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21. 发明授权

US09283353B2 Devices, systems and related methods for delivery of fluid to tissue 有权
标题翻译：用于将液体输送到组织的装置，系统和相关方法
公开(公告)号：US09283353B2
公开(公告)日：2016-03-15
申请号：US13133119
申请日：2009-12-04
申请人： Justin M. Crank , Kathryn Bertelson
发明人： Justin M. Crank , Kathryn Bertelson
IPC分类号： A61M25/00 , A61M5/30 , A61M39/12 , A61M39/10 , A61M5/32
CPC分类号： A61M5/30 , A61M5/3291 , A61M25/00 , A61M25/007 , A61M39/12 , A61M2039/1027 , A61M2210/1078 , A61M2210/1082 , A61M2210/1085 , A61M2210/1089
摘要： Described are devices useful to inject fluid to tissue without the use of a needle, and related methods; the devices include one or a combination of features such as ejection orifices (40), distal end control features, or combinations of these; the systems can include a fluid delivery system having an injector source and an access device; the access device can comprise a minimally invasive, tubular delivery lumen (34) such as a catheter or endoscope; the tube-like device further includes one or more apposing jets that are selectively fired to force the injection orifice of the tube-like device against the target tissue; selective firing can include a continuous firing during the injection to improve the efficiency of the treatment.
摘要翻译：描述了可用于将液体注入组织而不使用针的装置及相关方法; 这些装置包括一个或诸如喷射孔（40），远端控制特征或它们的组合的特征的组合; 该系统可以包括具有喷射源和进入装置的流体输送系统; 进入装置可以包括诸如导管或内窥镜的微创管状递送腔（34）; 管状装置还包括一个或多个喷射装置，其被选择性地烧制以迫使管状装置的喷射孔抵靠靶组织; 选择性烧制可以包括在注射期间的连续烧制以提高治疗效率。

22. 发明申请

US20130261540A1 HIGH-PRESSURE PNEUMATIC INJECTION SYSTEM AND METHOD 审中-公开
标题翻译：高压气动注射系统及方法
公开(公告)号：US20130261540A1
公开(公告)日：2013-10-03
申请号：US13994285
申请日：2011-12-16
申请人： Justin M. Crank
发明人： Justin M. Crank
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61B17/3203 , A61B17/3478 , A61B2017/22069 , A61M5/3015 , A61M25/007 , A61M25/04 , A61M25/1002 , A61M25/10184 , A61M37/00 , A61M2025/0681
摘要： A needleless or high-pressure injection system for injecting treatment or therapeutic fluid to tissue of the lower urinary tract, such as the prostate or bladder, is provided. The systems or devices can release the therapeutic fluid or “injectate” at high-pressure out of one or more orifices at the end of an elongate shaft inserted into the urethra. Various embodiments can include a pneumatic or fully-pneumatic system adapted to selectively release the high-pressure injectate, while also providing firing or triggering protection.
摘要翻译：提供了用于将治疗或治疗流体注射到下尿路组织例如前列腺或膀胱的无针或高压注射系统。这些系统或装置可以在插入尿道的细长轴的端部处从一个或多个孔中的高压释放治疗流体或“注射”。各种实施例可以包括适于选择性地释放高压注射器的气动或全气动系统，同时还提供击发或触发保护。

23. 发明申请

US20110160754A1 SPRING-LOADED ANASTOMOSIS DEVICE AND METHOD 审中-公开
标题翻译：弹簧载荷分析装置和方法
公开(公告)号：US20110160754A1
公开(公告)日：2011-06-30
申请号：US12982469
申请日：2010-12-30
申请人： Justin M. Crank
发明人： Justin M. Crank
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B2017/0641 , A61B2017/1135
摘要： An anastomosis device and related methods for performing an anastomosis procedure, such as rejoining a urethra with a bladder following a radical prostatectomy. The engagement structures each have deployable tines for grasping the tissue proximate to the end of the biological lumen and the opening in the bodily organ. The anastomosis device also has a positioning apparatus for dynamically maintaining the engagement structures in proximity throughout a healing process such that tissue to be joined remains in approximation.
摘要翻译：用于进行吻合手术的吻合装置和相关方法，例如在根治性前列腺切除术后用膀胱重新连接尿道。接合结构各自具有用于抓住靠近生物腔的端部的组织和身体器官中的开口的可展开的齿。吻合装置还具有定位装置，用于在整个愈合过程中动态地将接合结构保持在接近状态，使得待连接的组织保持近似。

