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21. 发明授权

US08007490B2 Reduced width dual-lumen catheter 有权
标题翻译：减少宽度双腔导管
公开(公告)号：US08007490B2
公开(公告)日：2011-08-30
申请号：US11875505
申请日：2007-10-19
申请人： Darin G. Schaeffer , Eric R. Hennessy
发明人： Darin G. Schaeffer , Eric R. Hennessy
IPC分类号： A61M25/00
CPC分类号： A61M25/10 , A61M2025/0037
摘要： A dual-lumen catheter for use in a body vessel. The catheter includes an elongate shaft having a longitudinal axis and defining at least a first and a second lumen. The elongate shaft has a cross sectional width normal to the longitudinal axis and a webbing section disposed between the two lumens. The webbing section has a webbing length less than the cross sectional width to reduce a tendency of the shaft to bend perpendicular to the webbing length when the shaft is rotated.
摘要翻译：用于体内血管的双腔导管。导管包括具有纵向轴线并限定至少第一和第二管腔的细长轴。细长轴具有垂直于纵向轴线的横截面宽度和设置在两个腔之间的织带部分。织带部分具有小于横截面宽度的织带长度，以减小当轴旋转时垂直于织带长度的轴弯曲的趋势。

22. 发明授权

US07919108B2 Taxane coatings for implantable medical devices 有权
标题翻译：可植入医疗器械的紫杉烷涂层
公开(公告)号：US07919108B2
公开(公告)日：2011-04-05
申请号：US11715975
申请日：2007-03-08
申请人： Priscilla Reyes , William F. Moore , Patrick H. Ruane , Darin G. Schaeffer , Melinda S. Morrell
发明人： Priscilla Reyes , William F. Moore , Patrick H. Ruane , Darin G. Schaeffer , Melinda S. Morrell
IPC分类号： A61F2/00 , A61F2/06 , A01N43/02
CPC分类号： A61L27/54 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61K31/337 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.
摘要翻译：本公开涉及涂覆有紫杉烷治疗剂（例如紫杉醇）的可植入医疗装置，其具有不同溶解速率的一种或多种固体形式。特别优选的涂层包括紫杉烷治疗剂的无定形和/或溶剂化固体形式，其提供耐久性涂层，其在期望的时间段内释放紫杉烷，其可以在不存在聚合物的情况下变化，通过选择固体形式的类型和量紫杉烷治疗剂在涂层中。其它优选实施方案涉及涂覆医疗装置的方法和治疗方法。涂层可以在体内容器内提供紫杉烷治疗剂的持续释放而不含聚合物以达到期望的紫杉醇洗脱速率。

23. 发明申请

US20100331817A1 THERAPEUTIC AGENT DELIVERY DEVICE WITH A DUAL BALLOON HAVING DISTAL TAPER APERTURES 有权
标题翻译：带双向气囊的治疗剂递送装置
公开(公告)号：US20100331817A1
公开(公告)日：2010-12-30
申请号：US12825965
申请日：2010-06-29
申请人： Darin G. Schaeffer , William F. Moore
发明人： Darin G. Schaeffer , William F. Moore
IPC分类号： A61M25/10
CPC分类号： A61M25/1011 , A61M25/104 , A61M2025/1013 , A61M2025/105 , A61M2025/1052
摘要： The present disclosure generally provides a multiple balloon assembly used as part of the distal region of a medical device that is capable of delivering a therapeutic agent into a body vessel having bodily fluid. The multiple balloon assembly comprises an inner balloon and an outer balloon. The outer balloon further comprises a proximal taper region, a middle region, and a distal taper region. The inflation of the inner balloon causes the middle region of the outer balloon to contact the inner wall of the body vessel, thereby, occluding the flow of fluid through the body vessel. The proximal taper region and the distal taper region are configured such that they do not touch the inner wall of the body vessel. One of the distal taper and proximal taper regions has a plurality of apertures configured to allow for the therapeutic agent to be delivered into the body vessel at a predetermined rate. A medical device that incorporates the multiple balloon assembly of the present disclosure, as well as a method for using the medical device and multiple balloon assembly are further disclosed.
摘要翻译：本公开通常提供多个气囊组件，其被用作医疗装置的远侧区域的一部分，其能够将治疗剂递送到具有体液的身体容器中。多球囊组件包括内球囊和外球囊。外球囊还包括近端锥形区域，中间区域和远端锥形区域。内球囊的膨胀导致外球囊的中间区域接触身体血管的内壁，从而阻塞通过体血管的流体流动。近端锥形区域和远端锥形区域构造成使得它们不接触身体血管的内壁。远端锥形和近端锥形区域中的一个具有多个孔，其构造成允许治疗剂以预定速率输送到体内容器。还公开了一种结合本公开的多球囊组件的医疗装置，以及用于使用医疗装置和多气囊组件的方法。

