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21. 发明授权

US07972354B2 Method and apparatus for impeding migration of an implanted occlusive structure 有权
标题翻译：阻止植入闭塞结构迁移的方法和装置
公开(公告)号：US07972354B2
公开(公告)日：2011-07-05
申请号：US11339975
申请日：2006-01-25
申请人： Anna G. Prestezog , Michael S. Mirizzi , Halil I. Karabey , John W. Rodriguez , Russell B. Thompson
发明人： Anna G. Prestezog , Michael S. Mirizzi , Halil I. Karabey , John W. Rodriguez , Russell B. Thompson
IPC分类号： A61B17/10
CPC分类号： A61B17/12186 , A61B17/06 , A61B17/12022 , A61B17/12031 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12181 , A61B17/1219 , A61B17/122 , A61B2017/00898 , A61B2017/0474 , A61B2017/06176 , A61B2017/1205
摘要： A method of treating a hollow anatomical structure of a patient comprises implanting a bioabsorbable fibrous body in a hollow anatomical structure. The body is secured in the hollow anatomical structure to limit migration of the body within the hollow anatomical structure.
摘要翻译：治疗患者的中空解剖结构的方法包括将生物可吸收纤维体植入中空解剖结构中。身体被固定在中空的解剖结构中以限制身体在中空解剖结构内的移动。

22. 发明授权

US07815661B2 Method and apparatus for implanting an occlusive structure 有权
标题翻译：用于植入闭塞结构的方法和装置
公开(公告)号：US07815661B2
公开(公告)日：2010-10-19
申请号：US11340183
申请日：2006-01-25
申请人： Michael S. Mirizzi , Anna G. Prestezog , Halil I. Karabey
发明人： Michael S. Mirizzi , Anna G. Prestezog , Halil I. Karabey
IPC分类号： A61F2/01
CPC分类号： A61B17/12186 , A61B17/06 , A61B17/12022 , A61B17/12031 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12181 , A61B17/1219 , A61B17/122 , A61B2017/00898 , A61B2017/0474 , A61B2017/06176 , A61B2017/1205
摘要： A method of treating a vein comprises accessing a vein at an access point spaced from a sapheno-femoral junction. A bioabsorbable fibrous body is implanted into the vein through the access point. The body is moved in the vein toward the sapheno-femoral junction.
摘要翻译：治疗静脉的方法包括在与隐窝 - 股骨连接处间隔开的入口处进入静脉。通过接入点将生物可吸收纤维体植入静脉。身体静脉移动到隐窝股骨交界处。

23. 发明申请

US20100160898A1 METHOD AND APPARATUS FOR STORAGE AND/OR INTRODUCTION OF IMPLANT FOR HOLLOW ANATOMICAL STRUCTURE 有权
标题翻译：用于存储和/或介绍中空解剖结构的植入物的方法和装置
公开(公告)号：US20100160898A1
公开(公告)日：2010-06-24
申请号：US12642699
申请日：2009-12-18
申请人： Michael S. Mirizzi
发明人： Michael S. Mirizzi
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12181 , A61B50/30 , A61B2017/00004 , A61B2017/1205 , A61B2017/12054
摘要： Apparatus for advancing a vascular implant into a blood vessel. The apparatus comprises a first elongate member, the first elongate member having sufficient column strength to function as a pusher member; and a second elongate member, the second elongate member being thinner than the first elongate member and extending to a distal end located at a first point which is at or near a distal end of the first elongate member. The elongate members form an implant retaining portion while the distal end of the second elongate member is located at the first point. The implant retaining portion is located proximal of the first point. The implant retaining portion comprises a space located between the elongate members and configured for receiving an implant portion, with the first elongate member on one side of the space and the second elongate member on another side. The implant retaining portion further comprises a proximal side and a distal side which further circumscribe the space. The proximal and distal sides are effective to prevent an implant received in the retaining portion from moving out of engagement with the retaining portion as the first elongate member is moved distally and proximally. The implant retaining portion is removable by withdrawing the second elongate member in a proximal direction with respect to the first elongate member, thereby moving the distal end of the elongate member proximally beyond the former location of the implant retaining portion. Associated methods, and other apparatus and methods, are also disclosed.
摘要翻译：用于将血管植入物推入血管的装置。该装置包括第一细长构件，第一细长构件具有足够的柱强度以用作推动构件; 和第二细长构件，所述第二细长构件比所述第一细长构件更薄并且延伸到位于所述第一细长构件的远端处或其附近的第一点处的远端。细长构件形成植入物保持部分，而第二细长构件的远端位于第一点处。植入物保持部分位于第一点的近侧。植入物保持部分包括位于细长构件之间并被构造成用于容纳植入部分的空间，第一细长构件位于空间的一侧，而第二细长构件位于另一侧。植入物保持部分还包括进一步围绕该空间的近侧和远侧。近侧和远侧有效地防止当第一细长构件向远侧和向近侧移动时，容纳在保持部分中的植入物移动离开与保持部分的接合。通过相对于第一细长构件在近端方向上取出第二细长构件来移除植入物保持部分，从而将细长构件的远端向近侧移动超过植入物保持部分的前一个位置。还公开了相关方法和其它装置和方法。