24. 发明授权

US07850649B2 Mechanical volume control for injection devices 有权
标题翻译：注射装置的机械体积控制
公开(公告)号：US07850649B2
公开(公告)日：2010-12-14
申请号：US11937617
申请日：2007-11-09
申请人： Justin M. Crank , Sidney F. Hauschild
发明人： Justin M. Crank , Sidney F. Hauschild
IPC分类号： A61M1/00
CPC分类号： A61B17/3478 , A61B17/32037 , A61M5/1452 , A61M5/16804 , A61M25/00
摘要： A needleless fluid delivery system allowing for selective control of amounts of therapeutic fluids that are administered to treatment sites within a patient. The fluid delivery system includes an injector source and an access device. The fluid delivery system generally includes an adjustable volume control system for selectively metering the amount of therapeutic fluid to be delivered to the treatment location. The adjustable volume control system generally includes a mechanical stop system with a plunger member and a stop member, wherein the plunger member and stop member physically interact to restrict a plunger insertion length which simultaneously controls an amount of therapeutic fluid expelled by said plunger.
摘要翻译：无针流体输送系统，其允许选择性地控制施用于患者内的治疗部位的治疗流体的量。流体输送系统包括注射器源和入口装置。流体输送系统通常包括可调节的体积控制系统，用于选择性地计量要输送到治疗位置的治疗流体的量。可调音量控制系统通常包括具有柱塞构件和止动构件的机械止动系统，其中柱塞构件和止动构件物理相互作用以限制柱塞插入长度，其同时控制由所述柱塞排出的治疗流体的量。

25. 发明授权

US07455737B2 Selective treatment of linear elastic materials to produce localized areas of superelasticity 有权
标题翻译：线性弹性材料的选择性处理产生超弹性的局部区域
公开(公告)号：US07455737B2
公开(公告)日：2008-11-25
申请号：US10647619
申请日：2003-08-25
申请人： Dennis A. Boismier , Justin M. Crank
发明人： Dennis A. Boismier , Justin M. Crank
IPC分类号： A61M29/00
CPC分类号： C22F1/006 , A61F2/01 , A61F2/82 , A61F2250/0042 , Y10S148/902
摘要： Methods of selectively treating linear elastic materials to produce localized areas of superelasticity and/or shape-memory are disclosed. In an illustrative method, a linear elastic workpiece may be formed into a particular shape by cold-forming or other low-temperature process, and incorporated into a medical device such as an embolic protection filter, vena cava filter, stent or guidewire. A heat source may be used to apply thermal energy to selective areas of the workpiece, imparting superelasticity to the material.
摘要翻译：公开了选择性处理线性弹性材料以产生超弹性和/或形状记忆的局部区域的方法。在一个示例性的方法中，线性弹性工件可以通过冷成型或其它低温工艺形成特定形状，并且并入医疗装置如栓塞保护过滤器，腔静脉过滤器，支架或导丝中。可以使用热源将热能施加到工件的选择区域，使材料具有超弹性。

