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21. 发明申请

US20110319473A1 COMPOSITIONS AND METHODS FOR ENHANCEMENT OF NUCLEIC ACID DELIVERY 审中-公开
标题翻译：用于增强核酸递送的组合物和方法
公开(公告)号：US20110319473A1
公开(公告)日：2011-12-29
申请号：US13171171
申请日：2011-06-28
申请人： Joseph Schmidt McGonigle , Joram Slager
发明人： Joseph Schmidt McGonigle , Joram Slager
IPC分类号： A61K31/713 , C07H21/02
CPC分类号： A61K9/19 , A61K9/1272 , A61K9/1647 , A61K9/1652 , A61K47/36 , A61K48/0041 , C12N15/88
摘要： Embodiments of the invention include devices and methods for delivery of nucleic acids as active agents. Embodiments of the invention include devices and methods for delivery of nucleic acids as active agents. In an embodiment, an article for delivering an active agent is included. The article can include a dehydrated complex including a nucleic acid, a transfection agent, and a saccharide protectant. The nucleic acid and transfection agent can form a liposome or a lipoplex. The dehydrated complex can be disposed within a polymeric matrix. The dehydrated complex can be disposed within a microparticle. Other embodiments are also included herein.
摘要翻译：本发明的实施方案包括用于递送核酸作为活性剂的装置和方法。本发明的实施方案包括用于递送核酸作为活性剂的装置和方法。在一个实施例中，包括用于递送活性剂的物品。该制品可以包括脱水复合物，其包括核酸，转染剂和糖类保护剂。核酸和转染剂可形成脂质体或脂质体。脱水复合物可以设置在聚合物基质内。脱水复合物可以设置在微粒内。本文还包括其它实施例。

22. 发明申请

US20110236454A1 INJECTABLE DRUG DELIVERY FORMULATION 失效
标题翻译：注射药物配送
公开(公告)号：US20110236454A1
公开(公告)日：2011-09-29
申请号：US13074212
申请日：2011-03-29
申请人： Joram Slager
发明人： Joram Slager
IPC分类号： A61F13/00 , A61K9/00 , A61K38/00 , A61K31/7088 , A61K47/30 , A61K47/36 , A61P27/06 , A61P27/12 , A61P3/10 , A61P31/00 , A61P31/10 , A61P31/12 , A61P35/00
CPC分类号： A61K9/0024 , A61F9/00 , A61K9/0051 , A61K9/06 , A61K47/36 , C08B30/18 , C08B31/006 , C08J3/075 , C08J2305/00
摘要： The invention provides an injectable formulation that includes an active agent; a biocompatible solvent system, crosslinkable polymers such as polysaccharides; and crosslinking agents; wherein the formulation is substantially free of water. The invention also provides a drug delivery depot formed from the injectable formulation wherein the polymers crosslink in the presence of water in the body of a patient, or in the air, prior to implantation in the patient. Also provided are methods of treatment using such formulations and drug delivery systems.
摘要翻译：本发明提供了包含活性剂的可注射制剂; 生物相容性溶剂体系，可交联聚合物如多糖; 和交联剂; 其中所述制剂基本上不含水。本发明还提供由可注射制剂形成的药物递送贮库，其中在植入患者之前，聚合物在患者身体或空气中的水存在下交联。还提供了使用这种制剂和药物递送系统的治疗方法。

