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21. 发明授权

US07524816B2 Peptides and supported peptides for treating skin diseases 有权
标题翻译：用于治疗皮肤疾病的肽和支持的肽
公开(公告)号：US07524816B2
公开(公告)日：2009-04-28
申请号：US10984270
申请日：2004-11-08
申请人： Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
发明人： Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
IPC分类号： A61K38/16
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold proteins is BBI.
摘要翻译：本发明提供用于治疗增殖性疾病的肽和负载肽。在特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载肽，例如红斑痤疮。在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。在一些最优选的实施方案中，支架蛋白是BBI。

22. 发明申请

US20080131932A1 EXPRESSION IN FILAMENTOUS FUNGI OF PROTEASE INHIBITORS AND VARIANTS THEREOF 有权
公开(公告)号：US20080131932A1
公开(公告)日：2008-06-05
申请号：US11848213
申请日：2007-08-30
申请人： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
发明人： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
IPC分类号： C07H21/04 , C12P1/00 , C12N15/00 , C12N15/74 , C12N5/02 , C12P21/04
CPC分类号： C12N15/80 , C07K14/811
摘要： Described herein are protease inhibitors, variants thereof and methods for their production.

23. 发明授权

US06297037B1 Oxidatively stable alpha-amylase 失效
标题翻译：氧化稳定的α-淀粉酶
公开(公告)号：US06297037B1
公开(公告)日：2001-10-02
申请号：US08194664
申请日：1994-02-10
申请人： Christopher C. Barnett , Colin Mitchinson , Scott D. Power , Carol A. Requadt
发明人： Christopher C. Barnett , Colin Mitchinson , Scott D. Power , Carol A. Requadt
IPC分类号： C12N928
CPC分类号： C12N9/2417 , C11D3/386 , C12N15/75 , C12P19/14
摘要： Novel alpha-amylase mutants derived from the DNA sequences of naturally occurring or recombinant alpha-amylases are disclosed. The mutant alpha-amylases, in general, are obtained by in vitro modifications of a precursor DNA sequence encoding the naturally occurring or recombinant alpha-amylase to generate the substitution (replacement) or deletion of one or more oxidizable amino acid residues in the amino acid sequence of a precursor alpha-amylase. Such mutant alpha-amylases have altered oxidative stability and/or altered pH performance profiles and/or altered thermal stability as compared to the precursor. Also disclosed are detergent and starch liquefaction compositions comprising the mutant amylases, as well as methods of using the mutant amylases.
摘要翻译：公开了衍生自天然存在或重组α-淀粉酶的DNA序列的新型α-淀粉酶突变体。通常，通过体外修饰编码天然存在或重组α-淀粉酶的前体DNA序列以产生氨基酸中一个或多个可氧化氨基酸残基的取代（置换）或缺失，获得突变体α-淀粉酶前体α-淀粉酶的序列。与前体相比，这种突变型α-淀粉酶具有改变的氧化稳定性和/或改变的pH性能特征和/或改变的热稳定性。还公开了包含突变淀粉酶的洗涤剂和淀粉液化组合物，以及使用突变淀粉酶的方法。

24. 发明授权

US5389536A Lipase from Pseudomonas mendocina having cutinase activity 失效
标题翻译：具有角质酶活性的假单胞菌的脂肪酶
公开(公告)号：US5389536A
公开(公告)日：1995-02-14
申请号：US705052
申请日：1991-05-23
申请人： Gregory L. Gray , Scott D. Power , Ayrookaran J. Poulose
发明人： Gregory L. Gray , Scott D. Power , Ayrookaran J. Poulose
IPC分类号： C12N9/18 , C12N9/20
CPC分类号： C12N9/18
摘要： A substantially enzymatically pure hydrolase is provided which is secreted by and isolatable from Pseudomonas mendocina ATCC 53552. Cloning the gene expressing the hydrolase into a suitable expression vector and culturing, such as fermenting the E. coli strain JM101 harboring a plasmid designated pSNtacII, has been found to provide surprisingly high yields of the hydrolase.
摘要翻译：提供了基本上酶的纯水解酶，其由门氏假单胞菌ATCC 53552分泌和分离。将表达水解酶的基因克隆到合适的表达载体中并培养，例如发酵含有命名为pSNtacII的质粒的大肠杆菌JM101 发现提供令人惊讶的高产率的水解酶。

25. 发明授权

US09084734B2 Peptide personal care compositions and methods for their use 有权
标题翻译：肽个人护理组合物及其使用方法
公开(公告)号：US09084734B2
公开(公告)日：2015-07-21
申请号：US11919717
申请日：2006-04-25
申请人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
发明人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
IPC分类号： A61K8/02 , A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. IN alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译：本发明提供用于治疗各种疾病和病症的肽和负载肽。在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。在一些实施方案中，本发明提供用于皮肤和/或毛发护理以及化妆品组合物的组合物。在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。在一些最优选的实施方案中，支架蛋白包含BBI。

