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21. 发明申请

US20070071807A1 CAPSULE-TYPE DRUG-RELEASING DEVICE AND CAPSULE-TYPE DRUG-RELEASING DEVICE SYSTEM 审中-公开
标题翻译：胶囊型药物释放装置和胶囊型药物释放装置系统
公开(公告)号：US20070071807A1
公开(公告)日：2007-03-29
申请号：US11536194
申请日：2006-09-28
申请人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
发明人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
IPC分类号： A61N1/00 , A61K9/48
CPC分类号： A61K9/0009 , A61K9/0097 , A61K9/48
摘要： A capsule-type drug-releasing device is capable of freely controlling the release and stoppage of a drug and causing neither the back flow of contents of a stomach, an intestine, or the like nor clogging with the contents. A capsule-type drug-releasing device may include: a capsule-shaped casing; a cation exchange membrane arranged on the surface of the casing; a drug solution holding portion arranged inside the casing and on the inner side of the cation exchange membrane; an anion exchange membrane arranged on the inner side of the drug solution holding portion; an electrolyte solution holding portion arranged on the inner side of the anion exchange membrane; an electrode arranged on the inner side of the electrolyte solution holding portion; an electric power source connected to the electrode; a control portion capable of controlling energization from the electric power source to the electrode; and a transceiver portion causing the control portion to receive a signal from the outside of an organism.
摘要翻译：胶囊型药物释放装置能够自由地控制药物的释放和停止，并且不会引起胃，肠等的内容物的反流，也不会堵塞内容物。胶囊型药物释放装置可以包括：胶囊型壳体; 设置在所述壳体的表面上的阳离子交换膜; 药液保持部，其配置在所述壳体内部和所述阳离子交换膜的内侧; 阴离子交换膜，其设置在药液保持部的内侧; 设置在阴离子交换膜的内侧的电解液保持部，设置在所述电解液保持部的内侧的电极; 连接到电极的电源; 控制部，其能够控制从所述电源向所述电极的通电; 以及使得所述控制部分从生物体的外部接收信号的收发器部分。

22. 发明申请

US20070048362A1 General purpose electrolyte solution composition for iontophoresis 审中-公开
标题翻译：用于离子电渗疗法的通用电解质溶液组合物
公开(公告)号：US20070048362A1
公开(公告)日：2007-03-01
申请号：US11512756
申请日：2006-08-29
申请人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30 , A61F13/00
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/325
摘要： A single electrolyte solution composition may be used in an anode side and in a cathode side of an iontophoresis device. The electrolyte solution may include a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, both a component that is likely to be relatively reduced and a component that is likely to be relatively oxidized.
摘要翻译：单个电解质溶液组合物可用于离子电渗装置的阳极侧和阴极侧。电解质溶液可以包括具有低于水的氧化还原电位的化合物，所述化合物组合包括可能相对减少的组分和可能相对氧化的组分。

23. 发明申请

US20100030128A1 IONTOPHORESIS DEVICE 审中-公开
标题翻译： IONTOPHORESIS设备
公开(公告)号：US20100030128A1
公开(公告)日：2010-02-04
申请号：US12065851
申请日：2006-09-01
申请人： Kazuma Mitsuguchi , Mitsugu Yamauchi , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Kazuma Mitsuguchi , Mitsugu Yamauchi , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/303
摘要： The transport efficiency of a drug using an iontophoresis device is increased using a negative pressure device.The iontophoresis device includes a working electrode assembly and a non-working electrode assembly for administering drug by iontophoresis. Each of the working electrode assembly and the non-working electrode assembly includes an adhesive surface configured to adhere to a biological interface. A DC electric power source is connected to the working electrode assembly and the non-working electrode assembly. The iontophoresis device further includes a negative pressure device integral with at least one of the working electrode assembly and the non-working electrode assembly and configured to maintain a negative pressure between the at least one of the working electrode assembly and the non-working electrode assembly and the biological interface.
摘要翻译：使用离子渗透装置的药物的输送效率使用负压装置增加。离子电渗装置包括工作电极组件和用于通过离子电渗疗法给药的非工作电极组件。工作电极组件和非工作电极组件中的每一个包括被配置为粘附到生物界面的粘合表面。直流电源连接到工作电极组件和非工作电极组件。离子电渗装置还包括与至少一个工作电极组件和非工作电极组件成一体的负压装置，并且构造成在工作电极组件和非工作电极组件中的至少一个之间保持负压和生物界面。

