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22. 发明专利

ES2324871T3 1H-PIRROLO(3,2-B, 3,2-C, Y 2,3-C)PIRIDINA-2-CARBOXAMIDAS SUSTITUIDAS Y ANALOGOS RELACIONADOS COMO INHIBIDORES DE CASEINA QUINASA I EPSILON. 未知
公开(公告)号：ES2324871T3
公开(公告)日：2009-08-18
申请号：ES04812567
申请日：2004-12-01
申请人： AVENTIS PHARMA INC
发明人： METZ WILLIAM A , HALLEY FRANK , DUTRUC-ROSSET GILLES , CHOI-SLEDESKI YONG MI , POLI GREGORY B , FINK DAVID M
IPC分类号： C07D471/04 , A61K31/437
摘要： Un compuesto de fórmula (I)** ver fórmula** en la que: R1 es H o alquilo C1-6; R2 es NR5R6; R3 es un arilo que es un anillo de carbonos monocíclico, bicíclico o tricíclico de hasta 7 miembros en cada anillo, y en el que al menos un anillo es aromático, estando dicho arilo opcionalmente sustituido con 1 a 3 sustituyentes seleccionados del grupo que consiste en metilendioxi, hidroxi, alcoxi C 1-6, halógeno, alquilo C 1-6, alquenilo C 2-6, alquinilo C 2-6, trifluorometilo, trifluorometoxi, -NO 2, -NH 2, -NH(alquilo C 1-6), -N(alquilo C 1-6) 2, -NH-acilo y -N(alquil C 1-6) acilo, siendo dicho grupo acilo un grupo hidrocarburo alifático saturado que tiene de 1 a 6 átomos de carbono, unido a un resto carbonilo; un heterociclo monocíclico C5-7 o un heterociclo bicíclico C8-11, teniendo dicho heterociclo de 1 a 3 heteroátomos seleccionados del grupo que consiste en N, O y S, y estando dicho heterociclo opcionalmente sustituido con 1 a 3 sustituyentes seleccionados del grupo que consiste en alcoxi C 1-6, hidroxi, halógeno, alquilo C 1-6, alquenilo C 2-6, alquinilo C 2-6, trifluorometilo, trifluorometoxi, -NO 2, -NH 2, -NH(alquilo C 1-6), -N(alquilo C 1-6) 2, -NH-acilo, y -N(alquil C1-6)acilo, siendo dicho grupo acilo un grupo hidrocarburo alifático saturado que tiene de 1 a 6 átomos de carbono unido a un resto carbonilo; R 4 es H, alquilo C 1-6, alquenilo C 2-6, alquinilo C 2-6, alcoxi C 1-6, CF 3, halógeno, SH, S-alquilo C 1-6, NO 2, NH 2 o NR5R6; R5 es H o alquilo C1-6; R 6 es H o alquilo C 1-6; X es S o S(O)n; uno de K, L o M es N y los otros dos miembros de K, L o M son cada uno C en los que R 4 está unido solo a un átomo K, L, M u otro átomo del anillo que sea C; m es 1, 2 ó 3; y n es 1 ó 2; o una de sus sales o estereoisómeros farmacéuticamente aceptable.

23. 发明专利

HK1098742A1 SUBSTITUTED 1H-PYRROLO [3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON 未知
公开(公告)号：HK1098742A1
公开(公告)日：2007-07-27
申请号：HK07105112
申请日：2007-05-15
申请人： AVENTIS PHARMA INC
发明人： METZ WILLIAM A , HALLEY FRANK , DUTRUC-ROSSET GILLES , CHOI-SLEDESKI YONG MI , POLI GREGORY B , FINK DAVID M , DOERFLINGER GILLES , HUANG BAO-GUO , GELORMINI ANN MARIE , GAMBOA JUAN A , GIOVANNI ANDREW , ROEHR JOACHIM E , TSAY JOSEPH T , CAMACHO FERNANDO , HURST WILLIAM J , HARNISH STEPHEN W , CHIANG YULIN
IPC分类号： A61K20090101 , A61K31/437 , C07D20090101 , C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase Iepsilon, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

24. 发明专利

ZA200309315B Pyrrolopyrimidines as protein kinase inhibitors. 未知
公开(公告)号：ZA200309315B
公开(公告)日：2004-09-27
申请号：ZA200309315
申请日：2003-11-28
申请人： AVENTIS PHARMA INC
发明人： COX PAUL JOSEPH , AMENDOLA SHELLEY , EDLIN CHRIS , HALLEY FRANK , BAUDOIN BERNARD , ALDOUS DAVID JOHN , MAJID TAHIR NADEEM , DEPRETS STEPHANIE DANIELE , PEDGRIFT BRIAN LESLIE , MCFARLANE EDWARDS MICHAEL MCLA
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101 , C07D , A61K , A61P