24. 发明授权

US06702802B1 Catheters with improved transition 有权
标题翻译：改善过渡的导管
公开(公告)号：US06702802B1
公开(公告)日：2004-03-09
申请号：US09596014
申请日：2000-06-15
申请人： David Hancock , David Chi , Michael S. Mirizzi , Peter S. Brown , Christopher C. Pfaff , Brett W. Cryer , Misty L. Pyatt
发明人： David Hancock , David Chi , Michael S. Mirizzi , Peter S. Brown , Christopher C. Pfaff , Brett W. Cryer , Misty L. Pyatt
IPC分类号： A61M2500
CPC分类号： A61F2/958 , A61F2002/9586 , A61M25/0054 , A61M25/10 , A61M2025/0063
摘要： The present invention is directed to a balloon catheter, such as a dilatation catheter and a stent delivery catheter with improved stiffness transition and specifically with no sudden changes in stiffness along the catheter length. The balloon catheters of the present invention may be used alone or be mounted with a stent in. The balloon catheters of the present invention may be used in peripheral, coronary, or neurovascular applications. The present catheter has more than one portion with different bending stiffness values, each portion comprising of components that gradually transition the bending stiffness of that portion to an adjacent portion, thus reducing the differential in bending stiffness in moving from one region to another, when the catheter is used alone or in combination with a stent in a stent delivery system.
摘要翻译：本发明涉及一种球囊导管，例如扩张导管和支架输送导管，其具有改善的刚度转变，具体而言沿导管长度没有突然的刚度变化。本发明的气囊导管可以单独使用或安装有支架。本发明的气囊导管可用于外周，冠状动脉或神经血管应用。本导管具有不止一个具有不同弯曲刚度值的部分，每个部分包括将该部分的弯曲刚度逐渐过渡到相邻部分的部件，从而减少了从一个区域移动到另一个区域时的弯曲刚度差异，导管单独使用或与支架在支架输送系统中组合使用。

25. 发明授权

US5974652A Method and apparatus for uniformly crimping a stent onto a catheter 失效
标题翻译：将支架均匀地压接在导管上的方法和装置
公开(公告)号：US5974652A
公开(公告)日：1999-11-02
申请号：US72925
申请日：1998-05-05
申请人： Richard M. Kimes , Michael S. Mirizzi
发明人： Richard M. Kimes , Michael S. Mirizzi
IPC分类号： A61F2/06 , A61F2/84 , A61M29/00 , B23P11/00 , B23P19/02
CPC分类号： A61F2/958 , A61F2002/9522 , Y10T29/49927 , Y10T29/53952 , Y10T29/53987 , Y10T29/53996
摘要： A stent crimping tool for firmly and uniformly crimping a stent onto a balloon catheter is constructed from a crimping section holding the stent and the balloon catheter therein, wherein the crimping is actuated by a shaft having an input end and an output end, engaging the crimping section at the output end. The shaft has a detent formed into the input end. A gripping member has an internal cavity to receive the input end, and includes a hole proximate to the shaft, wherein a ball bearing and a compression spring are located within the hole to bias the ball bearing toward the shaft and to engage the detent. When a torque is applied to the gripping member, it is transmitted through the ball bearing to the shaft; if the torque exceeds a predetermined magnitude, it overcomes the force of the spring on the ball bearing causing the bearing to slide out of the detent thereby disconnecting the applied torque from the shaft. The crimping section can be a rubber tube having a lumen holding the stent and catheter. When the shaft compresses the rubber tube as it advances, the lumen collapses and crimps the stent onto the catheter. In another embodiment, the crimping section is a coiled filament suspended at both ends and having an axial space holding the stent and catheter. Rotating the shaft twists the filament which in turn constricts and crimps the stent onto the catheter.
摘要翻译：用于将支架牢固且均匀地压接在球囊导管上的支架压接工具由将支架和气囊导管保持在其中的压接部分构成，其中，压接由具有输入端和输出端的轴致动，在输出端。轴具有形成输入端的制动器。夹持构件具有内部空腔以容纳输入端，并且包括靠近轴的孔，其中球轴承和压缩弹簧位于孔内以将球轴承朝向轴偏压并接合止动件。当扭矩施加到夹持构件时，其通过滚珠轴承传递到轴; 如果扭矩超过预定的大小，则它克服了滚珠轴承上的弹簧的力，导致轴承滑出制动器，从而将施加的扭矩与轴断开。卷曲部可以是具有保持支架和导管的内腔的橡胶管。当轴在橡胶管前进时压缩橡胶管时，管腔将支架折叠并卷曲到导管上。在另一个实施例中，卷曲部分是悬挂在两端并具有保持支架和导管的轴向空间的卷绕细丝。旋转轴扭转细丝，其又将支架收缩并卷曲到导管上。

