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21. 发明授权

US4650614A Refining of reaction grade 2-acrylamido-2-methylpropane sulfonic acid 失效
标题翻译：反应级2-丙烯酰氨基-2-甲基丙磺酸的精炼
公开(公告)号：US4650614A
公开(公告)日：1987-03-17
申请号：US402254
申请日：1982-07-27
申请人： Allan H. Jevne , Patrick T. Cahalan , Arthur J. Coury
发明人： Allan H. Jevne , Patrick T. Cahalan , Arthur J. Coury
IPC分类号： C07C309/04 , C07C143/02
CPC分类号： C07C303/44
摘要： Reaction grade 2-acrylamido-2-methylpropane sulfonic acid is refined by mildly heating a slurry-like suspension formed of the acid and a liquid monohydric alcohol, recovering the acid from the alcohol and subsequently drying it.
摘要翻译：通过温和加热由酸和液体一元醇形成的淤浆状悬浮液来精制反应级2-丙烯酰氨基-2-甲基丙磺酸，从醇中回收酸，随后将其干燥。

22. 发明申请

US20180258207A1 BIOSTABLE SEGMENTED ELASTOMERS AND THERMOPLASTICS AND METHODS OF MAKING AND USING THEREOF 审中-公开
公开(公告)号：US20180258207A1
公开(公告)日：2018-09-13
申请号：US15760830
申请日：2016-09-19
申请人： Arthur J. Coury , The Arizona Board of Regents on Behalf of The University of Arizona
发明人： Arthur J. Coury , Marvin J. Slepian
IPC分类号： C08F228/02 , C08F236/04 , C08F299/02 , C08K5/41 , A61L27/16 , A61L29/04 , A61L31/04
CPC分类号： C08F228/02 , A61L27/16 , A61L27/54 , A61L29/041 , A61L29/16 , A61L31/048 , A61L31/16 , C08F236/04 , C08F299/022 , C08F2810/30 , C08G75/00 , C08G75/0286 , C08G75/23 , C08G81/00 , C08G85/004 , C08K5/41 , C08L81/00
摘要： Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.

23. 发明申请

US20110305872A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITONS 有权
标题翻译：抗微生物，抗细菌免疫组织化学
公开(公告)号：US20110305872A1
公开(公告)日：2011-12-15
申请号：US13156677
申请日：2011-06-09
申请人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： B32B3/00 , D03D15/00 , D04H13/00 , B05D3/10
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译：一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟。

24. 发明授权

US5278200A Thromboresistant material and articles 失效
标题翻译：防血栓材料和物品
公开(公告)号：US5278200A
公开(公告)日：1994-01-11
申请号：US968796
申请日：1992-10-30
申请人： Arthur J. Coury , James R. Keogh , Christopher M. Hobot , Warren W. Howland
发明人： Arthur J. Coury , James R. Keogh , Christopher M. Hobot , Warren W. Howland
IPC分类号： A61L33/00 , A01N1/00
CPC分类号： A61L33/0041 , A61L33/0088
摘要： Biocompatible heparin-like material and surfaces thereof are made by co-polymerization of acrylic acid (AA) and 2-acrylamido-2-methyl propane sulfonic acid (AMPS) and attaching the copolymer to a suitable substrate or blending the copolymer into a suitable substrate. The material produced also possesses surface slip-properties and some decreased bacterial and platelet adherence.
摘要翻译：通过丙烯酸（AA）和2-丙烯酰氨基-2-甲基丙磺酸（AMPS）的共聚合制备生物相容性肝素样材料及其表面，并将共聚物连接到合适的底物上或将共聚物共混成合适的底物。所生产的材料还具有表面滑爽性，并且一些减少的细菌和血小板粘附。

