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21. 发明申请

US20080177347A1 Method for treating a subject having neuromuscular impairment of the diaphragm 审中-公开
标题翻译：用于治疗患有隔膜神经肌肉损伤的受试者的方法
公开(公告)号：US20080177347A1
公开(公告)日：2008-07-24
申请号：US12004932
申请日：2007-12-21
申请人： Amir J. Tehrani , Rose Province
发明人： Amir J. Tehrani , Rose Province
IPC分类号： A61N1/00
CPC分类号： A61N1/3601 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/08
摘要： A method for treating a subject is provided where at least two types of electrical stimulation are provided to cause diaphragm contraction. At least one type of stimulation is configured to bias lung volume of a subject. The stimulation method may include without being limited to a method to treat a subject having neuromuscular impairment of the diaphragm. The stimulation method may also include without being limited to a method to treat a subject who has been diagnosed with central sleep apnea.
摘要翻译：提供一种用于治疗受试者的方法，其中提供至少两种类型的电刺激以引起隔膜收缩。至少一种类型的刺激被配置成偏置受试者的肺容积。刺激方法可以包括但不限于治疗具有隔膜神经肌肉损伤的受试者的方法。刺激方法还可以包括但不限于治疗被诊断患有中枢性睡眠呼吸暂停的受试者的方法。

22. 发明申请

US20080183240A1 Device and method for manipulating minute ventilation 审中-公开
标题翻译：用于操作分钟通气的装置和方法
公开(公告)号：US20080183240A1
公开(公告)日：2008-07-31
申请号：US11981831
申请日：2007-10-31
申请人： Amir J. Tehrani , David Ligon
发明人： Amir J. Tehrani , David Ligon
IPC分类号： A61N1/36
CPC分类号： A61N1/36132 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： A stimulation device is provided that stimulates breathing to manipulate blood gas concentrations such as SaO2 or PCO2 and thereby treat underlying causes of breathing disorders and heart failure progression. A programmable device is provided for setting diaphragm stimulation waveforms that adjust minute ventilation about a predetermined baseline value. Normal breathing of the subject is observed to establish a baseline reference minute ventilation, and the device is programmed to produce stimulation waveforms that may provide either a decrease or an increase in the patients minute ventilation. The minute ventilation of the subject may be decreased or increased from the baseline level by decreasing or increasing a parameter that changes minute ventilators.
摘要翻译：提供刺激装置，其刺激呼吸以操纵血液浓度，例如SaO 2或PCO 2，从而治疗呼吸障碍和心力衰竭进展的潜在原因。提供了可编程装置，用于设置围绕预定基准值调节分钟通气的隔膜刺激波形。观察到受试者的正常呼吸以建立基线参考分钟通气，并且该装置被编程以产生刺激波形，其可以提供患者分钟通气的减少或增加。通过减少或增加改变分钟呼吸机的参数，可以使受试者的每分通气量从基线水平降低或增加。

23. 发明授权

US08412331B2 Breathing therapy device and method 有权
标题翻译：呼吸治疗装置及方法
公开(公告)号：US08412331B2
公开(公告)日：2013-04-02
申请号：US10966474
申请日：2004-10-15
申请人： Amir J. Tehrani , David Ligon
发明人： Amir J. Tehrani , David Ligon
IPC分类号： A61N1/18
CPC分类号： A61N1/36132 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： A device and method is provided for electrically stimulating the diaphragm to control breathing while inhibiting respiratory drive. A stimulation phase is identified. The stimulation phase is a period of time within the breathing cycle in which stimulation will inhibit respiratory drive. The respiratory drive inhibition may be used in a number of applications including but not limited to: improving or remodeling the heart in heart failure patients, treating apnea, chronic obstructive pulmonary disorder (COPD), and hypertension.
摘要翻译：提供了一种用于电刺激隔膜以控制呼吸同时抑制呼吸驱动的装置和方法。确定刺激阶段。刺激阶段是呼吸周期内刺激将阻止呼吸驱动的一段时间。呼吸驱动抑制可用于许多应用，包括但不限于：改善或改造心力衰竭患者的心脏，治疗呼吸暂停，慢性阻塞性肺病（COPD）和高血压。

24. 发明授权

US08200336B2 System and method for diaphragm stimulation 有权
标题翻译：隔膜刺激的系统和方法
公开(公告)号：US08200336B2
公开(公告)日：2012-06-12
申请号：US10966472
申请日：2004-10-15
申请人： Amir J. Tehrani , David Ligon
发明人： Amir J. Tehrani , David Ligon
IPC分类号： A61N1/08
CPC分类号： A61N1/36132 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： A stimulation device is provided that stimulates breathing to manipulate blood gas concentrations such as SaO2 or PCO2 and thereby treat underlying causes of breathing disorders and heart failure progression. A programmable device is provided for setting diaphragm stimulation waveforms that adjust minute ventilation about a predetermined baseline value. Normal breathing of the subject is observed to establish a baseline reference minute ventilation, and the device is programmed to produce stimulation waveforms that may provide either a decrease or an increase in the patients minute ventilation. The minute ventilation of the subject may be decreased or increased from the baseline level by decreasing or increasing a parameter that changes minute ventilators.
摘要翻译：提供刺激装置，其刺激呼吸以操纵诸如SaO2或PCO2的血液气体浓度，从而治疗呼吸障碍和心力衰竭进展的潜在原因。提供了可编程装置，用于设置围绕预定基准值调节分钟通气的隔膜刺激波形。观察到受试者的正常呼吸以建立基线参考分钟通气，并且该装置被编程以产生刺激波形，其可以提供患者分钟通气的减少或增加。通过减少或增加改变分钟呼吸机的参数，可以使受试者的每分通气量从基线水平降低或增加。