24. 发明申请

US20100131055A1 ARTIFICIAL VALVE PROSTHESIS WITH IMPROVED FLOW DYNAMICS 审中-公开
标题翻译：人工阀具有改进的流动动力学
公开(公告)号：US20100131055A1
公开(公告)日：2010-05-27
申请号：US12614878
申请日：2009-11-09
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure configured to enlarge the area adjacent the valve structure. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections.
摘要翻译：一种具有支撑结构的可膨胀静脉瓣，该支撑结构构造成扩大邻近瓣膜结构的区域。可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来产生扩大的口袋区域。

25. 发明申请

US20090171283A1 METHOD OF BONDING A DILATION ELEMENT TO A SURFACE OF AN ANGIOPLASTY BALLOON 审中-公开
标题翻译：将放射性元素与血管平滑肌的表面结合的方法
公开(公告)号：US20090171283A1
公开(公告)日：2009-07-02
申请号：US11965499
申请日：2007-12-27
申请人： Darin G. Schaeffer , Kimberly D. Roberts
发明人： Darin G. Schaeffer , Kimberly D. Roberts
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61M25/1034 , A61M2025/1031
摘要： A balloon catheter with dilation elements and method of fabricating thereof is provided that may be used to dilate and/or cut hardened regions of a body vessel. The balloon catheter is provided with dilation elements that extend along a surface of a balloon. One or both ends of the dilation element is inserted through corresponding apertures formed in the balloon neck. After inserting the one or both ends through the corresponding apertures, the ends are bonded into the material of the catheter shaft and the balloon.
摘要翻译：提供具有扩张元件的气囊导管及其制造方法，其可用于扩张和/或切割身体血管的硬化区域。球囊导管设置有沿气球表面延伸的扩张元件。扩张元件的一端或两端通过形成在气囊颈部中的相应孔插入。在将一个或两个端部插入相应的孔中之后，端部被接合到导管轴和气囊的材料中。

26. 发明申请

US20080086084A1 BALLOON CATHETER 有权
标题翻译：气球导管
公开(公告)号：US20080086084A1
公开(公告)日：2008-04-10
申请号：US11858658
申请日：2007-09-20
申请人： Darin G. Schaeffer , David G. Burton
发明人： Darin G. Schaeffer , David G. Burton
IPC分类号： A61M29/02
CPC分类号： A61M25/1029 , A61M25/1034 , A61M25/104 , A61M2025/1031 , A61M2025/1063
摘要： An balloon catheter is provided with an improved neck portion. The neck portion of the balloon is used to attach the end of the balloon to a catheter. Before attaching the balloon to the catheter, the neck portion is lengthened and thinned out to make the neck portion more flexible. Heat shrink tubing may be used to apply pressure to the neck portion to force the material of the neck portion to flow along a mandrel inserted into the neck portion.
摘要翻译：气囊导管设置有改进的颈部。气囊的颈部用于将气囊的端部附接到导管。在将气囊附接到导管之前，颈部被延长并变薄，使得颈部更柔韧。热收缩管可用于向颈部施加压力，以迫使颈部的材料沿着插入颈部的心轴流动。

27. 发明授权

US10226264B2 Apparatus and method for destruction of vascular thrombus 有权
公开(公告)号：US10226264B2
公开(公告)日：2019-03-12
申请号：US13555685
申请日：2012-07-23
申请人： Charles L. McIntosh , Ram H. Paul, Jr. , Darin G. Schaeffer , M. Kem Hawkins , Frank J. Fischer, Jr. , Grant T. Hoffman
发明人： Charles L. McIntosh , Ram H. Paul, Jr. , Darin G. Schaeffer , M. Kem Hawkins , Frank J. Fischer, Jr. , Grant T. Hoffman
IPC分类号： A61H1/00 , A61B17/22 , A61M25/10 , A61M37/00
摘要： A device for thrombolytic therapy is provided. The device includes an elongate catheter with a distal end portion and a proximal end portion and a first lumen extending through both distal and proximal end portions. The distal end portion of the catheter includes an echogenic tubular potion that defines or surrounds a portion of the first lumen. An expandable balloon coaxially surrounds the tubular portion. The tubular portion additionally includes a plurality of indentations defined upon an outer surface thereof.

