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21. 发明申请

WO2004037792A2 NOVEL NUCLEAR HORMONE RECEPTOR LIGANDS AND METHODS 审中-公开
标题翻译：新的核激素受体配体和方法
公开(公告)号：WO2004037792A2
公开(公告)日：2004-05-06
申请号：PCT/EP2003/010108
申请日：2003-09-10
申请人： KARO BIO AB , RUDA, Marcus , WENSBO, David
发明人： RUDA, Marcus , WENSBO, David
IPC分类号： C07D215/00
CPC分类号： C07D221/10
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as nuclear hormone receptor modulators. The compounds of the instant invention are ligands for nuclear hormone receptors and as such may be useful for treatment or prevention of a variety of conditions related to nuclear hormone functioning including proliferative diseases, cancers, benign prostate hyperplasia, adenomas and neoplasisms of the prostate, benign or malignant tumor cells containing the androgen receptor, cardiovascular diseases, angiogenic conditions or disorders, hirsutism, acne, hyperpilosity, inflammation, immune modulation, seborrhea, endometriosis, polycycstic ovary syndrome, androgen alopecia, hypogonadism, osteoporosis, suppressing spermatogenesis, libido, cachexia, anorexia, cancers expressing the estrogen receptor, prostate cancer, breast cancer, endometrial cancer, incontinence, hot flashes, vaginal dryness, menopause, contraception, pregnancy termination, cancers containing the progesterone receptor, endometriosis, cachexia, menopause fibrosis, labor induction, autoimmune diseases, impairment of cognitive functioning, cerebral degenerative disorders, Alzheimer's disease, psychotic disorders, type-II diabetes, congestive heart failure, disregulation of cholesterol or lipid homeostasis, and/or obesity.
摘要翻译：本发明涉及其化合物及其衍生物，其合成及其作为核激素受体调节剂的用途。本发明的化合物是核激素受体的配体，因此可用于治疗或预防与核激素功能相关的各种病症，包括增殖性疾病，癌症，良性前列腺增生，前列腺腺瘤和肿瘤，良性或含有雄激素受体的恶性肿瘤细胞，心血管疾病，血管生成病症或病症，多毛症，痤疮，高通气，炎症，免疫调节，脂溢性皮脂血症，子宫内膜异位症，多环性卵巢综合征，雄激素性脱发，性腺机能减退，骨质疏松症，抑制精子发生，性欲，恶病质，厌食症，表达雌激素受体的癌症，前列腺癌，乳腺癌，子宫内膜癌，失禁，潮热，阴道干燥，更年期，避孕，妊娠终止，含有孕酮受体的癌症，子宫内膜异位症，恶病质，绝经纤维化，劳动诱导，自身免疫性疾病，认知障碍老年痴呆症，精神障碍，II型糖尿病，充血性心力衰竭，胆固醇或脂质体内平衡失调和/或肥胖。

22. 发明公开

EP1529045A2 NEW COMPOUNDS 审中-公开
标题翻译： METABO谷氨酸异恶唑AS调节剂受体5
公开(公告)号：EP1529045A2
公开(公告)日：2005-05-11
申请号：EP03785036.9
申请日：2003-08-08
申请人： Astra Zeneca AB , NPS PHARMACEUTICALS, INC.
发明人： WENSBO, David , XIN, Tao , STEFANAC, Tomislav , ARORA, Jalaj , EDWARDS, Louise , ISAAC, Methvin , SLASSI, Abdelmalik , STORMANN, Thomas, M. , MCLEOD, Donald, A. , KERS, Annika , MALMBERG, Johan , OSCARSSON, Karin , GYBACK, Helena , JOHANSSON, Martin , MINIDIS, Alexander , WALDMAN, Magnus , YNGVE, Ulrika , OSTERWALL, Christoffer
IPC分类号： C07D413/12
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.

23. 发明申请

WO2009007420A1 NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES 审中-公开
标题翻译：新陈代谢ALPHA，不饱和度异喹啉
公开(公告)号：WO2009007420A1
公开(公告)日：2009-01-15
申请号：PCT/EP2008/059001
申请日：2008-07-10
申请人： Respiratorius AB , DALENCE, Maria , JOHANSSON, Martin , THORNQVIST OLTNER, Viveca , TOFTERED, Jörgen , WENSBO, David
发明人： DALENCE, Maria , JOHANSSON, Martin , THORNQVIST OLTNER, Viveca , TOFTERED, Jörgen , WENSBO, David
IPC分类号： C07D217/06 , C07D401/06 , A61P11/06 , A61P11/08 , A61K31/472 , A61K31/4725
CPC分类号： C07D401/06 , C07D217/06
摘要： The invention relates to novel compounds having the general formula (I), and which compounds are useful to manufacture a medicament to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma, and vasoconstriction, e.g. hypertension.
摘要翻译：本发明涉及具有通式（I）的新化合物，并且哪些化合物可用于制备治疗以支气管收缩为特征的病症或疾病的药物。 COPD和哮喘，以及血管收缩，例如。高血压。

24. 发明申请

WO2009007418A1 NOVEL BRONCHODILATING ISOQUINOLINE AMIDES 审中-公开
标题翻译：新型仲胺醇胺
公开(公告)号：WO2009007418A1
公开(公告)日：2009-01-15
申请号：PCT/EP2008/058991
申请日：2008-07-10
申请人： Respiratorius AB , DALENCE, Maria , JOHANSSON, Martin , THORNQVIST OLTNER, Viveca , TOFTERED, Jörgen , WENSBO, David
发明人： DALENCE, Maria , JOHANSSON, Martin , THORNQVIST OLTNER, Viveca , TOFTERED, Jörgen , WENSBO, David
IPC分类号： C07D217/06 , C07D401/06 , A61P11/06 , A61P11/08 , A61K31/4725
CPC分类号： C07D401/06
摘要： The invention relates to novel compounds having the general formula I, and which compounds are useful to manufacture a medicament to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma, and vasoconstriction, e.g. hypertension.
摘要翻译：本发明涉及具有通式I的新化合物，并且哪些化合物可用于制备治疗以支气管收缩为特征的病症或疾病的药物。 COPD和哮喘，以及血管收缩，例如。高血压。

