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21. 发明专利

DE10109858A1 未知
公开(公告)号：DE10109858A1
公开(公告)日：2002-09-05
申请号：DE10109858
申请日：2001-03-01
申请人： BAYER AG
发明人： HAERTER MICHAEL , HAHN MICHAEL G , HIRTH-DIETRICH CLAUDIA , KNORR ANDREAS , STAHL ELKE , STASCH JOHANNES-PETER , WUNDER FRANK
IPC分类号： A61P1/16 , A61K31/195 , A61K31/197 , A61P9/10 , A61P9/12 , C07B61/00 , C07C227/02 , C07C229/38 , C07C253/30 , C07C255/54 , C07C227/14 , A61K31/198
摘要： The invention relates to compounds of formula (I), to methods for their production and to the use thereof as medicaments.

22. 发明专利

DE19934321A1 New N-phenyl-naphthalenesulfonamide derivatives are antiviral agents especially useful for treating cytomegalovirus infections 未知
公开(公告)号：DE19934321A1
公开(公告)日：2001-01-25
申请号：DE19934321
申请日：1999-07-21
申请人： BAYER AG
发明人： ECKENBERG PETER , REEFSCHLAEGER JUERGEN , BENDER WOLFGANG , GOLDMANN SIEGFRIED , HAERTER MICHAEL , HALLENBERGER SABINE , KELDENICH JOERG , WEBER OLAF , HENNINGER KERSTIN
IPC分类号： A61P31/12 , C07C311/44 , C07C311/46 , C07C311/47 , C07C313/06 , C07C317/32 , C07D207/26 , C07D207/27 , C07D207/40 , C07D207/404 , C07D209/48 , C07D211/46 , C07D213/30 , C07D213/81 , C07D233/32 , C07D233/76 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/15 , C07D295/215 , C07D295/26 , A61K31/185 , C07D211/44 , C07D295/033 , C07D295/16 , C07D403/12
摘要： Amino-substituted naphthalenesulfonic acid N-phenylamide derivatives (I) are new. Amino-substituted naphthalenesulfonic acid N-phenylamide derivatives of formula (I) and their salts are new. R1 = H or 1-6C alkanoyl; R2 = alkyl substituted by saturated heterocyclyl; or -COR4, -SO2R5, -COOR6, -S(O)R7 or -C(=NH)R8, or R1, R2 = H if A or D = alkylsulfonyl, or NR1R2 = saturated or unsaturated ring containing upto 6C, one or two ring C optionally being replaced by 1 or 2 of O, S, SO, CO and NR16 and the ring optionally being fused with a benzo ring; R4 = alkyl (optionally substituted by NH2, alkoxycarbonylamino or saturated heterocyclyl), aromatic heterocyclyl, cycloalkyl, alkoxy or NR9R10; R9, R10 = H, alkyl (optionally substituted by 1-3 of halo, OH, COOH and alkoxy), 7-20C alkyl or phenyl (optionally substituted by COOH), or NR9R10 = saturated or unsaturated ring containing upto 7C, one or two ring C optionally being replaced by 1 or 2 of O, S, SO, CO and NR11; R11 = H or alkyl; R5 = 1-8C alkyl (optionally substituted by CF3, C2F5 or saturated heterocyclyl), cycloalkyl or NR12R13; R12, R13 = alkyl, or NR12R13 = saturated or unsaturated ring containing upto 6C, one or two ring C optionally being replaced by 1 or 2 of O, S, SO, CO and NR11; R6 = R15OCH2CH2OCH2CH2-, saturated heterocyclyl (optionally substituted by alkyl) or alkyl (optionally substituted by OH, alkoxy or saturated, unsaturated or aromatic heterocyclyl); R7, R15 = alkyl; R8 = NH2 or mono- or dialkylamino; R16 = H, alkyl (optionally substituted by halo) or 1-6C alkanoyl (optionally substituted by 1-3 halo); R3 = NHCOR17 or -CONHR17; R17 = alkyl (optionally substituted by 1-3 of OH, halo or (1-4C) alkoxycarbonyl), and A, D, E, G = H, halo, NO2,. CN, OH, COOH, CF3, OCF3. alkyl, alkoxy, 1-6C alkanoyloxy, alkoxycarbonyl or alkylsulfonyl; unless specified otherwise alkyl moieties have 1-6C and cycloalkyl moieties 3-7C; heterocyclyl groups are 5- or 6-membered and contain 1-3 of O, S and N as heteroatom(s). An Independent claim is included for the preparation of (I).

