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21. 发明申请

US20070129573A1 Process for the synthesis of eneamide derivatives 有权
标题翻译：合成烯酰胺衍生物的方法
公开(公告)号：US20070129573A1
公开(公告)日：2007-06-07
申请号：US10583902
申请日：2004-12-22
申请人： Alain Burgos , Blandine Bertrand , Sonia Roussiasse , Jean-Francois Pluvie , Sylvie Blanchet , Juliette Martin , Florence Perrin , Francoise Bourdeau
发明人： Alain Burgos , Blandine Bertrand , Sonia Roussiasse , Jean-Francois Pluvie , Sylvie Blanchet , Juliette Martin , Florence Perrin , Francoise Bourdeau
IPC分类号： C07C233/06
CPC分类号： C07C231/10 , C07C233/06 , C07C2602/08 , C07C2602/10
摘要： A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, which comprise: a hydrogenation/isomerization reaction in presence of a heterogeneous catalyst, of an oxime derivatives of formula (II) where R1, R2 and R3 are as defined above with an acyl derivative of formula (III) (R4CO)mX wherein R4, m and X are as defined above.
摘要翻译：制备由式（I）表示的烯 - 酰胺衍生物的方法，其中R 1和R 2和R 3独立地为氢原子，烷基，环烷基，环烷基烷基，烷基芳基，芳基，杂环，氰基，烷氧基，芳氧基，羧基，氨基甲酰基，-CONR 5 R 6（其中R 5和R 6独立地为所述被取代的环的烷基，芳基烷基或芳基被取代或不被官能团取代或与R5）或-COOR5基团其中R5是烷基，烷基芳基或芳基），所述烷基，环烷基，环烷基烷基，烷基芳基和芳基被官能团取代或不与R5取代; 或R 1和R 2一起形成环（该术语包括单环，二和更高多环系统）; R4是氢原子，烷基，芳基，烷基芳基，所述基团被卤素原子取代或不与Cl，Br或F取代; X是氧原子或离去基团，m是整数1或2; 当m为1时，X为离去基团; 当m为2时，X为氧原子，其包括：在非均相催化剂存在下的式（II）的肟衍生物，其中R 1，R 2和R 3如上所定义的肟衍生物与氢化/异构化反应，其中酰基衍生物为式（III）（R4CO）m X其中R4，m和X如上定义。

22. 发明申请

US20070055068A1 Method for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes which are used in asymmetric reduction reactions 失效
标题翻译：用于不对称还原反应的由恶唑硼烷 - 硼烷络合物衍生的手性化合物的原位制备方法
公开(公告)号：US20070055068A1
公开(公告)日：2007-03-08
申请号：US10574871
申请日：2004-10-11
申请人： Alain Burgos , Blandine Bertrand , Stephane Frein , Jean-Francois Pluvie , Sonia Roussiasse
发明人： Alain Burgos , Blandine Bertrand , Stephane Frein , Jean-Francois Pluvie , Sonia Roussiasse
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , C07F5/022
摘要： A process for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes, wherein a metal borohydride, a Lewis base and an inorganic acid ester are brought together and an optically active amino alcohol and optionally a halide are then added. The compound obtained is a complex that is useful as a catalyst in asymmetric reduction reactions. The reaction is performed by adding the substance to be reduced, particularly prochiral ketones or ether oximes, in order to synthesize chiral alcohols or chiral amines.
摘要翻译：原位制备衍生自恶唑硼烷 - 硼烷络合物的手性化合物的方法，其中将金属硼氢化物，路易斯碱和无机酸酯引入到一起，然后加入光学活性氨基醇和任选的卤化物。获得的化合物是可用作不对称还原反应中的催化剂的络合物。通过加入待还原物质，特别是前手性酮或醚肟进行反应，以合成手性醇或手性胺。

23. 发明申请

US20060149058A1 Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates 失效
标题翻译： 2-（2-芳基吗啉-2-基）乙醇衍生物和中间体的制备
公开(公告)号：US20060149058A1
公开(公告)日：2006-07-06
申请号：US11370399
申请日：2006-03-08
申请人： Alain Aulombard , Francoise Bernon , Sabrina Bonnefoy , Alain Burgos , Claude Cabos , Erice Lucas
发明人： Alain Aulombard , Francoise Bernon , Sabrina Bonnefoy , Alain Burgos , Claude Cabos , Erice Lucas
IPC分类号： C07D265/30
CPC分类号： C07D265/30 , C07B2200/07 , C07C33/483 , C07C45/46 , C07C45/562 , C07C215/30 , C07C225/16 , C07D303/08 , C07D487/04 , C07C49/80 , C07C47/273
摘要： The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor.
摘要翻译：本发明涉及制备本文所述的取代的2-乙烯基-2-芳基吗啉衍生物的方法。本发明还涉及2-乙烯基-2-芳基吗啉衍生物及其中间体。

24. 发明授权

US07038044B1 Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates 失效
标题翻译：制备2-（2-芳基吗啉-2-基）乙醇衍生物和中间体的方法
公开(公告)号：US07038044B1
公开(公告)日：2006-05-02
申请号：US10030600
申请日：2000-07-07
申请人： Alain Aulombard , Françoise Bernon , Sabrina Bonnefoy , Alain Burgos , Claude Cabos , Eric Lucas
发明人： Alain Aulombard , Françoise Bernon , Sabrina Bonnefoy , Alain Burgos , Claude Cabos , Eric Lucas
IPC分类号： C07D265/30
CPC分类号： C07D265/30 , C07B2200/07 , C07C33/483 , C07C45/46 , C07C45/562 , C07C215/30 , C07C225/16 , C07D303/08 , C07D487/04 , C07C49/80 , C07C47/273
摘要： The invention relates to a process for the preparation of substituted 2-(2-arylmorpholin-2-yl)ethanol derivatives.
摘要翻译：本发明涉及制备取代的2-（2-芳基吗啉-2-基）乙醇衍生物的方法。

25. 发明授权

US06953852B2 Preparation of 3-amino-1,2,4-benzotriazine dioxide 失效
公开(公告)号：US06953852B2
公开(公告)日：2005-10-11
申请号：US10494728
申请日：2002-11-08
申请人： Alain Burgos
发明人： Alain Burgos
IPC分类号： C07D253/08 , C07D253/10 , C07D253/065 , C07D271/08
CPC分类号： C07D253/10
摘要： Industrially applicable process for preparing 3-amino-1,2,4-benzotriazine 1,4-dioxide.

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