26. 发明授权

US09060773B2 Occlusive implant delivery devices and associated methods 有权
标题翻译：闭塞植入物输送装置及相关方法
公开(公告)号：US09060773B2
公开(公告)日：2015-06-23
申请号：US13328357
申请日：2011-12-16
申请人： Hoa D. Nguyen , Michael S. Mirizzi , Thomas C. Pham
发明人： Hoa D. Nguyen , Michael S. Mirizzi , Thomas C. Pham
IPC分类号： A61F6/06 , A61B17/12 , A61F2/80
CPC分类号： A61B17/12022 , A61B17/12099 , A61B2017/1205 , A61F2/80 , A61F2002/805
摘要： The various embodiments simplify the delivery of an occlusive implant to a hollow anatomical structure, such as a fallopian tube. For example, the delivery devices don't need to be retracted manually to deploy the implant. When the devices are activated, stored energy or a powered drive member induces movement of the various components. The operator need only position the distal ends of the devices at the treatment site and then commence deployment by, for example, flipping a switch or changing the position of an activation button. The present embodiments thus increase the efficacy of occlusion procedures by reducing the likelihood of operator error.
摘要翻译：各种实施例简化了闭塞植入物到中空解剖结构（例如输卵管）的递送。例如，递送装置不需要手动缩回以部署植入物。当设备被激活时，存储的能量或动力驱动构件引起各种部件的移动。操作者仅需要将设备的远端定位在治疗部位，然后通过例如翻转开关或改变激活按钮的位置来开始部署。因此，本实施例通过降低操作者错误的可能性来增加遮挡过程的功效。

27. 发明申请

US20150165169A1 Multiple Chamber, Expandable Therapeutic Agent Delivery Device 审中-公开
标题翻译：多室，可扩展的治疗剂递送装置
公开(公告)号：US20150165169A1
公开(公告)日：2015-06-18
申请号：US14555819
申请日：2014-11-28
申请人： Michael S. Mirizzi
发明人： Michael S. Mirizzi
IPC分类号： A61M25/10 , A61M25/00
CPC分类号： A61M25/1002 , A61M25/1029 , A61M2025/105 , A61M2025/1072 , A61M2025/1075 , A61M2025/1086
摘要： A device having multiple chambers may be configured to expand to contact a substantial section of an interior wall of a body structure or lumen in order to simultaneously exclude blood or other liquid from a target structure while providing for delivery of a therapeutic agent directly to the interior wall. The expandable device may be manufactured from a plurality of flat sheets of material heat sealed to one another to form an inflation chamber and one, two or more delivery chambers. The sheets may also be bonded to an elongate catheter body having inflation and delivery lumens. The excluding of blood flow and delivery of therapeutic agents are completed by the same device.
摘要翻译：具有多个腔室的装置可被构造成膨胀以接触身体结构或内腔的内壁的实质部分，以便同时从目标结构排除血液或其它液体，同时提供将治疗剂直接递送至内部壁。可膨胀装置可以由彼此热密封的多个平板材料制成，以形成充气室和一个，两个或更多个输送室。片材也可以结合到具有充气和输送内腔的细长导管体上。排除血液流量和治疗剂的输送由相同的装置完成。

