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21. 发明申请

US20100068228A1 Inducing Cellular Immune Responses to Hepatitis B Virus Using Peptide and Nucleic Acid Compositions 审中-公开
标题翻译：使用肽和核酸组合诱导乙型肝炎病毒的细胞免疫应答
公开(公告)号：US20100068228A1
公开(公告)日：2010-03-18
申请号：US12535966
申请日：2009-08-05
申请人： Alessandro SETTE , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro SETTE , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
IPC分类号： A61K39/29 , C07K7/06 , C07K7/08 , C07K2/00 , C07K14/00 , C07H21/00 , A61K38/02 , G01N33/567 , A61P31/12
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70539 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译：本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。

22. 发明申请

US20090012004A1 HLA binding peptides and their uses 审中-公开
标题翻译： HLA结合肽及其用途
公开(公告)号：US20090012004A1
公开(公告)日：2009-01-08
申请号：US11882719
申请日：2007-08-03
申请人： Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis
发明人： Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis
IPC分类号： A61K38/00 , C07K7/00 , A61P37/00
CPC分类号： A61K38/08 , A61K39/00 , A61K2039/55555 , C07K14/005 , C07K14/4748 , C07K14/70539 , C12N2730/10122 , C12N2770/24222
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen. The immunogenic peptide compositions of the present invention comprise immunogenic peptides having an HLA binding motif, where the peptide is from a target antigen. Target antigens of the present invention include prostate specific antigen (PSA), hepatitis B core and surface antigens (HBVc, HBVs) hepatitis C antigens, Epstein-Barr virus antigens, melanoma antigens (e.g., MAGE-1), human immunodeficiency virus (HIV) antigens, human papilloma virus (HPV) antigens, Lassa virus, mycobacterium tuberculosis (MT), p53, CEA, trypanosome surface antigen (TSA) and Her2/neu.
摘要翻译：本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。所述肽可用于引发针对所需抗原的免疫应答。本发明的免疫原性肽组合物包含具有HLA结合基序的免疫原性肽，其中肽来自靶抗原。本发明的靶抗原包括前列腺特异性抗原（PSA），乙型肝炎核心和表面抗原（HBVc，HBV）丙型肝炎抗原，爱泼斯坦 - 巴尔病毒抗原，黑素瘤抗原（例如MAGE-1），人类免疫缺陷病毒）抗原，人乳头瘤病毒（HPV）抗原，拉沙病毒，结核分枝杆菌（MT），p53，CEA，锥虫表面抗原（TSA）和Her2 / neu。

23. 发明授权

US07252829B1 HLA binding peptides and their uses 有权
标题翻译： HLA结合肽及其用途
公开(公告)号：US07252829B1
公开(公告)日：2007-08-07
申请号：US09189702
申请日：1998-11-10
申请人： Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis
发明人： Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis
IPC分类号： A61K38/08 , A61K38/10 , A61K39/00 , C07K4/12
CPC分类号： A61K38/08 , A61K39/00 , A61K2039/55555 , C07K14/005 , C07K14/4748 , C07K14/70539 , C12N2730/10122 , C12N2770/24222
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen. The immunogenic peptide compositions of the present invention comprise immunogenic peptides having an HLA binding motif, where the peptide is from a target antigen. Target antigens of the present invention include prostate specific antigen (PSA), hepatitis B core and surface antigens (HBVc, HBVs) hepatitis C antigens, Epstein-Barr virus antigens, melanoma antigens (e.g., MAGE-1), human immunodeficiency virus (HIV) antigens, human papilloma virus (HPV) antigens, Lassa virus, mycobacterium tuberculosis (MT), p53, CEA, trypanosome surface antigen (TSA) and Her2/neu. An example of an immunogenic peptide of the present invention corresponds to a peptide less than about 15 amino acids in length that comprises an HLA-A2.1 binding motif, where the peptide comprises the p53 sequence SMPPPGTRV.
摘要翻译：本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。所述肽可用于引发针对所需抗原的免疫应答。本发明的免疫原性肽组合物包含具有HLA结合基序的免疫原性肽，其中肽来自靶抗原。本发明的靶抗原包括前列腺特异性抗原（PSA），乙型肝炎核心和表面抗原（HBVc，HBV）丙型肝炎抗原，爱泼斯坦 - 巴尔病毒抗原，黑素瘤抗原（例如MAGE-1），人类免疫缺陷病毒）抗原，人乳头瘤病毒（HPV）抗原，拉沙病毒，结核分枝杆菌（MT），p53，CEA，锥虫表面抗原（TSA）和Her2 / neu。本发明的免疫原性肽的实例对应于包含HLA-A2.1结合基序的长度小于约15个氨基酸的肽，其中肽包含p53序列SMPPPGTRV。

24. 发明申请

US20070098776A1 HLA class I A2 tumor associated antigen peptides and vaccine compositions 审中-公开
标题翻译： HLA I类A2肿瘤相关抗原肽和疫苗组合物
公开(公告)号：US20070098776A1
公开(公告)日：2007-05-03
申请号：US11482832
申请日：2006-07-10
申请人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa Keogh , Robert Chesnut
发明人： John Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa Keogh , Robert Chesnut
IPC分类号： A61K9/127 , A61K39/00 , A61K38/10 , A61K38/08
CPC分类号： A61K9/0019 , A61K9/127 , A61K38/08
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译：一种组合物或疫苗组合物，其包含至少一种具有小于600个连续氨基酸的肽，其具有与CEA，HER2 / neu，MAGE2，MAGE3或p53的天然序列具有100％同一性，所述肽还包含至少一个选自表6。

