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21. 发明申请

WO2005023818A3 HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS 审中-公开
标题翻译：异种化合物作为药物活性剂
公开(公告)号：WO2005023818A3
公开(公告)日：2005-08-25
申请号：PCT/EP2004010161
申请日：2004-09-10
申请人： AXXIMA PHARMACEUTICALS AG , KOUL ANIL , KLEBL BERT , MUELLER GERHARD
发明人： KOUL ANIL , KLEBL BERT , MUELLER GERHARD
IPC分类号： A61K31/381 , C07D209/42 , C07D333/66 , C07D333/68 , C07D409/12 , C07D491/04 , C07D493/04 , C07D495/04 , C07D495/10 , A61P31/04
CPC分类号： C07D409/12 , C07D209/42 , C07D333/66 , C07D333/68 , C07D491/04 , C07D493/04 , C07D495/04 , C07D495/10
摘要： Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.
摘要翻译：描述的是杂双环化合物，例如4,5,6,7-四氢苯并[b]噻吩-3-羧酸酰胺，4,7-二氢-5H-噻吩并[2,3-c]噻喃-3-羧酸酰胺，4 ，7-二氢-5H-噻吩并[2,3-c]吡喃-3-羧酸酰胺或苯并[b]噻吩-3-羧酸酰胺及其药学上可接受的盐，这些衍生物用于预防和 /或治疗诸如感染性疾病，包括分泌细菌感染和机会性疾病，朊病毒疾病，免疫疾病，自身免疫疾病，双相和临床病症，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有至少一种杂双环化合物和/或其药学上可接受的盐的组合物。此外，公开了用于合成杂双环化合物的反应程序。

22. 发明申请

WO0172412A8 METHOD AND DEVICE FOR INVESTIGATING SUBSTANCE LIBRARIES 审中-公开
标题翻译：方法和设备建造和研究物质文库的
公开(公告)号：WO0172412A8
公开(公告)日：2001-12-13
申请号：PCT/EP0103530
申请日：2001-03-28
申请人： LASER & MED TECH GMBH , FREY ANDREAS , HELFMANN JUERGEN , SCHMIDT MARCUS ALEXANDER , MUELLER GERHARD
发明人： FREY ANDREAS , HELFMANN JUERGEN , SCHMIDT MARCUS ALEXANDER , MUELLER GERHARD
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C07H21/00
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00317 , B01J2219/00353 , B01J2219/00378 , B01J2219/00414 , B01J2219/00418 , B01J2219/00486 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07K1/045 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The aim of the invention is to investigate the bonding of substances to target molecules. This is achieved by means of a densely packed device wherein various target molecules are bonded in a large number of sample areas. Cross-contamination and evaporation need to be minimized. The active surface of the sample areas have to be maximized. The inventive solution resides in the use of carrier plates, containing densely packed capillary structures and having a very large inner surface despite small outer dimensions. 1000 times more molecules can be bonded than on a flat outer surface of a comparable size. Cross contamination is avoided by the lack of cross links between the capillaries. Evaporation is minimized by a small outer surface. After the inner surface of the capillaries has been silanized, peptides and peptidomimetics are synthesized in a locally targeted manner. The molecular interactions of components of the substance library with active substances in a solution or a suspension are investigated by means of a local resolution optical detection method. Handling, especially cleaning and covering with substances, is carried out in a simple manner by rinsing liquids through the capillary plate.
摘要翻译：研究的物质靶分子紧密堆积排列想要的结合，在许多样品中的每一个不同的目标分子附着的区域。交叉污染和蒸发应该被最小化以最大化样品区域的活性表面。根据本发明的解决方案在于使用含毛细结构的致密填充基质的，并因此具有小的外形尺寸非常大的内表面积。这种多个分子可以比在大小相当于1000倍的平坦的外表面接合。交叉污染是由缺乏的毛细管之间的联系防止蒸发是通过一个小的外部表面最小化。内毛细管表面，以位点定向的肽和肽模拟物的硅烷化后进行合成。在溶液或悬浮液制剂的物质文库的组分的分子间的相互作用的研究，通过位点的分辨率的光学检测方法来进行。处理，尤其是清洁和物质分配简单地通过通过毛细管板漂洗液体。