26. 发明授权

US07407497B2 System for connecting a compatibility liner with a source of perishable therapeutic 失效
标题翻译：将兼容性衬垫与易腐食品来源连接的系统
公开(公告)号：US07407497B2
公开(公告)日：2008-08-05
申请号：US11433584
申请日：2006-05-15
申请人： Justin M. Crank , Timothy A. Ostroot
发明人： Justin M. Crank , Timothy A. Ostroot
IPC分类号： A61M25/00
CPC分类号： A61M39/12 , A61M5/142 , A61M25/0097
摘要： A system for connecting a compatibility liner with a source of perishable therapeutic is provided. In one exemplary system for connecting a reservoir of perishable therapeutic with a lumen, a hollow hub having a first end and a second end is provided. The first end of the hollow hub, which contains a bond port, is in fluid communication with the second end. The second end of the hollow hub may contain a docking groove that is sized to couple a reservoir to it. The system also includes an inner hypo-tube having a proximal tip and an inner lumen. This inner lumen is lined with a therapeutic compatible lining and is in fluid communication with the second end of the hub through the proximal tip of the inner hypo-tube. The inner lining and the proximal tip in this system are configured to shield therapeutic ejected from the reservoir from contacting materials that can diminish the integrity of the therapeutic.
摘要翻译：提供了一种用于将兼容性衬垫与易腐食品治疗源连接的系统。在用于将易腐烂治疗剂的储存器与管腔连接的一个示例性系统中，提供了具有第一端和第二端的中空毂。包含接合端口的中空毂的第一端与第二端流体连通。中空轮毂的第二端可以包含一个对接凹槽，其尺寸设置成将储存器连接到其上。该系统还包括具有近端和内腔的内管。该内腔内衬有治疗相容的内衬，并通过内管的近端与流体通过毂的第二端流体连通。该系统中的内衬和近侧尖端构造成屏蔽从储存器喷出的治疗物质可能会降低治疗剂完整性的接触材料。

27. 发明授权

US06530912B2 Apparatus for connecting a compatibility liner with a source of perishable therapeutic 失效
标题翻译：用于将兼容性衬垫与易腐食品治疗源连接的装置
公开(公告)号：US06530912B2
公开(公告)日：2003-03-11
申请号：US09758129
申请日：2001-01-12
申请人： Justin M. Crank , Timothy A. Ostroot
发明人： Justin M. Crank , Timothy A. Ostroot
IPC分类号： A61M2500
CPC分类号： A61M39/12 , A61M5/142 , A61M25/0097
摘要： An apparatus for connecting a compatibility liner with a source of perishable therapeutic is provided. In one exemplary system for connecting a reservoir of perishable therapeutic with a lumen, a hollow hub having a first end and a second end is provided. The first end of the hollow hub, which contains a bond port, is in fluid communication with the second end. The second end of the hollow hub may contain a docking groove that is sized to couple a reservoir to it. The system also includes an inner hypo-tube having a proximal tip and an inner lumen. This inner lumen is lined with a therapeutic compatible lining and is in fluid communication with the second end of the hub through the proximal tip of the inner hypo-tube. The inner lining and the proximal tip in this system are configured to shield therapeutic ejected from the reservoir from contacting materials that can diminish the integrity of the therapeutic.
摘要翻译：提供了一种用于将兼容性衬垫与易腐食品治疗源连接的装置。在用于将易腐烂治疗剂的储存器与管腔连接的一个示例性系统中，提供了具有第一端和第二端的中空毂。包含接合端口的中空毂的第一端与第二端流体连通。中空轮毂的第二端可以包含一个对接凹槽，其尺寸设置成将储存器连接到其上。该系统还包括具有近端和内腔的内管。该内腔内衬有治疗相容的内衬，并通过内管的近端与流体通过毂的第二端流体连通。该系统中的内衬和近侧尖端构造成屏蔽从储存器喷出的治疗物质可能会降低治疗剂完整性的接触材料。

28. 发明授权

US09572648B2 Implantable slings and anchor systems 有权
标题翻译：植入式吊索和锚系统
公开(公告)号：US09572648B2
公开(公告)日：2017-02-21
申请号：US13334002
申请日：2011-12-21
申请人： Justin M. Crank , Kathryn A. Bertelson , Patricia M. Derus , Gary A. Rocheleau , Michael A. Knipfer
发明人： Justin M. Crank , Kathryn A. Bertelson , Patricia M. Derus , Gary A. Rocheleau , Michael A. Knipfer
IPC分类号： A61F2/04 , A61F2/00 , A61B17/04 , A61B17/06 , A61B17/28 , A61B17/00
CPC分类号： A61F2/0045 , A61B17/0401 , A61B17/0483 , A61B17/06109 , A61B17/2812 , A61B2017/0042 , A61B2017/00867 , A61B2017/0417 , A61B2017/0427 , A61B2017/0437 , A61B2017/0461
摘要： Various embodiments of a mesh or implant systems are provided. The implants can include one or more anchors, arms and the like. The anchors can include hingeable or patterned finger extension to facilitate tissue penetration and retention. Various tensioning and adjustment mechanisms, devices and methods are further provided for the implant systems.
摘要翻译：提供了网格或植入物系统的各种实施例。植入物可以包括一个或多个锚，臂等。锚固件可以包括可铰链或图案化的手指延伸以便于组织穿透和保留。进一步为植入系统提供各种张紧和调节机构，装置和方法。