24. 发明申请

US20100016781A1 Iontophoresis device selecting drug to be administered on the basis of information form sensor 审中-公开
标题翻译：离子渗透装置选择基于信息形式传感器施用的药物
公开(公告)号：US20100016781A1
公开(公告)日：2010-01-21
申请号：US11991234
申请日：2006-08-29
申请人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61N1/0444 , A61N1/08
摘要： An iontophoresis device including an electric power source. A first electrode assembly is electrically coupled to the electric power source to transdermally administer an ionic drug to an organism via iontophoresis while a second electrode assembly is electrically coupled to the electric power source as a counter electrode to the first electrode assembly. A sensor may be positioned proximate an internal or external portion of the organism and operable to determine information used to select and deliver the ionic drug to the organism.
摘要翻译：一种离子电渗疗法装置，包括电源。第一电极组件电耦合到电源，以通过离子电渗将离子药物透皮施用于生物体，而第二电极组件作为与第一电极组件的对电极电耦合到电源。传感器可以定位在生物体的内部或外部附近，并且可操作以确定用于选择并将离子药物递送到生物体的信息。

25. 发明申请

US20090299264A1 Electrode Assembly for Dry Type Iontophoresis 审中-公开
标题翻译：干式离子导入电极组件
公开(公告)号：US20090299264A1
公开(公告)日：2009-12-03
申请号：US11992671
申请日：2006-09-28
申请人： Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura
发明人： Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0444
摘要： An iontophoresis device capable of stably holding a drug for a long time period and of transdermally administering the drug at a high transport number during use. The iontophoresis device includes a drug holding portion to store the ionic drug in a dry state and at least an aqueous medium holding portion to store an aqueous medium. The drug holding portion exhibiting ion conductivity in response to a needle inserted into the aqueous medium holding portion from outside the electrode assembly such that the drug holding portion is supplied with the aqueous medium during use and the ionic drug dissolves in the aqueous medium.
摘要翻译：一种能够长时间稳定地保持药物并且在使用期间以高转运数量经皮给药的离子电渗疗装置。离子电渗装置包括药物保持部分，用于将离子药物储存在干燥状态，并且至少含有水性介质保持部分以存储水性介质。药物保持部分响应于从电极组件外部插入到水性介质保持部分中的针而显示离子传导性，使得在使用期间向药物保持部分供给水性介质，并且离子药物溶解在水性介质中。

26. 发明申请

US20070135754A1 ELECTRODE ASSEMBLY FOR IONTOPHORESIS FOR ADMINISTERING ACTIVE AGENT ENCLOSED IN NANOPARTICLE AND IONTOPHORESIS DEVICE USING THE SAME 审中-公开
标题翻译：电极组件用于管理用纳米颗粒和非离子表面活性剂包封的活性剂的静电放电
公开(公告)号：US20070135754A1
公开(公告)日：2007-06-14
申请号：US11537459
申请日：2006-09-29
申请人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
发明人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044 , A61N1/0444
摘要： An electrode assembly for iontophoresis may enable the administration of a non-ionic active agent ionized, or an active agent that is substantially insoluble in water, by iontophoresis. An electrode assembly used for iontophoresis may hold an active agent enclosed in an ionic nanoparticle.
摘要翻译：用于离子电渗疗法的电极组件可以通过离子电渗法施用电离的非离子活性剂或基本上不溶于水的活性剂。用于离子电渗疗法的电极组件可以包含封闭在离子纳米颗粒中的活性剂。

27. 发明授权

US07890164B2 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US07890164B2
公开(公告)日：2011-02-15
申请号：US11522095
申请日：2006-09-14
申请人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
发明人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0606 , A61N2005/063 , A61N2005/0644 , A61N2005/0651
摘要： An shaped iontophoresis device is capable of permeating an active agent (e.g., a drug solution) into an oral cavity, a skin cancer, or the like by iontophoresis in a pinpoint manner. A catheter-type iontophoresis device includes a small working electrode assembly and a small non-working electrode assembly at the tip of a holding portion. A first ion exchange membrane and a fourth ion exchange membrane at the tips of the assemblies are brought into close contact with a target area so that a drug solution is permeated by iontophoresis in a pinpoint manner. The working electrode assembly and the non-working electrode assembly are attached to the tip of a rod-shaped member. The rod-shaped member is detachable from the tip of the holding portion, and is exchangeable integrally with the portion. The iontophoresis device may advantageously take the form of a rod or catheter.
摘要翻译：成形的离子电渗装置能够以精确的方式通过离子电渗法将活性剂（例如药物溶液）渗透到口腔，皮肤癌等中。导管型离子电渗疗法装置包括小型工作电极组件和在保持部分的尖端处的小型非工作电极组件。在组件顶端的第一离子交换膜和第四离子交换膜与目标区域紧密接触，使得药液以精确的方式通过离子电渗渗透。工作电极组件和非工作电极组件附接到杆状构件的末端。杆状构件可从保持部的顶端拆卸，并且与该部分一体地更换。离子电渗装置可以有利地采取棒或导管的形式。