23. 发明申请

US20100260846A1 PARTICLES FOR DELIVERY OF NUCLEIC ACIDS AND RELATED DEVICES AND METHODS 有权
标题翻译：用于递送核酸的颗粒和相关设备和方法
公开(公告)号：US20100260846A1
公开(公告)日：2010-10-14
申请号：US12756632
申请日：2010-04-08
申请人： Joseph Schmidt McGonigle , Joram Slager
发明人： Joseph Schmidt McGonigle , Joram Slager
IPC分类号： A61K9/14 , A61K31/7088 , A61K47/48 , B05D7/00
CPC分类号： A61K9/1641 , A61K9/0024 , A61K9/1647 , A61K9/5084 , A61K48/0041 , A61L17/005 , A61L17/12 , A61L27/48 , A61L27/54 , A61L29/126 , A61L29/148 , A61L31/129 , A61L31/16 , A61L2300/258 , A61L2300/62 , C12N15/89 , C08L67/04
摘要： Embodiments of the invention include devices and methods for the release of nucleic acid complexes. In an embodiment the invention includes a nucleic acid delivery particle. The delivery particle can include a polymeric matrix including a polyethyleneglycol containing copolymer and a nucleic acid complex disposed within the polymeric matrix. The nucleic acid complex can include a nucleic acid and a carrier agent. In an embodiment the invention includes a medical device including a first polymeric matrix comprising a first polymer and a plurality of nucleic acid delivery particles disposed within the first polymeric matrix. The medical device can be configured to release the nucleic acid complex when the medical device is implanted within a subject. Other embodiments are included herein.
摘要翻译：本发明的实施方案包括用于释放核酸复合物的装置和方法。在一个实施方案中，本发明包括核酸递送颗粒。递送颗粒可以包括聚合物基质，其包含含聚乙二醇的共聚物和设置在聚合物基质内的核酸复合物。核酸复合物可以包括核酸和载体试剂。在一个实施方案中，本发明包括医疗装置，其包括第一聚合物基质，其包含第一聚合物和设置在第一聚合物基质内的多个核酸递送颗粒。医疗装置可被配置为当将医疗装置植入受试者内时释放核酸复合物。本文还包括其它实施例。

24. 发明授权

US08883208B2 Particles for delivery of nucleic acids and related devices and methods 有权
标题翻译：用于递送核酸的颗粒和相关设备和方法
公开(公告)号：US08883208B2
公开(公告)日：2014-11-11
申请号：US12756632
申请日：2010-04-08
申请人： Joseph Schmidt McGonigle , Joram Slager
发明人： Joseph Schmidt McGonigle , Joram Slager
IPC分类号： A61L27/48 , A61K9/50 , A61L17/00 , A61L29/12 , C12N15/89 , A61K9/16 , A61K48/00 , A61L31/12 , A61L17/12 , A61L27/54 , A61L31/16 , A61L29/14 , A61K9/00
CPC分类号： A61K9/1641 , A61K9/0024 , A61K9/1647 , A61K9/5084 , A61K48/0041 , A61L17/005 , A61L17/12 , A61L27/48 , A61L27/54 , A61L29/126 , A61L29/148 , A61L31/129 , A61L31/16 , A61L2300/258 , A61L2300/62 , C12N15/89 , C08L67/04
摘要： Embodiments of the invention include devices and methods for the release of nucleic acid complexes. In an embodiment the invention includes a nucleic acid delivery particle. The delivery particle can include a polymeric matrix including a polyethyleneglycol containing copolymer and a nucleic acid complex disposed within the polymeric matrix. The nucleic acid complex can include a nucleic acid and a carrier agent. In an embodiment the invention includes a medical device including a first polymeric matrix comprising a first polymer and a plurality of nucleic acid delivery particles disposed within the first polymeric matrix. The medical device can be configured to release the nucleic acid complex when the medical device is implanted within a subject. Other embodiments are included herein.
摘要翻译：本发明的实施方案包括用于释放核酸复合物的装置和方法。在一个实施方案中，本发明包括核酸递送颗粒。递送颗粒可以包括聚合物基质，其包含含聚乙二醇的共聚物和设置在聚合物基质内的核酸复合物。核酸复合物可以包括核酸和载体试剂。在一个实施方案中，本发明包括医疗装置，其包括第一聚合物基质，其包含第一聚合物和设置在第一聚合物基质内的多个核酸递送颗粒。医疗装置可被配置为当将医疗装置植入受试者内时释放核酸复合物。本文还包括其它实施例。

25. 发明授权

US08697105B2 Injectable drug delivery formulation 失效
标题翻译：注射药物递送配方
公开(公告)号：US08697105B2
公开(公告)日：2014-04-15
申请号：US13074212
申请日：2011-03-29
申请人： Joram Slager
发明人： Joram Slager
IPC分类号： A61F13/00 , A61K9/00 , A61K38/00 , A61K31/7088 , A61K47/30 , A61K47/36 , A61P27/06 , A61P27/12
CPC分类号： A61K9/0024 , A61F9/00 , A61K9/0051 , A61K9/06 , A61K47/36 , C08B30/18 , C08B31/006 , C08J3/075 , C08J2305/00
摘要： The invention provides an injectable formulation that includes an active agent; a biocompatible solvent system, crosslinkable polymers such as polysaccharides; and crosslinking agents; wherein the formulation is substantially free of water. The invention also provides a drug delivery depot formed from the injectable formulation wherein the polymers crosslink in the presence of water in the body of a patient, or in the air, prior to implantation in the patient. Also provided are methods of treatment using such formulations and drug delivery systems.
摘要翻译：本发明提供了包含活性剂的可注射制剂; 生物相容性溶剂体系，可交联聚合物如多糖; 和交联剂; 其中所述制剂基本上不含水。本发明还提供由可注射制剂形成的药物递送贮库，其中在植入患者之前，聚合物在患者身体或空气中的水存在下交联。还提供了使用这种制剂和药物递送系统的治疗方法。