28. 发明授权

US08469924B2 Method and apparatus for generating vascular treatment foam 有权
标题翻译：用于产生血管治疗泡沫的方法和装置
公开(公告)号：US08469924B2
公开(公告)日：2013-06-25
申请号：US11696696
申请日：2007-04-04
申请人： Hoa D. Nguyen , Michael S. Mirizzi
发明人： Hoa D. Nguyen , Michael S. Mirizzi
IPC分类号： A61M37/00
CPC分类号： B01F13/08 , A61B17/00008 , A61B2017/00778 , A61M5/008 , A61M5/178 , A61M5/1782 , A61M5/28 , A61M5/3129 , A61M5/3134 , A61M5/3137 , A61M2005/3104 , B01F13/0023 , B01F13/0818
摘要： Apparatus and methods for generating foam are disclosed. The inventions can be used for generating foam for sclerotherapy. A foaming element can be agitated within a foaming chamber by a drive unit that does not touch the foaming element, but actuates it from outside the foaming chamber. The foaming element and drive unit can be magnetically coupled. A syringe can be used to form a foaming chamber.
摘要翻译：公开了用于产生泡沫的装置和方法。本发明可用于产生用于硬化疗的泡沫。发泡元件可以通过不接触发泡元件的驱动单元在发泡室内搅动，而是从发泡室外部致动。发泡元件和驱动单元可以磁耦合。可以使用注射器来形成发泡室。

29. 发明授权

US08333786B2 Method and apparatus for implanting an occlusive structure 有权
标题翻译：用于植入闭塞结构的方法和装置
公开(公告)号：US08333786B2
公开(公告)日：2012-12-18
申请号：US12906961
申请日：2010-10-18
申请人： Michael S. Mirizzi , Anna G. Prestezog , Halil I. Karabey , John W. Rodriguez
发明人： Michael S. Mirizzi , Anna G. Prestezog , Halil I. Karabey , John W. Rodriguez
IPC分类号： A61B17/10
CPC分类号： A61B17/12186 , A61B17/06 , A61B17/12022 , A61B17/12031 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12181 , A61B17/1219 , A61B17/122 , A61B2017/00898 , A61B2017/0474 , A61B2017/06176 , A61B2017/1205
摘要： A method of treating a vein comprises accessing a vein at an access point spaced from a sapheno-femoral junction. A bioabsorbable fibrous body is implanted into the vein through the access point. The body is moved in the vein toward the sapheno-femoral junction.
摘要翻译：治疗静脉的方法包括在与隐窝 - 股骨连接处间隔开的入口处进入静脉。通过接入点将生物可吸收纤维体植入静脉。身体静脉移动到隐窝股骨交界处。

30. 发明授权

US08262695B2 Structures for permanent occlusion of a hollow anatomical structure 有权
标题翻译：中空解剖结构永久闭塞的结构
公开(公告)号：US08262695B2
公开(公告)日：2012-09-11
申请号：US11339978
申请日：2006-01-25
申请人： Halil I. Karabey , Anna G. Prestezog , Michael S. Mirizzi , Brian Farley , John W. Rodriguez , Russell B. Thompson
发明人： Halil I. Karabey , Anna G. Prestezog , Michael S. Mirizzi , Brian Farley , John W. Rodriguez , Russell B. Thompson
IPC分类号： A61B17/08
CPC分类号： A61B17/12186 , A61B17/06 , A61B17/12022 , A61B17/12031 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12181 , A61B17/1219 , A61B17/122 , A61B2017/00898 , A61B2017/0474 , A61B2017/06176 , A61B2017/1205
摘要： An apparatus for treating a hollow anatomical structure comprises an implant sized for insertion into a hollow anatomical structure. The implant comprises a plurality of loose, bulked fibers. The fibers are formed from one or more bioabsorbable materials.
摘要翻译：用于治疗中空解剖结构的装置包括尺寸适于插入中空解剖结构中的植入物。植入物包括多个松散的膨松纤维。纤维由一种或多种生物可吸收材料形成。

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