23. 发明申请

WO0073776A3 SEMICONDUCTOR GAS SENSOR, GAS SENSOR SYSTEM AND METHOD OF GAS ANALYSIS 审中-公开
标题翻译：半导体气体传感器，气体分析气体传感器的系统和方法
公开(公告)号：WO0073776A3
公开(公告)日：2001-07-26
申请号：PCT/DE0001510
申请日：2000-05-12
申请人： EADS DEUTSCHLAND GMBH , BECKER THOMAS , MUEHLBERGER STEPHAN , MUELLER GERHARD
发明人： BECKER THOMAS , MUEHLBERGER STEPHAN , MUELLER GERHARD
IPC分类号： G01N27/12 , G01N27/26 , G01N33/00
CPC分类号： G01N27/12 , G01N33/0011
摘要： The invention relates to a semiconductor gas sensor (10) comprising a gas-sensitive layer (5), a heater (3) for heating the layer to a defined measurement temperature and contact electrodes (6a, 6b) for measuring the electric resistance of the gas-sensitive layer (5), and a micro-chamber (7) in which the gas-sensitive layer (5) is positioned. The micro-chamber (7) can be closed off towards the exterior and is configured such that its volume is so small that at least one component of the gas or gas mixture to be analyzed is at least to a large extent depleted within a defined measurement period by reaction on the gas-sensitive layer. Owing to the limited gas supply and the reaction of one component of the gas during the measurement gases or gas mixtures containing several components can be analyzed, the measurement signal being obtained after at least one component has reacted. Several sensor elements with gas-sensitive layers can be arranged in the chamber, which can be operated at different temperatures. A gas-sensor system consists, for example, of at least two semiconductor gas sensors with micro-chambers (7) which are arranged in a system comprising gas lines and valves and can be individually filled.
摘要翻译：一种半导体气体传感器（10）用气体 - 敏感层（5），一加热器（3），用于将层加热到规定的测定温度和接触电极（6A，6B），用于测量气体敏感层的电阻（5）是一个微腔（ 7），其中，所述气体敏感层（5）布置。所述腔室（7）朝向可锁定到外部，并且设计为使得所述腔室体积是如此之小，通过使所述气体敏感层至少基本上耗尽的预定测量时间内的分析物的气体或气体混合物的至少一种组分。由于气体的有限供应和气体的组分的气体或气体混合物的测量期间该反应可以用多个部件进行分析。在这种情况下，办法是在测量信号的至少一个组分的反应之后进行。在腔室可以布置多个与气体敏感层的传感器元件，其可在不同的温度下操作。一种气体传感器系统包括例如在与设置在气体管线和阀门各个灌装系统微腔室（7）的至少两个半导体气体传感器。

24. 发明申请

WO9717009A3 ARRANGEMENT FOR ELECTROTHERMAL TREATMENT OF THE HUMAN OR ANIMAL BODY 审中-公开
标题翻译：人体或动物身体电热治疗的安排
公开(公告)号：WO9717009A3
公开(公告)日：1997-07-17
申请号：PCT/DE9602164
申请日：1996-11-07
申请人： LASER & MED TECH GMBH , MUELLER GERHARD , DESINGER KAI
发明人： MUELLER GERHARD , DESINGER KAI
IPC分类号： A61B18/00 , A61B18/14 , A61M3/02 , A61B
CPC分类号： A61B18/1482 , A61B18/1477 , A61B18/148 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00053 , A61B2018/00083 , A61B2018/00196 , A61B2018/0022 , A61B2018/00547 , A61B2018/00577 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00982 , A61B2018/126 , A61B2018/1425 , A61B2018/1467 , A61B2018/1472 , A61B2018/1861 , A61M3/0233
摘要： The invention relates to an arrangement (1) for electrothermal treatment of the human or animal body, in particular for tissue coagulation or electrotomy, with two electrodes (3, 4) for insertion into the body to be treated. The two electrodes (3, 4) are electrically insulated from each other and are at a distance from each other to produce an electric or electromagnetic field heating the body tissue in the treatment area, and each connected by a feed line with a current source arranged outside the body. An elongate catheter (2) is provided for joint insertion of the two electrodes (3, 4) into the body, which are staggered in relation to each other in the axial direction of the catheter (2) and connected to the catheter (2) or a component thereof.

