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21. 发明授权

US4415572A Piperazinylcarbostyril compounds 失效
标题翻译：哌嗪腈基稳定剂化合物
公开(公告)号：US4415572A
公开(公告)日：1983-11-15
申请号：US316572
申请日：1981-10-30
申请人： Michiaki Tominaga , Yung h. Yang , Hidenori Ogawa , Kazuyuki Nakagawa
发明人： Michiaki Tominaga , Yung h. Yang , Hidenori Ogawa , Kazuyuki Nakagawa
IPC分类号： C07D401/10 , A61K31/4704 , A61K31/495 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , C07D215/38 , C07D215/40 , C07D295/155 , C07D295/18 , C07D295/192 , C07D401/04 , C07D405/12 , C07D401/00
CPC分类号： C07D295/192 , C07D215/38 , C07D215/40 , C07D295/155 , C07D405/12
摘要： A piperazinylcarbostyril compound of the formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, or a phenyl-lower alkyl group;R.sup.2 represents a hydrogen atom or a lower alkoxy group;R.sup.3 represents a hydrogen atom, a lower alkanoyl group, a furoyl group, a pyridylcarbonyl group, a lower alkanesulfonyl group, a lower alkoxycarbonyl group, a lower alkoxycarbonyl-lower alkyl group, a phenylsulfonyl group which may be substituted with a lower alkyl group on the benzene ring thereof, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a phenylcarbonyl group, a phenyl-lower alkyl group or a phenyl-lower alkanoyl group where each of said phenylcarbonyl group, phenyl-lower alkyl group and phenyl-lower alkanoyl group may be substituted with 1 to 3 of a lower alkoxy group, a halogen atom, a lower alkyl group, a cyano group, a nitro group, an amino group, a hydroxy group, a lower alkanoylamino group, a lower alkylthio group and a lower alkanoyloxy group, or with a lower alkylenedioxy group on the benzene ring thereof; andthe bonding between the 3- and 4-positions of the carbostyril nucleus is a single bond or a double bond; or its pharmaceutically acceptable salt, useful as a cardiotonic agent.
摘要翻译：式（I）的哌嗪基卡必维尔化合物其中R 1表示氢原子，低级烷基，低级烯基，低级炔基或苯基低级烷基; R2表示氢原子或低级烷氧基; R3表示氢原子，低级烷酰基，糠酰基，吡啶基羰基，低级链烷磺酰基，低级烷氧基羰基，低级烷氧羰基 - 低级烷基，可被低级烷基取代的苯磺酰基，其苯环，低级烷基，低级烯基，低级炔基，苯基羰基，苯基 - 低级烷基或苯基 - 低级烷酰基，其中所述苯基羰基，苯基 - 低级烷基和苯基 - 低级烷酰基可以被1〜3个低级烷氧基，卤素原子，低级烷基，氰基，硝基，氨基，羟基，低级烷酰基氨基，低级烷硫基和低级烷酰氧基，或在其苯环上具有低亚烷基二氧基; 并且喹诺酮环的3-和4-位之间的键合是单键或双键; 或其药学上可接受的盐，可用作强心剂。

22. 发明申请

US20120226034A1 PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF 有权
标题翻译：制备苯甲腈化合物或其盐的方法
公开(公告)号：US20120226034A1
公开(公告)日：2012-09-06
申请号：US13474521
申请日：2012-05-17
申请人： Yasuhiro Torisawa , Kaoru Abe , Yasuaki Muguruma , Shigekazu Fujita , Hidenori Ogawa , Naoto Utsumi , Masahiro Miyake
发明人： Yasuhiro Torisawa , Kaoru Abe , Yasuaki Muguruma , Shigekazu Fujita , Hidenori Ogawa , Naoto Utsumi , Masahiro Miyake
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
摘要： This invention provides a process for preparing benzazepine compounds of the formula (1): wherein X1 is a halogen atom, R1 and R2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.
摘要翻译：本发明提供一种制备式（1）的苯并氮杂化合物的方法：其中X1是卤素原子，R1和R2是低级烷基，或其盐以及工业上高产率和高纯度的中间体苯甲酸化合物其可用作制备具有加压素拮抗活性的药学活性的2,3,4,5-四氢-1H-1-苯并氮杂化合物的中间体。