23. 发明专利

DE19919793A1 未知
公开(公告)号：DE19919793A1
公开(公告)日：2000-11-02
申请号：DE19919793
申请日：1999-04-30
申请人： BAYER AG
发明人： BENDER WOLFGANG , ECKENBERG PETER , GOLDMANN SIEGFRIED , HAERTER MICHAEL , HALLENBERGER SABINE , REEFSCHLAEGER JUERGEN , TRAPPE JOERG , WEBER OLAF
IPC分类号： A61K31/4035 , A61K31/404 , A61P31/12 , A61P31/22 , C07D209/04 , C07D209/08 , C07D209/44 , C07D405/12 , A61K31/40
摘要： The invention relates to novel compounds that are suitable for use as medicaments, to methods for producing said compounds and to their use as medicaments, especially as antiviral agents.

24. 发明专利

BR9907738A 未知
公开(公告)号：BR9907738A
公开(公告)日：2000-10-17
申请号：BR9907738
申请日：1999-01-09
申请人： BAYER AG
发明人： BENDER WOLFGANG , REEFSCHLAEGER JUERGEN , ECKENBERG PETER , GOLDMANN SIEGFRIED , HAERTER MICHAEL , HALLENBERGER SABINE , TRAPPE JOERG , WEBER OLAF
IPC分类号： C07D233/64 , A61K31/18 , A61K31/223 , A61K31/225 , A61K31/27 , A61K31/277 , A61K31/337 , A61K31/357 , A61K31/4164 , A61P31/12 , C07C311/44 , C07C311/46 , C07D233/26 , C07D233/54 , C07D305/06 , C07D319/06
摘要： The present invention relates to new naphthyl- and anilide-substituted sulphonamides of the general formula (I)in which the substituents A, D, E, G, R1, R2, R3, R4 and X have the meanings indicated,and to processes for their preparation and their use as antiviral agents, in particular against cytomegaloviruses.

25. 发明专利

DE19907701A1 New tricyclic indolyl-substituted oxazolidinone derivatives, useful as broad spectrum antibacterial agents of low toxicity 未知
公开(公告)号：DE19907701A1
公开(公告)日：2000-08-24
申请号：DE19907701
申请日：1999-02-23
申请人： BAYER AG
发明人： BARTEL STEPHAN , RADDATZ SIEGFRIED , HAERTER MICHAEL , ROSENTRETER ULRICH , WILD HANNO , ENDERMANN RAINER , KROLL HEIN-PETER
IPC分类号： C07D471/04 , A61K31/00 , C07D487/04
摘要： 3-(Tricyclic indolyl)-5-(substituted methyl)-2-oxazolidinones (I) are new. Oxazolidinone derivatives of formula (I) and their stereoisomers and salts are new. -U-V- = -CHR3-C(=D)-, -CHR4-CH2-, -CH2-CHR5- or -C(=G)-CH2-; n = 1-3; R2 = H, halo or 1-4C alkyl; E = H or halo; R3, R4 = H; 3-6C cycloalkyl; -COR6; up to 6C acyl (optionally substituted (os) by halo, OH or 1-5C alkoxy); 1-6C alkyl or 2-6C alkenyl (both os by CN, halo, COOH, up to 5C alkoxycarbonyl, OR9 or NR10R11; and/or by 6-14C aryl, itself os by halo, 1-6C alkyl, 1-6C alkoxy or up to 6C acyl); OR12; or NR13R14; D, G = O or S; R5 = OR15 or NR16R17; R6 = H, 1-6C alkoxy or NR7R8; R7 - R17 = H, Ph or 1-5C alkyl; R1 = N3, OR18, OSO2R19 or NHR21; R18 = H, 1-6C alkyl or up to 6C acyl; R19 = 1-6C alkyl or Ph; R21 = -C(=Q)-R22 or -P(O)(OR23)(OR24); Q = O or S; R22 = 1-8C alkyl, 1-8C alkoxy or CF3; 3-6C cycloalkyl (os by halo or 6-10C aryl); 6-10C aryl or 5- or 6-membered saturated or aromatic heterocycle containing 1-3 of S, N and/or O as heteroatoms (both os by 1 or 2 of halo, CN, NO2, OH and Ph); or NR25R26; R25, R26 = H, Ph, pyridyl or 1-5C alkyl (os by morpholino); R23, R24 = H or 1-4C alkyl. An Independent claim is included for the preparation of (I).