26. 发明申请

US20110229457A1 INJECTABLE DRUG DELIVERY SYSTEM 审中-公开
标题翻译：注射药物输送系统
公开(公告)号：US20110229457A1
公开(公告)日：2011-09-22
申请号：US13046547
申请日：2011-03-11
申请人： Timothy M. Kloke , Joram Slager , Laxma Gundlapally Reddy , David E. Babcock
发明人： Timothy M. Kloke , Joram Slager , Laxma Gundlapally Reddy , David E. Babcock
IPC分类号： A61K39/395 , A61K47/36 , A61K38/02 , A61K38/43 , A61K31/713 , A61P25/28 , A61P25/16 , A61P25/00 , A61P27/02 , A61P27/06 , A61P31/20 , A61P31/14 , A61P19/02 , A61K31/7088 , A61K31/7052
CPC分类号： A61K9/0024 , A61K9/0051 , A61K47/10 , A61K47/14 , A61K47/36 , A61K47/40 , C07K16/00 , C07K2317/55
摘要： The invention provides a formulation that includes a biocompatible solvent system, a biodegradable polymer that is substantially soluble in the biocompatible solvent system, and an active pharmaceutical ingredient that is substantially insoluble in the biocompatible solvent system. The formulation can form a drug-eluting implant, when injected into mammalian tissue. The solvent system and the biodegradable polymer can be selected so that the implant provides extended, delayed, controlled and/or modified release of the active pharmaceutical ingredient, for example, over the course of days, weeks or months.
摘要翻译：本发明提供了一种制剂，其包括生物相容性溶剂体系，基本上可溶于生物相容性溶剂体系的可生物降解聚合物，以及基本上不溶于生物相容性溶剂体系的活性药物成分。当注射到哺乳动物组织中时，制剂可以形成药物洗脱植入物。可以选择溶剂体系和可生物降解的聚合物，使得植入物提供活性药物成分的延长，延迟，受控和/或修饰释放，例如在数天，数周或数月的过程中。

27. 发明授权

US08936811B2 Device coated with glycogen particles comprising nucleic acid complexes 有权
标题翻译：涂覆有包含核酸复合物的糖原颗粒的装置
公开(公告)号：US08936811B2
公开(公告)日：2015-01-20
申请号：US12437287
申请日：2009-05-07
申请人： Joram Slager , Joseph Schmidt McGonigle
发明人： Joram Slager , Joseph Schmidt McGonigle
IPC分类号： A61K9/14 , A61K31/7052 , A61P43/00
CPC分类号： A61K9/1641 , A61K9/0024 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K47/543 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/6921 , A61K47/6923 , A61K47/6957 , A61K48/00 , C12N15/87
摘要： Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the invention can include an implantable medical device including a substrate, an elution control matrix disposed on the substrate; a plurality of particles disposed within the elution control matrix, and a plurality of nucleic acid complexes disposed within the particles, the nucleic acid complexes comprising a nucleic acid and a cationic carrier agent. Other embodiments are included herein.
摘要翻译：本发明的实施方案包括具有核酸复合物的颗粒，包括相同方法的医疗装置。在一个实施例中，本发明可以包括制造医疗装置的方法。该方法可以包括使核酸与阳离子载体接触以形成核酸复合物，将核酸复合物吸附到多孔颗粒上以形成含有核酸复合物的颗粒，将含有核酸复合物的颗粒与聚合物溶液混合以形成涂层混合物，并将涂覆混合物施加到基底上。在一个实施方案中，该方法可以包括使核酸与阳离子载体试剂接触以形成核酸复合物，将核酸复合物与材料组合以形成原位含有颗粒的核酸复合物，将核酸复合物颗粒与聚合物溶液混合形成涂料混合物，并将涂料混合物施加到基材上。在一个实施例中，本发明可以包括可植入医疗装置，其包括基底，设置在基底上的洗脱控制矩阵; 布置在洗脱控制基质内的多个颗粒，以及设置在颗粒内的多个核酸复合物，所述核酸复合物包含核酸和阳离子载体试剂。本文还包括其它实施例。

