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21. 发明申请

US20060078895A1 Methods for in situ generation of nucleic acid arrays 审中-公开
标题翻译：原位产生核酸阵列的方法
公开(公告)号：US20060078895A1
公开(公告)日：2006-04-13
申请号：US10963682
申请日：2004-10-12
申请人： Bill Peck , Lawrence DaQuino , Jeffrey Kernan
发明人： Bill Peck , Lawrence DaQuino , Jeffrey Kernan
IPC分类号： C40B40/08 , C40B50/04
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00596 , B01J2219/00626 , B01J2219/00659 , B01J2219/00691 , B01J2219/00722
摘要： Methods of producing nucleic acid arrays using an in situ nucleic acid synthesis protocol are provided. Embodiments include a functional group generation step performed by flowing a plurality of different fluids across the surface of a substrate in a manner such that any given lower density fluid is always above any given higher density fluid of the plurality. Also provided are the arrays produced using the subject methods, methods for use of the arrays, and devices for use in practicing the subject methods.
摘要翻译：提供了使用原位核酸合成方案产生核酸阵列的方法。实施方案包括通过使多种不同流体以基板的表面流动的方式进行的功能组生成步骤，使得任何给定的较低密度流体总是高于多个中任何给定的较高密度流体。还提供了使用主题方法产生的阵列，使用阵列的方法以及用于实践主题方法的装置。

22. 发明申请

US20060063274A1 Methods for manufacturing and using chemical array calibration devices 审中-公开
标题翻译：制造和使用化学阵列校准装置的方法
公开(公告)号：US20060063274A1
公开(公告)日：2006-03-23
申请号：US10948886
申请日：2004-09-23
申请人： Donald Schremp , Bill Peck , Stanley Woods
发明人： Donald Schremp , Bill Peck , Stanley Woods
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/278 , Y10T436/2575
摘要： The invention provides methods for manufacturing a chemical array reader calibration device. Embodiments include dispensing a volume of fluorescent dye coating composition from a pulse jet fluid deposition device onto a surface of a substrate to coat the surface with the fluorescent dye coating composition. Also provided are chemical array reader calibration devices and methods of using the subject chemical array reader calibration devices to calibrate a chemical array reader. Also provided are kits that include a chemical array reader calibration device.
摘要翻译：本发明提供了用于制造化学阵列阅读器校准装置的方法。实施例包括将一定体积的荧光染料涂料组合物从脉冲喷射流体沉积装置分配到基材的表面上以用荧光染料涂料组合物涂布表面。还提供了化学阵列读取器校准装置和使用主题化学阵列读取器校准装置来校准化学阵列读取器的方法。还提供了包括化学阵列读取器校准装置的试剂盒。

23. 发明申请

US20050201896A1 Fluid exit in reaction chambers 审中-公开
标题翻译：反应室中的流体出口
公开(公告)号：US20050201896A1
公开(公告)日：2005-09-15
申请号：US11043708
申请日：2005-01-24
申请人： Bill Peck
发明人： Bill Peck
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00337 , B01J2219/0036 , B01J2219/00378 , B01J2219/00389 , B01J2219/00477 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： Apparatus and methods are disclosed for controlling flow of fluid inside a chamber. A device comprises a chamber comprising at least one wall, a first opening for introducing a fluid into the interior of the chamber, and a second opening opposite the first opening. The at least one wall of the chamber is designed to provide a contracting section, a section having substantially constant cross-sectional area and a diffusing section through the chamber from the first opening to the second opening. The device may be employed as a gas outlet in a reaction chamber for conducting reactions where it is desired to control the internal atmosphere of the reaction chamber. The apparatus may be employed in the manufacture of biopolymers on the surface of a support such as an array of biopolymer features on the support. Also disclosed is a holding element for a support wherein the holding element is a low drag body.
摘要翻译：公开了用于控制腔室内的流体流动的装置和方法。一种装置包括：室，包括至少一个壁，用于将流体引入室的内部的第一开口和与第一开口相对的第二开口。腔室的至少一个壁被设计成提供收缩部分，具有基本上恒定的横截面面积的部分和通过从第一开口到第二开口的腔室的扩散部分。该装置可以用作反应室中的气体出口，用于在需要控制反应室内部气氛的地方进行反应。该装置可以用于在载体的表面上制造生物聚合物，例如载体上生物聚合物特征的阵列。还公开了用于支撑件的保持元件，其中保持元件是低阻力体。

24. 发明申请

US20050130210A1 Flow cell humidity sensor system 失效
标题翻译：流量计湿度传感器系统
公开(公告)号：US20050130210A1
公开(公告)日：2005-06-16
申请号：US10990941
申请日：2004-11-16
申请人： Bill Peck
发明人： Bill Peck
IPC分类号： G01N27/22 , C12Q1/68 , C12M1/34
CPC分类号： G01N27/225
摘要： A system for monitoring water concentration in gaseous sample is disclosed. It is readily applicable in the synthesis of biopolymer arrays/microarrays involving the use of water-sensitive reagents. A flow cell is provided in which a capacitance sensor is placed separate from a production or synthesis environment. Sample and dry gas may be provided to the flow cell via conduits and valves or a manifold system. Dry gas, such as N2, is used to dry the sensor or simply to maintain it in a dried condition. The same gas may be used to drive an optional venturi pump to draw sample for measurement into the cell from the synthesis environment.
摘要翻译：公开了一种监测气态样品中水浓度的系统。它很容易适用于涉及使用水敏试剂的生物聚合物阵列/微阵列的合成。提供了一种流动池，其中电容传感器与生产或合成环境分离放置。可以通过导管和阀或歧管系统向流动池提供样品和干燥气体。干燥的气体，例如N 2 N，用于干燥传感器或简单地将其保持在干燥状态。可以使用相同的气体来驱动可选的文丘里泵从合成环境中抽出样品用于测量。

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