25. 发明申请

WO9712559A2 DEVICE FOR REMOVING MATERIAL FROM A WORKPIECE BY LASER RADIATION 审中-公开
标题翻译：器件材料去除从工作中使用激光辐射
公开(公告)号：WO9712559A2
公开(公告)日：1997-04-10
申请号：PCT/DE9601788
申请日：1996-09-11
申请人： LASER & MED TECH GMBH , MUELLER GERHARD , ERTL THOMAS , BENTHIN HARTMUT
发明人： MUELLER GERHARD , ERTL THOMAS , BENTHIN HARTMUT
IPC分类号： A61C1/00 , A61C13/38 , B23K26/03 , B23K26/06 , B23K26/12 , A61B17/00 , B23K26/04
CPC分类号： B23K26/032 , A61C1/0046 , B23K26/0648 , B23K26/0665 , B23K26/12 , B23K26/128
摘要： A device for removing material from a workpiece, in particular for removing a hard substance, such as tooth enamel or dentine from a tooth, or for removing ceramic materials, has a laser for irradiating the workpiece in a locally limited ablation area where material is removed, and a handling part (1) which receives the laser or is connected thereto by an optical fibre element or by a mirror arrangement. The handling part (1) is used to position the laser beam (3) in the ablation area and has a distance measurement device (11 to 15, D1, D2) to monitor the depth of material removal. While the material is being removed, the distance measurement device (11 to 15, D1, D2) measures the distance to the workpiece surface in the ablation area and therefore the depth of material removal by means of the material-removing laser or of a measurement beam (11) generated by another laser.
摘要翻译：用于诸如牙釉或牙质从牙齿或用于从陶瓷材料中除去材料，用激光用于在局部限定消融区域照射所述工件的材料去除，激光去除硬齿物质除去材料和接收的工件，特别是一种装置或经由光导元件或者镜子布置用于将激光束定位（1）处理部分连接到其上（3）在消融区域，其中，所述处理部分（1），用于材料去除的深度控制（11〜15，D1，D2）包括在一个测距仪通过由激光服务于材料去除或通过另外的激光测量光束（11）在消融到工件表面的距离所产生的材料去除，从而来测量材料的深度。

26. 发明申请

WO9423478A3 Q-SWITCHED LASER SYSTEM, IN PARTICULAR FOR LASER LITHOTRIPSY 审中-公开
标题翻译： Q开关激光系统，特别适用于激光雷达
公开(公告)号：WO9423478A3
公开(公告)日：1995-01-12
申请号：PCT/DE9400362
申请日：1994-03-28
申请人： LASER MEDIZIN ZENTRUM GMBH , MUELLER GERHARD , PASHININ PAVEL
发明人： MUELLER GERHARD , PASHININ PAVEL
IPC分类号： A61B18/26 , H01S3/08 , H01S3/081 , H01S3/091 , H01S3/109 , H01S3/113 , A61B17/22
CPC分类号： H01S3/08 , A61B18/26 , H01S3/08013 , H01S3/08059 , H01S3/081 , H01S3/091 , H01S3/109 , H01S3/113
摘要： A Q-switched laser system, in particular for laser lithotripsy, has a laser-active medium (2.1) in a resonator, an optical pumping arrangement (2.3) and a passive Q-switch (3.2). A resonator extension (1.2) having an optical waveguide is associated to the laser-active medium (2.1) in order to increase the laser pulse length.