28. 发明授权

US08246576B2 Method and apparatus for delivery of a therapeutic agent with an expandable medical device 有权
标题翻译：用于用可扩张医疗装置递送治疗剂的方法和装置
公开(公告)号：US08246576B2
公开(公告)日：2012-08-21
申请号：US12774954
申请日：2010-05-06
申请人： Joram Slager
发明人： Joram Slager
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61M25/10 , A61B17/12022 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/00893 , A61F2/82 , A61F2250/0067 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/622 , A61M29/02 , A61M2025/105
摘要： Described herein is a medical device that has a collapsed configuration and an expanded configuration wherein one or more polymeric network layers are applied to the substrate and microparticles embedded in the polymeric network. The polymeric network layer or layers is/are configured to retain the microparticles when the device is in a collapsed configuration and to release the microparticles when the device is in an expanded configuration. Methods for delivering a therapeutic agent using the device and making the device are also disclosed.
摘要翻译：本文描述的是具有折叠构型和扩展构型的医疗装置，其中将一个或多个聚合物网络层施加到基底和嵌入聚合物网络中的微粒。聚合物网络层被配置为当装置处于折叠构型时保持微粒，并且当装置处于扩张构型时释放微粒。还公开了使用该装置递送治疗剂并制备该装置的方法。

29. 发明申请

US20110159098A1 STABILIZATION AND DELIVERY OF NUCLEIC ACID COMPLEXES 审中-公开
标题翻译：稳定和交付核酸复合物
公开(公告)号：US20110159098A1
公开(公告)日：2011-06-30
申请号：US12968365
申请日：2010-12-15
申请人： Joram Slager
发明人： Joram Slager
IPC分类号： A61K31/713 , A61K39/395 , A61K9/00 , A61K47/48 , A61P9/00 , A61P27/02 , A61P15/00 , A61P11/00 , A61P25/00 , C12N5/071
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/127 , A61K9/146 , C07K16/00 , C07K2317/55 , C12N15/111 , C12N15/87 , C12N2320/32
摘要： Compositions and methods for delivering nucleic acid, including siRNA, to a target cell are provided. In one embodiment, the composition includes the nucleic acid and a stabilizing protein. In another embodiment, the nucleic acid is complexed with a carrier, for example, a peptide carrier. In yet another embodiment, the nucleic acid combined with a protein which is cross-linked to form a proteinaceous controlled release matrix. Methods for making the compositions are also described.
摘要翻译：提供了将核酸（包括siRNA）递送至靶细胞的组合物和方法。在一个实施方案中，组合物包括核酸和稳定蛋白。在另一个实施方案中，核酸与载体例如肽载体复合。在另一个实施方案中，核酸与交联的蛋白质组合以形成蛋白质控制释放基质。还描述了制备组合物的方法。

30. 发明申请

US20100260850A1 Controlled Release Devices and Methods for Delivery of Nucleic Acids 审中-公开
标题翻译：用于递送核酸的控制释放装置和方法
公开(公告)号：US20100260850A1
公开(公告)日：2010-10-14
申请号：US12756493
申请日：2010-04-08
申请人： Joram Slager
发明人： Joram Slager
IPC分类号： A61K9/14 , A61K9/00 , A61K31/7088 , A61P43/00 , A61K31/7105
CPC分类号： A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/7007 , A61K47/6455 , A61K48/0041 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： Embodiments of the invention include devices and methods for the delivery of nucleic acids. In an embodiment the invention includes a controlled release device including a polymeric matrix and a nucleic acid delivery construct disposed within the polymeric matrix. The nucleic acid delivery construct can include a nucleic acid molecule and a peptide molecule. The nucleic acid delivery construct can be configured to exhibit elution properties of a peptide from the polymeric matrix. The polymeric matrix can be configured to elute the nucleic acid delivery construct. Other embodiments are included herein.
摘要翻译：本发明的实施方案包括用于递送核酸的装置和方法。在一个实施方案中，本发明包括包含聚合物基质和设置在聚合物基质内的核酸递送构建体的控制释放装置。核酸递送构建体可以包括核酸分子和肽分子。核酸递送构建体可以被配置为显示来自聚合物基质的肽的洗脱性质。聚合物基质可以被配置为洗脱核酸递送构建体。本文还包括其它实施例。

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