25. 发明申请

US20080183239A1 Breathing therapy device and method 审中-公开
标题翻译：呼吸治疗装置及方法
公开(公告)号：US20080183239A1
公开(公告)日：2008-07-31
申请号：US11981727
申请日：2007-10-31
申请人： Amir J. Tehrani , David Ligon
发明人： Amir J. Tehrani , David Ligon
IPC分类号： A61M16/00 , A61N1/00
CPC分类号： A61N1/36132 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： A device and method is provided for electrically stimulating the diaphragm to control breathing while inhibiting respiratory drive. A stimulation phase is identified. The stimulation phase is a period of time within the breathing cycle in which stimulation will inhibit respiratory drive. The respiratory drive inhibition may be used in a number of applications including but not limited to: improving or remodeling the heart in heart failure patients, treating apnea, chronic obstructive pulmonary disorder (COPD), and hypertension.
摘要翻译：提供了一种用于电刺激隔膜以控制呼吸同时抑制呼吸驱动的装置和方法。确定刺激阶段。刺激阶段是呼吸周期内刺激将阻止呼吸驱动的一段时间。呼吸驱动抑制可用于许多应用，包括但不限于：改善或改造心力衰竭患者的心脏，治疗呼吸暂停，慢性阻塞性肺病（COPD）和高血压。

26. 发明授权

US08509901B2 Device and method for adding to breathing 失效
标题翻译：添加呼吸的装置和方法
公开(公告)号：US08509901B2
公开(公告)日：2013-08-13
申请号：US11526949
申请日：2006-09-25
申请人： Amir J. Tehrani
发明人： Amir J. Tehrani
IPC分类号： A61N1/00
CPC分类号： A61N1/36132 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： A method and device is provided for adding to breathing by stimulating tissue to elicit a diaphragm response during intrinsic breathing.
摘要翻译：提供了一种方法和装置，用于通过刺激组织来增加呼吸以在内在呼吸期间引起隔膜反应。

27. 发明授权

US08467876B2 Breathing disorder detection and therapy delivery device and method 有权
标题翻译：呼吸障碍检测和治疗传递装置及方法
公开(公告)号：US08467876B2
公开(公告)日：2013-06-18
申请号：US10686891
申请日：2003-10-15
申请人： Amir J. Tehrani
发明人： Amir J. Tehrani
IPC分类号： A61N1/18
CPC分类号： A61N1/36132 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： A device and method are provided for managing the treatment of a patient with respiratory disorders or symptoms. Respiratory parameters are sensed and recorded and communicated to an external device to provide information to a patient and/or provider for further treatment or diagnosis. Also respiratory disorders such as apnea or hypoventilation may be treated by electrically stimulating the diaphragm muscle or phrenic nerve in response to a sensed respiratory parameter or characteristic.
摘要翻译：提供了一种用于管理患有呼吸障碍或症状的患者的治疗的装置和方法。呼吸参数被感测并记录并传送到外部设备，以向患者和/或供应商提供信息以进行进一步的治疗或诊断。还可以通过响应于感测到的呼吸参数或特征电刺激隔膜肌肉或膈神经来治疗呼吸系统疾病，例如呼吸暂停或通气不足。

28. 发明授权

US08348941B2 Demand-based system for treating breathing disorders 有权
标题翻译：用于治疗呼吸障碍的基于需求的系统
公开(公告)号：US08348941B2
公开(公告)日：2013-01-08
申请号：US11249718
申请日：2005-10-13
申请人： Amir J. Tehrani
发明人： Amir J. Tehrani
IPC分类号： A61N1/36
CPC分类号： A61N1/36132 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： A device and method are provided for managing the treatment of a patient with respiratory disorders or symptoms. Respiratory parameters are sensed and recorded and communicated to an external device to provide information to a patient and/or provider for further treatment or diagnosis. Also respiratory disorders such as apnea or hypoventilation may be treated by electrically stimulating the diaphragm muscle or phrenic nerve in response to a sensed respiratory parameter or characteristic.
摘要翻译：提供了一种用于管理患有呼吸障碍或症状的患者的治疗的装置和方法。呼吸参数被感测并记录并传送到外部设备，以向患者和/或供应商提供信息以进行进一步的治疗或诊断。还可以通过响应于感测到的呼吸参数或特征电刺激隔膜肌肉或膈神经来治疗呼吸系统疾病，例如呼吸暂停或通气不足。

29. 发明授权

US08255056B2 Breathing disorder and precursor predictor and therapy delivery device and method 有权
标题翻译：呼吸障碍和前兆预测因素及治疗方法
公开(公告)号：US08255056B2
公开(公告)日：2012-08-28
申请号：US10966421
申请日：2004-10-15
申请人： Amir J. Tehrani
发明人： Amir J. Tehrani
IPC分类号： A61N1/18
CPC分类号： A61N1/36132 , A61B5/0488 , A61B5/08 , A61B5/4818 , A61B5/7264 , A61N1/3601
摘要： A device and method for sensing breathing disorders, irregularities or insufficiencies is provided. One aspect includes sensing a precursor to an onset of a breathing disorder or episode of a breathing disorder and responding to sensing the precursor. Another aspect includes responding to treat the breathing disorder before manifestation of the disorder. Another aspect includes identifying a likelihood of a breathing disorder and responding using the likelihood and other information indicating onset or occurrence of a breathing disorder.
摘要翻译：提供了用于感测呼吸障碍，不规则或不足的装置和方法。一个方面包括感测前体到呼吸障碍或呼吸障碍的发作，并响应于感测前体。另一方面包括在症状出现之前应对呼吸障碍。另一方面包括识别呼吸障碍的可能性并使用表示呼吸障碍的发生或发生的可能性和其他信息进行响应。

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