29. 发明申请

US20160367749A1 METHOD AND APPARATUS FOR COMPENSATING FOR INJECTION MEDIA VISCOSITY IN A PRESSURIZED DRUG INJECTION SYSTEM 有权
标题翻译：加压注射系统注射液粘度的补充方法及装置
公开(公告)号：US20160367749A1
公开(公告)日：2016-12-22
申请号：US15233040
申请日：2016-08-10
申请人： Robert L. Rykhus , Justin M. Crank
发明人： Robert L. Rykhus , Justin M. Crank
IPC分类号： A61M5/145
CPC分类号： A61M5/1452 , A61M31/00 , A61M37/00 , A61M2205/3341 , A61M2205/70
摘要： A needleless injection system is provided to deliver therapeutic fluids to an internal treatment site in a patient, where the system is pressurized and is capable of compensating for differences in injection media viscosity and mechanical system characteristics. In one aspect, a needleless therapeutic fluid injection system is provided that includes modular, interchangeable components. In particular, the system includes a console that generally includes the electronic and/or hydraulic control components for the system, an injection chamber, and a shaft or catheter tube.
摘要翻译：提供无针注射系统以将治疗流体递送到患者的内部治疗部位，其中系统被加压并且能够补偿注射培养基粘度和机械系统特性的差异。一方面，提供了一种无针治疗流体注射系统，其包括模块化的可互换部件。特别地，该系统包括控制台，其通常包括用于系统的电子和/或液压控制部件，注射室以及轴或导管管。

30. 发明申请

US20160206849A1 NEEDLELESS INJECTION DEVICE COMPONENTS, SYSTEMS, AND METHODS 审中-公开
标题翻译：无针注射装置组件，系统和方法
公开(公告)号：US20160206849A1
公开(公告)日：2016-07-21
申请号：US15081405
申请日：2016-03-25
申请人： Robert L. Rykhus, JR. , Jason W. Ogdahl , Justin M. Crank
发明人： Robert L. Rykhus, JR. , Jason W. Ogdahl , Justin M. Crank
IPC分类号： A61M25/00 , A61M5/30 , A61M25/10
CPC分类号： A61M25/0026 , A61B1/00087 , A61B1/0014 , A61B17/0218 , A61B2017/00296 , A61B2017/00557 , A61B2017/22069 , A61M5/30 , A61M25/007 , A61M25/10 , A61M25/1034 , A61M31/00 , A61M2025/1054 , A61M2025/1081 , A61M2210/1078
摘要： Described are needleless injection systems and methods that involve features including one or more of a tissue tensioner and a fitting that includes or attaches to a shaft, exemplary embodiments including: an elastic sleeve sized to fit under tension about the distal end of a flexible scope, such as an endoscope; a non-metal, polymeric tube-like device being optionally attached to the elastic sleeve for delivering a therapeutic fluid to a treatment site within a patient wherein the elastic sleeve may include an integral balloon (tissue tensioner) feature that can be used to position the injection orifice of the tube-like device proximate a treatment area.
摘要翻译：描述的是无针注射系统和方法，其涉及包括组织张紧器和包括或附接到轴的配件中的一个或多个的特征，示例性实施例包括：尺寸适于在柔性范围的远端附近张紧的弹性套筒，如内窥镜; 非金属的聚合物管状装置可选地附接到弹性套筒上，用于将治疗流体输送到患者内的治疗部位，其中弹性套筒可以包括整体气囊（组织张紧器）特征，其可用于将管状装置的注射孔靠近治疗区域。

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