23. 发明授权

US08035924B2 Suspension for disc drive 有权
标题翻译：悬挂磁盘驱动器
公开(公告)号：US08035924B2
公开(公告)日：2011-10-11
申请号：US12079622
申请日：2008-03-27
申请人： Tsukasa Higashi , Hidenori Ogawa
发明人： Tsukasa Higashi , Hidenori Ogawa
IPC分类号： G11B5/60 , G11B21/21
CPC分类号： G11B5/486 , G11B5/484 , H05K1/0263 , H05K1/0393 , H05K1/056 , H05K3/06 , H05K3/38 , H05K2201/098
摘要： A suspension for disc drive includes a base plate, a load beam, and a flexure. The flexure includes a metal base member and a circuit member disposed along the metal base member. The circuit member extends in a longitudinal direction of the load beam. The circuit member includes a resin base member formed of an electrically insulating resin and conductors. The conductors are formed into predetermined circuit patterns by etching a deposited copper layer deposited on the resin base member. Each conductor has a cross section in the shape of a trapezoid such that the width of a surface of the conductor which faces the resin base member is greater than that of a surface of the conductor on the side opposite from the resin base member.
摘要翻译：用于盘驱动器的悬架包括基板，负载梁和挠曲件。弯曲部包括金属基部构件和沿着金属基部构件设置的电路构件。电路部件沿负载梁的长度方向延伸。电路构件包括由电绝缘树脂和导体形成的树脂基底构件。通过蚀刻沉积在树脂基底上的沉积的铜层，将导体形成预定的电路图案。每个导体具有呈梯形形状的横截面，使得与树脂基底构件相对的导体表面的宽度大于与树脂基底构件相反一侧的导体表面的宽度。

24. 发明授权

US07675713B2 Head suspension with flexure vibration clearance 有权
标题翻译：头部悬挂具有挠曲振动间隙
公开(公告)号：US07675713B2
公开(公告)日：2010-03-09
申请号：US11442813
申请日：2006-05-30
申请人： Hidenori Ogawa , Toshiki Ando
发明人： Hidenori Ogawa , Toshiki Ando
IPC分类号： G11B5/55
CPC分类号： G11B5/4833
摘要： A head suspension for a hard disk drive has a base attached to a carriage of the hard disk drive and is turned around a spindle. A load beam includes a rigid part and a resilient part which applies load onto a head at a front end of the load beam to write and read data to and from a disk arranged in the hard disk drive. The rigid part is supported to the base through the resilient part. A flexure is attached to at least the rigid part of the load beam and has read/write wiring patterns connected to the head. A recessed portion or a through-hole portion is formed in at least one of the load beam and the base for avoiding vibration contact of the flexure.
摘要翻译：用于硬盘驱动器的磁头悬架具有附接到硬盘驱动器的托架的基座并绕主轴转动。负载梁包括刚性部分和弹性部分，其将负载施加到负载梁的前端处的头部上以便从布置在硬盘驱动器中的盘写入数据和从其读取数据。刚性部分通过弹性部分支撑到基部。挠曲件至少连接到负载梁的刚性部分，并且具有连接到头部的读/写布线图案。在负载梁和基座中的至少一个中形成凹部或通孔部，以避免挠曲件的振动接触。