28. 发明授权

US08795288B2 Access device 有权
标题翻译：访问设备
公开(公告)号：US08795288B2
公开(公告)日：2014-08-05
申请号：US11874444
申请日：2007-10-18
申请人： Jeffry S. Melsheimer , Darin G. Schaeffer
发明人： Jeffry S. Melsheimer , Darin G. Schaeffer
IPC分类号： A61F11/00
CPC分类号： A61M25/0662 , A61B17/3415 , A61B2017/00243 , A61F2/95
摘要： A device for providing access to a treatment site within the body of a patient includes a tubular member having a first, generally elongated configuration for introduction into the body of the patient, and deployable therein to a second configuration. The second configuration includes an axially displaced segment along the distal portion of the tubular member. The tubular member includes a side port oriented along the axially displaced segment, and further includes a lumen communicating with the side port. The lumen and side port are sized for passage therethrough of an interventional device for delivery to the treatment site.
摘要翻译：用于提供对患者体内的治疗部位的通路的装置包括管状构件，其具有用于引入患者体内的第一大体上细长的构造，并且可部署到第二构造中。第二构造包括沿着管状构件的远端部分的轴向移位的段。管状构件包括沿轴向移位的段定向的侧端口，并且还包括与侧端口连通的管腔。管腔和侧端口的尺寸设置成用于通过其介入装置，用于输送到治疗部位。

29. 发明授权

US08784602B2 Balloon catheter for delivering a therapeutic agent 有权
标题翻译：用于递送治疗剂的气球导管
公开(公告)号：US08784602B2
公开(公告)日：2014-07-22
申请号：US13477774
申请日：2012-05-22
申请人： Darin G. Schaeffer , David Christian Lentz
发明人： Darin G. Schaeffer , David Christian Lentz
IPC分类号： A61M25/00
CPC分类号： A61M25/10 , A61M25/1027 , A61M2025/0004 , A61M2025/1013 , A61M2025/105 , A61M2025/1056
摘要： Catheter balloon assemblies (10) for delivering a therapeutic agent to a body vessel are provided, as well as related methods of manufacturing and methods of treatment. The catheter balloon assemblies may include a concentrically disposed dual balloon assembly at the distal portion of the catheter having an inner balloon (44), a porous outer balloon (42) concentrically arrayed around the inner balloon and a catheter shaft (30) adapted to deliver a therapeutic agent to the body vessel through the apertures in the outer balloon. Radial outward expansion of the inner balloon may urge the outer balloon into contact with the wall of a body vessel, where the therapeutic agent may be delivered from the catheter shaft through apertures in the outer balloon directly to the wall of the body vessel. Preferably, the catheter balloon assemblies include a stiffening' member (210) within the proximal portion and/or a plurality of lumens lined with a fluorinated hydrocarbon to independently inflate the inner balloon, deliver the therapeutic agent through the outer balloon and house a wire guide (50). The catheter balloon assemblies may provide improved tractability and/or pushability characteristics.
摘要翻译：提供了用于将治疗剂递送至身体血管的导管气囊组件（10），以及相关的制造方法和治疗方法。导管球囊组件可以包括在导管的远端部分处的同心设置的双球囊组件，其具有内球囊（44），围绕内球囊同心排列的多孔外球囊（42）和适于递送的导管轴通过外球囊中的孔，向身体血管施加治疗剂。内球囊的径向向外膨胀可以促使外球囊与体血管的壁接触，其中治疗剂可以通过外球囊中的孔直接从导管轴输送到身体血管的壁。优选地，导管球囊组件包括近端部分内的加强构件（210）和/或内衬有氟化烃的多个内腔，以独立地使内球囊膨胀，将治疗剂输送通过外气囊并容纳导线（50）。导管球囊组件可以提供改善的易处理性和/或可推动性特征。

30. 发明申请

US20130158559A1 DEVICE AND METHOD FOR MIXING AND DISPENSING A BONE CEMENT MIXTURE 有权
公开(公告)号：US20130158559A1
公开(公告)日：2013-06-20
申请号：US13331370
申请日：2011-12-20
申请人： Darin G. Schaeffer
发明人： Darin G. Schaeffer
IPC分类号： A61B17/58
CPC分类号： B01F13/0023 , A61B17/8822 , A61B17/8825 , A61B17/8833 , B01F11/0071 , B01F15/00506 , B01F15/0213 , B01F15/0226 , B01F15/0237 , B01F15/0278 , B01F2215/0029
摘要： In at least one embodiment of the present invention, a device for mixing and dispensing a bone cement mixture is provided. The device comprises a first chamber and a second chamber. The first chamber is for containing a first bone cement component. The second chamber is for containing a second bone cement component. A valve is in fluid communication with the first and second chambers. A first and a second plunger are respectively within the first and second chambers and are configured to actuate within their respective chambers. When the valve is in a first position actuating the first plunger advances the first bone cement component into the second chamber to form the bone cement mixture.

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