protein expression in a transformed host cell and vectors and transformed host cells for use in the processes.
摘要翻译：多链蛋白或多肽及其在通过重组DNA技术转化的宿主细胞中生产该多肽的方法。根据本发明的第一方面，描述了一种方法，其允许以产生蛋白或在单个宿主细胞的异源多链多肽，该方法包括转化用的DNA序列编码对每个所述的宿主细胞多肽链并在所述转化的宿主细胞中表达这些多肽链。根据本发明的另一方面，作为重组DNA技术产物获得具有完整可变结构域的重链或轻链Ig链或其片段。本发明还描述了用于提高转化的宿主细胞中蛋白质表达程度的方法以及用于所述方法中的载体和转化的宿主细胞。

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