26. 发明授权

US08841107B2 Hybrid alpha-amylases 有权
标题翻译：混合型α-淀粉酶
公开(公告)号：US08841107B2
公开(公告)日：2014-09-23
申请号：US13132881
申请日：2009-12-11
申请人： Scott D. Power , Andrew Shaw
发明人： Scott D. Power , Andrew Shaw
IPC分类号： C12N9/96 , C12N9/00 , C12N9/28
CPC分类号： C12N9/2417 , C07K2319/00 , G06F19/12 , G06F19/16
摘要： Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ? amylase. The sequence similarity between the two amylase sequences may be less than 60%. Conserving the wild-type 3D structure in the hybrid facilitates obtaining enzymatically active amylases. In one embodiment, one or both amylase sequences contribute residues to the B domain, resulting in particularly advantageous properties. For instance, replacement of the Ca2+ binding site in the B domain of the Termamyl-like ?-amylase with a B domain sequence of an archae ? amylase that does not bind Ca2+ can produce a hybrid that is fully active in the absence of Ca2+.
摘要翻译：提供杂交α-淀粉酶，其与野生型类戊酰样α-淀粉酶（例如芽孢杆菌淀粉酶）全部或部分共享保守的3D结构。在杂交体中，类戊酰样α-淀粉酶的N末端部分被来自古细菌的序列替代淀粉酶。两个淀粉酶序列之间的序列相似性可以小于60％。在杂交中保护野生型3D结构有助于获得酶活性淀粉酶。在一个实施方案中，一个或两个淀粉酶序列向B结构域贡献残基，导致特别有利的性质。例如，用具有古细菌的B结构域序列的Termamyl样α-淀粉酶的B结构域中的Ca 2+结合位点的替换不结合Ca2 +的淀粉酶可以产生在不存在Ca 2+的情况下完全活性的杂交体。

27. 发明申请

US20130065829A1 PEPTIDES AND SUPPORTED PEPTIDES FOR TREATING SKIN DISEASES 审中-公开
标题翻译：用于治疗皮肤疾病的肽和支持肽
公开(公告)号：US20130065829A1
公开(公告)日：2013-03-14
申请号：US13609116
申请日：2012-09-10
申请人： Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
发明人： Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
IPC分类号： C07K14/415 , A61P17/00 , A61K38/16
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein is BBI.
摘要翻译：本发明提供用于治疗增殖性疾病的肽和负载肽。在特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载肽，例如红斑痤疮。在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。在一些最优选的实施方案中，支架蛋白是BBI。

28. 发明申请

US20110086408A1 Hemicellulase Enriched Compositions for Enhancing Hydrolysis of Biomass 审中-公开
标题翻译：半纤维素酶增强生物质水解的成分
公开(公告)号：US20110086408A1
公开(公告)日：2011-04-14
申请号：US12933752
申请日：2009-03-20
申请人： Scott D. Power , Robert M. Caldwell , Suzanne E. Lantz , Edmund A. Larenas
发明人： Scott D. Power , Robert M. Caldwell , Suzanne E. Lantz , Edmund A. Larenas
IPC分类号： C12N9/42 , C12N9/40 , C12N9/18 , C12N9/26
CPC分类号： C12P19/14 , A61N1/05 , A61N1/0573 , A61N1/086 , A61N1/37 , C12N9/2437 , C12N9/2477 , C12N9/248 , C12P19/02 , C12P19/12 , C12Y301/01072 , C12Y301/01073 , C12Y302/01001 , C12Y302/01003 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01022 , C12Y302/01037 , C12Y302/01055 , C12Y302/01074 , C12Y302/01078 , C12Y302/01091 , C12Y302/01131 , C12Y302/01136 , Y10T29/49117
摘要： Described are compositions and methods relating to cellulase/hemicellulase enzyme blends for improving the enzymatic hydrolysis of cellulosic and hemicellulosic materials, as commonly found in biomass
摘要翻译：描述了与纤维素酶/半纤维素酶共混物相关的组合物和方法，用于改进纤维素和半纤维素材料的酶水解，如通常在生物质

29. 发明授权

US07803902B2 Modified variant bowman birk protease inhibitors 有权
标题翻译：改良型bowman birk蛋白酶抑制剂
公开(公告)号：US07803902B2
公开(公告)日：2010-09-28
申请号：US12252062
申请日：2008-10-15
申请人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
发明人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
IPC分类号： C07K14/00
CPC分类号： C07K14/811 , A61K8/64 , A61Q7/02
摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.
摘要翻译：本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法并在个人护理中使用修改后的变体BBPI。

30. 发明申请

US20100092409A1 PERSONAL CARE COMPOSITIONS COMPRISING MODIFIED VARIANT BOWMAN BIRK PROTEASE INHIBITORS 有权
标题翻译：包含改性变体BAMMAN BIRK蛋白酶抑制剂的个人护理组合物
公开(公告)号：US20100092409A1
公开(公告)日：2010-04-15
申请号：US12252032
申请日：2008-10-15
申请人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
发明人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
IPC分类号： A61Q17/04 , C07K14/00 , A61K38/10 , A61K38/08
CPC分类号： A61K8/64 , A61K38/55 , A61Q1/02 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q3/00 , A61Q3/02 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/002 , A61Q19/04 , A61Q19/10
摘要： The present invention relates to compositions that comprise modified variant Bowman Birk Protease Inhibitor proteins (BBPIs). The modified variant BBPIs comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses the compositions comprising the modified variant BBPIs, and the methods for making and using the compositions in personal care.
摘要翻译：本发明涉及包含修饰的变体Bowman Birk蛋白酶抑制蛋白（BBPI）的组合物。修饰的变体BBPI包含结合靶蛋白的肽，并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。本发明包括包含修饰变体BBPI的组合物，以及在个人护理中制备和使用组合物的方法。

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