28. 发明申请

US20070066932A1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US20070066932A1
公开(公告)日：2007-03-22
申请号：US11522095
申请日：2006-09-14
申请人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
发明人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0606 , A61N2005/063 , A61N2005/0644 , A61N2005/0651
摘要： An shaped iontophoresis device is capable of permeating an active agent (e.g., a drug solution) into an oral cavity, a skin cancer, or the like by iontophoresis in a pinpoint manner. A catheter-type iontophoresis device includes a small working electrode assembly and a small non-working electrode assembly at the tip of a holding portion. A first ion exchange membrane and a fourth ion exchange membrane at the tips of the assemblies are brought into close contact with a target area so that a drug solution is permeated by iontophoresis in a pinpoint manner. The working electrode assembly and the non-working electrode assembly 14 are attached to the tip of a rod-shaped member. The rod-shaped member is detachable from the tip of the holding portion, and is exchangeable integrally with the portion. The iontophoresis device may advantageously take the form of a rod or catheter.
摘要翻译：成形的离子电渗装置能够以精确的方式通过离子电渗法将活性剂（例如药物溶液）渗透到口腔，皮肤癌等中。导管型离子电渗疗法装置包括小型工作电极组件和在保持部分的尖端处的小型非工作电极组件。在组件顶端的第一离子交换膜和第四离子交换膜与目标区域紧密接触，使得药液以精确的方式通过离子电渗渗透。工作电极组件和非工作电极组件14附接到杆状构件的尖端。杆状构件可从保持部的顶端拆卸，并且与该部分一体地更换。离子电渗装置可以有利地采取棒或导管的形式。

29. 发明申请

US20060116628A1 Iontophoresis device 审中-公开
标题翻译：离子渗透装置
公开(公告)号：US20060116628A1
公开(公告)日：2006-06-01
申请号：US11172058
申请日：2005-06-30
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0436 , A61N1/0448
摘要： An iontophoresis device is capable of suppressing the change in a composition of a drug solution and/or an electrolyte solution of a working electrode structure, thereby allowing the working electrode structure to be retained in a stable state for a long period of time. The iontophoresis device includes: an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity is dissolved; and a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved. A first ion-exchange membrane for selectively passing the ions of the second polarity and a porous separation membrane for blocking passage of molecules and ions each having a molecular weight exceeding a threshold are placed between the electrolyte solution holding part and the drug solution holding part.
摘要翻译：离子电渗疗法装置能够抑制药液和/或工作电极结构体的电解质溶液的组成变化，从而使工作电极结构长期保持在稳定状态。离子电渗装置包括：电解液保持部，其用于保持电解质溶液，其中溶解有解离的电解质溶解于第一极性的第一电解质离子和第二极性的第二电解质离子; 并且溶解有溶液中解离药物的第一极性的药物离子和第二极性的药物抗衡离子的药液的药物溶液保持部溶解。用于选择性地通过第二极性的离子的第一离子交换膜和用于阻止分子量超过阈值的分子和离子通过的多孔分离膜被放置在电解质溶液保持部和药物溶液保持部之间。

30. 发明申请

US20060095001A1 Electrode and iontophoresis device 审中-公开
标题翻译：电极和离子电渗装置
公开(公告)号：US20060095001A1
公开(公告)日：2006-05-04
申请号：US11171953
申请日：2005-06-30
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/048 , A61N1/0492
摘要： There are provided an electrode that is capable of allowing a current to flow at a uniform current density from the entire surface of a conductive sheet during the passage of a current and that solves the problem of the transfer of metal ions to a living body. The electrode comprises a conductive terminal member formed of a non-metal material; and a conductive sheet formed of a non-metal material and attached to the terminal member, the conductive sheet having a specific resistance lower than a specific resistance of the terminal member. An lontophoresis device and a low-frequency treatment device utilizing the electrode is also disclosed.
摘要翻译：提供了一种电极，其能够在电流通过期间允许电流以均匀的电流密度从导电片的整个表面流动，并且解决了金属离子转移到生物体的问题。电极包括由非金属材料形成的导电端子构件; 以及由非金属材料形成并附接到端子构件的导电片，所述导电片具有比端子构件的电阻率低的电阻率。还公开了一种使用电极的离子电泳装置和低频处理装置。

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