27. 发明申请

WO2010084167A3 SURFACE IONIZATION GAS DETECTOR HAVING NANO-PEAKS 审中-公开
标题翻译：纳米TIPSOBERFLÄCHENIONISATIONS气体检测仪
公开(公告)号：WO2010084167A3
公开(公告)日：2011-01-13
申请号：PCT/EP2010050714
申请日：2010-01-22
申请人： EADS DEUTSCHLAND GMBH , MUELLER GERHARD , KRENKOW ANGELIKA , IRMER BERND , SCHADE SEBASTIAN , PENZKOFER CHRISTIAN
发明人： MUELLER GERHARD , KRENKOW ANGELIKA , IRMER BERND , SCHADE SEBASTIAN , PENZKOFER CHRISTIAN
IPC分类号： G01N27/62 , H01J27/26 , H01J49/16
CPC分类号： H01J49/168 , B82Y30/00 , G01N27/62 , G01N2030/647
摘要： The invention relates to a surface ionization gas detector (10) comprising an ionization area (12), over which an analysis gas can be conducted, and further comprising at least one detection device for detecting analysis gas ions, wherein the surface of the ionization area is provided with nano-peaks (30). This causes a concentration and thus a significant increase of the electric field at the pointed ends of the nano-peaks, which significantly improves the ion release, whereby the electric field thus can be significantly increased compared to a flat area, which leads to an increase of the ion emission by several orders of magnitude.
摘要翻译：在具有Ionisationsfläche（12），通过该气体分析可以进行一个Oberflächenionisations气体检测器（10），还包括至少一个检测装置，用于检测分析物气体离子与所述Ionisationsfläche纳米尖端（30）的表面设置。这将导致的浓度，因此，导致在尖端中电场显著增加纳米尖端，其中离子释放显著改善，由此电场可因此显著相比增加的平坦表面通过几个数量级的增加的离子发射的结束。

28. 发明申请

WO2008132138A9 DERIVATIVES OF 4,6-DISUBSTITUTED AMINOPYRIMIDINES 审中-公开
标题翻译： 4,6-取代氨基亚氨基嘧啶的衍生物
公开(公告)号：WO2008132138A9
公开(公告)日：2008-12-31
申请号：PCT/EP2008055015
申请日：2008-04-24
申请人： INGENIUM PHARMACEUTICALS GMBH , CHOIDAS AXEL , KLEBL BERT , MUELLER GERHARD , SCHWAB WILFRIED
发明人： CHOIDAS AXEL , KLEBL BERT , MUELLER GERHARD , SCHWAB WILFRIED
IPC分类号： C07D239/42 , A61K31/505 , A61P35/00
CPC分类号： C07D239/42
摘要： The present invention relates to methylenesulfone and methylenesulfonamide derivatives of 4,6-disubstituted aminopyrimidines having the general formula (II) as given below and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or the treatment of cell proliferative diseases, inflammation, cardiac hypertrophy and infectious diseases, especially viral infections such as HIV. Furthermore, the present invention is directed towards pharmaceutical composition containing at least one of the methylenesulfone or methylenesulfonamide derivatives of 4,6-disubstituted aminopyrimidines and/or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及具有下述通式（II）的4,6-二取代氨基嘧啶的亚甲基砜和亚甲基磺酰胺衍生物和/或其药学上可接受的盐，这些衍生物用作药物活性剂，特别是用于预防和/ 或治疗细胞增殖性疾病，炎症，心脏肥大和感染性疾病，特别是病毒感染如HIV。此外，本发明涉及含有4,6-二取代氨基嘧啶的亚甲基砜或亚甲基磺酰胺衍生物和/或其药学上可接受的盐中的至少一种的药物组合物。