26. 发明专利

AT242207T 未知
公开(公告)号：AT242207T
公开(公告)日：2003-06-15
申请号：AT99903617
申请日：1999-01-09
申请人： BAYER AG
发明人： BENDER WOLFGANG , REEFSCHLAEGER JUERGEN , ECKENBERG PETER , GOLDMANN SIEGFRIED , HAERTER MICHAEL , HALLENBERGER SABINE , TRAPPE JOERG , WEBER OLAF
IPC分类号： C07D233/64 , A61K31/18 , A61K31/223 , A61K31/225 , A61K31/27 , A61K31/277 , A61K31/337 , A61K31/357 , A61K31/4164 , A61P31/12 , C07C311/44 , C07C311/46 , C07D233/26 , C07D233/54 , C07D305/06 , C07D319/06
摘要： The present invention relates to new naphthyl- and anilide-substituted sulphonamides of the general formula (I)in which the substituents A, D, E, G, R1, R2, R3, R4 and X have the meanings indicated,and to processes for their preparation and their use as antiviral agents, in particular against cytomegaloviruses.

27. 发明专利

HU0105432A2 NEW BIPHENYL AND BIPHENYL-ANALOGOUS COMPOUNDS AS INTEGRIN ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE 未知
公开(公告)号：HU0105432A2
公开(公告)日：2002-05-29
申请号：HU0105432
申请日：1999-12-13
申请人： BAYER AG
发明人： ALBERS MARKUS , BRUEGGEMEIER ULF , DR GERDES CHRISTOPH , HAERTER MICHAEL , KELDENICH JOERG , LUSTIG KLEMENS , DR SCHMIDT DELF , STAHL ELKE , STELTE-LUDWIG BEATRIX , DR URBAHNS KLAUS , VAUPEL ANDREA
IPC分类号： C07D295/12 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/417 , A61K31/4184 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/5375 , A61P9/10 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , C07C269/06 , C07C271/22 , C07C273/18 , C07C275/42 , C07C303/40 , C07C311/06 , C07C311/10 , C07C311/14 , C07C311/19 , C07C311/37 , C07C311/46 , C07C311/47 , C07C335/20 , C07D207/22 , C07D213/40 , C07D213/55 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/82 , C07D231/18 , C07D233/50 , C07D233/54 , C07D233/64 , C07D233/84 , C07D233/88 , C07D233/90 , C07D235/10 , C07D235/14 , C07D235/30 , C07D261/10 , C07D261/14 , C07D263/58 , C07D277/20 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/54 , C07D277/82 , C07D285/10 , C07D285/12 , C07D285/135 , C07D285/14 , C07D295/13 , C07D295/15 , C07D307/14 , C07D307/16 , C07D307/52 , C07D307/68 , C07D333/34 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00 , C07F5/02
摘要： The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases. The compounds according to the invention have formula (1) wherein R , R , U, V, A, B, W, R , C and R have the meaning as defined in the claims.