25. 发明申请

WO2010097410A1 NOVEL BRONCHODILATING DIAZAHETEROARYLS 审中-公开
标题翻译：新浪微博DIAZAHETEROARYLS
公开(公告)号：WO2010097410A1
公开(公告)日：2010-09-02
申请号：PCT/EP2010/052343
申请日：2010-02-24
申请人： RESPIRATORIUS AB , JOHANSSON, Martin , THORNQVIST-OLTNER, Viveca , TOFTERED, Jörgen , WENSBO, David , DALENCE, Maria
发明人： JOHANSSON, Martin , THORNQVIST-OLTNER, Viveca , TOFTERED, Jörgen , WENSBO, David , DALENCE, Maria
IPC分类号： C07D471/04 , C07D519/00 , A61K31/4375 , A61P11/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The invention relates to novel compounds having the general formula (I), and which compounds are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma.
摘要翻译：本发明涉及具有通式（I）的新化合物，哪些化合物可用于治疗以支气管收缩为特征的疾病或疾病，例如， COPD和哮喘。

26. 发明授权

EP1723144B1 ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 有权
标题翻译：更多的多环化合物及其作为METABO谷氨酸受体的拮抗剂
公开(公告)号：EP1723144B1
公开(公告)日：2010-10-06
申请号：EP05802855.6
申请日：2005-02-15
申请人： AstraZeneca AB
发明人： EDWARDS, Louise , ISAAC, Methvin , JOHANSSON, Martin , KERS, Annika , MALMBERG, Johan , MCLEOD, Donald , MINIDIS, Alexander , STAAF, Karin , SLASSI, Abdelmalik , STEFANAC, Tomislav , STORMANN, Thomas , WENSBO, David , XIN, Tao , ARORA, Jalaj
IPC分类号： C07D413/12 , C07D413/14 , C07D487/04 , A61K31/519 , A61P25/28 , C07D413/06
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.

27. 发明公开

EP2121655A1 NOVEL 2-HETEROARYL SUBSTITUTED INDOLES 695 审中-公开
标题翻译：新的2-杂芳基取代的吲哚695
公开(公告)号：EP2121655A1
公开(公告)日：2009-11-25
申请号：EP08724189.9
申请日：2008-03-05
申请人： AstraZeneca AB
发明人： ARZEL, Erwan , SWAHN, Britt-Marie , WENSBO, David
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/497 , C07D403/04
CPC分类号： C07D401/04
摘要： The present invention relates to novel 2-heteroaryl substituted indole derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel 2-heteroaryl substituted indole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer?s disease therapeutic agents.

28. 发明公开

EP1981883A1 NOVEL HETEROARYL SUBSTITUTED BENZOTHIAZOLES 审中-公开
标题翻译：新杂 - 苯并噻唑
公开(公告)号：EP1981883A1
公开(公告)日：2008-10-22
申请号：EP07709290.6
申请日：2007-01-25
申请人： AstraZeneca AB
发明人： GRAVENFORS, Ylva , JONASSON, Catrin , MALMSTRÖM, Jonas , NORDVALL, Gunnar , PYRING, David , SLIVO, Can , SOHN, Daniel , STRÖM, Peter , WENSBO, David
IPC分类号： C07D417/04 , A61K31/4436 , A61K31/496 , A61P25/28 , C07D417/14 , C07D513/04
CPC分类号： C07D417/04 , C07B59/002 , C07D513/04
摘要： The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer's disease therapeutic agents.

29. 发明授权

EP2132201B1 NOVEL 2-HETEROARYL SUBSTITUTED BENZOTHIOPHENES AND BENZOFURANES 有权
标题翻译：新的2-杂芳基取代的苯并噻吩和苯并呋喃
公开(公告)号：EP2132201B1
公开(公告)日：2016-11-16
申请号：EP08724190.7
申请日：2008-03-05
申请人： AstraZeneca AB
发明人： ARZEL, Erwan , SWAHN, Britt-Marie , WENSBO, David
IPC分类号： C07D405/04 , A61K31/443 , A61K31/4436 , A61K31/501 , C07D409/04 , C07D471/04
CPC分类号： C07D405/04 , C07D409/04 , C07D471/04

30. 发明公开

EP2125800A1 NOVEL HETEROARYL SUBSTITUTED IMIDAZO Ý1,2 -A¨PYRIDINE DERIVATIVES 审中-公开
标题翻译：新型杂芳基取代咪唑并[1,2-A] -PYRIDINDERIVATE
公开(公告)号：EP2125800A1
公开(公告)日：2009-12-02
申请号：EP08705218.9
申请日：2008-01-21
申请人： AstraZeneca AB
发明人： VALLIN, Michaela , MALMSTRÖM, Jonas , PYRING, David , SLIVO, Can , WENSBO, David
IPC分类号： C07D471/04 , A61K31/437 , A61K51/00 , A61P25/28 , A61K101/00
CPC分类号： C07D471/04 , A61K49/10 , A61K51/041 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0463
摘要： The present invention relates to novel heteroaryl substituted imidazopyridine derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted imidazopyridine derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer's disease therapeutic agents.

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