29. 发明申请

WO2008074303A3 ONLINE SENSOR FOR MONITORING CHEMICAL CONTAMINATIONS IN HYDRAULIC FLUIDS 审中-公开
标题翻译：在线监测液压液体中化学污染物的传感器
公开(公告)号：WO2008074303A3
公开(公告)日：2008-09-25
申请号：PCT/DE2007002258
申请日：2007-12-15
申请人： EADS DEUTSCHLAND GMBH , AIRBUS FRANCE , CROS FRANCOIS , FICKER WILHELM , HERTENS DELPHINE , KRENKOW ANGELIKA , LEGNER WOLFGANG , MUELLER GERHARD , ZIEMANN THOMAS , VAN DEN BOSSCHE DOMINIQUE
发明人： CROS FRANCOIS , FICKER WILHELM , HERTENS DELPHINE , KRENKOW ANGELIKA , LEGNER WOLFGANG , MUELLER GERHARD , ZIEMANN THOMAS , VAN DEN BOSSCHE DOMINIQUE
IPC分类号： G01N21/35
CPC分类号： B60T17/22 , G01N21/3577 , G01N27/06 , G01N33/2876
摘要： An online sensor (1) for monitoring chemical contaminations in hydraulic fluids, having a receiving device (4) for the fluid to be monitored, the device having observations windows (3) disposed on two opposite sides, is characterized in that the online sensor (1) has an IR emitter (2) and an IR detector (5) comprising at least two, preferably four detector fields for IR spectroscopy, wherein the fields are disposed opposite of each other on both observations windows (3). This provides a sensor that is capable of detecting the maintenance-relevant parameters of hydraulic fluids based on phosphate esters online, which is to say without having to withdraw the same from the airplane's hydraulic system and remove the same as a sample.
摘要翻译：用于与接收单元（4）监控化学污染物中的液压流体用于监测流体，其被布置在两个相对的侧面观察窗在线传感器（1）（3），其特征在于，所述在线传感器（1）具有用于IR光谱学的至少两个，优选四个检测器场的IR发射器（2）和IR检测器（5），其布置为与两个观察窗（3）相对。这提供了能够在线确定基于磷酸酯的液压流体的维护参数的传感器，而不会将其从飞机液压系统中撕下并作为样本。

30. 发明申请

WO0243067A3 INTEGRATED MEMORY WITH AN ARRANGEMENT OF NON-VOLATILE MEMORY CELLS AND METHOD FOR THE PRODUCTION AND OPERATION OF AN INTEGRATED MEMORY 审中-公开
标题翻译：具有非易失性存储器电池及其制造方法和操作集成内存组成的阵列集成的内存
公开(公告)号：WO0243067A3
公开(公告)日：2002-12-05
申请号：PCT/DE0104091
申请日：2001-10-29
申请人： INFINEON TECHNOLOGIES AG , MUELLER GERHARD , SCHLOESSER TILL
发明人： MUELLER GERHARD , SCHLOESSER TILL
IPC分类号： H01L27/105 , G11C11/15 , H01L21/8246 , H01L27/112 , G11C11/16
CPC分类号： H01L27/224 , B82Y10/00 , G11C11/15 , H01L27/228
摘要： An integrated memory with an arrangement of non-volatile ferromagnetic storage based memory cells, comprising high-power memory cells having a magnetoresisitive effect (1) with transistor control, and low-cost memory cells having a magnetoresistive effect (2) with memory elements (60) connected between the word lines (70) and bit lines (50). The memory elements (60) directly connected between a bit and a word line (60) are preferably used in the form of memory cell fields which can be superposed on top of the memory cells (1) with a transistor (9), resulting in a high integration density. Production costs are reduced significantly by producing the memory, which comprises two types of cells and meets all system requirements, in a single module and single operation cycle.
摘要翻译：一种集成电路存储器，包括非易失性阵列，建立在铁磁性存储存储器单元包括强大的存储器单元用磁阻效应（1）与晶体管的控制和成本存储单元与字线（70）和位线之间的磁阻效应（2）（50） - 连通的存储元件（60）。直接连接的位线和字线的存储元件（60）之间在可堆叠一（1），其具有晶体管（9），从而达到一个高的集成密度的存储器单元中的其他存储单元阵列上面被优选使用。通过使由两种类型的组，从而满足在存储器块和处理结果的所有的系统要求，制造成本显着降低。

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