25. 发明申请

US20070059799A1 Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开
标题翻译：使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答
公开(公告)号：US20070059799A1
公开(公告)日：2007-03-15
申请号：US11522314
申请日：2006-09-18
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： C07K14/005 , A61K38/00 , A61K2039/5154 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译：本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。

26. 发明申请

US20050271676A1 Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions 审中-公开
标题翻译：使用肽和核酸组合物诱导人免疫缺陷病毒-1的细胞免疫应答
公开(公告)号：US20050271676A1
公开(公告)日：2005-12-08
申请号：US11045024
申请日：2005-01-28
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian Livingston , Robert Chesnut , Denise Baker , Esteban Celis , Ralph Kubo , Howard Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian Livingston , Robert Chesnut , Denise Baker , Esteban Celis , Ralph Kubo , Howard Grey
IPC分类号： A61K39/00 , C07H21/04 , C07K14/16
CPC分类号： C07K14/005 , A61K2039/5154 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6018 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human immunodeficiency virus (HIV) epitopes, and to develop epitope-based vaccines directed towards HIV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HIV infection.
摘要翻译：本发明使用我们对抗原被T细胞识别并制备人免疫缺陷病毒（HIV）表位的机制的知识，并开发针对HIV的基于表位的疫苗。更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗HIV感染。

27. 发明申请

US20120015401A1 PLASMODIUM FALCIPARUM ANTIGENS AND METHODS OF USE 审中-公开
标题翻译： PLASMODIUM FALCIPARUM抗原和使用方法
公开(公告)号：US20120015401A1
公开(公告)日：2012-01-19
申请号：US13189765
申请日：2011-07-25
申请人： Alessandro Sette , Denise L. Doolan , Daniel J. Carucci , John Sidney , Scott Southwood
发明人： Alessandro Sette , Denise L. Doolan , Daniel J. Carucci , John Sidney , Scott Southwood
IPC分类号： C12P21/02 , C12N1/19 , C12N1/21 , C12N5/10 , C07H21/00 , C12N15/63
CPC分类号： C12Q1/6837 , A61K39/00 , C07K14/445 , Y02A50/412 , Y10S424/802
摘要： The subject invention provides novel Plasmodium falciparum antigens and novel polynucleotides encoding these antigens. Also provided by the subject invention are methods of using these antigens and polynucleotides.
摘要翻译：本发明提供新型恶性疟原虫抗原和编码这些抗原的新型多核苷酸。本发明还提供了使用这些抗原和多核苷酸的方法。

28. 发明授权

US08017745B2 Plasmodium falciparum antigens and methods of use 有权
标题翻译：恶性疟原虫抗原及使用方法
公开(公告)号：US08017745B2
公开(公告)日：2011-09-13
申请号：US10537642
申请日：2003-12-08
申请人： Alessandro Sette , Denise L. Doolan , Daniel J. Carucci , John Sidney , Scott Southwood
发明人： Alessandro Sette , Denise L. Doolan , Daniel J. Carucci , John Sidney , Scott Southwood
IPC分类号： C07H21/02 , A61K39/015 , A61K45/00 , A61B5/055 , C12N5/00 , C12N15/00
CPC分类号： C12Q1/6837 , A61K39/00 , C07K14/445 , Y02A50/412 , Y10S424/802
摘要： The subject invention provides novel Plasmodium falciparum antigens and novel polynucleotides encoding these antigens. Also provided by the subject invention are methods of using these antigens and polynucleotides.
摘要翻译：本发明提供新型恶性疟原虫抗原和编码这些抗原的新型多核苷酸。本发明还提供了使用这些抗原和多核苷酸的方法。

29. 发明申请

US20060093617A1 Peptides for inducing a CTL and/or HTL response to hepatitis C virus 审中-公开
标题翻译：用于诱导丙型肝炎病毒的CTL和/或HTL应答的肽
公开(公告)号：US20060093617A1
公开(公告)日：2006-05-04
申请号：US11140487
申请日：2005-05-31
申请人： Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert Chesnut , Mark Newman , Alessandro Sette , John Sidney , Scott Southwood
发明人： Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert Chesnut , Mark Newman , Alessandro Sette , John Sidney , Scott Southwood
IPC分类号： A61K39/29 , C07K14/18
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients.
摘要翻译：本发明涉及衍生自丙型肝炎病毒（HCV）的肽和编码它们的核酸。肽是在宿主中引起CTL和/或HTL应答的肽。本发明还涉及用于预防和治疗HCV感染的组合物和疫苗以及用于检测患者中HCV暴露的诊断方法。

30. 发明申请

US20060079453A1 Hla binding peptides and their uses 审中-公开
标题翻译： Hla结合肽及其用途
公开(公告)号：US20060079453A1
公开(公告)日：2006-04-13
申请号：US10530061
申请日：2003-10-03
申请人： John Sidney , Scott Southwood , Alessandro Sette
发明人： John Sidney , Scott Southwood , Alessandro Sette
IPC分类号： A61K48/00 , A61K38/16 , A61K38/17 , A61K9/127
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/35 , C07K14/4746 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/70539 , C07K14/82 , C07K2319/01 , C12N2710/16222 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2770/24222
摘要： Provided herein are peptides in certian pathogens and/or human or murine proteins that are identified as capable of binding one or more MHC molecules and inducing an immume response in a system. Also provided are compositions that include one or more of the peptides and methods for inducing an immune reponse in a system by administering the compositions to the system.
摘要翻译：本文提供了证实为能够结合一种或多种MHC分子并在系统中诱导中止反应的证人病原体和/或人或鼠蛋白质中的肽。还提供了包含一种或多种肽的组合物和通过将组合物施用于系统在系统中诱导免疫应答的方法。

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