25. 发明授权

US4226244A Electrical connector for implantable electrical generators 失效
标题翻译：用于可植入发电机的电连接器
公开(公告)号：US4226244A
公开(公告)日：1980-10-07
申请号：US929315
申请日：1978-07-31
申请人： Arthur J. Coury , Frank J. Wilary
发明人： Arthur J. Coury , Frank J. Wilary
IPC分类号： A61N1/375 , A61N1/36
CPC分类号： A61N1/3752
摘要： A preformed electrical connector for use with body implantable stimulators, such as heart pacemakers, having a signal generator and at least one electrical lead electrically and mechanically connected to each other through the preformed electrical connector. The connector carries at least one terminal to establish electrical contact between the signal generator and electric lead, passageways being provided in the connector body to accept and guide the signal generator feedthrough pin and electrical lead into contact with the terminal. In a preferred embodiment, the terminal is provided with intersecting bores such that the feedthrough pin and electrical lead form electrical contact within or by means of the terminal. The pin may be welded or press fit to the terminal and the lead may be attached to the terminal by means of a setscrew. The preformed connector may be mechanically fastened or fastened with an adhesive to the implantable stimulator. The connector may include one or two terminals and may then connect one or two sets of feedthrough pins and respective electrical lead wires.
摘要翻译：一种用于身体植入式刺激器（例如心脏起搏器）的预成型电连接器，其具有信号发生器和通过预先形成的电连接器彼此电连接和机械连接的至少一个电引线。连接器承载至少一个端子以建立信号发生器和电引线之间的电接触，通道设置在连接器主体中，以接收和引导信号发生器馈通销和电引线与端子接触。在优选实施例中，端子设置有相交的孔，使得馈通销和电引线在端子内或借助端子形成电接触。销可以焊接或压配合到端子，并且引线可以通过固定螺丝附接到端子。预成型连接器可以用粘合剂机械地紧固或固定到可植入刺激器。连接器可以包括一个或两个端子，并且然后可以连接一组或两组馈通引脚和相应的电引线。

26. 发明授权

US09096703B2 Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions 有权
标题翻译：非结垢，抗微生物，抗血栓形成的移植物组合物
公开(公告)号：US09096703B2
公开(公告)日：2015-08-04
申请号：US13156677
申请日：2011-06-09
申请人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： C08F255/02 , A61L29/06 , A61L29/08 , A61L33/00 , C08F291/00 , C08J7/16 , C08J7/18 , C08G18/83 , C08G64/42 , C08G77/38
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译：一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟。

27. 发明申请

US20110305909A1 ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES 有权
标题翻译：具有非浮选表面的制品及其制备方法，不改变物理性质
公开(公告)号：US20110305909A1
公开(公告)日：2011-12-15
申请号：US13156904
申请日：2011-06-09
申请人： Douglas J.K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Douglas J.K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： B32B27/00 , B32B27/40 , B05D3/02 , B05D3/12 , B05D3/00
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
摘要翻译：本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。这些方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理特性，然后在经处理的基材表面上形成接枝的聚合物层。

28. 发明申请

US20110305898A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS 审中-公开
标题翻译：抗微生物，抗血栓形成组合物
公开(公告)号：US20110305898A1
公开(公告)日：2011-12-15
申请号：US13156708
申请日：2011-06-09
申请人： Zheng Zhang , Jun Li , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Zheng Zhang , Jun Li , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： B32B3/00 , B32B9/04 , B32B27/40 , B32B27/00 , B32B17/06 , D04H13/00 , D03D15/00 , A61L33/00 , B32B15/04
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/252 , A61L2300/404 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B32B5/022 , B32B5/024 , B32B5/16 , B32B5/26 , B32B5/30 , B32B9/00 , B32B9/005 , B32B9/04 , B32B9/041 , B32B9/043 , B32B9/047 , B32B9/048 , B32B15/04 , B32B15/043 , B32B15/08 , B32B15/14 , B32B15/16 , B32B27/08 , B32B27/12 , B32B27/14 , B32B27/28 , B32B27/281 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/38 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/538 , B32B2307/7145 , B32B2307/732 , B32B2535/00 , Y10T428/24364 , Y10T428/26 , Y10T428/265 , Y10T428/2962 , Y10T428/31504 , Y10T428/31551 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855 , Y10T442/30 , Y10T442/60
摘要： The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.
摘要翻译：本发明一般涉及具有包含接枝聚合物材料的非结垢表面的制品，例如医疗装置。表面抗生物材料的粘附。

29. 发明授权

US5799384A Intravascular radially expandable stent 失效
公开(公告)号：US5799384A
公开(公告)日：1998-09-01
申请号：US736001
申请日：1996-10-23
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
IPC分类号： A61F2/00 , A61F2/82 , A61F2/88 , B23P11/00
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.

30. 发明授权

US4883854A Hydroxyl functional monomers 失效
标题翻译：羟基官能单体
公开(公告)号：US4883854A
公开(公告)日：1989-11-28
申请号：US251261
申请日：1988-09-30
申请人： Arthur J. Coury , Christopher M. Hobot
发明人： Arthur J. Coury , Christopher M. Hobot
IPC分类号： C07C271/16 , C08G18/32 , C08G18/38 , C08G18/50 , C08G18/61 , C08G71/04
CPC分类号： C08G18/3831 , C08G18/5045 , C08G18/61 , C08G71/04
摘要： By reacting polyamines with ethylene carbonate, hydroxyethyl urethane diols and polyols are produced. These diols and polyols are particularly useful for the synthesis of polyurethanes by reaction with diisocyanates or polyisocyanates.

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