25. 发明授权

US06432874B1 Thermally sensitive recording medium 失效
标题翻译：热敏记录介质
公开(公告)号：US06432874B1
公开(公告)日：2002-08-13
申请号：US09572088
申请日：2000-05-17
申请人： Tadakazu Fukuchi , Kaoru Hamada , Kunio Takebayashi , Hidenori Ogawa , Yoshimi Midorikawa , Reiko Sato , Yoshihide Kimura
发明人： Tadakazu Fukuchi , Kaoru Hamada , Kunio Takebayashi , Hidenori Ogawa , Yoshimi Midorikawa , Reiko Sato , Yoshihide Kimura
IPC分类号： B41M540
CPC分类号： B41M5/44 , B41M5/30
摘要： A thermally sensitive recording paper having a recording surface which when a postage stamp or a revenue stamp is adhered to the recording surface requires at least ten cycles of a removal test procedure to remove at least one third of the adhered surface of the stamp from the recording surface of the thermally sensitive recording paper, wherein the removal test procedure comprises adhering the postage stamp or revenue stamp to the recording surface of the thermally sensitive recording paper, hanging the recording paper over an iron bar of about 8 mm diameter with the postage stamp or revenue stamp on an outer surface of the recording paper, adjusting the recording paper such that equal lengths are on either side of the iron bar, attaching to one end of the thermally sensitive recording paper a weight of about 500 g, holding the other end of the thermally sensitive recording paper by hand and carrying out a pull down ant put back cycle motion of the hand to move the postage stamp or revenue stamp over the iron bar until at least a portion of the postage stamp or revenue stamp is removed from the surface of the recording paper.
摘要翻译：一种具有记录表面的热敏记录纸，当邮票或收入印记附着在记录表面上时，需要至少十个循环的去除测试程序，以从记录中去除印模的粘附表面的至少三分之一热敏记录纸的表面，其中去除测试程序包括将邮票或收入印章粘贴到热敏记录纸的记录表面上，将该记录纸用约8mm直径的铁棒用邮资戳或记录纸的外表面上的收入印章，调整记录纸，使得相同的长度在铁棒的任一侧上，附着在热敏记录纸的一端，重量约为500g，保持另一端手感热敏记录纸，并执行拉下蚂蚁放回手的循环运动，以移动邮票或邮寄场地邮票在铁条上，直到从记录纸的表面移除至少一部分邮票或收据。

26. 发明授权

US5652247A Carbostyril derivatives 失效
标题翻译：卡波他汀衍生物
公开(公告)号：US5652247A
公开(公告)日：1997-07-29
申请号：US359081
申请日：1994-12-14
申请人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： C07D215/22 , C07D215/227 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04 , C07D521/00 , C07H15/26 , A61K31/47 , A61K31/495 , C07D215/16 , C07D215/36
CPC分类号： C07D215/227 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04 , C07H15/26
摘要： Novel carbostyril derivatives of the formula: ##STR1## wherein R.sup.1 is H, NO.sub.2, alkoxy, alkoxycarbonyl, alkyl, halogen, optionally substituted amino, OH, CN, COOH, alkanoyloxy, hydrazinocarbonyl; q is 1 to 3, and R is a group of the formula: ##STR2## [wherein R.sup.2 is H, alkoxycarbonyl, optionally substituted phenoxycarbonyl, phenylalkenyl-CO--, optionally substituted phenylalkanoyl, alkanoyl, alkenyl-CO--, optionally substituted phenyl-SO.sub.2 --, --CONR.sup.8 R.sup.9, optionally substituted heterocyclic group-CO--, naphthyl-CO--, thienylalkanoyl, tricyclo[3.3.1.1]alkanoyl, ##STR3## (R.sup.13 is OH, optionally substituted alkoxy, --NR.sup.32 R.sup.33, --O--A--(E).sub.l --NR.sup.4 R.sup.5, --(B).sub.l --NR.sup.6 R.sup.7, etc.),n is 1 or 2, m is 0 or 1 to 3, R.sup.3 is alkyl, R.sup.10 is --(CO).sub.l --NR.sup.11 R.sup.12 ], and the bond between 3- and 4-position of carbostyril nucleus is single or double bond,which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
摘要翻译：其中R1是H，NO2，烷氧基，烷氧基羰基，烷基，卤素，任选取代的氨基，OH，CN，COOH，烷酰氧基，肼基羰基; q为1至3，并且R为下式基团：其中R 2为H，烷氧基羰基，任选取代的苯氧基羰基，苯基烯基-CO-，任选取代的苯基烷酰基，烷酰基，烯基-CO-，任选取代的苯基 - SO 2 - ，-CONR 8 R 9，任选取代的杂环基-CO-，萘基-CO-，噻吩基烷酰基，三环[3.3.1.1]烷酰基，（R 13是OH，任选取代的烷氧基，-NR 32 R 33，-OA-（E） 1-NR4R5， - （B）1-NR6R7等），n为1或2，m为0或1至3，R 3为烷基，R 10为 - （CO）1 -NR 11 R 12] 喹诺酮单核苷酸和4-位是单或双键，具有优良的加压素拮抗作用，可作为血管舒张剂，降血压药，利尿剂，血小板凝集抑制剂和含有该化合物作为活性成分的血管加压素拮抗剂组合物。