29. 发明专利

DE19909785A1 New 1-heterocyclyl-5-carbonylaminomethyl-isoxazoline and 1-heterocyclyl-5-thionocarbonylaminomethyl-isoxazoline derivatives useful as antibacterial agents in human and veterinary medicine 未知
公开(公告)号：DE19909785A1
公开(公告)日：2000-09-07
申请号：DE19909785
申请日：1999-03-05
申请人： BAYER AG
发明人： WILD HANNO , RADDATZ SIEGFRIED , HAERTER MICHAEL , ROSENTRETER ULRICH , BARTLE STEPHAN , ENDERMANN RAINER , KROLL HEIN-PETER
IPC分类号： C07D413/04 , C07D498/04 , A61K31/42 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D513/04
摘要： 1-Heterocyclyl-5-(thiono)carbonylaminomethyl-isoxazoline derivatives (I) are new. 1-Heterocyclyl-5-(thiono)carbonylaminomethyl-isoxazoline derivatives of formula (I) and their tautomers and salts are new. Z' = O or S; R = H, alkoxy, benzyloxy, CF3, cycloalkyl (optionally substituted by halo or aryl), aryl or saturated or aromatic heterocyclyl (each optionally mono- or disubstituted by halo, CN, NO2, OH or phenyl), alkyl (optionally substituted by phenoxy, benzyloxy, COOH, halo, alkoxycarbonyl, acyl or heterocyclyl), or optionally mono- or disubstituted amino; A = group of formula (a) - (h); G , L , M = H, COOH, halo, CN, CHO, CF3, NO2, alkyl, or optionally mono- or disubstituted aminocarbonyl; R = H, cycloalkylcarbonyl, cycloalkyl, alkoxycarbonyl, alkyl or alkenyl optionally substituted by one of 15 groups selected from pyrrolidin-3-yl, 5-nitro-pyrid-2-yl, pyrid-2-yl, pyrid-4-yl, piperidin-4-yl, 1-benzyl-piperidin-4-yl, 1-benzyl-pyrrolidin-3-yl, COCl3 (sic), acyl optionally substituted with 4 groups, optionally mono- or disubstituted amino or aminocarbonyl, optionally substituted sulfonylamino or aminosulfonyl, or (alkyl, benzyl, phenyl or tolyl)-S(O)f; f = 0-2; D , E = O or S; or E = substituted imino when R is not H; R , R 1', R 1'' = H or halo; D , D2', D2'' = N, or C optionally substituted by groups; E , E2' and E2'' = N or C optionally substituted by 11 groups; L , L2' and L2'' = N or C optionally substituted by 8 groups; Q = O, S, SO2, SO, CO, or C optionally mono- or disubstituted by halo; T = C optionally mono- or disubstituted by 5 groups, CO, CS or optionally substituted methylidene or imino; V = O, S, SO, or SO2; W = O, S, CO, CS, SO, SO2, optionally substituted amino, or C optionally mono- or disubstituted by halo, alkyl or benzyl or monosubstituted with alkoxy, acyloxy or benzyloxy; Y = CO or C optionally mono- or disubstituted by halo, alkyl or benzyl or monosubstituted with alkoxy, acyloxy or benzyloxy; or W + Y = -CH=CH-; R = H, halo, or alkyl; E = H or halo; A + D = C(R )(R )L C(R )(R ) or C(R )(R )L3'C(R )(R )C(R )(R ); L , L3' = O, NH, or N substituted by COOH, cycloalkyl, alkoxycarbonyl or optionally substituted acyl; D , D4' and D4'' = H, COOH, halo, CN, CHO, CF3, NO2, or alkoxy, alkoxycarbonyl, alkylthio, acyl or alkyl; E , E4' = CH2, O, S, SO, or SO2; L = O, S, or optionally substituted imino; R - R , R - R = H, or alkyl or alkenyl each optionally substituted by aryl or heteroaryl; or R + R , R + R , R + R , R + R = =O, =CH2 or aryl-substituted or heteroaryl-substituted methylidene; R , R , R = H, alkyl, alkoxycarbonyl, or arylcarbonyl, heteroarylcarbonyl or alkylcarbonyl (each optionally substituted). The full definitions are given in the DEFINITIONS (Full Definitions) Field.

30. 发明专利

CA2439756C SUBSTITUTED AMINODICARBOXYLIC ACID DERIVATIVES WITH PHARMACEUTICAL PROPERTIES 未知
公开(公告)号：CA2439756C
公开(公告)日：2011-01-11
申请号：CA2439756
申请日：2002-02-22
申请人： BAYER AG
发明人： ALONSO-ALIJA CRISTINA , HAERTER MICHAEL , HAHN MICHAEL , PERNERSTORFER JOSEF , WEIGAND STEFAN , STASCH JOHANNES-PETER , WUNDER FRANK
IPC分类号： C07D333/20 , A61K31/085 , A61K31/191 , A61K31/197 , A61K31/235 , A61K31/275 , A61K31/381 , A61K31/44 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P21/00 , C07B61/00 , C07C227/16 , C07C229/38 , C07D213/65
摘要： The invention relates to the use of compounds of formula (I) and of their salts and stereoisomers for producing medicaments used in the treatment of cardiovascular diseases.

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