27. 发明专利

AU2002314325B2 Pyrrolopyrimidines as protein kinase inhibitors 未知
公开(公告)号：AU2002314325B2
公开(公告)日：2009-01-08
申请号：AU2002314325
申请日：2002-06-21
申请人： AVENTIS PHARMA INC
发明人： MAJID TAHIR NADEEM , PEDGRIFT BRIAN LESLIE , MCLAY LAIN MCFARLANE , BAUDOIN BERNARD , HALLEY FRANK , COX PAUL JOSEPH , EDWARDS MICHAEL , DEPRETS STEPHANIE DANIELE , ALDOUS DAVIS JOHN , AMENDOLA SHELLEY , EDLIN CHRIS
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00
摘要： This invention is directed to compounds of the formula (I) to N-oxides, prodrugs, acid bioisosteres, pharmaceutically acceptable salts or solvates of such compounds, or N-oxides, prodrugs, or acid bioisosteres of such salts or solvates, to compositions comprising such compounds, and to methods of treatment comprising administering, to a patient in need thereof, such compounds and compositions.

28. 发明专利

HU0400300A2 PYRROLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：HU0400300A2
公开(公告)日：2007-08-28
申请号：HU0400300
申请日：2002-06-21
申请人： AVENTIS PHARMA INC
发明人： COX PAUL JOSEPH , MAJID TAHIR NADEEM , AMENDOLA SHELLEY , DEPRETS STEPHANIE DANIELE , EDLIN CHRIS , PEDGRIFT BRIAN LESLIE , HALLEY FRANK , EDWARDS MICHAEL , BAUDOIN BERNARD , MCLAY LAIN , ALDOUS DAVIS JOHN
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00
摘要： This invention is directed to compounds of the formula (I) to N-oxides, prodrugs, acid bioisosteres, pharmaceutically acceptable salts or solvates of such compounds, or N-oxides, prodrugs, or acid bioisosteres of such salts or solvates, to compositions comprising such compounds, and to methods of treatment comprising administering, to a patient in need thereof, such compounds and compositions.

29. 发明专利

BRPI0417520A 未知
公开(公告)号：BRPI0417520A
公开(公告)日：2007-03-06
申请号：BRPI0417520
申请日：2004-12-01
申请人： AVENTIS PHARMA INC
发明人： METZ WILLIAM A , HALLEY FRANK , DUTRUC-ROSSET GILLES , CHOI-SLEDESKI YONG MI , POLI GREGORY B , FINK DAVID M , DOERFLINGER GILLES , HUANG BAO-GUO , GELORMINI ANN MARIE , GIOVANNI ANDREW , ROEHR JOACHIM E , TSAY JOSEPH T , CAMACHO FERNANDO , HURST WILLIAM J , HARNISH STEPHEN W , CHIANG YULIN
IPC分类号： A61K31/437 , C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase Iepsilon, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

30. 发明专利

TNSN03144A1 PYRROLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS 未知
公开(公告)号：TNSN03144A1
公开(公告)日：2005-12-23
申请号：TNSN03144
申请日：2002-06-21
申请人： AVENTIS PHARMA INC
发明人： MAJID TAHIR NADEEM , PEDGRIFT BRIAN LESLIE , HALLEY FRANK , EDWARDS MICHAEL , BAUDOIN BERNARD , ALDOUS DAVIS JOHN , COX PAUL JOSEPH , AMENDOLA SHELLEY , DEPRETS STEPHANIE DANIELE , EDLIN CHRIS , MCLAY LAIN MCFARLANE
IPC分类号： A61K31/505 , A61K31/519 , A61K31/5377 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D487/04
摘要： THIS INVENTION IS DIRECTED TO COMPOUNDS OF THE FORMULA (I) : TO N-OXIDES, PRODRUGS, ACID BIOISOSTERES, PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES OF SUCH COMPOUNDS, OR N-OXIDES, PRODRUGS, OR ACID BIOISOSTERES OF SUCH SALTS OR SOLVATES, TO COMPOSITIONS COMPRISING SUCH COMPOUNDS, AND TO METHODS OF TREATMENT COMPRISING ADMINISTERING, TO A PATIENT IN NEED THEREOF, SUCH COMPOUNDS AND COMPOSITIONS.

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