27. 发明授权

US4593035A Carbostyril derivatives 失效
标题翻译：卡波他汀衍生物
公开(公告)号：US4593035A
公开(公告)日：1986-06-03
申请号：US679632
申请日：1984-12-10
申请人： Michiaki Tominaga , Hidenori Ogawa , Takafumi Fujioka , Yung-hsiung Yang , Kazuyuki Nakagawa
发明人： Michiaki Tominaga , Hidenori Ogawa , Takafumi Fujioka , Yung-hsiung Yang , Kazuyuki Nakagawa
IPC分类号： A61K31/47 , A61P9/08 , A61P9/10 , A61P9/12 , C07D215/38 , C07D407/12
CPC分类号： C07D407/12 , C07D215/38
摘要： Novel carbostyril derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a lower alkyl group, R.sup.2 is a lower alkyl group or a group of the formula: ##STR2## R.sup.3 is a lower alkylthio group, a lower alkyl group, a lower alkoxy group, phenoxy group, a phenyl(lower)alkoxy group, a lower alkenyloxy group, a phenyl group which may have a substituent selected from a lower alkoxy and a lower alkylenedioxy group on the phenyl ring, or a group of the formula: --NR.sup.4 R.sup.5 (R.sup.4 and R.sup.5 are the same or different and are each hydrogen atom or a lower alkyl group), and X is oxygen atom or sulfur atom, provided that when R.sup.1 is hydrogen atom and R.sup.2 is the group of the formula: ##STR3## X is not oxygen atom and R.sup.3 is not a lower alkyl group, and a pharmaceutically acceptable salt thereof, which show excellent pharmacological activities, such as myocardial contract increasing activity and coronary blood flow increasing activity and are useful for the treatment of heart diseases such as congestive heart failure.
摘要翻译：式（1）的新型喹诺酮衍生物：其中R 1是氢原子或低级烷基，R 2是低级烷基或下式的基团：R 3是低级烷硫基，低级烷基基团，低级烷氧基，苯氧基，苯基（低级）烷氧基，低级烯氧基，可具有选自苯环上的低级烷氧基和低级亚烷基二氧基的取代基的苯基，或一组式-NR4R5（R4和R5相同或不同，各自为氢原子或低级烷基），X为氧原子或硫原子，条件是当R 1为氢原子且R 2为式：X不是氧原子，R 3不是低级烷基，其药学上可接受的盐，其具有优异的药理活性，例如心肌收缩增加活性和冠状动脉血流增加活性，并且可用于治疗心脏病如充血性他艺术失败。

28. 发明授权

US4585774A Aniline derivatives and cardiotonic composition 失效
标题翻译：苯胺衍生物和强心组成
公开(公告)号：US4585774A
公开(公告)日：1986-04-29
申请号：US432902
申请日：1982-09-29
申请人： Michiaki Tominaga , Yung-hsiung Yang , Hidenori Ogawa , Kazuyuki Nakagawa
发明人： Michiaki Tominaga , Yung-hsiung Yang , Hidenori Ogawa , Kazuyuki Nakagawa
IPC分类号： A61K31/495 , A61K31/496 , A61P9/04 , C07D295/10 , C07D295/15 , C07D295/16 , C07D295/18 , C07D295/192
CPC分类号： C07D295/192 , C07C255/00 , C07D295/15
摘要： Aniline derivatives of the formula: ##STR1## wherein R.sup.0, R.sup.1 and R.sup.2 are the same or different and each is a hydrogen atom, a halogen atom, a nitro group, an amino group, a carboxy group, a cyano group, a hydroxy group, a sulfonamido group, a lower alkyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkanoyl group, a lower alkylamino group, a lower alkylthio group, a lower alkanoylamino group or a group of the formula ##STR2## wherein R.sup.5 and R.sup.6 are the same or different and each is a hydrogen atom, a lower alkyl group or a C.sub.3 to C.sub.8 cycloalkyl group or together with the nitrogen atom a morpholino, piperidino, piperazino or pyrrolidino group; R.sup.3 is a cyano group, a nitro group, a halogen atom, a lower alkyl group or a lower alkoxy group; m is an integer of 1 to 3; R.sup.4 is a hydrogen atom or a lower alkyl group; and A is a lower alkylene group. The derivatives are useful as cardiotonics.
摘要翻译： PCT No.PCT / JP82 / 00152 Sec。 371日期：1982年9月29日 102（e）日期1982年9月29日PCT提交1982年5月4日PCT公布。出版物WO82 / 03861 日本11月11日，下式的苯胺衍生物：其中R 0，R 1和R 2相同或不同，各自为氢原子，卤素原子，硝基，氨基，羧基，氰基，羟基，亚磺酰氨基，低级烷基，低级烷氧基羰基，低级烷氧基，低级烷酰基，低级烷基氨基，低级烷硫基，低级烷酰基氨基或低级烷氧基其中R 5和R 6相同或不同，并且各自为氢原子，低级烷基或C 3至C 8环烷基，或与氮原子一起形成吗啉代，哌啶子基，哌嗪基或吡咯烷基; R3是氰基，硝基，卤素原子，低级烷基或低级烷氧基; m为1〜3的整数。 R4是氢原子或低级烷基; A为低级亚烷基。衍生物可用作强心剂。

29. 发明授权

US4487772A Carbostyril derivatives and their salts 失效
标题翻译：卡波他汀衍生物及其盐
公开(公告)号：US4487772A
公开(公告)日：1984-12-11
申请号：US348709
申请日：1982-02-16
申请人： Michiaki Tominaga , Yung-hsiung Yang , Hidenori Ogawa , Kazuyuki Nakagawa
发明人： Michiaki Tominaga , Yung-hsiung Yang , Hidenori Ogawa , Kazuyuki Nakagawa
IPC分类号： C07C215/06 , A61K31/44 , A61K31/4704 , A61P9/04 , C07C205/57 , C07D215/20 , C07D215/227 , C07D215/48 , C07D265/16 , C07D295/04 , C07D403/06 , C07D413/12 , C07D401/06 , A61K31/495
CPC分类号： C07D215/48 , C07C205/57
摘要： Carbostyril derivatives of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group and R.sup.2 and R.sup.3 may be the same or different and each is a substituted or unsubstituted lower alkyl group, or R.sup.2 and R.sup.3 may form, together with the adjacent nitrogen atom, a 5- or 6-membered saturated heterocyclic ring which may be substituted or unsubstituted. The derivatives are useful as the active ingredient in cardiotonic compositions.
摘要翻译：其中R1是氢原子，低级烷基，低级烯基，低级炔基或苯基 - 低级烷基的通式为“IMAGE”的卡波他特尔衍生物，R 2和R 3可以相同或不同，取代或未取代的低级烷基，或R 2和R 3可与相邻的氮原子一起形成可被取代或未取代的5或6元饱和杂环。该衍生物可用作强心剂组合物中的活性成分。

30. 发明授权

US4454130A Morpholino and oxazoline substituted carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same 失效
标题翻译：吗啉代和恶唑啉取代的喹诺酮衍生物，其制备方法和含有它们的强心组合物
公开(公告)号：US4454130A
公开(公告)日：1984-06-12
申请号：US525812
申请日：1983-08-22
申请人： Michiaki Tominaga , Yung-hsiung Yang , Hidenori Ogawa , Kazuyuki Nakagawa
发明人： Michiaki Tominaga , Yung-hsiung Yang , Hidenori Ogawa , Kazuyuki Nakagawa
IPC分类号： C07C215/06 , A61K31/44 , A61K31/4704 , A61P9/04 , C07C205/57 , C07D215/20 , C07D215/227 , C07D215/48 , C07D265/16 , C07D295/04 , C07D403/06 , C07D413/12 , A61K31/47 , A61K31/535
CPC分类号： C07D215/48 , C07C205/57
摘要： Novel carbostyril derivatives and their pharmaceutically acceptable salts represented by the formula (1). ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group, R.sup.2 and R.sup.3 form, together with the adjacent nitrogen atom and further with an additional oxygen atom, a 5- or 6-membered saturated heterocyclic ring which may have a lower alkyl group or a phenyl-lower alkyl group as the substituent; the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton being a single or double bond. The derivatives are useful as the active ingredient in cardiotonic compositions.
摘要翻译：新型喹诺酮衍生物及其由式（1）表示的药学上可接受的盐。（1）其中R1是氢原子，低级烷基，低级烯基，低级炔基或苯基 - 低级烷基，R2和R3与相邻的氮原子一起形成，进一步与另外的氧原子，可以具有低级烷基或苯基 - 低级烷基作为取代基的5-或6-元饱和杂环; 喹诺酮骨架中3-和4-位之间的碳 - 碳键是单键或双键。该衍生物可用作强心剂组合物中的活性成分。

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